Navigation Links
Bacteria research offers hope for new vaccine against meningococci

Each year 170,000 people around the world die of this type of meningitis, according to the World Health Organization, WHO. Bacterial meningitis, as the disease is called, can even spark epidemics: in Africa 250,000 people were affected in a matter of weeks in the late 1990s. Without treatment, mortality among those who contract the disease is 85-90 percent, with treatment some 10-15 percent. Patients also run a high risk of serious disability after recovery.

Only humans are susceptible to infection from meningococci. In its modeling system Ann-Beth Jonsson’s research team therefore used mice that produce the human receptor that the bacteria bind to. Marking the bacteria to emit light, the scientists used cameras to monitor their activities in the living mice during the course of the disease.

“The bacteria are almost knocked out by the immune defense system, but then they resurge, this time with alterations in the surface protein. What’s more, we discovered that the bacteria aggregate in the thyroid and can impact hormone production during the infection,?says Ann-Beth Jonsson.

The study also shows that bacteria that lack a certain adhesin (the protein that the bacteria cells use to adhere to the receptors) could not attach to mucous linings.

Thanks to the new system the research team has developed, it is now possible to rapidly and effectively monitor the function of various vaccine candidates and new drugs, obviating the numerous costly and time-consuming tests that have been necessary until now. At the same time, the system provides a clear picture of the process of infection.

“With these findings as tools, we can continue to study the course of the disease and test vaccines on living organisms. Moreover we will be able to find new strategies for improving the prognoses for those who are affected by meningococcus disorders,?says Ann-Beth Jonsson.
'"/>

Source:Public Library of Science


Page: 1

Related biology news :

1. Bacteria collection sheds light on urinary tract infections
2. Solution to Pollution: New Bacteria Eats Toxic Waste
3. The Bacterias guide to survival
4. UF Researchers Map Bacterial Proteins That Cause Tooth Loss
5. Bacterial genome sheds light on synthesizing cancer-fighting compounds
6. Where Bacteria Get Their Genes
7. Bacteria feed on smelly breath (and feet)
8. New insight into autoimmune disease: Bacterial infections promote recognition of self-glycolipids
9. Bacteria use hosts immune response to their competitive advantage
10. Say what? Bacterial conversation stoppers
11. Bacteria are key to green plastics, drugs
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:12/15/2016)... 15, 2016 ... Research and Markets has announced the addition of the ... The report forecasts the global military biometrics market to grow ... The report has been prepared based on an in-depth market analysis with ... growth prospects over the coming years. The report also includes a discussion ...
(Date:12/15/2016)... Dec. 15, 2016  There is much more to ... starting the engine. Continental will demonstrate the intelligence of ... Vegas . Through the combination of the keyless ... and biometric elements, the international technology company is opening ... and authentication. "The integration of biometric elements ...
(Date:12/12/2016)... -- Researchers at Trinity College, Dublin, are opening up ... material with Silly Putty. The mixture (known as "G-putty") ... sense pulse, blood pressure, respiration, and even the ... The research team,s findings were published Thursday in ... Due ...
Breaking Biology News(10 mins):
(Date:1/21/2017)... 2017 Interpace Diagnostics Group, Inc. (NASDAQ: ... clinically useful molecular diagnostic tests and pathology services, ... securities purchase agreement with three  institutional investors to ... stock in a registered direct offering.  In a ... sell to the same investors warrants to purchase ...
(Date:1/20/2017)... 20, 2017 Stock-Callers.com explores the ... influenced the most recent performances of select equities. In ... RGLS ), Abeona Therapeutics Inc. (NASDAQ: ... ), and Sage Therapeutics Inc. (NASDAQ: SAGE ... View Research, global Biotech market size is expected to reach $604.40 billion by ...
(Date:1/19/2017)... -- Market Research Future has a half cooked research report on Global ... rapidly and expected to reach USD 450 Million by the end ... ... been assessed as a swiftly growing market and expected that the ... future. There has been a tremendous growth in the prevalence of ...
(Date:1/19/2017)... ... January 19, 2017 , ... November ... to leading biopharmaceutical and medical device manufacturers and regulators, is proud to announce ... Part 11-compliant email client designed to provide product vigilance departments with the flexibility ...
Breaking Biology Technology: