Navigation Links
Detailed 3-D image catches a key regulator of neural stem cell differentiation in action

rase II from reading and switching on neuronal genes in tissues where they shouldn't be expressed, such as skin, muscle and liver. In the nervous system Scp1 is switched off, enabling RNA polymerase II to efficiently transcribe information encoded by neuronal genes and driving the maturation of neural stem cells into specialized neurons.

"Scp1 is an interesting twist on how genes can be regulated during development," says Pfaff. "In the past there has been a lot of emphasis on chromatin modifications and physical access to genes, but Scp1 regulates the activity of the enzyme that transcribes genes directly," he adds.

Scp1 is not the only protein that directly influences the activity of RNA polymerase II. A constantly fluctuating brigade of enzymatic foot soldiers regulates RNA polymerase II's activity by chemically modifying the long cord-like tail that hangs from its globular structure, like a chain on a light fixture.

Enzymes called kinases turn the "light" on by adding small phosphate chemical groups - giving RNA polymerase the go-ahead to transcribe genes - while removal of those phosphates by phosphatases like Scp1 turns out the light, effectively stopping RNA polymerase in its tracks.

Noel and postdoctoral fellow Yan Zhang, Ph.D, analyzed the crystal structure of Scp1 and RNA polymerase together and obtained a 3-dimensional image showing how Scp1 hangs onto the seven amino acid residues reiterated in the polymerase tail. "We captured Scp1 bound to a single seven amino-acid long repeat containing specific phosphates," explains Zhang, the paper's first author. "It turns out that only three amino acids are important for Scp1's ability to know how to remove phosphates from RNA polymerase."

She adds that knowing how enzymes like Scp1 precisely recognize that seven amino acid stretch is exactly the kind of "unambiguous information relevant for the design of a chemical inhibitor by a process known as structure-ba
'"/>

Source:Salk Institute


Page: 1 2 3

Related biology news :

1. Key heart and Alzheimers disease protein imaged for first time in native state
2. New MRI technique quickly builds 3-D images of knees
3. Everything in its place: Researchers identify brain cells used to categorize images
4. With record resolution and sensitivity, tool images how life organizes in a cell membrane
5. Researchers image molecular motor structural changes
6. CSIRO imagery shows Outer Great Barrier Reef at risk from river plumes
7. Novel computed imaging technique uses blurry images to enhance view
8. Ultrasound upgrade produces images that work like 3-D movies
9. Researchers wake up viruses inside tumors to image and then destroy cancers
10. Novel system developed to turn data into real-time, interactive 3-D images
11. White blood cell waste disposal system plays critical regulatory role
Post Your Comments:
(Date:2/24/2015)... DUBLIN , Feb. 24, 2015 Research ... announced the addition of the "Global 2D ... offering. The analysts forecast the ... a CAGR of 32.12% over the period 2014-2019 ... devices in non-traditional sectors is one of the ...
(Date:2/13/2015)... Feb. 13, 2015 ACT Genomics Co., ... aims to transform cancer genomic information into precision ... company has raised US$ 8 million in the its ... Taipei, Taiwan , ACT Genomics ... With the aim to implement next generation sequencing ...
(Date:2/10/2015)... 10, 2015  Alere Inc. (NYSE: ALR), a ... results for the quarter ended December 31, 2014. ... President of Alere said, "We made substantial progress ... the global leader in rapid diagnostics and delivering ... Health divestiture in early January enabled us to ...
Breaking Biology News(10 mins):Global 2D Gesture Recognition Market 2015-2019 with Cognitec Systems, CogniVue, eyeSight Mobile Technologies & PointGrab Dominating 2ACT Genomics Raises $8 Million in its First Private Funding Round 2Alere Inc. Announces Fourth Quarter 2014 Results 2Alere Inc. Announces Fourth Quarter 2014 Results 3Alere Inc. Announces Fourth Quarter 2014 Results 4Alere Inc. Announces Fourth Quarter 2014 Results 5Alere Inc. Announces Fourth Quarter 2014 Results 6Alere Inc. Announces Fourth Quarter 2014 Results 7Alere Inc. Announces Fourth Quarter 2014 Results 8Alere Inc. Announces Fourth Quarter 2014 Results 9Alere Inc. Announces Fourth Quarter 2014 Results 10Alere Inc. Announces Fourth Quarter 2014 Results 11Alere Inc. Announces Fourth Quarter 2014 Results 12Alere Inc. Announces Fourth Quarter 2014 Results 13Alere Inc. Announces Fourth Quarter 2014 Results 14Alere Inc. Announces Fourth Quarter 2014 Results 15Alere Inc. Announces Fourth Quarter 2014 Results 16Alere Inc. Announces Fourth Quarter 2014 Results 17Alere Inc. Announces Fourth Quarter 2014 Results 18Alere Inc. Announces Fourth Quarter 2014 Results 19Alere Inc. Announces Fourth Quarter 2014 Results 20Alere Inc. Announces Fourth Quarter 2014 Results 21Alere Inc. Announces Fourth Quarter 2014 Results 22Alere Inc. Announces Fourth Quarter 2014 Results 23Alere Inc. Announces Fourth Quarter 2014 Results 24Alere Inc. Announces Fourth Quarter 2014 Results 25Alere Inc. Announces Fourth Quarter 2014 Results 26Alere Inc. Announces Fourth Quarter 2014 Results 27Alere Inc. Announces Fourth Quarter 2014 Results 28Alere Inc. Announces Fourth Quarter 2014 Results 29Alere Inc. Announces Fourth Quarter 2014 Results 30Alere Inc. Announces Fourth Quarter 2014 Results 31Alere Inc. Announces Fourth Quarter 2014 Results 32Alere Inc. Announces Fourth Quarter 2014 Results 33Alere Inc. Announces Fourth Quarter 2014 Results 34
... of physicists and neuroscientists has reported a breakthrough in ... seven times faster than currently possible. In a ... PLoS ONE , a University of California, Berkeley, physicist ... University in the United Kingdom describe two improvements that ...
... patients suffering from chronic liver diseases are currently ... organs donated for transplantation. However, hepatocytes derived from ... alternative for the future. Scientists from the Max ... hepatocytes from embryonic stem cells with hepatocytes from ...
... December, 2010 - NIZO food research, in association with ... information products and services, announces the 7th NIZO Dairy ... Arnhem, The Netherlands. The conference aims to ... texture research. It will provide a unique opportunity for ...
Cached Biology News:Major advance in MRI allows much faster brain scans 2Major advance in MRI allows much faster brain scans 3Major advance in MRI allows much faster brain scans 4Major advance in MRI allows much faster brain scans 5Different sources, same result 27th NIZO Dairy Conference to focus on flavor and texture, innovations in dairy 2
(Date:3/2/2015)... , March 2, 2015 ... to bottom.   Moments ago, Analysts Review ... Sunshine Heart (NASDAQ: SSH ), Synergetics ... Syneron Medical (NASDAQ: ELOS ), Spectranetics (NASDAQ: ... Analysts Review provides a single unified platform for investors, to ...
(Date:3/2/2015)... , March 2, 2015 VG ... developing therapies for autoimmune and infectious diseases, announced ... has issued an important new composition of matter ... through the targeting of CLIP. ... technology underlying VG Life Sciences, VG1177, a synthetic ...
(Date:3/2/2015)... MIAMI (PRWEB) March 02, 2015 ... a newly formed alliance with Shenzhen HANK Bioengineering ... M.D., Ph.D. The alliance will establish a stem ... Guangdong Province, China in September 2015. , Shenzhen ... by Zhang, an award-winning scientist, microbiologist and virologist, ...
(Date:3/1/2015)... London, UK (PRWEB) March 01, 2015 ... a partnership agreement for quality market research promotion ... and sell research reports worked out by DataGroup ... Department at Market Publishers Ltd, commented on the ... to have DataGroup Booksellers in our team of ...
Breaking Biology Technology:Quarterly Report Card of Biotechnology Companies: New Research on Sunshine Heart, Synergetics USA, Syneron Medical, Spectranetics and Thoratec 2Quarterly Report Card of Biotechnology Companies: New Research on Sunshine Heart, Synergetics USA, Syneron Medical, Spectranetics and Thoratec 3Quarterly Report Card of Biotechnology Companies: New Research on Sunshine Heart, Synergetics USA, Syneron Medical, Spectranetics and Thoratec 4VG Life Sciences Granted Key Composition Of Matter Patent 2VG Life Sciences Granted Key Composition Of Matter Patent 3Global Stem Cells Group Announces Alliance with HANK Bioengineering Co., Ltd. in Shenzhen, China 2Global Stem Cells Group Announces Alliance with HANK Bioengineering Co., Ltd. in Shenzhen, China 3Market Publishers Ltd and DataGroup Booksellers Sign Partnership Agreement 2Market Publishers Ltd and DataGroup Booksellers Sign Partnership Agreement 3
... 4 /Xinhua-PRNewswire-FirstCall/ -- China,Biologic Products, Inc. (OTC Bulletin ... leading plasma-based pharmaceutical companies in the,People,s Republic of ... it,s common stock was approved for quotation on ... Financial Industry,Regulatory Authority (FINRA)., "We are pleased ...
... VICL ) today announced that Vijay Samant, ... in a roundtable discussion,"An Industry Call to Action: ... Development," and present an overview of the,company,s programs ... at the Biotechnology Industry Organization (BIO) and BIO ...
... SGXP ) will announce financial results for ... March 12, 2008. The announcement will be,followed by ... a.m. Pacific Time.,Mike Grey, President and Chief Executive ... the conference call to discuss financial,results and business ...
Cached Biology Technology:China Biologic Products Commences Trading on OTC Bulletin Board 2Vical to Present at BIO and BVGH Global Health Partnering Event 2Vical to Present at BIO and BVGH Global Health Partnering Event 3SGX Pharmaceuticals Schedules Teleconference and Webcast for Fourth Quarter and Full Year 2007 Results 2
... EPS 1001 Power Supply, 1. ... maximum.Constant voltage, constant current, and constant ... read-outs for precision and reproducibility.Stores and ... ultrathin flatbed gels on Multiphor ...
Human CCL26/Eotaxin-3 MAb (Clone 115002)...
Prostaglandin E2 Luminex Standard Product Lines: Unspecified...
Request Info...
Biology Products: