Navigation Links
Detailed 3-D image catches a key regulator of neural stem cell differentiation in action

Researchers at the Salk Institute for Biological Studies in collaboration with scientists at the University of California, San Diego (UCSD) took a high resolution "action shot" of a protein switch that plays a crucial role in the development of the nervous system. Their findings, published in the Dec. 8 issue of the journal Molecular Cell, provide a template for the design of small molecule inhibitors to control that switch, a protein called Scp1, at will.

"Scp1 is an important brake that regulates the transition from neuronal precursor to mature neuron," explains senior author Joseph Noel, Ph.D, a Howard Hughes Medical Institute investigator at Salk. "Loosening the brake with an inhibitor would allow us to influence the timing of neuronal differentiation," he adds.

A finely tuned network of molecular "on" and "off" switches orchestrates the differentiation of embryonic stem cells into different tissue types. Being able to manipulate individual switches would allow scientists to nudge embryonic stem cells into becoming specific cell types, a plus for both basic research and potential therapies.

"At the moment, the differentiation of stem cells into neurons in a Petri dish is a little bit like a black box and not very efficient," explains co-author Samuel Pfaff, Ph.D., a professor in the Salk's Gene Expression Laboratory, who together with co-author Gordon Gill, Ph.D., of the Departments of Medicine and Cellular and Molecular Medicine at UCSD, found that Scp1 silences neuron-specific genes in non-neuronal cells last year. "Having a specific inhibitor would give us a lot of insight into the development of the fetal nervous system and would allow us to chemically push embryonic stem cells to acquire a neuronal fate in an informed way," adds Pfaff.

Scp1 belongs to group of proteins called small carboxyl-terminal phosphatases (SCPs) that are expressed in almost all tissues of the body. When active, Scp1 prevents the enzyme RNA polyme
'"/>

Source:Salk Institute


Page: 1 2 3

Related biology news :

1. Key heart and Alzheimers disease protein imaged for first time in native state
2. New MRI technique quickly builds 3-D images of knees
3. Everything in its place: Researchers identify brain cells used to categorize images
4. With record resolution and sensitivity, tool images how life organizes in a cell membrane
5. Researchers image molecular motor structural changes
6. CSIRO imagery shows Outer Great Barrier Reef at risk from river plumes
7. Novel computed imaging technique uses blurry images to enhance view
8. Ultrasound upgrade produces images that work like 3-D movies
9. Researchers wake up viruses inside tumors to image and then destroy cancers
10. Novel system developed to turn data into real-time, interactive 3-D images
11. White blood cell waste disposal system plays critical regulatory role
Post Your Comments:
(Date:6/25/2015)... PRINCETON, N.J. , June 25, 2015  TAKE ... awarded a patent by the United States Patent and ... Data Standardization". This process leverages TAKE Solutions, Clinical Accelerators ... by over 50% (when compared to standardization without the ... At the heart ...
(Date:6/24/2015)... June 22, 2015 ... addition of the "Huawei Ascend Mate 7 ... to their offering. Huawei,s technological choice ... opposite direction than Apple,s and Samsung,s one. The ... developed by Fingerprint Cards, a main actor in ...
(Date:6/23/2015)... 2015   Valencell, a leader in ... a recent study that illustrates its PerformTek biometric ... activity. In a study conducted at Valencell,s Biometric ... the Apple Watch against a chest strap – ... activity. The study demonstrated that Valencell,s biometric technology ...
Breaking Biology News(10 mins):TAKE Solutions Awarded Patent By USPTO 2Huawei Ascend Mate 7 Fingerprint Sensor - Reverse Costing Analysis 2Valencell Delivers Breakthrough Heart Rate Accuracy on the Wrist 2Valencell Delivers Breakthrough Heart Rate Accuracy on the Wrist 3
... [Brown University] If you want to understand a novel, it ... up the plot from somewhere in the middle. The same goes ... sense of it is to look at it head to tail. ... University, DNA molecules have a convenient tendency to cooperate. The ...
... colleagues have shown that one of the mechanisms involved in hearing ... that isn,t interesting enough, the UI scientists advanced their knowledge of ... by making use of the fruit fly "love song." To ... to know that the auditory system of the fruit fly contains ...
... Parents of newborn babies are always creeping into the nursery ... Alternatively, they might let baby sleep in their room, hoping ... too late. In future, a romper suit with an integrated ... stops breathing. The cornerstone of the sensor system is a ...
Cached Biology News:DNA prefers to dive head first into nanopores 2DNA prefers to dive head first into nanopores 3UI researcher learns mechanism of hearing is similar to car battery 2Romper suit to protect against sudden infant death 2Romper suit to protect against sudden infant death 3
(Date:6/26/2015)...  A San Francisco company, Pembient, recently announced it ... horn: beer in China and ... response to the emerging industry, two leading rhino conservation ... synthetic rhino horn.  The International ... International (SRI) released a joint statement ...
(Date:6/26/2015)... ... June 26, 2015 , ... DNA Genotek, a ... OraSure Technologies, Inc. (Nasdaq: OSUR) today announced that it has awarded grants to ... Microbiome Grant Program. The company has awarded its OMNIgene®â€¢GUT fecal/stool collection ...
(Date:6/25/2015)... DUBLIN , June 25, 2015 ... Markets ( http://www.researchandmarkets.com/research/vxtfvv/2015_market ) has announced the ... Analysis of the Global Cancer Diagnostics ... CSFs, Hormones, Immunohistochemical Stains--Hospitals, Commercial Labs, ... offering.       (Logo: http://photos.prnewswire.com/prnh/20130307/600769) ...
(Date:6/25/2015)... 25, 2015  BioMed Realty Trust, Inc. (NYSE: ... ILMN ), a world leader in genomics focused on ... genome, has signed a 20-year lease for a 155,000 ... Cambridge, England . The project will ... highly skilled workforce in the dynamic research cluster anchored ...
Breaking Biology Technology:Rhino Experts Oppose Synthetic Rhino Horn as Solution to Poaching Crisis 2DNA Genotek Inc. Announces Recipients of Gut Microbiome Grant Program 2DNA Genotek Inc. Announces Recipients of Gut Microbiome Grant Program 3Analysis of the Global Cancer Diagnostics Industry 2015-2020: Oncogenes, Biochemical Markers, Lymphokines, GFs, CSFs, Hormones, Immunohistochemical Stains 2Analysis of the Global Cancer Diagnostics Industry 2015-2020: Oncogenes, Biochemical Markers, Lymphokines, GFs, CSFs, Hormones, Immunohistochemical Stains 3BioMed Realty And Illumina Announce New Build-To-Suit Laboratory Building In Cambridge's Growing Life Science Cluster 2BioMed Realty And Illumina Announce New Build-To-Suit Laboratory Building In Cambridge's Growing Life Science Cluster 3
... Next Clinical StudiesOMAHA, Neb. and HOUSTON, May 11 ... Power3 Medical Products, Inc. (OTC Bulletin Board: PWRM), ... and NuroPro(R) PD tests for Alzheimer,s and Parkinson,s ... meeting in Seattle, WA. The NuroPro tests help ...
... Inc. (Pink Sheets: NNLX) is pleased to announce the ... and target research and development efforts for products. ... vastly expanded scope of expertise in both medicine and ... of numerous NanoLogix patents, has resigned from the NanoLogix ...
... Panel DiscussionATLANTA, May 11 , WHAT: GeoVax Labs, ... publicly traded biopharmaceutical company developing human, ... Virus) and other ... the future and plans to expand preventative trials, currently in, ...
Cached Biology Technology:Transgenomic and Power3 Medical Introduce NuroPro(R) Tests for Alzheimer's and Parkinson's Diseases at AAN Annual Meeting 2Transgenomic and Power3 Medical Introduce NuroPro(R) Tests for Alzheimer's and Parkinson's Diseases at AAN Annual Meeting 3Transgenomic and Power3 Medical Introduce NuroPro(R) Tests for Alzheimer's and Parkinson's Diseases at AAN Annual Meeting 4Transgenomic and Power3 Medical Introduce NuroPro(R) Tests for Alzheimer's and Parkinson's Diseases at AAN Annual Meeting 5A Global View: NanoLogix Creates Science Advisory Board 2A Global View: NanoLogix Creates Science Advisory Board 3A Global View: NanoLogix Creates Science Advisory Board 4A Global View: NanoLogix Creates Science Advisory Board 5
... Non-ionic Detergent Removal , , ... virtually no cross-reactivity with other proteins , ... , Economical new surface technology, not ... often interfere with protein analysis. SurfactAway offers ...
SDS-OutT SDS Precipitation Reagent...
... TRAC is a platform for fully automated ... It can easily be configured for applications ... molecular biology.TRAC allows closed loop screening, which ... hit list generating, cherry picking and follow ...
... Series of systems provide fast and reliable scalable automation ... development laboratories. Staccato systems are available in three base ... Series. ... All Staccato Application ...
Biology Products: