Navigation Links
Driver of anthrax toxicity could lead to late-stage therapy

nd the "protective antigen carrier" of anthrax toxin, allowing its delivery into cells.

The new findings "reveal a previously unsuspected biological role" for LRP6, a gene earlier found to play important roles in pathways underlying early development and cell proliferation, the researchers said. The discovery also suggests potential new avenues for treating late-stage anthrax disease, they added.

While antibiotics, such as Cipro, can fight the anthrax bacteria when the disease is caught early, such drugs do nothing to dispel the accumulated toxin, the researchers explained. In contrast, drugs that target the host protein LRP6, or other components of the host machinery integral to the toxin's internalization, might offer a novel method to prevent the toxin from infiltrating and killing cells.

"Our discovery of the role of LRP6 in anthrax toxicity and the demonstration that antibodies directed against the extracellular domain of LRP6 can protect cells grown in culture against killing by anthrax toxin suggest that the immunological targeting of LRP6 may prove useful in protecting against the effects of accumulated toxin during the late stages of anthrax disease when antibacterial methods normally are no longer of therapeutic value," the researchers wrote.


'"/>

Source:Cell Press


Page: 1 2

Related biology news :

1. Scientists seek answers on what activates deadly anthrax spores
2. Antibodies from plants protect against anthrax
3. Defensins neutralize anthrax toxin
4. Critical step traced in anthrax infection
5. US Army plans to bulk-buy anthrax
6. New antibody shows promise as cure for anthrax
7. Effective, safe anthrax vaccine can be grown in tobacco plants
8. UCSD study finds anthrax toxins also harmful to fruit flies
9. Scientists design potent anthrax toxin inhibitor
10. Newly discovered protein kills anthrax bacteria by exploding their cell walls
11. Combating anthrax: Results of study published this month as researchers look for a better vaccine
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Driver anthrax toxicity could lead late stage therapy

(Date:6/25/2015)... N.J. , June 25, 2015  TAKE Solutions ... a patent by the United States Patent and Trademark ... Standardization". This process leverages TAKE Solutions, Clinical Accelerators to ... over 50% (when compared to standardization without the accelerators), ... At the heart of ...
(Date:6/24/2015)... June 24, 2015 Biometry authentication provider ... biometric password solution one face in. ... one face in, entering the expanding biometric ... affordable multifactor-authentication biometric answer to the password problem. ... in partnership with KeyLemon, one face in allows ...
(Date:6/18/2015)... NEW YORK , June 18, 2015 ... in US$ Million by the following Product Segments, which ... Immunoassay Systems, Chemiluminescence Immunoassay Systems, Radio Immunoassay Systems, and ... for the US, Canada , ... Asia-Pacific , Latin America ...
Breaking Biology News(10 mins):TAKE Solutions Awarded Patent By USPTO 2KeyLemon Announces Partnership With Biometric Password Solution onefacein 2Global Immunoassay Systems Market 2Global Immunoassay Systems Market 3Global Immunoassay Systems Market 4Global Immunoassay Systems Market 5Global Immunoassay Systems Market 6Global Immunoassay Systems Market 7Global Immunoassay Systems Market 8Global Immunoassay Systems Market 9Global Immunoassay Systems Market 10Global Immunoassay Systems Market 11Global Immunoassay Systems Market 12Global Immunoassay Systems Market 13Global Immunoassay Systems Market 14Global Immunoassay Systems Market 15Global Immunoassay Systems Market 16Global Immunoassay Systems Market 17Global Immunoassay Systems Market 18Global Immunoassay Systems Market 19Global Immunoassay Systems Market 20Global Immunoassay Systems Market 21Global Immunoassay Systems Market 22Global Immunoassay Systems Market 23Global Immunoassay Systems Market 24Global Immunoassay Systems Market 25Global Immunoassay Systems Market 26Global Immunoassay Systems Market 27Global Immunoassay Systems Market 28Global Immunoassay Systems Market 29
... Regulatory Submissions Leadership Strengthened with Clinical ... Services and Standards-Based Data Management, WHIPPANY, N.J. ... announced today it agreed to terms to acquire ... moving to,standards-based regulatory submissions, the acquisition further strengthens,ISI,s ...
... Intelligence Corporation (OTC Bulletin Board: CICI) ("CIC"),a leading ... in the financial industry and the recognized leader ... Michael Betts to,the CIC Board of Directors. ... in the insurance and,financial services industries and holds ...
... Sept. 12 J. Michael McConnell, Director of,National ... of Defense,for Intelligence will provide valuable insights into ... for implementing the United States,Intelligence Community 100 Day ... Conference: The Office of the Director of ...
Cached Biology News:Image Solutions, Inc. Acquires Zurich Biostatistics, Inc. 2Image Solutions, Inc. Acquires Zurich Biostatistics, Inc. 3Michael A. Betts, Seasoned Financial Services Executive, Joins CIC Board of Directors 2Michael A. Betts, Seasoned Financial Services Executive, Joins CIC Board of Directors 3
(Date:7/7/2015)... Mass. (PRWEB) , ... July 07, 2015 , ... ... a growing demand for biologic are some of the factors driving the pharmaceutical ... of drug manufacturers, as well as contract manufacturing organizations (CMOs), are driving market ...
(Date:7/7/2015)... ... July 07, 2015 , ... 4MD Medical , the ... offering an exclusive scholarship opportunity for women across the country to earn $2,000 toward ... they continue their education,” said Rochelle Schwartz, Founder of 4MD Medical and successful business ...
(Date:7/7/2015)...  In the farthest reaches of the Amazon rainforest, ... came together in a quest to save their ancestral ... in May in a remote village on the frontier ... concluded over two years work and culminated in the ... by an Amazonian tribe. The 500-page repository details medicinal ...
(Date:7/7/2015)... -- SME,s Advanced Manufacturing Media is proud to announce the ... young men and women who have demonstrated leadership and ... Manufacturing Engineering magazine highlights these ... Among the standouts: Christopher Tyler , 28, who ... topology of flapping wing vehicles; Kathryn Tillery-Merk , ...
Breaking Biology Technology:More Drug Companies Increasing Outsourcing Budgets; CMO Partners Spring Up as Market Thrives, According to BCC Research 2More Drug Companies Increasing Outsourcing Budgets; CMO Partners Spring Up as Market Thrives, According to BCC Research 34MD Medical Announces $2,000 Scholarship Opportunity in Conjunction with American Business Women’s Association (ABWA) 24MD Medical Announces $2,000 Scholarship Opportunity in Conjunction with American Business Women’s Association (ABWA) 3Amazonian Tribe Creates First Encyclopedia of Indigenous Medicine 2Amazonian Tribe Creates First Encyclopedia of Indigenous Medicine 3Amazonian Tribe Creates First Encyclopedia of Indigenous Medicine 4SME's Advanced Manufacturing Media Recognizes "30 Under 30" Future Leaders of Manufacturing 2SME's Advanced Manufacturing Media Recognizes "30 Under 30" Future Leaders of Manufacturing 3SME's Advanced Manufacturing Media Recognizes "30 Under 30" Future Leaders of Manufacturing 4SME's Advanced Manufacturing Media Recognizes "30 Under 30" Future Leaders of Manufacturing 5
... ... The Chinese Biopharmaceutical Association-USA (CBA) announced today that it ... Maryland, US. ,The event will highlight current breakthroughs, new ... develop a platform for communication and collaboration among biopharmaceutical companies, ...
... organisms on earth, carry an extra coating of protection ... latest issue of the journal Current Biology . ... the bacteria that cause botulism, tetanus, and anthrax survive ... by researchers at New York University,s Center for Genomics ...
... A team from Stevens Institute of Technology, consisting ... students: Wuming Jing, Xi Chen, and Zhenbo Fu ... and Yong Shi from the Department of Mechanical ... the IEEE/National Institute of Standards and Technology (NIST) ...
Cached Biology Technology:Chinese Biopharmaceutical Association Holds 15th Annual Conference in Rockville, MD, June 12 - 13 2Chinese Biopharmaceutical Association Holds 15th Annual Conference in Rockville, MD, June 12 - 13 3Biologists discover an extra layer of protection for bacterial spores 2Stevens team places third in 2010 IEEE/NIST Mobile Microrobotics Challenge 2
...
... Kits are designed to speed up the PCR ... products, regardless of sequence or type of polymerase ... those that are difficult to clone by other ... or code for potentially detrimental proteins can be ...
... Blunt-Ended PCR Cloning Kit, 40 reactions. ... cloning of all PCR products with ... cloning approaches by offering consistently better ... 25-fold more positive clones.Amplicons generated by ...
Antibodies were affinity purified using epitopes specific to XLF immobilized on solid support....
Biology Products: