Navigation Links
Boston University biomedical engineers win major grant for pursuit of the '$1,000 Genome'

Two Boston University biomedical engineers have won a major National Institutes of Health (NIH) grant to continue groundbreaking research aimed at reducing the cost of sequencing individual human genomes to about $1,000.

Boston University Associate Professor of Biomedical Engineering and Physics Amit Meller was among nine researchers chosen for the NIH's National Human Genome Research Institute "$1,000 Genome" grants nationally. Meller and co-principal investigator Zhiping Weng, also a BU biomedical engineer, won $2.2 million over the next three years for their research, in addition to some $600,000 Meller has already received from NIH for this work.

Meller is using novel methods to decode the sequence of bases on a DNA strand at the molecular level. Using beams of electrons, Meller punches tiny holes in thin silicon films, then pulls strands of DNA through these "nanopores" using an electric current. Each base is identified by a florescent marker attached to it, which allows the researchers to record the sequence of bases as the strand emerges from the nanopore. Meller has devised a system of lasers and highly sensitive detectors which greatly increase the process' resolution. He is the only researcher in the world using this method, which he names "Opti-Pore."

Weng's involvement centers on bioinformatics ?using computational methods to organize the large amount of data collected.

Meller said he is grateful for the grant, which validates his approach to DNA sequencing. "We are very close to a proof of principle that we can read a small number of these bases, perhaps six or eight, using this method," said Meller. "From there, it is a small step to reading tens, and later hundreds, at a time. That would produce an orders-of-magnitude reduction in the cost of sequencing individuals' DNA."

According to NIH, sequencing the 3 billion base pairs on a human genome using current technology costs about $10 million. Reducing the cos t to $1,000 or less would bring DNA sequencing into the realm of routine medical care, enabling doctors to diagnose and treat patients more effectively based on their individual genetic profiles.


'"/>

Source:Boston University


Related biology news :

1. University of Manchester makes made-to-measure skin and bones a reality using inkjet printers
2. New protein discovered by Hebrew University researchers
3. Next Generation Body Scanner Launched By The University Of Manchester
4. Roundup®highly lethal to amphibians, finds University of Pittsburgh researcher
5. Green catalyst destroys pesticides and munitions toxins, finds Carnegie Mellon University
6. University of Nevada, Reno research team discovers hormone that causes malaria mosquito to urinate
7. Carnegie Mellon University research reveals how cells process large genes
8. University of Delaware researchers develop cancer nanobomb
9. University of Arizona plant scientists to unravel maize genome
10. Team led by Carnegie Mellon University scientist finds first evidence of a living memory trace
11. University of Utah to help build bionic arm
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/2/2017)... 2, 2017 Summary This report provides ... its partnering interests and activities since 2010. ... Read the full report: ... since 2010 report provides an in-depth insight into the partnering ... On demand company reports are prepared upon purchase ...
(Date:2/28/2017)... , Feb. 28, 2017   Acuant , a ... globally, announces significant enhancements to new and core technologies ... New products include mobile and desktop Acuant FRM TM ... - a real time manual review of identity ... technology provides the fastest and most accurate capture software ...
(Date:2/24/2017)... Spain , Feb. 24, 2017  EyeLock LLC, a ... demonstrate its elite iris biometric solution on the ... X16 LTE at Mobile World Congress 2017 ... Qualcomm,s Booth in Hall 3, Stand 3E10. ... the Qualcomm Haven™ security platform—a combination of ...
Breaking Biology News(10 mins):
(Date:3/27/2017)... Infectex Ltd., a Russian portfolio company of Maxwell Biotech Venture Fund (MBVF), ... the standard drug therapy regimen in patients with multidrug-resistant pulmonary tuberculosis (MDR-TB). SQ109 is ... ) and the US National Institutes of Health. ... ... ...
(Date:3/27/2017)... The new research portal will give visitors quick and ... Valero Energy , offering extensive market research on their performance ... ... The latest trend gaining momentum in the ... though touted as a green alternative to fossil fuels, is ...
(Date:3/27/2017)... 2017  Trovagene, Inc. (NASDAQ: TROV), a precision medicine ... Bill Welch , will be presenting at this ... AM EDT at the Essex House in ... Scientific Officer, Mark Erlander , Ph.D., will also ... The presentation will be webcast live at ...
(Date:3/24/2017)... 24, 2017 MiMedx Group, Inc. (NASDAQ: MDXG), ... placental tissue allografts and patent-protected processes to develop and ... healthcare, announced today  that it will present at the ... , NY.  Parker H. "Pete" Petit, Chairman and CEO, ... Christopher M. Cashman , EVP and Chief Commercialization Officer, ...
Breaking Biology Technology: