Navigation Links
Compounds in plastic packaging act as environmental estrogens altering breast genes

Compounds found in plastic products used to wrap or contain food and beverages have aroused concerns as possible cancer-causing agents because they can sometimes leach out of the plastic and migrate into the food, especially after heating or when the plastic is old or scratched. In two studies funded by the National Institute of Environmental Health Sciences, researchers at Fox Chase Cancer Center in Philadelphia have demonstrated that two plasticizer compounds, BPA and BBP, are environmental estrogens capable of affecting gene expression in the mammary glands of young female laboratory rats exposed to the compounds through their mothers' milk.

Raquel Moral, Ph.D., a postdoctoral associate in the Fox Chase laboratory of Jose Russo, M.D., presented the results today at the 96th Annual Meeting of the American Association for Cancer Research. Russo is director of the Breast Cancer and the Environment Research Center at Fox Chase. After the morning poster session, he will give an oral presentation on "Estrogens as Carcinogens in the Human Breast."

"Development of breast cancer entails multiple events, in which estrogen appears to play an important role," explained Russo. "Our laboratory has pioneered an in vitro system of cell transformation using estrogens and their metabolites as carcinogenic agents in human breast cells. Our data show that each compartment of the breast has specific differentially expressed genes that provide a genomic signature according to the increasing maturation of the organ.

"Estrogenic agents involved in breast development and possibly in breast cancer may include foreign estrogens, or xenoestrogens, that are used in manufacturing a number of products. The studies of BPA and BBP in young rats were designed to see whether exposure to these hormonally active biological compounds could alter the genomic signatures of the mammary gland during critical stages of development." BPA (bisphenol A) is a synthetic resin used in foo
'"/>

Source:Fox Chase Cancer Center


Page: 1 2

Related biology news :

1. First-ever Compounds To Target Only Metastatic Cells Are Highly Effective Against Breast, Prostate, And Colon Cancers
2. Engineers improve plastics potential for use in implants by linking it to biological material
3. Bacteria are key to green plastics, drugs
4. A new window into structural plasticity in the adult visual cortex
5. Microbes convert Styrofoam? into biodegradable plastic
6. Potato blight pathogenicity explained by genome plasticity
7. Iowa State researchers improving plastics made from corn and soy proteins
8. Carnegie Mellon scientists use green approach to transform plastics manufacturing
9. Revealing the machinery underlying the plastic juvenile brain
10. Relationship of brain and skull more than just packaging
11. Loosen up, DNA: Leukemia gene changes genetic packaging
Post Your Comments:
(Date:6/24/2015)... 2015 This report provides market analysis of ... years. It contains an analysis of the drivers, challenges, ... impact from the short, medium, and long term perspective ... market, and technology trends that currently, prevail in the ... authorities to efficiently manage the increasing marine traffic and ...
(Date:6/24/2015)... , June 24, 2015 Biometry ... with emerging biometric password solution one face in. ... one face in, entering the ... ground-breaking and affordable multifactor-authentication biometric answer to the ... technology, provided in partnership with KeyLemon, one face ...
(Date:6/23/2015)... N.C. , June 23, 2015   ... today announced the results of a recent study ... accuracy on the wrist during activity. In a ... technology was compared along with the Apple Watch ... accurately measuring heart rate during activity. The study ...
Breaking Biology News(10 mins):Automatic Identification System Market by Class, by Platform, by Application and by Geography - Global Forecasts & Analysis to 2014 - 2020 2KeyLemon Announces Partnership With Biometric Password Solution onefacein 2Valencell Delivers Breakthrough Heart Rate Accuracy on the Wrist 2Valencell Delivers Breakthrough Heart Rate Accuracy on the Wrist 3
... preserve grapes could help prevent allergies and boost healthy compounds ... Industry, the magazine of the SCI. The same technique could ... without the added sulphites that can cause asthma and other ... in storage for months and are usually treated with sulphur ...
... Researchers at Columbia University’s Mailman School of Public Health ... cancer. Using DNA isolated from serum samples as ... tumor suppressor genes that have been associated with the ... to prospectively examine potential biomarkers for early detection of ...
... normally used to treat insomnia, temporarily improved brain function ... in which the person is alert but cannot speak ... and eat without assistance after receiving the drug for ... the March 2007 issue of Annals of Neurology ( ...
Cached Biology News:Grape expectations for healthier wine 2Mailman School of Public Health researchers report blood DNA can be early predictor of liver cancer 2Insomnia drug can improve brain function 2
(Date:7/6/2015)... Worcester, Mass. (PRWEB) , ... July 06, 2015 ... ... by Worcester Polytechnic Institute (WPI), offers new insights into how virulent fungi adapt ... block their spread, and how that battle leaves them temporarily weakened. These insights ...
(Date:7/6/2015)... Mass. (PRWEB) , ... July 06, 2015 , ... ... of simpler and cheaper molecular diagnostic tests are key drivers of the global ... growth of personalized medicine and the introduction of new companion diagnostic tests will ...
(Date:7/6/2015)... , July 6, 2015 ImmunoCellular Therapeutics, Ltd. ... an agreement with Novella Clinical (Novella), to ... patients with newly diagnosed glioblastoma. Novella is a full-service, ... to small to mid-sized oncology companies. The ICT-107 phase ... the US, Europe and ...
(Date:7/3/2015)... ... 2015 , ... The Alexander Group, a 30-year old, global ... typically known for its consummate professionalism-- embarks each year in a whacky marketing ... their day jobs. , "Our motto has always been work hard play hard," ...
Breaking Biology Technology:Worcester Polytechnic Institute Co-directs Study That Provides New Insights into the Genetics of Drug-Resistant Fungal Infections 2Worcester Polytechnic Institute Co-directs Study That Provides New Insights into the Genetics of Drug-Resistant Fungal Infections 3Worcester Polytechnic Institute Co-directs Study That Provides New Insights into the Genetics of Drug-Resistant Fungal Infections 4Demand for Personalized Medicine, Innovative Molecular Diagnostic Tests Spurring Big Growth, According to BCC Research 2Demand for Personalized Medicine, Innovative Molecular Diagnostic Tests Spurring Big Growth, According to BCC Research 3ImmunoCellular Therapeutics Establishes Agreement with Novella Clinical to Conduct ICT-107 Phase 3 Registration Trial in Glioblastoma 2The Alexander Group Declares Their Independence with a Bit of Levity 2
... INC. (Nasdaq: VION ) today announced that the ... 7.75% Convertible Senior Notes due,2012 (the "Notes"). The aggregate ... Company paid $2,260,416.67 in interest through the issuance of,shares ... in,2,539,200 shares of Common Stock, based on today,s closing ...
... Ltd. (NASDAQ: HCTL ), today announced unaudited results for ... Revenues for the first six months of 2007 were ... of 2006. The gross profit for the,first half of the ... in 2006. The net loss for such period was $(319) ...
... Advanced Life Sciences,Holdings, Inc. (Nasdaq: ADLS ), ... Listings Qualifications Department informed the Company that the,market ... million for 10,consecutive days, which is the requirement ... to Marketplace Rule 4450(b)(1)(A). Nasdaq,also informed the Company ...
Cached Biology Technology:Vion Pharmaceuticals Pays Interest on 7.75% Convertible Senior Notes 2Vion Pharmaceuticals Pays Interest on 7.75% Convertible Senior Notes 3Healthcare Technologies Reports Loss for 2007 Second Quarter & Six Months Results 2Healthcare Technologies Reports Loss for 2007 Second Quarter & Six Months Results 3Advanced Life Sciences Announces Receipt of Nasdaq Staff Letter 2Advanced Life Sciences Announces Receipt of Nasdaq Staff Letter 3Advanced Life Sciences Announces Receipt of Nasdaq Staff Letter 4
streptavidin, Alexa Fluor® 750–allophycocyanin conjugate (Alexa Fluor® 750–allophycocyanin streptavidin) *1 mg/mL*...
AedestaTM Animal Organ/Tissue Perfusion Soln....
Reusble. Uses in conjunction with the Apoptotic Cell Isolation Kit....
EGTA, 10 g. Ethylene glycol-O,O-bis-[2-amino-ethyl]-N,N,N,N,-tetraacetic acid.Assay: > 99.0%. Category: Nucleotides & Enzymes & Biochemicals, Ultrapure Biochemicals ....
Biology Products: