Navigation Links
Bacteria research offers hope for new vaccine against meningococci

Each year 170,000 people around the world die of this type of meningitis, according to the World Health Organization, WHO. Bacterial meningitis, as the disease is called, can even spark epidemics: in Africa 250,000 people were affected in a matter of weeks in the late 1990s. Without treatment, mortality among those who contract the disease is 85-90 percent, with treatment some 10-15 percent. Patients also run a high risk of serious disability after recovery.

Only humans are susceptible to infection from meningococci. In its modeling system Ann-Beth Jonsson’s research team therefore used mice that produce the human receptor that the bacteria bind to. Marking the bacteria to emit light, the scientists used cameras to monitor their activities in the living mice during the course of the disease.

“The bacteria are almost knocked out by the immune defense system, but then they resurge, this time with alterations in the surface protein. What’s more, we discovered that the bacteria aggregate in the thyroid and can impact hormone production during the infection,?says Ann-Beth Jonsson.

The study also shows that bacteria that lack a certain adhesin (the protein that the bacteria cells use to adhere to the receptors) could not attach to mucous linings.

Thanks to the new system the research team has developed, it is now possible to rapidly and effectively monitor the function of various vaccine candidates and new drugs, obviating the numerous costly and time-consuming tests that have been necessary until now. At the same time, the system provides a clear picture of the process of infection.

“With these findings as tools, we can continue to study the course of the disease and test vaccines on living organisms. Moreover we will be able to find new strategies for improving the prognoses for those who are affected by meningococcus disorders,?says Ann-Beth Jonsson.
'"/>

Source:Public Library of Science


Page: 1

Related biology news :

1. Bacteria collection sheds light on urinary tract infections
2. Solution to Pollution: New Bacteria Eats Toxic Waste
3. The Bacterias guide to survival
4. UF Researchers Map Bacterial Proteins That Cause Tooth Loss
5. Bacterial genome sheds light on synthesizing cancer-fighting compounds
6. Where Bacteria Get Their Genes
7. Bacteria feed on smelly breath (and feet)
8. New insight into autoimmune disease: Bacterial infections promote recognition of self-glycolipids
9. Bacteria use hosts immune response to their competitive advantage
10. Say what? Bacterial conversation stoppers
11. Bacteria are key to green plastics, drugs
Post Your Comments:
(Date:2/5/2015)... , Jan. 27, 2015   Marvin ... globally deployed, innovative test solutions for military, ... delivery of its TS-323 GENASYS Test ... Company (LMSSC). GENASYS is a high-performance PXI-based ... mission-critical applications that require performance functional testing. ...
(Date:2/5/2015)... , Jan. 28, 2015 NXT-ID, Inc. (NASDAQ: ... "Company"), a biometric authentication company focused on the growing ... upcoming RedChip Global Online CEO Conference on January 29 ... Gino Pereira , CEO of NXT-ID will present ... product, the Wocket smart wallet and its full suite ...
(Date:2/5/2015)... , Jan. 30, 2015  It is gratifying to ... and potential for genomic science as a means to ... prevention and treatment.  I was honored to participate in ... precision medicine program. Since the 1980s ... of genomics—from the first sequenced genome of a free ...
Breaking Biology News(10 mins):Marvin Test Solutions' GENASYS Platform Advances Mission-Critical Aerospace Production Test 2Marvin Test Solutions' GENASYS Platform Advances Mission-Critical Aerospace Production Test 3Marvin Test Solutions' GENASYS Platform Advances Mission-Critical Aerospace Production Test 4CEO of NXT-ID, Inc. to Discuss Company's Biometric Technologies at RedChip Online Conference January 29th 2CEO of NXT-ID, Inc. to Discuss Company's Biometric Technologies at RedChip Online Conference January 29th 3J. Craig Venter, Ph.D., Co-Founder and CEO, Human Longevity, Inc. (HLI) Participates in White House Precision Medicine Event 2
... solved with the discovery that the tiny 3 mm long ... same buoyancy control as whales. Reporting this week in ... Antarctic Survey describe how Southern Ocean copepods a crustacean ... during winter when seas are stormy and food scarce. To ...
... of us receives approximately 60 new mutations in our genome ... the first-ever direct measure of new mutations coming from mother ... For the first time, researchers have been able to answer ... and did most of them come from mum or dad? ...
... A dramatically better computer tool for finding the ... St. Jude Children,s Research Hospital Washington University Pediatric ... algorithm to help identify the chromosomal rearrangements and DNA ... computational method is known as CREST, short for Clipping ...
Cached Biology News:We are all mutants 2We are all mutants 3Researchers improve method for finding genetic mistakes that fuel cancer 2Researchers improve method for finding genetic mistakes that fuel cancer 3
(Date:3/4/2015)... Bruno, CA. (PRWEB) March 04, 2015 ... (CRO) headquartered in the San Francisco Bay Area, will ... Trials (OCT) Israel Conference 2015 on March 25th ... Clinical seeks to build relationships with Israeli life science ... (FDA) clinical trials. The company’s services span all phases ...
(Date:3/4/2015)... Follow us on LinkedIn ... fastest growing technologies in the life sciences industry. Growing ... driving growth in nucleic acid detection technologies like qPCR ... expressions will continue to benefit the qPCR and dPCR ... from pharma, biotech, food & beverage to animal feed, ...
(Date:3/3/2015)... , March 3, 2015  Halozyme Therapeutics, Inc. (NASDAQ: ... Global Healthcare Conference in Miami, FL ... David A. Ramsay , Chief Financial Officer, will provide ... through the "Investors" section of Halozyme,s corporate website at ... 90 days following the event. To access the live webcast, ...
(Date:3/3/2015)... March 3, 2015  Neurocrine Biosciences, Inc. (Nasdaq: ... , President and Chief Executive Officer of Neurocrine Biosciences, ... in Miami.   The live presentation takes ... PT).  The presentation will be webcast and may be ... Listeners are encouraged to visit the ...
Breaking Biology Technology:PRC Clinical to Present at Inaugural Outsourcing in Clinical Trials Israel Conference 2015 on March 25 and 26th in Tel Aviv 2PRC Clinical to Present at Inaugural Outsourcing in Clinical Trials Israel Conference 2015 on March 25 and 26th in Tel Aviv 3PRC Clinical to Present at Inaugural Outsourcing in Clinical Trials Israel Conference 2015 on March 25 and 26th in Tel Aviv 4Focus on Quantifying Nucleic Acid Molecules Spurs Growth in the qPCR & dPCR Instrumentation Market, According to a New Report by Global Industry Analysts, Inc. 2Focus on Quantifying Nucleic Acid Molecules Spurs Growth in the qPCR & dPCR Instrumentation Market, According to a New Report by Global Industry Analysts, Inc. 3Focus on Quantifying Nucleic Acid Molecules Spurs Growth in the qPCR & dPCR Instrumentation Market, According to a New Report by Global Industry Analysts, Inc. 4Halozyme Therapeutics To Present At The Barclays 2015 Global Healthcare Conference 2
... Biopharma Inc., a Canadian,biopharmaceutical company, announced that ... first contracts with customers in biopharmaceutical development ... 30 minutes from Toronto,s Pearson,International Airport, Therapure ... development and manufacture of complex biological,products. Leveraging ...
... Sept. 3 Wyeth (NYSE: WYE ),today ... to Vice,President, Corporate Communications. Reporting to Timothy P. ... be responsible for all,internal and external communications for ... consumer health care and animal health,-- around the ...
... held September 24 to 26 in Kansas City. , ... ... (USP) Convention’s 2008 Annual Scientific Meeting (ASM) will be held in ... opportunity to interact with the USP experts responsible for establishing internationally ...
Cached Biology Technology:Therapure Biopharma Inc. opens for business with first client contracts 2Wyeth Names Daniel J. McIntyre Vice President, Corporate Communications 2USP's 2008 Annual Scientific Meeting to Convene Scientific Experts from Around the World 2USP's 2008 Annual Scientific Meeting to Convene Scientific Experts from Around the World 3
Anti-Mouse C-10, Biotin (Polyclonal) (rabbit IgG)...
... to Taura Syndrome Virus Coat ... all tested applications). ... VTNSEGSTIL MNDIPITNQN VVLSKNVTDN LFEVQDQALI ESLSRDVLLH ... N terminal amino acids 25/100 ...
Anti-rat Dipeptidyl Peptidase IV (DPP IV), CD26, Clone 5E8, Monoclonal Antibody...
Purified Mouse anti-Hu Actopaxin (pS8) Storage Temperature: Refrigerate(2 to 8C)...
Biology Products: