Navigation Links
Clam embryo study shows pollutant mixture adversely affects nerve cell development

A scientist at the Marine Biological Laboratory (MBL) has published the results of an EPA-funded clam embryo study that supports her hypothesis that, when combined, the pollutants bromoform, chloroform, and tetrachloroethylene--a chemical cocktail known as BCE--can act synergistically to alter a key regulator in nerve cell development. While scientists have previously studied the effects of these pollutants individually, this is the first time anyone has demonstrated that BCE's components can work together to adversely affect neuron growth in a model organism. The study, which is reported in the January 2005 issue of Environmental Toxicology and Pharmacology, is the first step toward understanding how exposure to BCE might affect human nerve cell development--knowledge that may one day provide clues about such neurological mysteries as autism spectrum disorder or attention deficit hyperactivity disorder.

To test her hypothesis, MBL scientist Carol Reinisch and her colleagues treated developing surf clam embryos (Spisula solidissima) with different combinations of BCE and studied their effects on nerve cell growth. "On a cellular level, clam neurons are extremely useful in studying basic mechanisms of cell development," says Reinisch, an expert in PCB-induced neurotoxicity. "Of the different combinations and strengths of BCE components tested, we found that all three together induce the greatest adverse response. Treating the embryos with the triple mixture resulted in increased production of a subunit of an enzyme called protein kinase A (PKA), which previous research suggests plays a role in neural development," says Reinisch. "Fluctuations in PKA may influence not only neuronal maturation but also how neuronal networks are constructed during development," she says. Alterations of this enzyme may affect neural development and neural connections by activating or inactivating other proteins. Demonstrating that clam embryos are affected by BCE paves the way for
'"/>

Source:Eurekalert


Page: 1 2 3

Related biology news :

1. Priming embryonic stem cells to fulfill their promise
2. Current human embryonic stem cell lines contaminated UCSD/Salk team finds
3. Researchers devise way to mass-produce embryonic stem cells
4. Researchers find new genes necessary to make embryo
5. Protein helps regulate the genes of embryonic stem cells
6. Scientists discover that three overlapping signals in embryo help get the backbone right
7. Breakthrough isolating embryo-quality stem cells from blood
8. Vitamin As paradoxical role in influencing symmetry during embryonic development revealed
9. Scientists succeed in cloning human embryos from eggs matured in the lab
10. Human embryonic stem cells have the potential to develop into eggs and sperm in the laboratory
11. Canadas first embryonic stem cell lines
Post Your Comments:
(Date:8/29/2014)... Some species of marine phytoplankton, such as the prolific ... vitamin B1 (thiamine), researchers have discovered. The finding contradicts ... many other eukaryotic microbes depend on scarce supplies of ... really different way to think about the ocean," says ... The ISME Journal paper with CIFAR fellows ...
(Date:8/29/2014)... of the Tibetan plateau -- the largest topographic anomaly ... both its profound effect on climate and its reflection ... GSA Bulletin , Katharine Huntington and colleagues employ a ... modern and fossil snail shells to investigate the uplift ... , Views range widely on the timing of surface ...
(Date:8/28/2014)... have identified a handful of bacterial culprits that may ... and ulcerative colitis, using patients, own intestinal immune responses ... 28 in the journal Cell . , Trillions ... plays a critical role in the development and progression ... number of bacterial species affect a person,s susceptibility to ...
Breaking Biology News(10 mins):Not all phytoplankton in the ocean need to take their vitamins 2Not all phytoplankton in the ocean need to take their vitamins 3Snails tell of the rise and fall of the Tibetan Plateau 2Snails tell of the rise and fall of the Tibetan Plateau 3Snails tell of the rise and fall of the Tibetan Plateau 4Snails tell of the rise and fall of the Tibetan Plateau 5Snails tell of the rise and fall of the Tibetan Plateau 6Snails tell of the rise and fall of the Tibetan Plateau 7Yale study identifies possible bacterial drivers of IBD 2
... coral bleaching prediction system indicates that there will be ... the event will probably not be severe. NOAA issued ... the 11th International Coral Reef Symposium in Ft. Lauderdale, ... a risk of widespread bleaching in the Northwestern Hawaiian ...
... Mass., July 10, 2008 -- The National Institutes of ... to Williams College Assistant Professor of Biology Lara D. ... or CMT. CMT is the most common inherited ... 2,500 individuals. CMT usually shows dominant inheritance and symptoms ...
... a million electrical signals pulsing through your body. At the ... the ion channel. A new study by researchers from ... a meter in ion channels. This movement is critical to ... close in response to changes in voltage across the membrane. ...
Cached Biology News:New NOAA coral bleaching prediction system calls for low level of bleaching in Caribbean this year 2Researchers catch ion channels in their opening act 2Researchers catch ion channels in their opening act 3
(Date:8/30/2014)... 2014 The Global and China ... in-depth study on the current state of the ... , The report provides a basic overview of ... structure. Global market analysis and Chinese domestic market ... developments, trends and competitive landscape of the market. ...
(Date:8/29/2014)... (PRWEB) August 29, 2014 Pittcon is ... MacDonald, and colleague Koichiro Matsuda, Horiba Scientific, have organized ... September 5, 2014. JASIS , Asia’s largest analytical ... 2014, in Makuhari Messe, Japan. , The four ... for Bioanalysis from Single Molecules to Single Cells” will ...
(Date:8/29/2014)... (PRWEB) August 29, 2014 A major ... the biotech start-up dense realm of Boston-Cambridge, is gaining ... able investors. James Sherley, the Director of Boston’s Adult ... the local and national visibility of his company an ... 2013. , In addition to a social media marketing ...
(Date:8/28/2014)... Lawrence, MA (PRWEB) August 28, 2014 “This ... single test to screen from 0 to 150 ppb,” said ... test is a significant benefit to plant owners and USDA-GIPSA ... corn and other commodities. Testing can take place in a ... Not only can the plant test the feed and grain ...
Breaking Biology Technology:Electrical Insulating Varnish Market World, China Regional Analysis & 2020 Forecasts Available at DeepResearchReports.com 2Electrical Insulating Varnish Market World, China Regional Analysis & 2020 Forecasts Available at DeepResearchReports.com 3Fifth Annual U.S. Symposium at JASIS Organized by Pittcon’s Program Chairman Hub MacDonald 2The Adult Stem Cell Technology Center, LLC Participates in Multiple Stem Cell and Regenerative Medicine Conferences Before Year End 2The Adult Stem Cell Technology Center, LLC Participates in Multiple Stem Cell and Regenerative Medicine Conferences Before Year End 3The Adult Stem Cell Technology Center, LLC Participates in Multiple Stem Cell and Regenerative Medicine Conferences Before Year End 4
... nation combats an,alarming rise in chronic diseases, the ... a new report on the next,generation of medicines ... patients., The report found that America,s pharmaceutical ... Michigan - are,testing a record 633 new biotech ...
... ... Bioprocess Industry, ELKTON, Md., ... -- an online interactive design tool that,provides step-by-step instructions for ... STA-PURE(SM) Bioprocess Configurator is unique to the,bioprocess industry. Available at ...
... on Track, SAN MATEO, Calif., Sept. 24 ... company focused on developing and,commercializing novel pain management ... to the European Medicines Agency,s (EMEA) Day 120,questions ... in peripheral neuropathic pain., NeurogesX, MAA for ...
Cached Biology Technology:New Report on 633 Biotechnology Medicines Under Development Released in Michigan 2New Report on 633 Biotechnology Medicines Under Development Released in Michigan 3Gore's Legacy of Innovation Extends From Products to Processes 2Gore's Legacy of Innovation Extends From Products to Processes 3NeurogesX Responds to EMEA's Day 120 Questions 2NeurogesX Responds to EMEA's Day 120 Questions 3
Human RXR beta/NR2B2 MAb (Clone H7341) Keywords: RXRbeta, RXRbeta, Retinoid X Receptor beta...
PSMD1 Antibody...
Terrific Broth, 1 kg. Mixture of casein peptone, yeast extract, K2HPO4, and KH2PO4.Used at 47 g/l for E. coli growth with higher cell densities. Category: Nucleotides & Enzymes & Biochemicals, Ultrap...
... 1200L sets the new standard for ... incorporating the latest technologies and providing ... analytical needs. The Atmospheric Pressure ... Quadrupole Analyzer provide superior selectivity and ...
Biology Products: