Navigation Links
Cheaper, better disease treatments expected from faster approach to developing antibodies

A method of mass-producing disease-fighting antibodies entirely within bacteria has been developed by a research group at The University of Texas at Austin.

The group led by Dr. George Georgiou developed the new antibody-production approach to improve upon processes used previously to identify new drugs. Drug companies have used those more time- and labor-intensive processes to develop antibodies for treating rheumatoid arthritis, cancer and other diseases.

The new approach developed in collaboration with Dr. Brent Iverson overcomes those obstacles, and has other advantages.

"Our approach can provide a significant time savings," said Georgiou, "and it enables antibodies to be isolated to treat human diseases that may not be possible to obtain otherwise."

The results were published online Sunday, April 15, in Nature Biotechnology.

Bacteria are easy to grow in an inexpensive broth. As a result, harmless forms of the bacterium E. coli have already been used as factories to produce antibodies (protective proteins of the human body that fight viruses, cancer cells and other harmful agents). However, previous approaches required an antibody that looked promising to be transferred from bacteria to mammalian cells to pursue large-scale, commercial production.

Getting mammalian cells to produce lots of antibodies costs more, and can take several months. The direct bacterial approach developed by the laboratory of the professor of chemical engineering, biomedical engineering, and molecular genetics and microbiology shaves weeks off the production process. Based on the method's early success, Georgiou has begun a collaboration to identify antibodies to treat arthritis and asthma.

In Georgiou's E-clonal antibody method, an antibody that is produced by an E. coli bacterium becomes tethered to one of its inner surfaces, or membranes. Small "errors" in the genes that produce antibodies are introduced. These
'"/>

Source:University of Texas at Austin


Page: 1 2

Related biology news :

1. Chemists create Superbowl molecule; May lead to better health
2. Protein discovery could unlock the secret to better TB treatment
3. Signaling protein builds bigger, better bones in mice
4. Harnessing microbes, one by one, to build a better nanoworld
5. Two are better than one
6. Discovery may lead to better Candidiasis drug
7. Insects, viruses could hold key for better human teamwork in disasters
8. Atmosphere may cleanse itself better than previously thought
9. Could better mangrove habitats have spared lives in the 2004 tsunami?
10. Muscle repair: Making a good system better, faster; implications for aging, disease
11. Plant genes identified that can form basis for crops better adapted to environmental conditions
Post Your Comments:
(Date:4/23/2014)... most in their mid-thirties and forties, face a ... within two decades. "Mutant" protein clusters, long blamed ... been the primary focus of therapies in development ... from Prof. Gerardo Lederkremer and Dr. Julia Leitman ... and Immunology, in collaboration with Prof. Ulrich Hartl ...
(Date:4/23/2014)... NY. (Apr. 23 2014) A team ... stem cells (hNSCs) into the brains of nonhuman ... 22 and 24 months found that the hNSCs ... did not cause tumors. , The study will ... Cell Transplantation but is currently freely available ...
(Date:4/23/2014)... group decision increases with the abundance of brains involved ... variety of factors as often happens in life ... groups actually tend to make more accurate decisions while ... pieces of information. , The findings present a significant ... the "wisdom of crowds," wherein individual observations even ...
Breaking Biology News(10 mins):On the defensive 2On the defensive 3Study finds long-term survival of human neural stem cells transplanted into primate brain 2Too many chefs: Smaller groups exhibit more accurate decision-making 2Too many chefs: Smaller groups exhibit more accurate decision-making 3
... new study describes how bacteria use a previously unknown means ... have modified a common "housekeeping" enzyme in a way that ... The study appears in the Proceedings of the ... in chemical warfare with one another, and many antibiotics used ...
... A 12-week treatment of the fermented soy germ-based ... LDL cholesterol and improved vascular stiffness, all factors that ... first-of-its-kind peer-reviewed study reported in a poster at the ... study is the first to provide evidence that a ...
... by a University of Cincinnati undergraduate student and two team ... found to work in continuously recording the habits of snakes. ... Archival Tags (LATs) on snakes, since the LAT devices were ... to LATs, ability to measure temperature and pressure measuring ...
Cached Biology News:Team discovers how bacteria resist a 'Trojan horse' antibiotic 2Soy-based S-equol supplement reduces metabolic syndrome risk factors 2Soy-based S-equol supplement reduces metabolic syndrome risk factors 3UC research: Tracking Lake Erie water snake in fight against invasive fish 2UC research: Tracking Lake Erie water snake in fight against invasive fish 3
(Date:1/15/2014)... 15, 2014 Freeslate, Inc ., ... announced that Lupin Limited, one of India’s top five ... Protégé PharmD System for high throughput solid form ... focused on a wide range of quality, affordable generic ...
(Date:1/14/2014)... 2014 Carahsoft and CDS Federal Services ... 2014 at 2pm EST (11am PST), “Natural Language Processing: ... on how technology can turn raw, heterogeneous data into ... agencies. The online webinar will last approximately one hour. ...
(Date:1/14/2014)... 2014 EquitiesIQ, a leading informational research ... Alliqua is an emerging biomedical company acquiring, developing, manufacturing, ... market. , Free report download: http://equitiesiq.com/reports/alliqua/ , ... management team and Board, which launched the company’s new ...
(Date:1/14/2014)... In recent years, growing suspicion about the pharmaceutical ... and promotion has led to unprecedented levels of public ... about the insidious impact of commercialization of research, has ... the world’s biggest pharmas for illegal marketing activities, allegations ...
Breaking Biology Technology:Lupin Selects Freeslate’s CM Protégé PharmD System to Accelerate Polymorph Screening for Drug Development 2Lupin Selects Freeslate’s CM Protégé PharmD System to Accelerate Polymorph Screening for Drug Development 3Webcast - Natural Language Processing: Converting Raw Data into Actionable Knowledge – Hosted by Carahsoft and CDS Federal Services 2EquitiesIQ Initiates Coverage of Alliqua, Inc. 2EquitiesIQ Initiates Coverage of Alliqua, Inc. 3The Sunshine Act: Necessary Regulation or Unnecessary Dysregulation? New Life Science Webinar Hosted by Xtalks and IRB Services 2The Sunshine Act: Necessary Regulation or Unnecessary Dysregulation? New Life Science Webinar Hosted by Xtalks and IRB Services 3
... A team of Spanish scientists from a variety of ... the peridunal lagoons in the Doana National Park. Results ... regressing, largely due to the extraction of underground water ... effects of the ecosystem itself are further aggravating the ...
... Fibrocell Science, Inc. (OTCBB: FCSC) announced today that the ... Gene Therapies Advisory Committee reviewed azfibrocel-T, an autologous cell ... severe nasolabial fold wrinkles in adults. The committee voted ... on azfibrocel-T demonstrated efficacy, and 6 yes to 8 ...
... ( www.booshoot.com ) today announced that its ... of Martha Stewart "Dreamers Into Doers" program - an ... passions into a successful for-profit or non-profit career. ... in the for-profit category for her innovative and groundbreaking ...
Cached Biology Technology:Huelva is swallowing up coastal lagoons in Doñana 2Fibrocell Science, Inc. Reports Outcome of FDA Advisory Committee Meeting on Azfibrocel-T for Wrinkles 2Booshoot Founder & CEO Jackie Heinricher Honored as Visionary Entrepreneur by Martha Stewart 2