Navigation Links
Cheaper, better disease treatments expected from faster approach to developing antibodies

A method of mass-producing disease-fighting antibodies entirely within bacteria has been developed by a research group at The University of Texas at Austin.

The group led by Dr. George Georgiou developed the new antibody-production approach to improve upon processes used previously to identify new drugs. Drug companies have used those more time- and labor-intensive processes to develop antibodies for treating rheumatoid arthritis, cancer and other diseases.

The new approach developed in collaboration with Dr. Brent Iverson overcomes those obstacles, and has other advantages.

"Our approach can provide a significant time savings," said Georgiou, "and it enables antibodies to be isolated to treat human diseases that may not be possible to obtain otherwise."

The results were published online Sunday, April 15, in Nature Biotechnology.

Bacteria are easy to grow in an inexpensive broth. As a result, harmless forms of the bacterium E. coli have already been used as factories to produce antibodies (protective proteins of the human body that fight viruses, cancer cells and other harmful agents). However, previous approaches required an antibody that looked promising to be transferred from bacteria to mammalian cells to pursue large-scale, commercial production.

Getting mammalian cells to produce lots of antibodies costs more, and can take several months. The direct bacterial approach developed by the laboratory of the professor of chemical engineering, biomedical engineering, and molecular genetics and microbiology shaves weeks off the production process. Based on the method's early success, Georgiou has begun a collaboration to identify antibodies to treat arthritis and asthma.

In Georgiou's E-clonal antibody method, an antibody that is produced by an E. coli bacterium becomes tethered to one of its inner surfaces, or membranes. Small "errors" in the genes that produce antibodies are introduced. These
'"/>

Source:University of Texas at Austin


Page: 1 2

Related biology news :

1. Chemists create Superbowl molecule; May lead to better health
2. Protein discovery could unlock the secret to better TB treatment
3. Signaling protein builds bigger, better bones in mice
4. Harnessing microbes, one by one, to build a better nanoworld
5. Two are better than one
6. Discovery may lead to better Candidiasis drug
7. Insects, viruses could hold key for better human teamwork in disasters
8. Atmosphere may cleanse itself better than previously thought
9. Could better mangrove habitats have spared lives in the 2004 tsunami?
10. Muscle repair: Making a good system better, faster; implications for aging, disease
11. Plant genes identified that can form basis for crops better adapted to environmental conditions
Post Your Comments:
(Date:8/20/2015)... , Aug. 20, 2015 The wearable ... that are active and healthy. However, wearable technology ... hospital environment to help improve diagnostic capabilities and ... from the Wearable Technologies Conference 2015 , ... applications for wearables in healthcare.    ...
(Date:8/18/2015)... 2015  Navitas today announced that it ... Submission Content Management webinar scheduled on August ... to the Implementation of Regulatory Submission Standards ... industry, vendors, health authorities, consultants and the ... a standard method of implementing electronic submission ...
(Date:8/12/2015)... 12, 2015 As the digital ... innovation and advanced biometrics technology is accelerating beyond expectations.  ... rely on using their credit cards, the digital currency, ... for payment services led by companies in the space ... Google, Inc. (NASDAQ: GOOG ), Apple Inc. (NASDAQ: ...
Breaking Biology News(10 mins):Leaf Healthcare Releases Video from Wearable Technology Conference on New Applications for Wearables in the Hospital Environment 2Leaf Healthcare Releases Video from Wearable Technology Conference on New Applications for Wearables in the Hospital Environment 3Navitas, a Key Contributor in IRISS Forum Webinar 2Navitas, a Key Contributor in IRISS Forum Webinar 3Digital Wallet Devices & Mobile Payment Management Services Gain a Distinct Advantage in the Digital Payment Evolution as Demand Continues to Grow 2Digital Wallet Devices & Mobile Payment Management Services Gain a Distinct Advantage in the Digital Payment Evolution as Demand Continues to Grow 3Digital Wallet Devices & Mobile Payment Management Services Gain a Distinct Advantage in the Digital Payment Evolution as Demand Continues to Grow 4Digital Wallet Devices & Mobile Payment Management Services Gain a Distinct Advantage in the Digital Payment Evolution as Demand Continues to Grow 5Digital Wallet Devices & Mobile Payment Management Services Gain a Distinct Advantage in the Digital Payment Evolution as Demand Continues to Grow 6
... at Iowa State University have discovered a previously unknown ... Yanhai Yin, an assistant professor in genetics, development and ... called brassinosteroids. The hormone controls the growth of cells. ... how large the plant grows, says Yin. , "Previously, ...
... the oldest synthetic malaria drug, the methylene blue stain, ... a significant contribution to the long-term eradication called for ... study on 160 children with malaria in Burkina Faso, ... have shown that in combination with newer malaria drugs, ...
... Some researchers hope to turn plants into a renewable, ... have to learn how to convert plant biomass into ... efficiently. In new research, chemists have successfully converted cellulose ... the building block called HMF in one step. ...
Cached Biology News:ISU researcher identifies genetic pathway responsible for much of plant growth 2Old stain in a new combination 2Old stain in a new combination 3Plastic that grows on trees, part two 2
(Date:9/4/2015)... ... September 04, 2015 , ... November Research ... services and software tools to pharmaceutical and life sciences organizations, today announced the ... Mobile is a mobile data intake solution that enables field sales representatives, clinical ...
(Date:9/3/2015)... CITY, Calif. , Sept. 3, 2015 /PRNewswire/ ... today that five abstracts highlighting the performance and ... have been accepted for oral and poster presentations ... Lung Cancer,s 16th World Conference on Lung Cancer. ... Center; the University of California, Davis; the University ...
(Date:9/3/2015)...  StemProtein LLC, a leading manufacturer of stem ... Cell Technologies Inc., announced today that it appoints ... StemProtein. Silberg will help advance the Company,s patented ... Factors (SCFs), a significant consumer opportunity. ... biopharmaceutical industries with substantial executive level experience with ...
(Date:9/3/2015)... ... September 03, 2015 , ... Michigan-based technology startup ... early 2016. , The device, called the Halo H1, is a wearable ... sensing technology. These sensors track trending interstitial fluid levels in the body, in ...
Breaking Biology Technology:November Research Group’s PRIMO Mobile Goes Live at Allergan Japan 2Leading Cancer Centers to Present Clinical Utility Data For Guardant360 At IASLC's 16th World Conference on Lung Cancer in Denver Sept. 6-9 2Leading Cancer Centers to Present Clinical Utility Data For Guardant360 At IASLC's 16th World Conference on Lung Cancer in Denver Sept. 6-9 3Leading Cancer Centers to Present Clinical Utility Data For Guardant360 At IASLC's 16th World Conference on Lung Cancer in Denver Sept. 6-9 4StemProtein Names Thomas H. Silberg As CEO, To Focus On Stem Cell Secreted Proteins Addresing A Variety Of Health And Beauty Related Needs 2StemProtein Names Thomas H. Silberg As CEO, To Focus On Stem Cell Secreted Proteins Addresing A Variety Of Health And Beauty Related Needs 3Technology Startup Halo Wearables to Unveil Non-Invasive Hydration Monitoring Device Early 2016 2
... ... distribute feedstock for E-Fuel MicroFueler™ , ... Sacramento (Vocus) June 4, 2009 -- California Governor Arnold Schwarzenegger joined ... Corp. unveiled the final production model of the revolutionary E-Fuel MicroFueler, a portable micro-refinery ...
... WEBCAST WEDNESDAY, JUNE 10, 2009 , , SAN ... NBIX ) announced today that Kevin Gorman, President and Chief ... 8th Annual Needham Life Sciences Conference in New York. ... 10, 2009 at 1:30 p.m. Eastern Time (ET)/10:30 a.m. Pacific ...
... , BRAINTREE, Mass., June 4 Haemonetics Corporation (NYSE: ... for the District of Massachusetts has made a ruling in ... January 2009, a jury issued a verdict in favor of ... a U.S. Haemonetics patent. The jury awarded Haemonetics $15.7 ...
Cached Biology Technology:GreenHouse Energy, Governor Schwarzenegger Join in Driving the Future of Fueling in California 2GreenHouse Energy, Governor Schwarzenegger Join in Driving the Future of Fueling in California 3Neurocrine Biosciences to Present at the 8th Annual Needham Life Sciences Conference 2Haemonetics Receives Favorable Ruling in Patent Lawsuit against Competitive Technology 2
...
Convenient 10X buffer concentrate used to maximize binding to the solid phase in microwell ELISA. Formulated to provide optimal pH and ionic strength for binding of antibodies and some antigens. Co...
... again Guava is making flow cytometry accessible to ... will appreciate the latest addition to Guavas on-demand ... Mini easy to use, surprisingly affordable, very ... and 3-color detection. The Guava EasyCyte Mini has ...
... systems provide automated, higher throughput screening of ... tubes. This flexible sample format makes the ... basic research, target validation, assay development, and ... the Guava PCA-96 uses a green laser ...
Biology Products: