Navigation Links
Examination of internal 'wiring' of yeast, worm, and fly reveals conserved circuits

First-of-its-kind analysis published in the Feb. 8 PNAS supports the concept of a basic wiring diagram for all eukaryotes.

Researchers in California, Israel, and Germany have compared three distantly related species ?baker's yeast, a worm, and the fruit fly ?and reported that protein "wiring" connections in one species are often conserved in all three. This first-of-its-kind analysis of three higher level organisms published in the February 8 issue of Proceedings of the National Academy of Sciences supports both the concept of a basic wiring diagram for all eukaryotic cells, and the idea that more selective pharmaceuticals could be designed to tweak the wiring plan of human cells to more effectively treat diseases while also generating fewer side-effects.

"We're basically now able to open the hood of yeast, worm, and fly cells and look at the protein interactions inside," said Trey Ideker, a bioengineering professor at the University of California, San Diego and one of the nine co-authors of the paper. "Ultimately, this type of wiring analysis will help us more fully explain how the diversity of life developed on the planet, and more practically, how a pathogen differs from its human host, or a diseased cell differs from it healthy counterpart at the most informative level of detail."

For centuries, systematic comparisons of animal, plant, and microbial species was based on painstaking measurements of anatomic features. Beginning in the late-1970s, DNA sequencing technology permitted biologists to identify the precise subunit sequence of every gene in the genomes of everything from malaria pathogens and mosquitoes to mouse and human. Databases of genomic information have been combined with databases that list the precise subunit sequence of proteins as well. Cross-species DNA and protein comparisons have become routine for all biologists with computerized search programs, the most popular of which is called BLAST.

The wiring analysis r
'"/>

Source:University of California - San Diego


Page: 1 2 3 4

Related biology news :

1. New GI technologies improve internal organ visualization
2. UCSD researchers discover internal compass of immune cell
3. Researchers create artificial enzyme that mimics the bodys internal engine
4. From a lowly yeast, researchers divine a clue to human disease
5. A bacterial genome reveals new targets to combat infectious disease
6. First real-time view of developing neurons reveals surprises, say Stanford researchers
7. NYU study reveals how brains immune system fights viral encephalitis
8. Study reveals new technique for fingerprinting environmental samples
9. Study reveals dramatic difference between breast cancers in US and Africa
10. UCSD research reveals mechanism involved with type of fatal epilepsy
11. Study reveals candidate targets for anti-retroviral therapeutics
Post Your Comments:
(Date:4/18/2014)... University] Asteroid and comet impacts can cause widespread ... or even global scales. But new research from Brown ... of ancient life at the time of an impact. ... Schultz has found fragments of leaves and preserved organic ... impacts in Argentina. The material could provide a snapshot ...
(Date:4/17/2014)... COLUMBIA, Mo. April 17 In the most densely ... States, forests reflect two centuries of human needs, values ... logging and clearing forests for agriculture and development, have ... today, a U.S. Forest Service study reports. , The ... forest conditions and management needs in the Northern United ...
(Date:4/17/2014)... Double-stapled peptide inhibits RSV infection , Respiratory ... lower respiratory tract infections, generating life-threating illness in ... preventive therapies are limited. RSV enters host cells ... a six-helix fusogenic bundle. Small interfering peptides that ... however, these peptides are highly susceptible to degradation. ...
Breaking Biology News(10 mins):Impact glass stores biodata for millions of years 2Impact glass stores biodata for millions of years 3Five anthropogenic factors that will radically alter northern forests in 50 years 2Five anthropogenic factors that will radically alter northern forests in 50 years 3JCI online ahead of print table of contents for April 17, 2014 2JCI online ahead of print table of contents for April 17, 2014 3JCI online ahead of print table of contents for April 17, 2014 4JCI online ahead of print table of contents for April 17, 2014 5JCI online ahead of print table of contents for April 17, 2014 6
... ground to deforestation and urban sprawl, one development seems to ... snaps have enabled them to conquer new territory around their ... of satellite data from the Smithsonian Environmental Research Center and ... Proceedings of the National Academy of Sciences . An ...
... future losses in deep-sea marine life, using advanced climate models. Results ... from the impacts of climate change. An international team ... to 38 per cent in the North Atlantic and over five ... driven by a reduction in the plants and animals that live ...
... large, clinical trials of vitamin supplements, including some that ... harmful, have a flawed methodology that renders them largely ... a new analysis suggests. Many projects have tried ... human diet the same way they would a powerful ...
Cached Biology News:Climate change spurs tropical mangroves to expand in the north 2Major reductions in seafloor marine life from climate change by 2100 2Most clinical studies on vitamins flawed by poor methodology 2Most clinical studies on vitamins flawed by poor methodology 3
(Date:1/14/2014)... provider of strategic communications services to corporations and organizations preparing for ... United States and Europe , today ... to the firm,s Washington, D.C. office. ... years of service as Associate Commissioner for the Office of External ...
(Date:1/14/2014)... 2014 The largest international professional organization of ... therapeutic derivatives thereof has endorsed an educational program ... the challenges of adulterated herb and botanical products. ... The Society for Medicinal Plant and Natural ...
(Date:1/14/2014)... January 14, 2014 In recent years, ... and methods in product development and promotion has led ... This mistrust, fueled by concerns about the insidious impact ... reports of spectacular fines to the world’s biggest pharmas ...
(Date:1/14/2014)... 2014   Kinaxis ®, provider of RapidResponse ®, a ... operations planning ( S&OP ) service, is proud to be ... will be held at the Hilton San Diego Bayfront, January ... Elisabeth Kaszas , Director of Supply Chain at Amgen, ...
Breaking Biology Technology:Former FDA Associate Commissioner Returns To 3D Communications 2World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 2World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 3World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 4World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 5World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 6World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 7World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 8The Sunshine Act: Necessary Regulation or Unnecessary Dysregulation? New Life Science Webinar Hosted by Xtalks and IRB Services 2The Sunshine Act: Necessary Regulation or Unnecessary Dysregulation? New Life Science Webinar Hosted by Xtalks and IRB Services 3Event Alert: Kinaxis Customer to Present at the Biomanufacturing Summit "Supply Chain: Improving Network Effectiveness" 2
... MADISON The seventh annual G. Steven Burrill Technology ... new ideas and student creativity, as 14 teams of University ... to exhibit their business plans to a panel of judges. ... an opportunity to create new businessesget out of the faculty ...
... bank can now remove the guesswork out of customer profitability ... separate divisions of Wisconsin-based Fiserv. Security National Bank , ... from any of its desktops and identify its most profitable ... we treat them that way, but we also want to ...
... of services that help small businesses incorporate, has announced ... use to manage annual state requirements. , , BizComply ... due dates for annual report, tax and other filings, ... state requirements and ongoing formalities is often at the ...
Cached Biology Technology:Technology and business merge at UW Burrill Competition 2Technology and business merge at UW Burrill Competition 3
... involves using many of the automation concepts ... handling requirements are similar to those for ... have 24 or 48 wells with well ... throughput, the number of wells has increased ...
... The Reverse-iT™ One-Step Kit is ... reproducibility in RT-PCR. It has been ... process. The Reverse-iT™ One-Step Kit ... RTases and ABgene®s Thermoprime Plus DNA ...
... E F L P E P Q H ... L E(19) PA1-072 detects munc-18 interacting protein 3 ... in Western blot procedures. By Western blot, ... Mint3 from AtT20 cell extract.,PA1-072 immunizing peptide corresponds ...
Custom LNA Oligonucleotide synthesis ,High quality Custom LNA Oligonucleotides are available for a variety of different specialty applications and innovative products. ,Please inquire for further...
Biology Products: