Navigation Links
Brain size may depend upon how neural cells are cleaved

Howard Hughes Medical Institute researchers have discovered a novel way in which the brain size of developing mammals may be regulated. They have identified a signaling pathway that controls the orientation in which dividing neural progenitor cells are cleaved during development.

The way these cells are sliced during development is critical because at later stages of neurogenesis, vertical cleavage gives rise to two mature neurons that are incapable of further division, while horizontal cleavage yields one neuron and one progenitor cell that can continue to support brain growth.

The researchers speculate that this type of regulatory decision point may play a powerful role in determining the ultimate size of the mammalian brain. Inherited disorders that cause the brain to develop too small or too large may also influence this developmental pathway.

Howard Hughes Medical Institute investigator Li-Huei Tsai and postdoctoral fellow Kamon Sanada, both at Harvard Medical School, published their findings in the July 15, 2005, issue of the journal Cell.

The researchers drew on studies by other researchers that showed that the orientation of cleavage planes in dividing neural progenitor cells in the neocortex determines the fate of the resulting daughter cells. However, nothing was known about the molecular signaling mechanism that regulates the decision to cleave one way or another, said Tsai.

Studies in fruit flies and roundworms had hinted that major regulatory molecules called heterotrimeric G proteins play a role in orienting the mitotic spindles that govern the orientation of cell cleavage during cell division, or mitosis.

"Based on that knowledge, we knew that heterotrimeric G proteins were very good candidates as regulators of the plane of cell division in neural precursors," said Tsai.

"And this is a very important question, because how these cells divide ultimately determines the final number of cells that will
'"/>

Source:Howard Hughes Medical Institute


Page: 1 2 3

Related biology news :

1. Drug That Tags Decision-making Areas Of The Brain May Aid
2. NYU Study Reveals How Brains Immune System Fights Viral Encephalitis
3. Transport System Smuggles Medicines Into Brain
4. Bird Brains Show How Trial and Error May Contribute to Learning
5. VCU Researchers Identify Networks Of Genes Responding To Alcohol In The Brain
6. Wiley announces publication of Databasing the Brain
7. Scientists Propose Sweeping Changes to Naming of Bird Neurosystems to Acknowledge Their True Brainpower
8. Brain-mapping technique aids understanding of sleep, wakefulness
9. Some Brain Cells Change Channels To Fine-tune The Message
10. Brain Scans Reveal How Gene May Boost Schizophrenia Risk
11. Brain-injury rehabilitation depends on acetylcholine circuitry
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Brain size may depend upon how neural cells are cleaved

(Date:7/28/2014)... Solanum pennellii , a wild relative of the ... of researchers including the labs headed by Professors Neelima ... of Plant Biology. The new genome information may help ... published July 27 in the journal Nature Genetics ... Aachen University in Germany. The UC Davis labs carried ...
(Date:7/28/2014)... bug hunter, but the target of his work consists ... with special methods and instruments. Benjamin Hause, an assistant ... at Kansas State University, recently published an article about ... an important find in the United States. , "We ... what it was," Hause said. "We used next-generation sequencing ...
(Date:7/28/2014)... July 28, 2014 Research and Markets ... Market in Latin America 2014-2018" report to their ... Biometrics measure and analyze biological data. These systems ... eye retinas, voice patterns, and hand measurements from the ... stored templates. The main purpose of a biometrics system ...
Breaking Biology News(10 mins):Researcher using next-generation sequencing to rapidly identify pathogens 2Researcher using next-generation sequencing to rapidly identify pathogens 3Biometrics Market in Latin America 2014-2018 2
... Could a computer model help stabilize the tuna ... ethanol fuel without jeopardizing food production? Those ... scientists, applied mathematicians, economists, biologists and environmental scientists ... Sustainability, being launched with a $10 million grant ...
... The development of powerful supercomputers capable of ... an eye mark a technological milestone capable of ... business worldwide. Researchers at the University of Miami,s ... with NCAR (National Center for Atmospheric Research), COLA ...
... COLD SPRING HARBOR, N.Y. (Sept. 4, 2008) ... and animalshave biological rhythms, where the timing and duration ... them to adapt and survive, even under fluctuating environmental ... made to understand the molecular basis of these rhythms ...
Cached Biology News:Cornell gets $10 million NSF grant to establish new sustainability institute 2Petascale climate modeling heats up at University of Miami 2Petascale climate modeling heats up at University of Miami 3Interdisciplinary volume on biological rhythms serves as both primer and in-depth resource 2
(Date:7/28/2014)... 2014 Research and Markets has announced ... 2014-2018" report to their offering. ... a technique used to determine the size of a particle ... crucial to analyze the size of particles as it can ... is performed to determine the behavior and nature of a ...
(Date:7/26/2014)... Canada Endoscopy Visualization Systems Market Outlook ... Canada Endoscopy Visualization Systems market. The report provides ... units) and average prices (in US dollars) within ... Endoscopy Visualization Systems and Low-End Endoscopy Visualization Systems. ... , The report also provides company shares and ...
(Date:7/25/2014)... July 25, 2014 Amgen (NASDAQ: ... declared a $0.61 per share dividend for the third ... Sept. 5, 2014, to all stockholders of record as ... About Amgen Amgen is committed to ... serious illnesses by discovering, developing, manufacturing and delivering innovative ...
(Date:7/25/2014)... researchers from the University of Leicester has furthered ... the potential to create new materials using nanosized ... published in the prestigious academic journal Physical ... to examine in rich detail the structure and ... an acetylene molecule and a single helium atom. ...
Breaking Biology Technology:Global Particle Size Analysis Market 2014-2018 2Canada Endoscopy Visualization Systems Market Outlook to 2020: MarketResearchReports.Biz 2Canada Endoscopy Visualization Systems Market Outlook to 2020: MarketResearchReports.Biz 3Canada Endoscopy Visualization Systems Market Outlook to 2020: MarketResearchReports.Biz 4Canada Endoscopy Visualization Systems Market Outlook to 2020: MarketResearchReports.Biz 5Amgen Announces 2014 Third Quarter Dividend 2Amgen Announces 2014 Third Quarter Dividend 3Breakthrough laser experiment reveals liquid-like motion of atoms in an ultra-cold cluster 2Breakthrough laser experiment reveals liquid-like motion of atoms in an ultra-cold cluster 3
... the American Academy ... of Dermatology, FREEPORT, N.Y., ... and its natural receptor,OCTN- 1, are a natural part of the skin,s ... in photoaged,skin. The data was presented at the Poster Session at the ...
... Feb. 11 Emisphere,Technologies, Inc. (Nasdaq: EMIS ), ... delivery of therapeutic molecules using its,eligen(R) technology, today announced ... CEO & Investor Conference on February 12, 2008 on,its ... page of the,Emisphere Web site at http://www.emisphere.com/ir.asp ...
... On Monday, January 28, The Royal,Marsden Hospital ... Modulated Arc Therapy (VMAT)* treatment in the ... the treatment, the hospital,used its existing Elekta ... control system., (Logo: http://www.newscom.com/cgi-bin/prnh/20020318/ELEKTALOGO ...
Cached Biology Technology:AGI Dermatics Clinical Data Identifies L-Ergothioneine as Part of Skin's Natural Antioxidant System 2Emisphere Technologies to Web Cast BIO CEO & Investor Conference Presentation February 12 2Elekta Announces First Volumetric Modulated Arc Therapy Cancer Treatment at Royal Marsden Hospital 2
odz, odd Oz/ten-m homolog 1 [Source:RefSeq_peptide;Acc:NP_055068] Antigen: Recombinant Protein Epitope Signature Tag (PrEST)....
Rabbit polyclonal to FANCE ( Abpromise for all tested applications). entrezGeneID: 2178 SwissProtID: Q9HB96...
Rabbit polyclonal to NIRF ( Abpromise for all tested applications). Antigen: Synthetic peptide derived from residues 186-235 of human NIRF. Entrez Gene ID: 115426 Swiss Protein ID: Q96PU...
...
Biology Products: