Navigation Links
Deficiency of growth hormone and IGF-1 reduces cancer and kidney disease, but creates other problems

Deficiencies of growth hormone and similar compounds may reduce cancer and kidney disease late in life, but also may lead to cartilage degeneration and impaired memory and learning ability, according to research at Wake Forest University Baptist Medical Center and four other institutions.

The researchers used a rat model to explore the effects of growth hormone and another compound, IGF-1 (insulin-like growth factor 1) on adult rats and found paradoxical effects, according to William E. Sonntag, Ph.D., professor of physiology and pharmacology at Wake Forest University Baptist Medical Center and the lead investigator.

"Things that happen when you are an adolescent may have an impact on how long you live and what you die of," he said.

"The presence of growth hormone and IGF-1 is necessary for maintenance of cognitive function and prevention of cartilage degeneration," Sonntag and his colleagues reported in an article in Endocrinology, published on-line today. But the hormones also increase cancer and other diseases that limit lifespan.

The researchers developed a strain of dwarf rats that were naturally deficient in both growth hormone and in IGF-1. To mimic the rise in growth hormone and IGF-1 during adolescence in normal rats, some of these deficient rats were given growth hormone while they were between 4 and 14 weeks of age ?rat adolescence. Then hormone treatment was stopped and the animals had lower growth hormone and IGF-1 levels the rest of their lives.

That had an effect on cancer: 88 percent of "normal" male rats have tumors at death. The male rats that had a lifelong deficiency of growth hormone had substantially fewer tumors ?63 percent ?and the percent of tumors that were fatal was reduced from 57 percent to 31 percent.

The same pattern occurred for kidney disease, which was found in 74 percent of the normal male animals at the time of their deaths. None of the growth-hormone deficient animals developed kidne
'"/>

Source:Wake Forest University Baptist Medical Center


Page: 1 2

Related biology news :

1. Iron Deficiency Sparks Dramatic Changes In Gene Expression
2. Plants, animals share molecular growth mechanisms
3. U-M scientists find genes that control growth of common skin cancer
4. Researchers discover chemical compounds that affect plant growth
5. Physical and functional interaction of key cell growth molecules linked to cancer
6. Hormones and growth: The control of body size and developmental growth rate in fruit flies
7. Researchers find molecule that inhibits regrowth of spinal nerve cells
8. Gradient guides nerve growth down spinal cord
9. Suppressing growth hormone in early adulthood may prevent cancer
10. Scientists discover genetic pathway responsible for breast cancer cell growth
11. Breath of the dragon: ERS-2 and Envisat reveal impact of economic growth on Chinas air quality
Post Your Comments:
(Date:6/25/2015)... 2015 According to a ... & Area), Technology, Material (Optical Prism, Piezoelectric, Capacitive ... & Others) & Geography - Global Forecast to ... market is expected to reach $14,500.07 Million by ... Browse 76 market Tables and 109 Figures ...
(Date:6/24/2015)... NEW YORK , June 24, 2015 ... Systems market, over the next six years. It contains ... affect the industry, along with their impact from the ... It also discusses the industry, market, and technology ... expected that the need of concerned authorities to efficiently ...
(Date:6/23/2015)... Minn. , June 23, 2015   ... company that supports the entire spectrum of clinical ... iMedNet ™ , the company,s intuitive, ... been awarded a Silver 2015 Stevie® Award by ... Health Products & Services Website category.  The American ...
Breaking Biology News(10 mins):Fingerprint Sensors Market Worth $14,500.07 Million by 2020 2Fingerprint Sensors Market Worth $14,500.07 Million by 2020 3Fingerprint Sensors Market Worth $14,500.07 Million by 2020 4Automatic Identification System Market by Class, by Platform, by Application and by Geography - Global Forecasts & Analysis to 2014 - 2020 2MedNet Solutions' iMedNet eClinical Wins Silver Stevie Award 2
... expected to attend the sixth annual biomedical engineering showcase ... The annual event, to be held from 7: 30 ... professionals and academics interested in the applied-life sciences. ... the Biomedical Frontier: Neuro-engineering, Imaging and Assistive Technologies" will ...
... International Society for Computational Biology (ISCB) are delighted to ... journal Bioinformatics will once again become an ... Bioinformatics and the ISCB have always shared ... new official partnership. ISCB members enjoy a substantial discount ...
... mutations in a gene that helps the body metabolize ... are at higher risk for side effects, including compromised ... new research. Published online Feb. 18 by the ... , the study suggests this genetic approach could also ...
Cached Biology News:NJIT to host major biomedical engineering showcase and career fair 2Gene mutation increases drug toxicity, rejection risk in pediatric kidney transplants 2Gene mutation increases drug toxicity, rejection risk in pediatric kidney transplants 3
(Date:6/30/2015)... July 1, 2015 R-Japan Co.,Ltd. obtained the license ... of Regenerative Medicine from the Ministry of Health, Labour and ... 2015. The fact that R- Japan ... the auditing from Pharmaceuticals and Medical Devices Agency (PMDA) on ... it to provide stem cell manufacturing service to medical institutions. ...
(Date:6/30/2015)... Santa Clara CA (PRWEB) , ... June 30, ... ... force microscopy (AFM) is hosting a webinar to provide advanced scientific research into ... material science, bio science and energy. Touted as 'the wonder material of ...
(Date:6/30/2015)...  Today, Americord Registry, one of the fastest growing cord ... a partner at Kirkland & Ellis LLP, as the newest ... http://photos.prnewswire.com/prnh/20150630/226958LOGO   "We are thrilled about ... Martin Smithmyer , CEO of Americord. "He brings a wealth ... assist Americord,s growth and vision." Andrew Horne ...
(Date:6/30/2015)... ... June 30, 2015 , ... Noblis, ... government, announced in a paper published this week in the scientific journal Viruses ... the diagnostic techniques currently used to detect the Ebola virus. Noblis worked with ...
Breaking Biology Technology:R-Japan Obtained Autologous Stem Cell Manufacturing License from the Ministry of Health, Labour and Welfare 2How Graphene–based Nanomaterials and Films Revolutionize Science Explained in July 9 Webinar Hosted by Park Systems 2How Graphene–based Nanomaterials and Films Revolutionize Science Explained in July 9 Webinar Hosted by Park Systems 3How Graphene–based Nanomaterials and Films Revolutionize Science Explained in July 9 Webinar Hosted by Park Systems 4Americord Registry Announces Andrew Horne as Advisory Board Member 2Noblis and Government Scientists Identify New Genomic Signatures of Ebola Using Whole Genomic Sequencing and Innovative BioVelocity Analytics Tool 2Noblis and Government Scientists Identify New Genomic Signatures of Ebola Using Whole Genomic Sequencing and Innovative BioVelocity Analytics Tool 3Noblis and Government Scientists Identify New Genomic Signatures of Ebola Using Whole Genomic Sequencing and Innovative BioVelocity Analytics Tool 4
... , Trial conducted pursuant to Special Protocol ... CITY, Dec. 16 /PRNewswire-FirstCall/ - AEterna Zentaris Inc. (NASDAQ: ... biopharmaceutical company focused on oncology and endocrine therapy, today ... ("Keryx") ( KERX), of a Phase 3 registration clinical ...
... , , SAN MARINO, Calif., Dec. 15 Epeius ... genetic medicine, gained international validation of the cutting-edge science behind ... the world rediscovered the Cyclin G1 gene to ... and thus a prime target for anti-cancer therapies. Recently, scientists ...
... , , , SAN DIEGO, Dec. 15 Aethlon Medical, Inc. ... and Dr. Wayne Comper have joined the Science Advisory ... Comper are leading researchers in the exosome field. ESI, a wholly ... discovery that the Hemopurifier®, a medical device being advanced as an ...
Cached Biology Technology:AEterna Zentaris Partner, Keryx, Initiates Phase 3 Registration Trial with Perifosine (KRX-0401) for the Treatment of Patients with Advanced Multiple Myeloma 2AEterna Zentaris Partner, Keryx, Initiates Phase 3 Registration Trial with Perifosine (KRX-0401) for the Treatment of Patients with Advanced Multiple Myeloma 3AEterna Zentaris Partner, Keryx, Initiates Phase 3 Registration Trial with Perifosine (KRX-0401) for the Treatment of Patients with Advanced Multiple Myeloma 4AEterna Zentaris Partner, Keryx, Initiates Phase 3 Registration Trial with Perifosine (KRX-0401) for the Treatment of Patients with Advanced Multiple Myeloma 5Scientists Rediscover Gene Target for Cancer Therapy 2Scientists Rediscover Gene Target for Cancer Therapy 3Aethlon Medical Appoints Jeff Schorey and Wayne Comper to Exosome Sciences Advisory Board 2Aethlon Medical Appoints Jeff Schorey and Wayne Comper to Exosome Sciences Advisory Board 3Aethlon Medical Appoints Jeff Schorey and Wayne Comper to Exosome Sciences Advisory Board 4Aethlon Medical Appoints Jeff Schorey and Wayne Comper to Exosome Sciences Advisory Board 5
... EPS 301 Power Supply, 1. ... maximum.Constant voltage or constant current modes.Single-unit ... precision and reproducibility.Suitable for submarine, mini ... as well as semidry and mini ...
... Supply, 1. 1000 V, 400 mA, ... and constant power modes.Single-unit increments in ... reproducibility.Stores and recalls three protocols.Outstanding choice ... Multiphor II or GenePhor systems. ...
Mouse TrkC Affinity Purified Polyclonal Ab...
Immunogen: Full length M32 fusion protein. Storage: -20 C, Avoid Freeze/Thaw Cycles...
Biology Products: