Navigation Links
Detailed 3-D image catches a key regulator of neural stem cell differentiation in action

rase II from reading and switching on neuronal genes in tissues where they shouldn't be expressed, such as skin, muscle and liver. In the nervous system Scp1 is switched off, enabling RNA polymerase II to efficiently transcribe information encoded by neuronal genes and driving the maturation of neural stem cells into specialized neurons.

"Scp1 is an interesting twist on how genes can be regulated during development," says Pfaff. "In the past there has been a lot of emphasis on chromatin modifications and physical access to genes, but Scp1 regulates the activity of the enzyme that transcribes genes directly," he adds.

Scp1 is not the only protein that directly influences the activity of RNA polymerase II. A constantly fluctuating brigade of enzymatic foot soldiers regulates RNA polymerase II's activity by chemically modifying the long cord-like tail that hangs from its globular structure, like a chain on a light fixture.

Enzymes called kinases turn the "light" on by adding small phosphate chemical groups - giving RNA polymerase the go-ahead to transcribe genes - while removal of those phosphates by phosphatases like Scp1 turns out the light, effectively stopping RNA polymerase in its tracks.

Noel and postdoctoral fellow Yan Zhang, Ph.D, analyzed the crystal structure of Scp1 and RNA polymerase together and obtained a 3-dimensional image showing how Scp1 hangs onto the seven amino acid residues reiterated in the polymerase tail. "We captured Scp1 bound to a single seven amino-acid long repeat containing specific phosphates," explains Zhang, the paper's first author. "It turns out that only three amino acids are important for Scp1's ability to know how to remove phosphates from RNA polymerase."

She adds that knowing how enzymes like Scp1 precisely recognize that seven amino acid stretch is exactly the kind of "unambiguous information relevant for the design of a chemical inhibitor by a process known as structure-ba
'"/>

Source:Salk Institute


Page: 1 2 3

Related biology news :

1. Key heart and Alzheimers disease protein imaged for first time in native state
2. New MRI technique quickly builds 3-D images of knees
3. Everything in its place: Researchers identify brain cells used to categorize images
4. With record resolution and sensitivity, tool images how life organizes in a cell membrane
5. Researchers image molecular motor structural changes
6. CSIRO imagery shows Outer Great Barrier Reef at risk from river plumes
7. Novel computed imaging technique uses blurry images to enhance view
8. Ultrasound upgrade produces images that work like 3-D movies
9. Researchers wake up viruses inside tumors to image and then destroy cancers
10. Novel system developed to turn data into real-time, interactive 3-D images
11. White blood cell waste disposal system plays critical regulatory role
Post Your Comments:
(Date:9/30/2014)... conducted by the Ocean Health Index rates the ... overall health. In addition, for the first time, ... ocean regions beyond national jurisdiction (high-seas areas) ... safeguarding biodiversity and providing sustainable food sources. , ... a partnership led by scientists from UC Santa ...
(Date:9/30/2014)... team of environmental scientists and engineers, led by ... a three-year, $5.25 million grant from the U.S. ... Research to make a direct positive impact on ... and disposal of radioactive contaminants. , "Understanding the ... dealing with environmental aspects of nuclear technologies is ...
(Date:9/30/2014)... and farm runoff in Hawaii is causing tumors in ... The study, published Tuesday in the peer-reviewed open-access journal ... ends up in algae that the turtles eat, promoting ... and internal organs. , Scientists at Duke University, the ... Administration (NOAA) conducted the study to better understand the ...
Breaking Biology News(10 mins):Rating the planet's oceans 2Rating the planet's oceans 3Researchers get $5.25 million to advance nuclear technologies in South Carolina 2Pollution linked to lethal sea turtle tumors 2Pollution linked to lethal sea turtle tumors 3
... Keith and his team are working to efficiently capture the ... technology. In research conducted at the U of C, ... to reduce carbon dioxide (CO2) the main greenhouse gas ... simple machine that can capture the trace amount of CO2 ...
... The Fraser fir is gaining popularity among American ... favor Fraser fir for its conical shape, dark ... Consumer surveys indicate that the shape of ... Christmas tree selection, followed by needle retention, species, ...
... ARTICLE #1 FOR IMMEDIATE RELEASE Evidence that inexpensive ... Energy & Fuels Amid sticker-shock fuel prices, researchers ... tests verifying that a simple, inexpensive device attached to a ... to 20 percent. That translates into several more precious miles ...
Cached Biology News:Carbon dioxide 'scrubber' captures greenhouse gases 2Carbon dioxide 'scrubber' captures greenhouse gases 3Consumers influence christmas tree styles 2American Chemical Society's Weekly PressPac -- Sept. 24, 2008 2American Chemical Society's Weekly PressPac -- Sept. 24, 2008 3American Chemical Society's Weekly PressPac -- Sept. 24, 2008 4American Chemical Society's Weekly PressPac -- Sept. 24, 2008 5American Chemical Society's Weekly PressPac -- Sept. 24, 2008 6American Chemical Society's Weekly PressPac -- Sept. 24, 2008 7American Chemical Society's Weekly PressPac -- Sept. 24, 2008 8
(Date:9/30/2014)... bio-mimicking analog of one of nature,s most efficient ... team led by Alejandro Briseno of the University ... in developing long-sought polymer architecture to boost power-conversion ... electronic devices. , Briseno, with colleagues and ... Stanford University and Dresden University of Technology, Germany, ...
(Date:9/30/2014)... 30, 2014 Shimadzu Scientific Instruments ... easy-to-use and highly precise tool for measuring displacement ... elongation. With 1000-mm maximum movement distance, the DSES-1000 ... a gauge length of 10 mm. In addition, ... above 50-mm stroke and within +/- 100 µm ...
(Date:9/30/2014)... Proove Biosciences , the commercial and ... a new genetic test built upon research from their ... will provide physicians with an objective way to ... are stratified between individuals. With this new test, physicians ... a genetic predisposition that will affect their pain tolerance. ...
(Date:9/30/2014)... -- CORD:USE Cord Blood Bank – www.corduse.com ... into an Equity and Exclusive Services Agreement with Tianhe Stem ... patented technologies for the isolation of human cord blood-derived ... performing Phase I/II clinical trials in China ... Tianhe,s Stem Cell Educator Therapy showing that the therapy ...
Breaking Biology Technology:Blades of grass inspire advance in organic solar cells 2Blades of grass inspire advance in organic solar cells 3Shimadzu’s New Long-Travel Extensometer Increases Precision for Soft Material Testing 2Proove Biosciences is Now Offering the Proove Pain Perception Genetic Test to Help Physicians Assess Patient Pain Tolerance Levels 2Proove Biosciences is Now Offering the Proove Pain Perception Genetic Test to Help Physicians Assess Patient Pain Tolerance Levels 3CORD:USE is Pleased to Announce it has Partnered with Tianhe Stem Cell Biotechnologies, Developer of Cord Blood Stem Cell Therapy Showing Promising Results in Clinical Trials for the Treatment of Diabetes and Autoimmune Diseases 2CORD:USE is Pleased to Announce it has Partnered with Tianhe Stem Cell Biotechnologies, Developer of Cord Blood Stem Cell Therapy Showing Promising Results in Clinical Trials for the Treatment of Diabetes and Autoimmune Diseases 3CORD:USE is Pleased to Announce it has Partnered with Tianhe Stem Cell Biotechnologies, Developer of Cord Blood Stem Cell Therapy Showing Promising Results in Clinical Trials for the Treatment of Diabetes and Autoimmune Diseases 4
... number of US clinics, CHICAGO, IL, Sept. ... first commercially available bionic hand, today revealed details ... Assembly of the American,Orthotic and Prosthetic Association (AOPA). ... RACE Team and Partner Program are designed to ...
... 10 /Xinhua-PRNewswire-FirstCall/ -- Yongye Biotechnology,International, Inc. (OTC ... leading developer, producer and distributor of nutrients ... of China, today announced that it closed ... led by,Black River Asset Management, pursuant to ...
... Discovery of New Class of Anti-Inflammatory ... ... of The,Dr. Paul Janssen Award for Biomedical Research, Professor Marc Feldmann,FMedSci, FAA, ... Institute of Rheumatology, Imperial College London, are,being honored during a scientific symposium ...
Cached Biology Technology:Touch Bionics unveils innovative partner and reimbursement programs at AOPA 2Touch Bionics unveils innovative partner and reimbursement programs at AOPA 3Yongye Biotechnology International Raises $9.4 Million in Private Placement 2Yongye Biotechnology International Raises $9.4 Million in Private Placement 3Johnson & Johnson Honors 2008 Recipients of The Dr. Paul Janssen Award for Biomedical Research 2Johnson & Johnson Honors 2008 Recipients of The Dr. Paul Janssen Award for Biomedical Research 3Johnson & Johnson Honors 2008 Recipients of The Dr. Paul Janssen Award for Biomedical Research 4
... Lambda Protein Phosphatase ( ... protein phosphatase with activity ... and tyrosine residues. It ... product of the ORF221 ...
Angiotensin Converting Enzyme [Porcine Kidney, ACE, Peptidyl-dipeptidase A]...
Oven mesh sheets, large, 23 x 23cm, pack of 5...
Preparation Note: Prepared essentially by method of Singer, T.P., J. Biol. Chem., 174, 11 (1948). Quality Clarifier: Contains lipase Unit Definition: One unit will hydrolyze 1.0 μmole of p-ni...
Biology Products: