Navigation Links
Examination of internal 'wiring' of yeast, worm, and fly reveals conserved circuits

First-of-its-kind analysis published in the Feb. 8 PNAS supports the concept of a basic wiring diagram for all eukaryotes.

Researchers in California, Israel, and Germany have compared three distantly related species ?baker's yeast, a worm, and the fruit fly ?and reported that protein "wiring" connections in one species are often conserved in all three. This first-of-its-kind analysis of three higher level organisms published in the February 8 issue of Proceedings of the National Academy of Sciences supports both the concept of a basic wiring diagram for all eukaryotic cells, and the idea that more selective pharmaceuticals could be designed to tweak the wiring plan of human cells to more effectively treat diseases while also generating fewer side-effects.

"We're basically now able to open the hood of yeast, worm, and fly cells and look at the protein interactions inside," said Trey Ideker, a bioengineering professor at the University of California, San Diego and one of the nine co-authors of the paper. "Ultimately, this type of wiring analysis will help us more fully explain how the diversity of life developed on the planet, and more practically, how a pathogen differs from its human host, or a diseased cell differs from it healthy counterpart at the most informative level of detail."

For centuries, systematic comparisons of animal, plant, and microbial species was based on painstaking measurements of anatomic features. Beginning in the late-1970s, DNA sequencing technology permitted biologists to identify the precise subunit sequence of every gene in the genomes of everything from malaria pathogens and mosquitoes to mouse and human. Databases of genomic information have been combined with databases that list the precise subunit sequence of proteins as well. Cross-species DNA and protein comparisons have become routine for all biologists with computerized search programs, the most popular of which is called BLAST.

The wiring analysis r
'"/>

Source:University of California - San Diego


Page: 1 2 3 4

Related biology news :

1. New GI technologies improve internal organ visualization
2. UCSD researchers discover internal compass of immune cell
3. Researchers create artificial enzyme that mimics the bodys internal engine
4. From a lowly yeast, researchers divine a clue to human disease
5. A bacterial genome reveals new targets to combat infectious disease
6. First real-time view of developing neurons reveals surprises, say Stanford researchers
7. NYU study reveals how brains immune system fights viral encephalitis
8. Study reveals new technique for fingerprinting environmental samples
9. Study reveals dramatic difference between breast cancers in US and Africa
10. UCSD research reveals mechanism involved with type of fatal epilepsy
11. Study reveals candidate targets for anti-retroviral therapeutics
Post Your Comments:
(Date:2/13/2015)... 2015 ACT Genomics Co., Ltd., a ... transform cancer genomic information into precision diagnosis and ... raised US$ 8 million in the its first private ... Taipei, Taiwan , ACT Genomics has developed ... aim to implement next generation sequencing (NGS) and ...
(Date:2/11/2015)... According to a ... Product (Cards and Readers, Biometrics, Controllers, Management Software), ... Healthcare, Education) and By Geography - Global Forecast and Analysis to ... Control Market is expected to reach $10.4 ... of 10.6% between 2014 and 2020. ...
(Date:2/5/2015)... North Carolina , 5. Februar 2015 ... Jahr als spezialisiertes Logistikunternehmen und hat eine ... einzige klinische Logistikfirma (Clinical Logistics Organization – ... der neuen Kampagne lautet First , ... Foto: http://photos.prnewswire.com/prnh/20150205/173753 ...
Breaking Biology News(10 mins):ACT Genomics Raises $8 Million in its First Private Funding Round 2Access Control Market Worth $10.4 Billion by 2020 2Access Control Market Worth $10.4 Billion by 2020 3Access Control Market Worth $10.4 Billion by 2020 4Marken startet Kampagne mit Patienten im Mittelpunkt 2Marken startet Kampagne mit Patienten im Mittelpunkt 3
... has been the inspiration for countless books and movies, ... engineers. Researchers at the California Institute of Technology (Caltech) ... intelligencenot in a robot or a silicon chip, but ... to have made an artificial neural network out of ...
... Mobile devices have become as common as the stethoscope in ... read test results, access diagnostic tools and take patient notes, ... smartphone or using a flash drive. These mobile devices are ... huge security risks to patient information. In less ...
... LOS ALAMOS, New Mexico, July 20, 2011Researchers at the ... Great Lakes Bioenergy Research Center have found a potential ... materials such as corn leaves and stalks, or switch ... Journal of the American Chemical Society , Los Alamos ...
Cached Biology News:Caltech researchers create the first artificial neural network out of DNA 2Caltech researchers create the first artificial neural network out of DNA 3Caltech researchers create the first artificial neural network out of DNA 4Mobile Devices Pose New Security Risks for Patients; Five Experts Share Insights on mHealth 2Mobile Devices Pose New Security Risks for Patients; Five Experts Share Insights on mHealth 3Mobile Devices Pose New Security Risks for Patients; Five Experts Share Insights on mHealth 4Mobile Devices Pose New Security Risks for Patients; Five Experts Share Insights on mHealth 5Researchers find potential key for unlocking biomass energy 2
(Date:3/2/2015)... Resilinc released online today its ... summarizes and analyzes nearly 700 unique supply chain notifications ... global event monitoring and alert reporting service. Supply chain ... period of the email service to receive early warnings ... impact revenue, market share, customer satisfaction, and shareholder value. ...
(Date:3/2/2015)... 2015  Pfenex Inc. (NYSE MKT: PFNX), a ... biosimilar therapeutics, today announced that it will be ... in Miami, FL at the Loews Miami Beach Hotel.  Dr. ... Pfenex, will provide an overview of the company,s ... ET. A live audio webcast and archive of ...
(Date:3/2/2015)... BARBARA, Calif. , March 2, 2015 /PRNewswire/ ... biotechnology company developing therapies for autoimmune and infectious ... Office (USPTO) has issued an important new composition ... system function through the targeting of CLIP. ... targeted peptide technology underlying VG Life Sciences, VG1177, ...
(Date:3/1/2015)... London, UK (PRWEB) March 01, 2015 ... a partnership agreement for quality market research promotion ... and sell research reports worked out by DataGroup ... Department at Market Publishers Ltd, commented on the ... to have DataGroup Booksellers in our team of ...
Breaking Biology Technology:Resilinc Publishes 2014 EventWatch™ Supply Chain Disruption Annual Report 2Resilinc Publishes 2014 EventWatch™ Supply Chain Disruption Annual Report 3VG Life Sciences Granted Key Composition Of Matter Patent 2VG Life Sciences Granted Key Composition Of Matter Patent 3Market Publishers Ltd and DataGroup Booksellers Sign Partnership Agreement 2Market Publishers Ltd and DataGroup Booksellers Sign Partnership Agreement 3
... AMEX: SNT ) announced that that Leslie J. ... DATE: December 1, 2011 TIME: 10:00 AM EST LINK: ... now" button. This will be a live, interactive ... questions in real-time both in the presentation hall as well ...
... Molecular Devices, LLC, the prominent source of powerful ... release of a much-anticipated customizable extension to its suite ... (Logo:  http://photos.prnewswire.com/prnh/20100406/SF82092LOGO ) Version ... the 51st annual meeting of the American Society for ...
... lead roles in a study that identified a portion ... embryonic stem cells (hESCs). The study was a worldwide ... of Sheffield (UK), Paul Robson of the Genome Institute ... Institute (BTI), and Barbara Knowles and others in the ...
Cached Biology Technology:Senesco Technologies, Inc. to Webcast, Live, at RetailInvestorConferences.com on December 1st 2Senesco Technologies, Inc. to Webcast, Live, at RetailInvestorConferences.com on December 1st 3Innovative MetaMorph® NX Software Shatters Barriers Between Researchers and Image Analysis Goals with Exclusive Visual Workflow 2Innovative MetaMorph® NX Software Shatters Barriers Between Researchers and Image Analysis Goals with Exclusive Visual Workflow 3Singapore scientists lead human embryonic stem cell study 2Singapore scientists lead human embryonic stem cell study 3
... PGE2 is one of several isoprostanes produced from ... potent renal vasoconstrictor in the rat. 8-iso PGE2 ... values of 0.5 and 5 µM, respectively. When ... at a concentration of 4 mg/kg/min, 8-iso PGE2 ...
... Source: Tritirachium album Description: Proteinase ... used in a wide range of applications purified ... bonds mainly following the carboxyl group of N-substituted ... and is classified as a serine protease. Proteinase ...
Proliferin (C-14)...
Porcine Pulmonary Artery Endothelial Cells (PPAEC) (>500,000 cells)...
Biology Products: