Navigation Links
Detailed 3-D image catches a key regulator of neural stem cell differentiation in action

rase II from reading and switching on neuronal genes in tissues where they shouldn't be expressed, such as skin, muscle and liver. In the nervous system Scp1 is switched off, enabling RNA polymerase II to efficiently transcribe information encoded by neuronal genes and driving the maturation of neural stem cells into specialized neurons.

"Scp1 is an interesting twist on how genes can be regulated during development," says Pfaff. "In the past there has been a lot of emphasis on chromatin modifications and physical access to genes, but Scp1 regulates the activity of the enzyme that transcribes genes directly," he adds.

Scp1 is not the only protein that directly influences the activity of RNA polymerase II. A constantly fluctuating brigade of enzymatic foot soldiers regulates RNA polymerase II's activity by chemically modifying the long cord-like tail that hangs from its globular structure, like a chain on a light fixture.

Enzymes called kinases turn the "light" on by adding small phosphate chemical groups - giving RNA polymerase the go-ahead to transcribe genes - while removal of those phosphates by phosphatases like Scp1 turns out the light, effectively stopping RNA polymerase in its tracks.

Noel and postdoctoral fellow Yan Zhang, Ph.D, analyzed the crystal structure of Scp1 and RNA polymerase together and obtained a 3-dimensional image showing how Scp1 hangs onto the seven amino acid residues reiterated in the polymerase tail. "We captured Scp1 bound to a single seven amino-acid long repeat containing specific phosphates," explains Zhang, the paper's first author. "It turns out that only three amino acids are important for Scp1's ability to know how to remove phosphates from RNA polymerase."

She adds that knowing how enzymes like Scp1 precisely recognize that seven amino acid stretch is exactly the kind of "unambiguous information relevant for the design of a chemical inhibitor by a process known as structure-ba
'"/>

Source:Salk Institute


Page: 1 2 3

Related biology news :

1. Key heart and Alzheimers disease protein imaged for first time in native state
2. New MRI technique quickly builds 3-D images of knees
3. Everything in its place: Researchers identify brain cells used to categorize images
4. With record resolution and sensitivity, tool images how life organizes in a cell membrane
5. Researchers image molecular motor structural changes
6. CSIRO imagery shows Outer Great Barrier Reef at risk from river plumes
7. Novel computed imaging technique uses blurry images to enhance view
8. Ultrasound upgrade produces images that work like 3-D movies
9. Researchers wake up viruses inside tumors to image and then destroy cancers
10. Novel system developed to turn data into real-time, interactive 3-D images
11. White blood cell waste disposal system plays critical regulatory role
Post Your Comments:
(Date:8/10/2015)... and TELTOW, Germany , August ... (SMI), a world leader in Eye Tracking Technology ... of its OEM Eye Tracking Platform for integration into ... Platform contains reference designs for seamless integration of eye ... virtual reality HMDs and augmented reality smart glasses. Omnivision,s ...
(Date:8/6/2015)... Calif. , Aug. 6, 2015  Today, ... will visit Crossmatch ™ to learn firsthand ... and protect data. Crossmatch is a world leader ... technologies and expertise are helping federal agencies and ... and security.   "The vast majority ...
(Date:8/6/2015)... Aug. 6, 2015 Synaptics Inc. (NASDAQ: ... interface solutions, today announced collaboration with Microsoft on ... 10. Microsoft leveraged Synaptics, deep expertise in human ... Through stringent testing, Synaptics, advanced ... with Microsoft,s Precision TouchPad (PTP) specification empowering OEMs ...
Breaking Biology News(10 mins):SMI Completes OEM Eye Tracking Platform to Cover All Consumer Displays 2SMI Completes OEM Eye Tracking Platform to Cover All Consumer Displays 3Rep. Honda to Visit Crossmatch in Redwood City 2Synaptics Chosen for Human Interface Co-Development on Windows 10 2
... and instead reduce fossil-fuel use for the sake of the ... the University of Washington and one from the University of ... issue of the journal Nature (Jan. 26) that ... the environment as a reason to curb the use of ...
... MIT researchers have discovered that certain photosynthetic ocean ... viruses are really con artists carrying genetic material taken ... host into using its own machinery to activate the ... relationship. The con occurs when a grifter ...
... officers can now register online to the 2012 General ... brings together over 10,000 scientists from all over the ... and space sciences. EGU,s General Assembly is an ... recent developments in topics as diverse as shale gas ...
Cached Biology News:Commentary in Nature: Can economy bear what oil prices have in store? 2Commentary in Nature: Can economy bear what oil prices have in store? 3Viruses con bacteria into working for them 2Viruses con bacteria into working for them 3European Geosciences Union General Assembly, April 22-27, 2012, Vienna, Austria 2
(Date:9/2/2015)... 2015 Research ... the addition of Jain PharmaBiotech,s new report ... to their offering. The ... fluorescence in situ hybridization (FISH), comparative genomic ... includes application of nanobiotechnology, microarrays, real-time polymerase ...
(Date:9/2/2015)... , Sept. 2, 2015 Australian prostate cancer ... prestigious Australian science prize recognising ,outstanding, science that uses ... to globally launch a novel prostate cancer diagnostic test ... high level consortium taking out the peer-reviewed Australian Museum ... Research. This prize is awarded for ...
(Date:9/2/2015)... , September 2, 2015 BiondVax ... of the National Institute of Allergy and Infectious Diseases (NIAID), ... the Department of Health and Human Services (HHS), to launch ... the United States in the 2015-16 timeframe. ... vaccine candidate, Multimeric-001 (M-001), as a primer vaccine, which would ...
(Date:9/2/2015)... ... September 02, 2015 , ... Temarry Recycling's new $100,000 ... to energy process and continue to contribute to the sustainability of our natural ... to Energy process has been operating at their Mexico facility, Recicladora Temarry, for ...
Breaking Biology Technology:Global Cytogenetics Technologies Study 2015-2025 - Latest Markets and Companies Analysis 2Global Cytogenetics Technologies Study 2015-2025 - Latest Markets and Companies Analysis 3Prostate Cancer Company Minomic Wins Prestigious Eureka Science Prize 2Prostate Cancer Company Minomic Wins Prestigious Eureka Science Prize 3BiondVax Announces Intent to Launch a Phase 2 Trial in the United States in Collaboration with the U.S. National Institutes of Health 2BiondVax Announces Intent to Launch a Phase 2 Trial in the United States in Collaboration with the U.S. National Institutes of Health 3Temarry Recycling’s New $100,000 Waste to Energy Renovation 2
... EVRY, France, May 5 Novagali Pharma, ... the Company,s,Investigational New Drug Application (IND) to ... (Nova21027), for the treatment of glaucoma has ... Administration (FDA). Catioprost(R) is a,topical ocular proprietary ...
... Insmed Inc. (Nasdaq: INSM ), a ... from The NASDAQ Stock Market that it has regained ... requirement, and further, that it currently complies with all ... with the bid price rule, the Company was required ...
... lamps have been used to control outbreaks of measles, ... and hospitals since the 1930,s. UVGI (Ultraviolet Germicidal Irradiation) ... 1955 Mumps epidemic and helped eliminate a Varicella (Chicken ... recently, UVGI units were installed into Hong Kong hospitals ...
Cached Biology Technology:Novagali Pharma Announces FDA Clearance of IND for Phase III of Catioprost(R), its Cationic Emulsion of Latanoprost in Patients With Glaucoma 2Insmed Regains NASDAQ Compliance 2Swine Flu Fears Generate Interest in UV Disinfection Technologies...Again 2
... The Genome Sequencer 20 System revolutionizes DNA ... parallel fashion. The Genome Sequencer 20 ... Reagents and consumables for library construction, ... mapping and de novo assembly ...
Compound(s) tested through a broad panel of 38 ligand binding and enzyme assays targeting the Central Nervous System. Used to determine selectivity and potential CV/Renal liabilities of compounds....
... Normal Human Serum-Single Donor • Human ... who are found to be negative by ... (s) (HIV-1Ag), Antibodies to Human Immunodeficiency Virus ... Nonreactive for Hepatitis B Surface Antigen (HbsAg) ...
Compound(s) screened through any number of client selected assays. Client also selects number of concentrations and replicates....
Biology Products: