Navigation Links
Boston University biomedical engineers win major grant for pursuit of the '$1,000 Genome'

Two Boston University biomedical engineers have won a major National Institutes of Health (NIH) grant to continue groundbreaking research aimed at reducing the cost of sequencing individual human genomes to about $1,000.

Boston University Associate Professor of Biomedical Engineering and Physics Amit Meller was among nine researchers chosen for the NIH's National Human Genome Research Institute "$1,000 Genome" grants nationally. Meller and co-principal investigator Zhiping Weng, also a BU biomedical engineer, won $2.2 million over the next three years for their research, in addition to some $600,000 Meller has already received from NIH for this work.

Meller is using novel methods to decode the sequence of bases on a DNA strand at the molecular level. Using beams of electrons, Meller punches tiny holes in thin silicon films, then pulls strands of DNA through these "nanopores" using an electric current. Each base is identified by a florescent marker attached to it, which allows the researchers to record the sequence of bases as the strand emerges from the nanopore. Meller has devised a system of lasers and highly sensitive detectors which greatly increase the process' resolution. He is the only researcher in the world using this method, which he names "Opti-Pore."

Weng's involvement centers on bioinformatics ?using computational methods to organize the large amount of data collected.

Meller said he is grateful for the grant, which validates his approach to DNA sequencing. "We are very close to a proof of principle that we can read a small number of these bases, perhaps six or eight, using this method," said Meller. "From there, it is a small step to reading tens, and later hundreds, at a time. That would produce an orders-of-magnitude reduction in the cost of sequencing individuals' DNA."

According to NIH, sequencing the 3 billion base pairs on a human genome using current technology costs about $10 million. Reducing the cos t to $1,000 or less would bring DNA sequencing into the realm of routine medical care, enabling doctors to diagnose and treat patients more effectively based on their individual genetic profiles.


'"/>

Source:Boston University


Related biology news :

1. University of Manchester makes made-to-measure skin and bones a reality using inkjet printers
2. New protein discovered by Hebrew University researchers
3. Next Generation Body Scanner Launched By The University Of Manchester
4. Roundup®highly lethal to amphibians, finds University of Pittsburgh researcher
5. Green catalyst destroys pesticides and munitions toxins, finds Carnegie Mellon University
6. University of Nevada, Reno research team discovers hormone that causes malaria mosquito to urinate
7. Carnegie Mellon University research reveals how cells process large genes
8. University of Delaware researchers develop cancer nanobomb
9. University of Arizona plant scientists to unravel maize genome
10. Team led by Carnegie Mellon University scientist finds first evidence of a living memory trace
11. University of Utah to help build bionic arm
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/23/2017)... ITHACA, N.Y. , June 23, 2017  IBM ... in dairy research, today announced a new collaboration using ... the chances that the global milk supply is impacted ... project, Cornell University has become the newest academic institution ... Chain, a food safety initiative that includes IBM Research, ...
(Date:5/6/2017)... 5, 2017 RAM Group , ... new breakthrough in biometric authentication based on a ... properties to perform biometric authentication. These new sensors are ... created by Ram Group and its partners. This sensor ... supply chains and security. Ram Group is a ...
(Date:4/13/2017)... , April 13, 2017 UBM,s Advanced ... will feature emerging and evolving technology through ... Innovation Summits will run alongside the expo portion of ... sessions, panels and demonstrations focused on trending topics within ... advanced design and manufacturing event will take place June ...
Breaking Biology News(10 mins):
(Date:7/20/2017)... ... ... Corporate Directors Forum is recognizing six San Diego directors for their extraordinary ... The awards will be presented Thursday, September 7th, from 6 to 9 p.m. at ... significantly positive contributions in the boardrooms of some of our region’s most respected and ...
(Date:7/18/2017)... ... July 18, 2017 , ... G-CON today announced ... Trademark Office for its Patent Applications 14/858,857 and 13/669,785 both entitled Modular, Self-Contained, ... applications further expand the protection of G-CON’s R&D investments and validate the G-CON ...
(Date:7/17/2017)... ... 17, 2017 , ... The Academy of Model Aeronautics (AMA) will host Aviation ... will take place from 9 a.m. to 2 p.m. at the International Aeromodeling Center ... , Aviation Adventure Day will be packed with entertaining activities for the entire family. ...
(Date:7/17/2017)... Lake City, Utah (PRWEB) , ... July 17, ... ... “Company”), a molecular diagnostics company that has developed and intends both to manufacture ... and started trading on the NASDAQ Capital Market. , Headquartered in Sandy, Utah, ...
Breaking Biology Technology: