Navigation Links
Cheaper, better disease treatments expected from faster approach to developing antibodies

A method of mass-producing disease-fighting antibodies entirely within bacteria has been developed by a research group at The University of Texas at Austin.

The group led by Dr. George Georgiou developed the new antibody-production approach to improve upon processes used previously to identify new drugs. Drug companies have used those more time- and labor-intensive processes to develop antibodies for treating rheumatoid arthritis, cancer and other diseases.

The new approach developed in collaboration with Dr. Brent Iverson overcomes those obstacles, and has other advantages.

"Our approach can provide a significant time savings," said Georgiou, "and it enables antibodies to be isolated to treat human diseases that may not be possible to obtain otherwise."

The results were published online Sunday, April 15, in Nature Biotechnology.

Bacteria are easy to grow in an inexpensive broth. As a result, harmless forms of the bacterium E. coli have already been used as factories to produce antibodies (protective proteins of the human body that fight viruses, cancer cells and other harmful agents). However, previous approaches required an antibody that looked promising to be transferred from bacteria to mammalian cells to pursue large-scale, commercial production.

Getting mammalian cells to produce lots of antibodies costs more, and can take several months. The direct bacterial approach developed by the laboratory of the professor of chemical engineering, biomedical engineering, and molecular genetics and microbiology shaves weeks off the production process. Based on the method's early success, Georgiou has begun a collaboration to identify antibodies to treat arthritis and asthma.

In Georgiou's E-clonal antibody method, an antibody that is produced by an E. coli bacterium becomes tethered to one of its inner surfaces, or membranes. Small "errors" in the genes that produce antibodies are introduced. These
'"/>

Source:University of Texas at Austin


Page: 1 2

Related biology news :

1. Chemists create Superbowl molecule; May lead to better health
2. Protein discovery could unlock the secret to better TB treatment
3. Signaling protein builds bigger, better bones in mice
4. Harnessing microbes, one by one, to build a better nanoworld
5. Two are better than one
6. Discovery may lead to better Candidiasis drug
7. Insects, viruses could hold key for better human teamwork in disasters
8. Atmosphere may cleanse itself better than previously thought
9. Could better mangrove habitats have spared lives in the 2004 tsunami?
10. Muscle repair: Making a good system better, faster; implications for aging, disease
11. Plant genes identified that can form basis for crops better adapted to environmental conditions
Post Your Comments:
(Date:6/25/2015)... 2015  Imagine a tool specifically designed to help ... life. That,s exactly what USANA,s True Health Assessment ... portable health program provides a personalized approached to measuring ... your lifestyle and nutrition. At the ... night, USANA,s THA was honored with the Industry Innovation ...
(Date:6/24/2015)... , June 24, 2015  Synaptics Inc. (NASDAQ: ... interface solutions, today announced that Sharp has selected ... secure authentication for its latest flagship smartphone device, ... than 200 million shipments of its fingerprint ID ... Synaptics, strength, scalability and leadership in the biometrics ...
(Date:6/23/2015)... DUBLIN , June 22, 2015 ... has announced the addition of the "Body-Worn ... Share, Growth, Trends and Forecast 2014 - 2020" ... report offers strategic analysis of the global body-worn ... market has been segmented on the basis of ...
Breaking Biology News(10 mins):@USANAinc's Personalized Nutrition Program Wins Industry Innovation Award 2Synaptics Brings Natural ID Technology to Sharp's Newest Flagship Smartphone 2Body-Worn Temperature Sensors Market - Global Industry Analysis 2
... in behaviour among the population have accelerated the recent decline ... in Science shows how there has been an almost 50 ... researchers attribute to people delaying when they first have sex ... fell most steeply at young ages, with a drop in ...
... one of the oldest healing remedies known to medicine, ... A review article in the most recent issue of ... the data. , Scientists performed 22 trials involving 2,062 ... 16 trials that were performed on experimental animals. Honey ...
... created in this cool movie , ,Scientists ... created polymer nanotubes that are unusually long (about 1 centimeter) ... Described in a new paper in Proceedings of the National ... as channels for tiny volumes of chemicals in nanofluidic reactor ...
Cached Biology News:HIV decline in Zimbabwe linked to behavioural change 2Stable polymer nanotubes may have a biotech future 2
(Date:7/7/2015)... , ... July 07, 2015 , ... CSM, a leading ... as Vice President of Finance. Morse has an extensive background in financial management and ... the CSM team. In his new role, Morse will oversee all financial areas of ...
(Date:7/6/2015)... UK (PRWEB) , ... July 06, 2015 , ... ... other medical fields holds potential to reveal how blood flows in the brain ... damage to the brain. , A new article published in the journal ...
(Date:7/6/2015)... , July 6, 2015  Approximately 1% of ... integrated into their chromosomes. These individuals are three times ... study published in one of the nation,s leading medical ... Medicine in Canada.  Photo - http://photos.prnewswire.com/prnh/20150706/230685 ... herpesvirus 6 (HHV-6) causes roseola (also known as "sixth ...
(Date:7/6/2015)... 2015 Research and ... of the "Biotechnology for the Non-Biotechnologist" ... the Non-Biotechnologist, ideal for non-Scientists and Scientists needing ... potential of biotechnology. Ideal for Non-Scientists ... principles, techniques, and potential of biotechnology ...
Breaking Biology Technology:CSM Appoints Michael Morse as Vice President of Finance 2Reducing Stroke Damage May be Next Application for OCT Technology Now Widely Used in Eye and Vision Healthcare 2Reducing Stroke Damage May be Next Application for OCT Technology Now Widely Used in Eye and Vision Healthcare 3Inherited Herpes Virus Increases the Risk of Angina Reports HHV-6 Foundation 2Inherited Herpes Virus Increases the Risk of Angina Reports HHV-6 Foundation 3
... Amnis Corporation and Gene Company, Ltd.,announced today ... Company,will sell and service the Amnis ImageStream(R) system ... Hong Kong, Shanghai,Beijing and Guangzhou now have access ... extremely pleased to have begun what we expect ...
... and Company) (NYSE: BDX ), a global medical technology company,announced ... Bank of America 2008 Healthcare Conference ... Bernstein 24th Annual Strategic Decisions Conference 2008 ... A live webcast of BD,s presentations can be accessed from the ...
... May 7 /PRNewswire-FirstCall/ Varian, Inc. (NasdaqGS:,VARI) announced that ... Glover,as a new director. Glover is the seventh ... appointed for a term expiring at the annual ... is Senior Vice President, Operations and Chief Financial ...
Cached Biology Technology:Amnis and Gene Company, Ltd. Announce Agreement to Market ImageStream Technology in China 2James T. Glover Appointed to Board of Directors of Varian, Inc. 2
Umbilical cord blood mesenchymal stem cells, For immunohistochemistry (IHC) Cell Chip with Human Umbilical Cord Blood Progenitor Cells...
Human peripheral blood CD19+ B cells, For immunohistochemistry (IHC) Cell Chip with Human Peripheral Blood Monocytes, B Cells, NK Cells and Stem Cells...
Umbilical cord blood CD14+ Monocytes, For immunohistochemistry (IHC) Cell Chip with Human Umbilical Cord Blood Monocytes, B Cells and NK Cells...
Umbilical cord blood basophils, For immunohistochemistry (IHC)...
Biology Products: