Navigation Links
Compound from marine bacteria shows potential as multiple myeloma therapy

An anti-cancer compound derived from bacteria dwelling in ocean-bottom sediments appears in laboratory tests to be a potent killer of drug-resistant multiple myeloma cells, and potentially with less toxicity than current treatments, report Dana-Farber Cancer Institute researchers in the November issue of Cancer Cell.

The experimental compound, NPI-0052, has been found to block or inhibit cancer cells' proteasomes from working effectively. The proteasome work as a cell's "garbage disposal," chewing up and disposing of old, unwanted proteins. With their proteasome jammed, cells die from the backup of damaged proteins.

"Proteasome inhibition is a key therapeutic target and bortezomib (Velcade tm) was the first in a new class of compounds in multiple myeloma. NPI-0052 is a novel proteasome inhibitor with a chemical structure and action that is distinct from bortezomib, and has the promise of being even more effective for patients," says Kenneth Anderson, MD, director of the Jerome Lipper Multiple Myeloma Center at Dana-Farber, and senior author of the report.

The compound will be moved into Phase I clinical trials in early 2006, say officials of Nereus Pharmaceuticals in San Diego, the developer of NPI-0052. The compound will be tested as a single agent and subsequently in combination with other treatments.

Multiple myeloma is a currently incurable cancer of the bone marrow that causes a plunge in the production of vital red and white blood cells. Although relatively rare, it is the second most common type of blood cancer and accounts for 11,000 deaths annually in the United States. Bortezomib, approved by the Food and Drug Administration in 2003 for relapsed myeloma patients and subsequently for patients who have received at least one prior treatment, demonstrated in clinical trials that it extended the time to disease progression and also improved survival.

Though less toxic than conventional chemotherapy, bortezomib does have
'"/>

Source:Dana-Farber Cancer Institute


Page: 1 2 3

Related biology news :

1. First-ever Compounds To Target Only Metastatic Cells Are Highly Effective Against Breast, Prostate, And Colon Cancers
2. Newly Discovered Compound Blocks Known Cancer-Causing Protein
3. Compounds in plastic packaging act as environmental estrogens altering breast genes
4. Compound might defeat African sleeping sickness, clinical trial beginning this month
5. Compound from Chinese medicine shows promise in head and neck cancer
6. Anti-cancer Compound In Beer Gaining Interest
7. Compound in dairy products targets diabetes
8. Compound eyes, evolutionary ties
9. Sequencing of marine bacterium will help study of cell communication
10. Solutions that reduce death of marine life reeled in by International Smart Gear Competition
11. UN environmental agency steps up battle against marine pollution
Post Your Comments:
(Date:7/31/2014)... SHELTON, Conn. , July 31, 2014 /PRNewswire/ ... on the growing m-commerce market, reminds investors and ... generation smart wallet, Wocket™, that it will be on-air ... biometrically secure Wocket smart wallet will be featured ... consumer oriented television show that airs on the ...
(Date:7/30/2014)... Research at New York University is paving the ... damage in civilians and military troops exposed to ... , An article in the current issue ... advancement in detoxifying organophosphates, which are compounds commonly ... process was developed by NYU School of Engineering ...
(Date:7/30/2014)... protected and tended her eggs until they hatched 4.5 ... 2014 in the open-access journal PLOS ONE ... and colleagues. , Octopuses typically have a single reproductive ... take care of their fertilized eggs until they hatch. ... to 3 months, but little is known about the ...
Breaking Biology News(10 mins):NXT-ID's Next Generation Biometric Smart Wallet Featured on NewsWatch Consumer Show on the History Channel and FYI Network Today, July 31st 2NXT-ID's Next Generation Biometric Smart Wallet Featured on NewsWatch Consumer Show on the History Channel and FYI Network Today, July 31st 3Engineering a protein to prevent brain damage from toxic agents 2Deep-sea octopus has longest-known egg-brooding period 2
... vaccine for cattle can effectively reduce levels of E. ... University study has found. The vaccine is also effective using ... help cut costs for the beef industry. David Renter, ... project that researched the effectiveness of products used to prevent ...
... For years, scientists have debated how big a role ... Tree loss is a natural process, but it is ... habitat for many other species. Using high resolution 3-D ... determined tree losses across savannas of Kruger National Park. ...
... Saladax Biomedical, Inc., a privately held company developing ... promise of personalized medicine for new and existing ... existing relationship with Bristol-Myers Squibb Company (NYSE: ... Early Development Collaboration Agreement, which may include multiple ...
Cached Biology News:A new line of defense: Researchers find cattle vaccine works to reduce E. coli O157:H7 2Airborne technology helps manage elephants 2Saladax Biomedical Enters into Master Collaboration Agreement with Bristol-Myers Squibb 2
(Date:7/31/2014)... mathematician (1912-1954), is famous for a number of breakthroughs, ... 1936 he published a paper, which laid the foundation ... a computer algorithm. He next played a pivotal role ... cracked the German military codes, enabling the Allies to ... the late 1940,s he turned his attention to artificial ...
(Date:7/31/2014)... July 31, 2014 According to ... "Quantum Dots Market - Global Industry Analysis, Size, Share, ... was valued at USD 88.5 million in 2011, which ... growing at a CAGR of 53.8% from 2013 to ... Report at  http://www.transparencymarketresearch.com/quantum-dots.html Increasing demand for ...
(Date:7/31/2014)... , July 31, 2014 Research ... "Global Genomics Market 2014-2018" report to their ... Genomics is the study of the genetic material ... be a strong basis for the discovery and development ... human diseases or health conditions. Genomics is supported by ...
(Date:7/31/2014)... Held at the Stanford Cancer Center, the ... the disease and its treatment. Survivors will find information ... as updates on the state-of-the-art with respect to newer ... organizing this educational opportunity,” says KCA CEO Bill Bro, ... colleagues have put together a program that balances the ...
Breaking Biology Technology:A mathematical theory proposed by Alan Turing in 1952 can explain the formation of fingers 2A mathematical theory proposed by Alan Turing in 1952 can explain the formation of fingers 3Global Quantum Dots Market is Expected to Reach USD 8,246.8 Million in 2023: Transparency Market Research 2Global Quantum Dots Market is Expected to Reach USD 8,246.8 Million in 2023: Transparency Market Research 3Global Quantum Dots Market is Expected to Reach USD 8,246.8 Million in 2023: Transparency Market Research 4Global Genomics Market 2014-2018: Key Vendors are F. Hoffmann-La Roche, Life Technologies, Qiagen and Illumina 2
... 15 Forest,Laboratories, Inc. (NYSE: FRX ), ... to discuss aclidinium bromide clinical and pre-clinical,data findings ... webcast, which will include a slide presentation and ... 2008 at 9:30am New York time, 3:30pm CET,2:30pm ...
... Israel, May 15 Modigene Inc. (OTC,Bulletin Board: ... develop longer-acting versions of already approved,therapeutic proteins, today ... upcoming Acumen BioFin Rodman & Renshaw 5th Annual ... Central European Summer Time),on May 20, 2008., ...
... MOUNT LAUREL, N.J., May 15 MedQuist ... clinical documentation,workflow technology and services, and StructuRad ... today they have agreed to,integrate and use ... for Radiology(TM) speech recognition solution product., ...
Cached Biology Technology:Forest Laboratories, Inc. and Laboratorios Almirall, S.A. to Host Webcast to Discuss Aclidinium Bromide Data Presentations at the American Thoracic Society Annual Congress 2MedQuist and StructuRad Form Partnership to Integrate Report Macros into SpeechQ for Radiology(TM) 2
... space and organize gloves, safety glasses, ... are the perfect benchtop storage bins ... processing and manufacturing. Clear static-dissipative PVC ... they attract. Open-slot design for easy ...
... space and organize gloves, safety glasses, ... are the perfect benchtop storage bins ... processing and manufacturing. Clear static-dissipative PVC ... they attract. Many other sizes and ...
... Microarrays designed for genome-wide microRNA ... flexible and powerful Paraflo microfluidic on-chip ... as part of our comprehensive microRNA ... Content The Mammals microRNA Microarray ...
... is critical to the maintenance of ... proteins as important and diverse as ... shock and stress response, antigen presentation, ... ion channels, cell cycle regulation, transcription, ...
Biology Products: