Navigation Links
Commonly used antidepressants may also affect human immune system

, between immune cells that is normally only found between neurons," Ahern said.

In addition to Ahern, Peta Connell, Ph.D., from the Robarts Research Institute in Canada, was also a co-lead researcher on the study. Scientists from the Robarts Research Institute also contributed to the work.

In the brain, serotonin transmission between neurons is associated with feelings of pleasure, mood, and appetite, and the class of antidepressants known as SSRIs keeps serotonin active within the synaptic spaces between neurons, enhancing the chemical's positive effects. Unlike in the brain, which uses chemical messengers to communicate between nerve cells, the immune system is believed to "converse" through physical contact -- one type of immune cell touches another, setting off a response.

Specifically, "antigen presenting cells" display their antigens (bits of a foreign invader) to T-cells, and a resulting physical coupling between the antigens and the T-cells will prompt the T-cells to divide and expand in population, triggering an immune response designed to destroy the invader. This process may take hours.

What the Georgetown researchers found, however, is that dendritic cells -- the most powerful of the antigen-presenting cells and the ones that can find invaders that have never infected the body and "educate" the immune system to fight them -- also use serotonin to quickly excite a T-cell response. They discovered that these dendritic cells can rapidly secrete serotonin, which activates serotonin receptors on certain types of T-cells.

"In addition to the physical contact, it surprised us to find that these immune cells also have machinery to take up serotonin and to secrete it in an excitatory manner," Ahern said. "The point behind this transmission is not entirely clear, but it appears to be an additional way of stimulating a T cell response."

Drugs that block serotonin reuptake "likely change some of the parameters of T-ce
'"/>

Source:Georgetown University Medical Center


Page: 1 2 3

Related biology news :

1. Harmful Bacterium Commonly Found in Poultry May Survive Refrigeration and Frozen Storage Combined
2. In SAD patients, autumn antidepressants can prevent winter depression
3. Suicide risk does not increase when adults start using antidepressants, study finds
4. Cytoplasm affects the number of vertebrae in carp-goldfish clones
5. Clam embryo study shows pollutant mixture adversely affects nerve cell development
6. A new study examines how shared pathogens affect host populations
7. Researchers discover chemical compounds that affect plant growth
8. WHO Warns Of Increased Risk Of Vector-borne Diseases In Tsunami-affected Areas
9. Road salt affects mitigation wetlands
10. Retrovirus struck ancestors of chimpanzees and gorillas millions of years ago, but did not affect ancestral humans
11. Exercise training in ordinary people affects the activity of 500 genes
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Commonly used antidepressants may also affect human immune system

(Date:11/4/2014)... November 4, 2014   ... growth   Fuel3D , a developer of ... funding round totaling $6.4 million (£4 million). This funding builds ... earlier this year and paves the way for the commercial ... The funding round was led by Chimera Partners and ...
(Date:11/3/2014)... , Nov. 3, 2014 Research and ... "Cell Therapy - Technologies, Markets and Companies" to ... cell therapy technologies and methods, which have already started to ... stem cell transplantation is replacing the old fashioned bone marrow ... Cell therapy is bound to become a part of medical ...
(Date:11/3/2014)... and preterm birth are linked to increased risk for ... the American College of Rheumatology (ACR) journal, Arthritis ... and pre-term babies were not at greater risk of ... According to the ACR, 27 million Americans over the ... of OA range from mild to severe and include ...
Breaking Biology News(10 mins):Fuel3D Secures $6.4 Million in Expansion Funding 2Fuel3D Secures $6.4 Million in Expansion Funding 3Global Cell Therapy - Technologies, Markets and Companies: 2014 Report 2Global Cell Therapy - Technologies, Markets and Companies: 2014 Report 3Preterm, low birth-weight babies may need new hips in adulthood 2
... fuel sources are lighting a fire under research to turn ... Bill 20, signed this week by Gov. Rick Perry, compliments ... used. The new law requires more renewable energy to be ... consumer energy needs and agriculture industry trends with the legislation ...
... some day be defeated by a single treatment, according ... University of Georgia's College of Veterinary Medicine. , Their ... and Marburg and includes investigators from Vanderbilt University Medical ... The study is being funded by a grant from ...
... Berkeley, has found that damage to a cell's DNA sets ... of a marker recognized by the body's immune system. , ... advanced online issue of Nature, shed light on a long-standing ... are able to attack tumors - can differentiate cells that ...
Cached Biology News:Researchers find ways to turn manure into power 2Researchers find ways to turn manure into power 3Researcher at UGA College of Veterinary Medicine identifies new way of combating viral diseases 2New study finds how cells with damaged DNA alert the immune system 2New study finds how cells with damaged DNA alert the immune system 3
(Date:11/22/2014)...   , ... zu KLOX    Mariano ... Officer bestellt    KLOX ist bestens ... zugelassenen Behandlungssystems zur Wundheilung zu beginnen    , ... sehr erfreut, die folgenden personellen Veränderungen anzukündigen: ...
(Date:11/21/2014)... (PRWEB) November 20, 2014 Offering a ... Sartorius Entris Balance promotion . The Sartorius Entris ... a durable, high accuracy, and easy-to-maintain balance entry level ... Germany. It was designed to help customer’s bridge the ... a balance that is very durable. Sartorius is the ...
(Date:11/21/2014)... 2014 The November 2014 issue of ... open access journal featuring the following articles:, ... preserve photoresponsiveness in the retina , DNA ... hybridization using chromogenic substrates in zebrafish , ... protein electrophoresis , Nuclear LC3-positive puncta in ...
(Date:11/21/2014)... Dallas, Texas (PRWEB) November 21, 2014 ... Industry” is a professional and in-depth research report ... information, including its definition, classification, application, and industry ... research covers the international market analysis, including China’s ... covering macroeconomic environment & economic situation analysis. The ...
Breaking Biology Technology:KLOX Technologies meldet Neubesetzung von Führungspositionen 2KLOX Technologies meldet Neubesetzung von Führungspositionen 3KLOX Technologies meldet Neubesetzung von Führungspositionen 4KLOX Technologies meldet Neubesetzung von Führungspositionen 5Pipette.com Announces an Extension on the Sartorius Entris Balance Promotion to the End of 2014 2BioTechniques: The International Journal of Life Science Methods Announces the Publication of the November 2014 Issue—Available in Print and Online 2BioTechniques: The International Journal of Life Science Methods Announces the Publication of the November 2014 Issue—Available in Print and Online 3International Transformer Industry - Analysis on Applications, Development & Forecasts Now Available at ReportsnReports.com 2International Transformer Industry - Analysis on Applications, Development & Forecasts Now Available at ReportsnReports.com 3
... Del., July 13 ParagonRx, a Delaware-based company which specializes in ... website - www.paragonrx.com - that includes a ... in complying with new FDA requirements to ensure the medical benefits ... , "REMS, or Risk Evaluation and ...
... , NEWARK, N.J., July 13 ... technology-based Life Science company announced today that at ATS Labs using ... Ygiene(TM) formula produced a 100% Total Kill of ... required AOAC Sporicidal Test utilizing spore impregnated then knotted suture loops ...
... , HOLMDEL, N.J., July 13 ... quality and compliance management software, today announced that ... products, has deployed Sparta,s TrackWise ((R)) Enterprise Quality ... across its manufacturing operations in Canada and the United ...
Cached Biology Technology:ParagonRx Creates New Website Featuring REMS Help Center for Pharma 2BioNeutral's Ygiene(TM) Hospital Grade Achieves World Class Independent Test Results in Killing Life Threatening Spores/Organisms 2BioNeutral's Ygiene(TM) Hospital Grade Achieves World Class Independent Test Results in Killing Life Threatening Spores/Organisms 3BioNeutral's Ygiene(TM) Hospital Grade Achieves World Class Independent Test Results in Killing Life Threatening Spores/Organisms 4Sparta Systems' TrackWise(R) Solution Delivers Workforce Training and Learning Initiatives for Cangene Corporation 2Sparta Systems' TrackWise(R) Solution Delivers Workforce Training and Learning Initiatives for Cangene Corporation 3Sparta Systems' TrackWise(R) Solution Delivers Workforce Training and Learning Initiatives for Cangene Corporation 4
... spatulas have been designed to save time ... those interested in eliminating the recycling and ... is individually packaged, RNase/DNase free, non-pyrogenic and ... new product number, created to easily match ...
... mechanical harvesting of cells • Blade design ... with the growth surface • Designed for ... Individually wrapped • Sterilized by gamma radiation ... is a new product number, created to ...
... kit for a single fragment based screening project: , ... , 96 shape-diverse mixtures of 4 (5 ... files for structure refinement , Individual compounds ... are at ca. 50 mM. Supplied in 5 96-well trays. ...
... interferons are cytopathic effect inhibition assays, also ... The neutralization assay measures the antibody's ability ... cytokine. Sample types include; tissue culture supernatents; ... assays, one unit is defined as the ...
Biology Products: