Navigation Links
Compounds in plastic packaging act as environmental estrogens altering breast genes

Compounds found in plastic products used to wrap or contain food and beverages have aroused concerns as possible cancer-causing agents because they can sometimes leach out of the plastic and migrate into the food, especially after heating or when the plastic is old or scratched. In two studies funded by the National Institute of Environmental Health Sciences, researchers at Fox Chase Cancer Center in Philadelphia have demonstrated that two plasticizer compounds, BPA and BBP, are environmental estrogens capable of affecting gene expression in the mammary glands of young female laboratory rats exposed to the compounds through their mothers' milk.

Raquel Moral, Ph.D., a postdoctoral associate in the Fox Chase laboratory of Jose Russo, M.D., presented the results today at the 96th Annual Meeting of the American Association for Cancer Research. Russo is director of the Breast Cancer and the Environment Research Center at Fox Chase. After the morning poster session, he will give an oral presentation on "Estrogens as Carcinogens in the Human Breast."

"Development of breast cancer entails multiple events, in which estrogen appears to play an important role," explained Russo. "Our laboratory has pioneered an in vitro system of cell transformation using estrogens and their metabolites as carcinogenic agents in human breast cells. Our data show that each compartment of the breast has specific differentially expressed genes that provide a genomic signature according to the increasing maturation of the organ.

"Estrogenic agents involved in breast development and possibly in breast cancer may include foreign estrogens, or xenoestrogens, that are used in manufacturing a number of products. The studies of BPA and BBP in young rats were designed to see whether exposure to these hormonally active biological compounds could alter the genomic signatures of the mammary gland during critical stages of development." BPA (bisphenol A) is a synthetic resin used in foo
'"/>

Source:Fox Chase Cancer Center


Page: 1 2

Related biology news :

1. First-ever Compounds To Target Only Metastatic Cells Are Highly Effective Against Breast, Prostate, And Colon Cancers
2. Engineers improve plastics potential for use in implants by linking it to biological material
3. Bacteria are key to green plastics, drugs
4. A new window into structural plasticity in the adult visual cortex
5. Microbes convert Styrofoam? into biodegradable plastic
6. Potato blight pathogenicity explained by genome plasticity
7. Iowa State researchers improving plastics made from corn and soy proteins
8. Carnegie Mellon scientists use green approach to transform plastics manufacturing
9. Revealing the machinery underlying the plastic juvenile brain
10. Relationship of brain and skull more than just packaging
11. Loosen up, DNA: Leukemia gene changes genetic packaging
Post Your Comments:
(Date:8/24/2015)... TOWN, South Africa , August 24, 2015 ... Germany ,s largest biometrics manufacturer DERMALOG and ... with the "2015 African Biometrics Company of the Year ... in Nigeria .   -Cross ... and http://www.presseportal.de/nr/8896 - On Thursday evening, ...
(Date:8/20/2015)... Calif. , Aug. 20, 2015   ... focused on improving the user experience and security ... vision technologies, today announced that its TrulySecure™ ... biometric authentication software to be FIDO Certified™. ... TrulySecure for compliance with the FIDO UAF (Universal ...
(Date:8/18/2015)... 2015  Navitas today announced that it ... Submission Content Management webinar scheduled on August ... to the Implementation of Regulatory Submission Standards ... industry, vendors, health authorities, consultants and the ... a standard method of implementing electronic submission ...
Breaking Biology News(10 mins):Frost & Sullivan Honors DERMALOG with Biometrics Prize for Achievements in Africa 2Frost & Sullivan Honors DERMALOG with Biometrics Prize for Achievements in Africa 3TrulySecure From Sensory Becomes First Face and Voice Biometrics Technology to be FIDO UAF Certified 2TrulySecure From Sensory Becomes First Face and Voice Biometrics Technology to be FIDO UAF Certified 3TrulySecure From Sensory Becomes First Face and Voice Biometrics Technology to be FIDO UAF Certified 4TrulySecure From Sensory Becomes First Face and Voice Biometrics Technology to be FIDO UAF Certified 5Navitas, a Key Contributor in IRISS Forum Webinar 2Navitas, a Key Contributor in IRISS Forum Webinar 3
... April 27 /PRNewswire-Asia/ -- Wonder Auto Technology,Inc. (Nasdaq: WATG ) ... and engine components in China ,wins a contract from a world-class customer ... Mechanical Parts Co., Ltd ("Wanyou"). , , ... On 23 April, Wanyou has gained trail orders from a ...
... ST. IVES, England , April 27 Lancaster ... this year,s MotorMart Autojumble in Beaulieu from 15th to 16th May. ... to and answer any questions classic car owners may have. Visit ... you can also benefit from their show offer of up to ...
... CLARA, Calif. , April 27 Phoenix ... the TecDAX, has signed a framework agreement with MiaSole, ... panels based in Santa Clara, California . The ... extend its product portfolio with another quality supplier capable ...
Cached Biology News:Wonder Auto Obtains a New World-class Customer in Germany 2Wonder Auto Obtains a New World-class Customer in Germany 3Take Advantage of Lancaster's Offers at This Year's Autojumble 2Take Advantage of Lancaster's Offers at This Year's Autojumble 3Phoenix Solar AG and MiaSole Sign Multi-Year Framework Agreement for the Delivery of Thin-Film Solar Modules 2Phoenix Solar AG and MiaSole Sign Multi-Year Framework Agreement for the Delivery of Thin-Film Solar Modules 3
(Date:8/27/2015)... The National Necrotizing Fasciitis Foundation ... by doctors at Vanderbilt University Hospital in ... and Dr. John Crew , director of the ... Center in Daly City, CA. ... pioneered by Dr. Crew, that had previously saved the ...
(Date:8/27/2015)... 27, 2015 /PRNewswire/ - BIOREM Inc. (TSXV: BRM) ("Biorem" or "the ... ended June 30, 2015. Biorem,s complete second quarter financial statements and ... FINANCIAL HIGHLIGHTS: in ,000,s except earnings per shareThree-months ended , Six -months ... , 2015 , 2014 Revenue , 4,709 ... 4,433 Gross profit , 1,656 , 56 ...
(Date:8/27/2015)... , August 27, 2015 GlassesOff ... image processing functions in the human vision system, announced today ... point guard Chris Paul to develop a ... who want to improve their real-life on-court performance. ... court, whether it is shooting a ball or blocking a ...
(Date:8/27/2015)... ... August 27, 2015 , ... METTLER TOLEDO's ... narrows down the product choices to a manageable shortlist of bench and floor ... to models that fit best with the customer’s industry and application. , ...
Breaking Biology Technology:Patient's Life and Eyes Saved from Gruesome Flesh-Eating Infection Consuming Her Face 2Patient's Life and Eyes Saved from Gruesome Flesh-Eating Infection Consuming Her Face 3BIOREM Reports $718,000 Net Earnings for the Second Quarter 2BIOREM Reports $718,000 Net Earnings for the Second Quarter 3Eight-Time All-Star Chris Paul and GlassesOff Partner to Develop Innovative Mobile App Designed to Improve On-Court Performance 2Eight-Time All-Star Chris Paul and GlassesOff Partner to Develop Innovative Mobile App Designed to Improve On-Court Performance 3METTLER TOLEDO Updates Online Scale Selection Tool 2
... Calif., Oct. 12, 2011 Life Technologies ... announced the Applied Biosystems QuantStudio™ 12K Flex ... that enables cost-effective and efficient interrogation of hundreds of ... run. The growing demand of biomarker screening ...
... The National Science Foundation (NSF) has selected a University ... class of NSF Innovation Corps awards. The I-Corps Awards ... and connects scientists to entrepreneurial resources. "The idea ... intellectual property from the lab into the commercial world," ...
... 11, 2011 ThermoGenesis Corp. (NASDAQ: KOOL ... that process and store adult stem cells, said today ... (AXP) which is used to concentrate stem cells from ... & Drug Administration (SFDA) in China. This represents the ...
Cached Biology Technology:Life Technologies Announces Flagship PCR Instrument that Enables Cost-Effective, High-Throughput Screening Applications 2Life Technologies Announces Flagship PCR Instrument that Enables Cost-Effective, High-Throughput Screening Applications 3Life Technologies Announces Flagship PCR Instrument that Enables Cost-Effective, High-Throughput Screening Applications 4Penn team wins entrepreneurial innovation award 2ThermoGenesis Announces Acceptance of AXP® Submission by Regulatory Body in China 2ThermoGenesis Announces Acceptance of AXP® Submission by Regulatory Body in China 3
... The Heraeus HERAcell is the ideal ... including development of ova or embryos at ... specifically designed to provide everything needed to ... , , Safe and stable incubation conditions ...
... Anti-M13 polyclonal antibody was derived from rabbit ... particles.Recombinant protein domains such as antibody fragments ... pIII and displayed on phage using phagemid-based ... utilized in the Ph.D. libraries. Anti-M13 pIII ...
... T4 Polynucleotide Kinase catalyzes the ... ATP to the 5-terminus of ... a 5-hydroxyl group. The enzyme, ... may be used to phosphorylate ...
... IVF are designed for human in vitro ... setup and operation, and convenience. Chamber, ... displayed on the control panel. Our signature ... by way of the thermal printer inside ...
Biology Products: