Navigation Links
Cancer drug slows poxvirus in mice

Mice given a relatively new cancer drug can survive an otherwise lethal dose of vaccinia virus, a relative of smallpox virus, report scientists supported by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health. The findings, say the investigators, suggest that Gleevec or similar drugs might be useful in preventing adverse side effects of smallpox vaccine. The classic smallpox vaccine is made from live, weakened vaccinia virus and is not recommended for people with compromised immunity, except in emergency situations where they may have been exposed to smallpox virus.

"This study helps illuminate the cellular machinery used by poxviruses to exit infected cells, and also provides new support for the concept of treating viral infections by targeting specific host cell molecules rather than the viruses themselves," says NIAID Director Anthony S. Fauci, M.D.

The senior author of the paper, published online this week in the journal Nature Medicine, is Daniel Kalman, Ph.D., of Emory University School of Medicine in Atlanta.

Like all viruses, poxviruses co-opt various cellular molecules and processes to enter a cell, replicate and then spread to uninfected cells. Using lab-grown cells, Dr. Kalman and his colleagues identified specific cell proteins vaccinia uses to detach from an infected cell and move toward an uninfected cell. The proteins, members of the Abl-family (pronounced "able") of tyrosine kinases, are well known to cancer investigators because mutation of one family member, Abl, causes a rare form of cancer known as chronic myelogenous leukemia (CML). Gleevec inhibits Abl-family tyrosine kinases and has proved very useful in treating CML.

To learn whether Gleevec could prevent or lessen vaccinia's ability to spread in a living organism, the researchers treated mice with either saline solution or with Gleevec at a dose equivalent to that given to humans being treated for CML. Ne
'"/>

Source:NIH


Page: 1 2 3

Related biology news :

1. Adding Radiation Therapy To Chemotherapy Improves Survival In Patients With High-risk Breast Cancer
2. Jump-starting T Cells In Skin Cancer
3. Deficient DNA Repair Capacity Associated With Increased Risk Of Breast Cancer
4. Fox Chase Cancer Center scientists identify immune-system mutation
5. Breakthrough Microarray-based Technology for the Study of Cancer
6. Yale Scientists Find MicroRNA Regulates Ras Cancer Gene
7. Fundamental Finding Yields Insight into Stem Cells, Cancer; Opens Door to Drug Discovery
8. First-ever Compounds To Target Only Metastatic Cells Are Highly Effective Against Breast, Prostate, And Colon Cancers
9. Gene Vaccine Protects Mice Against Development Of Her2/neu Breast Cancer
10. New Breast Cancer Test Could Save Lives
11. Estrogen-like Component of Plastic Stimulates Growth of Certain Prostate Cancer Cells
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Cancer drug slows poxvirus mice

(Date:7/21/2015)... 2015 Today, ZTE announced its Android smartphone ... as expected revenues in 2015 that relate to sales of FPC1025 ... of approximately 2,200 MSEK for 2015. Jörgen Lantto, CEO ... manufacturer in China and we are proud ... 5 for Axon , its first ...
(Date:7/13/2015)... NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" ... on the growing mobile commerce market, announced today ... BEHAVIORAL-DIRECTED AUTHENTIATION METHOD AND SYSTEM. ... method to make payments.  With this patent, NXT-ID ... its groundbreaking voice-direct payment patent application, with behavior-directed ...
(Date:7/8/2015)... , July 8, 2015 Summary Pancreatic ... the fourth most fatal, with a mortality rate of ... prognosis of pancreatic cancer patients has highlighted a significant ... is not being met by the current market. ... of products with varying molecule types and mechanisms of ...
Breaking Biology News(10 mins):FPC's Touch Fingerprint Sensor FPC1025 in ZTE's Smartphone Axon 2NXT-ID Patents Behavior-Directed Payments 2NXT-ID Patents Behavior-Directed Payments 3NXT-ID Patents Behavior-Directed Payments 4Frontier Pharma: Pancreatic Cancer - Identifying and Commercializing First-in-Class Innovation 2Frontier Pharma: Pancreatic Cancer - Identifying and Commercializing First-in-Class Innovation 3
... a paper published today in Diabetologia , a team at ... the enzyme AMP kinase (AMPK) as key to the molecular mechanism ... spina bifida and some heart defects among babies born to women ... type 1 or type 2 -- work vigilantly to control their ...
... (PHB) is a thermoplastic polyester which occurs naturally in ... megaterium . Even though PHB is biodegradable and is ... traditionally too expensive to produce to replace petroleum-based plastics. ... Microbial Cell Factories describes an alternative method ...
... time, researchers have found a way to inject a precise ... living cell without a needle. The technique uses electricity ... and into a cell in a fraction of a second. ... University describe the technique in the online edition of the ...
Cached Biology News:Joslin study finds clue to birth defects in babies of mothers with diabetes 2Researchers do precise gene therapy without a needle 2Researchers do precise gene therapy without a needle 3
(Date:8/3/2015)... , August 3, 2015 ... the commercialization of its Bio-electrical Signal Therapy device ("BST ... treatment of hard to heal chronic wounds, today announced ... with Chemipal, an Israeli distributor specializing in medical devices, ... Chemipal is a 70 years old, sales, ...
(Date:8/3/2015)... , August 3, 2015 According ... on 3D Cell Culture: Asia ... Market Research, the global 3D cell culture market was valued at ... expand at a CAGR of 29.1% to account for ... Report with TOC:  http://www.persistencemarketresearch.com/market-research/3d-cell-cultures-market.asp 3D cell ...
(Date:8/3/2015)... ... August 03, 2015 , ... Sterlitech Corporation introduces the compact, ... of analytical laboratory equipment. With optimized features, such as PTFE-coated contact surfaces, an ... and maintenance-free solution for a broad range of vacuum filtration applications. , Featuring ...
(Date:7/31/2015)... ... July 31, 2015 , ... Global Resorcinol Market 2015-2019 is ... on the global resorcinol industry. The report highlights the various growth prospects and ... and analysis of primary and secondary inputs from the existing players of the ...
Breaking Biology Technology:E-QURE Corp Signs Second Distribution Agreement in Israel 2E-QURE Corp Signs Second Distribution Agreement in Israel 3Global 3D Cell Culture Market Will Reach US$ 2,717.6 Million by 2020: Persistence Market Research 2Global 3D Cell Culture Market Will Reach US$ 2,717.6 Million by 2020: Persistence Market Research 3Global 3D Cell Culture Market Will Reach US$ 2,717.6 Million by 2020: Persistence Market Research 4Sterlitech Launches New Line of Vacuum Pumps 2Resorcinol Market to Grow at 6% CAGR to 2019 Says New Research Report at ReportsnReports.com 2Resorcinol Market to Grow at 6% CAGR to 2019 Says New Research Report at ReportsnReports.com 3Resorcinol Market to Grow at 6% CAGR to 2019 Says New Research Report at ReportsnReports.com 4
... in three short months! The major stock indices looked pretty ... up steam in the second quarter with the Dow Jones ... eight percent growth for the first half. Not far behind was ... the first quarter and 7% growth for the half year. , ...
... controversy over its proposed overhaul of the state's healthcare system ... pare back additional funding for the Act 255 tax credit ... Joint Committee on Finance. , ,The caucus voted to delete ... investment and early-stage seed investment tax credits. , ,According ...
... CEOs caught up in the scandals of WorldCom, ENRON, and TYCO ... Grigsby . The people on this video make them look like ... for people trying to make a living to support their families. ... in the last couple of years that have not been able ...
Cached Biology Technology:Midwest life science stocks kept sizzling in Q2 2Midwest life science stocks kept sizzling in Q2 3Midwest life science stocks kept sizzling in Q2 4Midwest life science stocks kept sizzling in Q2 5Midwest life science stocks kept sizzling in Q2 6Senate Democrats strip additional Act 255 funding from budget 2A disgusting video: U.S. companies sell out Americans 2A disgusting video: U.S. companies sell out Americans 3A disgusting video: U.S. companies sell out Americans 4
... Designed specifically for ... mammalian cells. Low toxicity reagent ... a wide range of cell ... greater than 95% of target ...
... Definitive Performance The TSQ ... quantitation excellence in bioanalytical and environmental analysis. ... source ESI and APCI probes, a titanium ... for increased robustness and sensitivity. Its ...
... This stain is used to distinguish ... the Artisan™ Staining System. The Trichrome stain ... and smooth muscle and to identify an ... Masson's Trichrome stain, muscle is stained red, ...
... w/ OutputCumulates a score of movement counts, similar ... it.can track up to 6 subjects at once, ... triggered. Can outpt a sync pulse to ... Can use animal location and timing information to ...
Biology Products: