Navigation Links
Commonly used antidepressants may also affect human immune system

, between immune cells that is normally only found between neurons," Ahern said.

In addition to Ahern, Peta Connell, Ph.D., from the Robarts Research Institute in Canada, was also a co-lead researcher on the study. Scientists from the Robarts Research Institute also contributed to the work.

In the brain, serotonin transmission between neurons is associated with feelings of pleasure, mood, and appetite, and the class of antidepressants known as SSRIs keeps serotonin active within the synaptic spaces between neurons, enhancing the chemical's positive effects. Unlike in the brain, which uses chemical messengers to communicate between nerve cells, the immune system is believed to "converse" through physical contact -- one type of immune cell touches another, setting off a response.

Specifically, "antigen presenting cells" display their antigens (bits of a foreign invader) to T-cells, and a resulting physical coupling between the antigens and the T-cells will prompt the T-cells to divide and expand in population, triggering an immune response designed to destroy the invader. This process may take hours.

What the Georgetown researchers found, however, is that dendritic cells -- the most powerful of the antigen-presenting cells and the ones that can find invaders that have never infected the body and "educate" the immune system to fight them -- also use serotonin to quickly excite a T-cell response. They discovered that these dendritic cells can rapidly secrete serotonin, which activates serotonin receptors on certain types of T-cells.

"In addition to the physical contact, it surprised us to find that these immune cells also have machinery to take up serotonin and to secrete it in an excitatory manner," Ahern said. "The point behind this transmission is not entirely clear, but it appears to be an additional way of stimulating a T cell response."

Drugs that block serotonin reuptake "likely change some of the parameters of T-ce
'"/>

Source:Georgetown University Medical Center


Page: 1 2 3

Related biology news :

1. Harmful Bacterium Commonly Found in Poultry May Survive Refrigeration and Frozen Storage Combined
2. In SAD patients, autumn antidepressants can prevent winter depression
3. Suicide risk does not increase when adults start using antidepressants, study finds
4. Cytoplasm affects the number of vertebrae in carp-goldfish clones
5. Clam embryo study shows pollutant mixture adversely affects nerve cell development
6. A new study examines how shared pathogens affect host populations
7. Researchers discover chemical compounds that affect plant growth
8. WHO Warns Of Increased Risk Of Vector-borne Diseases In Tsunami-affected Areas
9. Road salt affects mitigation wetlands
10. Retrovirus struck ancestors of chimpanzees and gorillas millions of years ago, but did not affect ancestral humans
11. Exercise training in ordinary people affects the activity of 500 genes
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Commonly used antidepressants may also affect human immune system

(Date:12/19/2014)... 18, 2014   LaunchKey , the first decentralized ... and Internet of Things era, today announced the close ... round was led by Metamorphic Ventures with participation from ... VegasTechFund, and others.  LaunchKey has raised $4 million to ... its team and bring LaunchKey to market in 2015. ...
(Date:12/17/2014)... 16, 2014 Valencell, a leader in performance ... technology to industry leaders such as Intel, Jabra, Atlas, ... biometric wearable products. These products will be showcased at ... Las Vegas . "Our partners ... and robust – with the clinical data to back ...
(Date:12/11/2014)... 09, 2014 Research and Markets ... ( http://www.researchandmarkets.com/research/twhjll/biometrics_market ) has announced the addition ... Region 2015-2019"  report to their offering. ... is advances in technology. With continuous advances in ... to the latest standard that meets the needs ...
Breaking Biology News(10 mins):LaunchKey Raises $3 Million in Additional Funding Led by Metamorphic Ventures 2LaunchKey Raises $3 Million in Additional Funding Led by Metamorphic Ventures 3Valencell PerformTek Biometrics Power the Most Accurate Wearables at CES 2015 2Biometrics Market in the APAC Region 2015-2019: Key Vendors are 3M Cogent, NEC, Safran and Suprema 2
... , The bottled water, soda pop, or micro brew-beer that ... cities contains a natural chemical imprint related to geographic location. ... imprint in your hair that could be used to track ... believed to be the first concerted effort to describe the ...
... looking for new antibiotics: A new research published in the ... ( http://www.fasebj.org ) explains for the first time how honey ... protein that they add to the honey, called defensin-1, which ... infections and to develop new drugs that could combat antibiotic-resistant ...
... WEST LAFAYETTE, Ind. - Fast-food restaurants can supersize French ... to supersize a type of apple. Peter Hirst, a ... in some Gala apple trees causes some apples to grow ... reported in the current issue of the Journal of ...
Cached Biology News:Beverages leave 'geographic signatures' that can track people's movements 2Honey as an antibiotic: Scientists identify a secret ingredient in honey that kills bacteria 2Apples grow larger when cells don't divide, study shows 2
(Date:12/19/2014)... Dec. 19, 2014  Roche (SIX: RO, ROG; OTCQX: ... Inc. (Bina), a privately held company based in ... Bina provides a big data platform for centralized ... data. Bina,s proprietary on-market Genomic Management Solution, Bina-GMS ... to perform fast and scalable analyses to maximize ...
(Date:12/19/2014)... 18, 2014 BioPlus Specialty ... specialty pharmacies, has an expanded team of Regional ... consultants for prescriber offices in their regions, with ... “We have a variety of Regional Pharmaceutical Care ... specializing in hepatitis C help prescribers understand all ...
(Date:12/19/2014)... Reports from CDC show ... from one or more chronic health conditions - including ... address some of these diseases, but may not eliminate ... face. While implanted nerve stimulation devices today offer relief, ... which can induce side effects. , To eliminate ...
(Date:12/19/2014)... With only 2 weeks left of ... Sartorius Biohit products . The product specials include Buy ... Pipette Trade-in Program, and free pipette tips. , Sartorius ... the world. They are ideal for lab technicians performing ... ,     Full volume range of 0.1 uL to ...
Breaking Biology Technology:Roche acquires Bina Technologies and enters the genomic informatics market 2Roche acquires Bina Technologies and enters the genomic informatics market 3BioPlus Specialty Pharmacy Expands ‘Regional Pharmaceutical Care Liaison’ Team 2BioPlus Specialty Pharmacy Expands ‘Regional Pharmaceutical Care Liaison’ Team 3Draper Wins GSK Funding for Smaller, Smarter Implantable Devices 2Major Pipette Distributor Pipette.com Announces Sartorius Year End Specials 2
... June 2, 2011 Morphotek®, Inc., a subsidiary of ... multi-center, phase II study of MORAb-004 for the treatment ... potentially first-in-class monoclonal antibody that specifically binds to endosialin/tumor ... its safety and therapeutic activity at two dosages. ...
... Calif., June 2, 2011 Life Technologies Corporation ... performed in cooperation with the University Hospital Muenster, Germany, on ... bacterium at the root of the deadly outbreak in Germany ... strains. The data obtained from the DNA ...
... electrodes have been coated with a drug-loaded polymer in ... a number of neurological symptoms, such as those associated ... In a study published today, 2 June 2011, ... researchers have developed a novel technology to precisely modulate ...
Cached Biology Technology:Morphotek®, Inc. Announces Initiation of MORAb-004 Phase II Study in Melanoma 2Morphotek®, Inc. Announces Initiation of MORAb-004 Phase II Study in Melanoma 3DNA Sequencing Data Reveals New Hybrid E. coli Strain is Cause of German Outbreak 2DNA Sequencing Data Reveals New Hybrid E. coli Strain is Cause of German Outbreak 3DNA Sequencing Data Reveals New Hybrid E. coli Strain is Cause of German Outbreak 4New technology could inspire brain implant for detecting and treating seizures 2
... Kit is based on quantification of the ... and free orthophosphate. The rapid color formation ... on a spectrophotometer (600-660 nm) or on ... kits have been optimized to offer superior ...
... Chemicon Select Tissue Arrays are intended ... individual tissues were fixed in neutral buffered ... identification and diagnosis was performed by certified ... their paraffin blocks and relocated into a ...
... The desk-top XCAT 50 X-Ray System from KUBTEC ... to provide two and three dimensional representation of ... provides volumetric reconstruction of specimen X-ray images, the ... provide high level of detail in standard 2D ...
... BTX, the leader in electroporation products and ... innovative product line for experiment optimization and ... is a breakthrough in Molecular Delivery. The ... procedures that typically limited the number of ...
Biology Products: