Navigation Links
Driver of anthrax toxicity could lead to late-stage therapy

nd the "protective antigen carrier" of anthrax toxin, allowing its delivery into cells.

The new findings "reveal a previously unsuspected biological role" for LRP6, a gene earlier found to play important roles in pathways underlying early development and cell proliferation, the researchers said. The discovery also suggests potential new avenues for treating late-stage anthrax disease, they added.

While antibiotics, such as Cipro, can fight the anthrax bacteria when the disease is caught early, such drugs do nothing to dispel the accumulated toxin, the researchers explained. In contrast, drugs that target the host protein LRP6, or other components of the host machinery integral to the toxin's internalization, might offer a novel method to prevent the toxin from infiltrating and killing cells.

"Our discovery of the role of LRP6 in anthrax toxicity and the demonstration that antibodies directed against the extracellular domain of LRP6 can protect cells grown in culture against killing by anthrax toxin suggest that the immunological targeting of LRP6 may prove useful in protecting against the effects of accumulated toxin during the late stages of anthrax disease when antibacterial methods normally are no longer of therapeutic value," the researchers wrote.


'"/>

Source:Cell Press


Page: 1 2

Related biology news :

1. Scientists seek answers on what activates deadly anthrax spores
2. Antibodies from plants protect against anthrax
3. Defensins neutralize anthrax toxin
4. Critical step traced in anthrax infection
5. US Army plans to bulk-buy anthrax
6. New antibody shows promise as cure for anthrax
7. Effective, safe anthrax vaccine can be grown in tobacco plants
8. UCSD study finds anthrax toxins also harmful to fruit flies
9. Scientists design potent anthrax toxin inhibitor
10. Newly discovered protein kills anthrax bacteria by exploding their cell walls
11. Combating anthrax: Results of study published this month as researchers look for a better vaccine
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Driver anthrax toxicity could lead late stage therapy

(Date:8/6/2015)... BOSTON and TELTOW, Germany ... the 2015 Siggraph Conference, SensoMotoric Instruments (SMI) ... augmented reality , based on Epson,s Moverio ... eye tracking platform. With this new solution, unprecedented quality ... multi-modal, hands-free interaction with context-sensitive displays. For the first ...
(Date:8/5/2015)... VIEW, Calif. , Aug. 5, 2015 ... exhibits continuous growth in applications, penetration into newer sectors, ... after year. The global biosensors space has seen the ... exited the market so far. (Photo - ... Frost & Sullivan, Analysis of the Global Biosensors ...
(Date:7/31/2015)... 31. juli 2015 Den 10. internationale konference ... BGI fra den 22. - 25. oktober i ... sin 10-års fødselsdag i år. Siden starten i 2006 ... møder på ,omik,-feltet, og er en af de mest ... ICG-10 fokuserer på nylige gennembrud og fremskridt inden for ...
Breaking Biology News(10 mins):SMI Shows First Eye Tracking Upgrade for Augmented Reality Glasses 2SMI Shows First Eye Tracking Upgrade for Augmented Reality Glasses 3Innovative Biosensors Incite Use in Non-Traditional Applications 2Innovative Biosensors Incite Use in Non-Traditional Applications 3Innovative Biosensors Incite Use in Non-Traditional Applications 4Den 10. internationale konference om Genomics (ICG-10) åbner i oktober 2
... from Past Emergency Response , In a special ... lessons learned during past incidents involving emergency evacuations, ... emergency response (some involving radiation). Presenters use these ... paper ("Assessment of Emergency Response Planning and Implementation ...
... Society for Microbiology (ASM) Eli Lilly and Company Research ... Professor of Biology and Geobiology, Massachusetts Institute of Technology. ... microbiology or immunology by an individual on the threshold ... a pioneering young scientist who has championed the field ...
... 2008The 2008 American Society for Microbiology (ASM) Gen-Probe ... Vice-President, Technical and Business Development, IHRC, Inc., Atlanta, ... has exhibited exemplary leadership and service in the ... known worldwide for applying molecular biology techniques to ...
Cached Biology News:Emergency response and nanotechnology 2American Society for Microbiology honors Dianne K. Newman 2American Society for Microbiology honors Bala Swaminathan 2
(Date:8/26/2015)... 2015 Despite recent market ... optimism in biotech,s forecast is the recent run ... advancements.  Active biotechnology & healthcare companies with recent ... PBIO), Sequenom, Inc. (NASDAQ: SQNM ), Sarepta ... Corp. (NASDAQ: RPTP ) and EnteroMedics Inc. ...
(Date:8/26/2015)... ... 2015 , ... The 2015 Epigenomics & Metabolomics Meeting in Boston ... Asymmetrex to share the first report on progress with its crowdsourcing campaign designed ... tissue stem cells. , With a name like “H2A.Z asymmetry,” the new biomarker would ...
(Date:8/25/2015)... CARDIFF, UK (PRWEB) , ... August 25, 2015 ... ... accurately determining whether breast tissue lesions are cancerous is described by University of ... the international society for optics and photonics. , In “ Breast cancer diagnosis ...
(Date:8/25/2015)... , Aug. 25, 2015 Human Longevity, Inc. (HLI), ... Winham has joined the company as Chief Operating Officer. ... medical operations and technical experience, will report directly to HLI,s ... In this new role as COO, Winham will be responsible ... as well as all facility operations. HLI currently has three ...
Breaking Biology Technology:New Collaborations & Mergers For Research of Molecular Biomarkers in Human Diseases & Clinical Trials for Cancer Therapies Fueling Growth in Multi-Billion Dollar Life Sciences Market 2New Collaborations & Mergers For Research of Molecular Biomarkers in Human Diseases & Clinical Trials for Cancer Therapies Fueling Growth in Multi-Billion Dollar Life Sciences Market 3New Collaborations & Mergers For Research of Molecular Biomarkers in Human Diseases & Clinical Trials for Cancer Therapies Fueling Growth in Multi-Billion Dollar Life Sciences Market 4New Collaborations & Mergers For Research of Molecular Biomarkers in Human Diseases & Clinical Trials for Cancer Therapies Fueling Growth in Multi-Billion Dollar Life Sciences Market 5New Collaborations & Mergers For Research of Molecular Biomarkers in Human Diseases & Clinical Trials for Cancer Therapies Fueling Growth in Multi-Billion Dollar Life Sciences Market 6New Collaborations & Mergers For Research of Molecular Biomarkers in Human Diseases & Clinical Trials for Cancer Therapies Fueling Growth in Multi-Billion Dollar Life Sciences Market 7Asymmetrex Reports Positive Indicators for Crowdsourcing Campaign to Evaluate New Biomarker for Counting Adult Tissue Stem Cells for the First Time 2Asymmetrex Reports Positive Indicators for Crowdsourcing Campaign to Evaluate New Biomarker for Counting Adult Tissue Stem Cells for the First Time 3Asymmetrex Reports Positive Indicators for Crowdsourcing Campaign to Evaluate New Biomarker for Counting Adult Tissue Stem Cells for the First Time 4New Optical Method Promises Faster, More Accurate Diagnosis of Breast Cancer 2New Optical Method Promises Faster, More Accurate Diagnosis of Breast Cancer 3New Optical Method Promises Faster, More Accurate Diagnosis of Breast Cancer 4Human Longevity, Inc. Hires Life Sciences Leader, Mark Winham, as Chief Operating Officer 2
... Almost by accident, I find myself on what must surely ... the past few months, I have tried the best designs ... I've tried has great strengths and a few tradeoffs, usually ... along comes a Bluetooth wireless headset from a newcomer to ...
... major advantages , ,MADISON, Wis. Wisconsins biotechnology ... feature appearing in the June issue of Modern Drug ... clusters in Madison and Milwaukee, and attributes the growth ... and universities, the Wisconsin Alumni Research Foundation , ...
... lack of funding cited as problems , ,MADISON ... and keep customers happy isnt exactly a revolutionary practice. ... lack funding, even the smallest technological alteration can be ... Matt Miszewski and other speakers described this paradox and ...
Cached Biology Technology:The quest for the perfect headset 2The quest for the perfect headset 3Wisconsin biotech sector featured in scientific magazine 2Wisconsin biotech sector featured in scientific magazine 3State CIO discusses IT and government 2