Navigation Links
Depression model leaves mice with molecular scar

In addition to triggering a depression-like social withdrawal syndrome, repeated defeat by dominant animals leaves a mouse with an enduring "molecular scar" in its brain that could help to explain why depression is so difficult to cure, suggest researchers funded by the National Institutes of Health's (NIH) National Institute of Mental Health (NIMH).

In mice exposed to this animal model of depression, silencer molecules turned off a gene for a key protein in the brain's hippocampus. By activating a compensatory mechanism, an antidepressant temporarily restored the animals' sociability and the protein's expression, but it failed to remove the silencers. A true cure for depression would likely have to target this persistent stress-induced scar, say the researchers, led by Eric Nestler, M.D., The University of Texas Southwestern Medical Center, who report on their findings online in Nature Neuroscience during the week of February 26, 2005.

"Our study provides insight into how chronic stress triggers changes in the brain that are much more long-lived than the effects of existing antidepressants," explained Nestler.

Mice exposed to aggression by a different dominant mouse daily for 10 days became socially defeated; they vigorously avoided other mice, even weeks later. Expression of a representative gene in the hippocampus, a memory hub implicated in depression, plummeted three-fold and remained suppressed for weeks. However, chronic treatment with an antidepressant (the tricyclic imipramine) restored expression of the gene for brain derived neurotrophic factor (BDNF) to normal levels and reversed the social withdrawal behavior. BDNF in the hippocampus has been linked to memory, learning and depression, but Nestler said social defeat stress probably similarly affects other genes there as well.

The researchers pinpointed how social defeat changes the BDNF gene's internal machinery. They traced the gene expression changes to long-lasting mo
'"/>

Source:NIH/National Institute of Mental Health


Page: 1 2

Related biology news :

1. Depression gene may weaken mood-regulating circuit
2. Scientists identify new model Of NK cell development
3. Genrate: a generative model that finds and scores new genes and exons in genomic microarray data
4. Molecular models advance the fight against malaria
5. NYU and MSKCC research provides model for understanding chemically induced cancer initiation
6. Genetic therapy reverses nervous system damage in animal model of inherited human disease
7. Disease progression model of pancreatic cancer developed by Penn researchers
8. A new way to share models of biological systems
9. Understanding biases in epidemic models important when making public health predictions
10. Climate model links higher temperatures to prehistoric extinction
11. Gene therapy advance treats hemophilia in mouse models
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Depression model leaves mice with molecular scar

(Date:10/30/2014)... Biological membranes are mainly composed of lipid bilayers. ... ions onto lipid membranes helps clarify functional processes ... a quantitative description of the equilibria between lipid ... Zbigniew Figaszewski from the University of Bialystok, Poland, ... findings, just published in EPJ E . ...
(Date:10/29/2014)... air pollutants released by unconventional oil and gas production ... published today in the open access journal Environmental ... formaldehyde were found. The study is the first to ... near production sites and could be used to supplement ... come from reserves that do not readily flow to ...
(Date:10/29/2014)... study of its kind to date, researchers have used ... the risk for autism. Joseph Buxbaum, Ph.D., Icahn School ... Daly, Ph.D., Broad Institute of Harvard and MIT, and ... affected children, parents and unrelated people. They identified changes ... the risk for autism spectrum disorder (ASD) – a ...
Breaking Biology News(10 mins):Ion adsorption matter in biology 2Air quality and unconventional oil and gas sites 2Air quality and unconventional oil and gas sites 3
... As a key step toward providing patients with treatments ... and the International Genomics Consortium (IGC) have launched a new ... personalized medicine. Called Paradigm, the new nonprofit company brings ... two leaders in using genetic information to understand and treat ...
... Society for Reef Studies, has published online a study ... Museum of Los Angeles County (NHM) about an invasive ... species was previously restricted to Pacific waters, but surprisingly, ... the Atlantic. Its presence near Brazilian and Caribbean ports ...
... DURHAM, N.H., August 15, 2012 A new report ... and concludes that the climate of the Northeast has ... outlines the effects of climate change on multiple aspects ... States and eastern Canada and concludes with recommendations on ...
Cached Biology News:Creating a future of personalized medicine: U-M forms joint venture for DNA diagnostics 2Invasive brittle star species hits Atlantic Ocean 2Climate change effects, potential mitigation in Northeast forests subject of Forest Service Report 2
(Date:10/31/2014)... 2014 Having access to safe drinking ... battle in many corners of the globe. It’s a ... in northwestern Bolivia where many have been sickened by ... Fairfield University’s School of Engineering has been working to ... (UAC), “the united college for the peasants.” A branch ...
(Date:10/31/2014)... 2014 Two separate delegations of ... by Charm Sciences at its Andover, Massachusetts facility ... the US, the participants discussed international systems for ... and process verification, and received hands-on technical training ... the first visit to the United States for ...
(Date:10/31/2014)... October 31, 2014 This is ... and China Biocides industry. The report provides basic ... industry chain structure as well as industry overview. ... China’s domestic market as well as Global industry ... The report on the Chinese biocides industry ...
(Date:10/31/2014)... VA (PRWEB) October 31, 2014 ... and sustainability consultancy, announced today that Dr. Harvey ... Principal Consultant and will work closely with senior ... will also continue to serve at The Hamner ... Triangle Park, North Carolina, where he is Director, ...
Breaking Biology Technology:Fairfield University School of Engineering project reduces illness in rural community 2Fairfield University School of Engineering project reduces illness in rural community 3Charm Sciences Hosts Executives from Latin America for Dairy Safety Executive Seminar 2Biocides Market for International & Chinese Regional Development Analysis Now Available at DeepResearchReports.com 2Biocides Market for International & Chinese Regional Development Analysis Now Available at DeepResearchReports.com 3Internationally recognized health scientist Dr. Harvey Clewell renews association with ENVIRON 2Internationally recognized health scientist Dr. Harvey Clewell renews association with ENVIRON 3
... really be hacked in just 30 minutes? Not according to a ... recent media reports for sensationalism after they reported on a public ... out login accounts to potential hackers. , ,In that case, it ... to the computer to take full control of it. But ...
... Credit unions could take better advantage of available ... UW E-Business Consortium. , ,According to the Federal Trade Commission, ... the last five years 10 million last year. While ... fact that they could be is a pressing worry for ...
... reach the inboxes of their subscribers, it's time to consider ... , ,The right inbox? Priceless. , ,Unwanted e-mail, or ... not uncommon for inboxes to average hundreds of e-mails a ... welcomed or relevant. Most consumers have some degree of spam ...
Cached Biology Technology:What's an inbox worth? 2What's an inbox worth? 3What's an inbox worth? 4
...
Tan solid. A glycoside used to permeabilize cellular membranes. Exhibits hemolytic activity. Contaminants: ash: ≤10%. Soluble in H 2 O. pH 4.4 - 4.6. RTECS VQ1400000, CAS 8047-15-2. References:...
...
... utilizes a silica based spin filter membrane to ... desired DNA band is cut from an agarose ... unit. The gel slice is melted irreversibly in ... is bound to the silica spin filter membrane ...
Biology Products: