Navigation Links
Anthrax inhibitor counteracts toxin, may lead to new therapeutics

Researchers from Rensselaer Polytechnic Institute and the University of Toronto have designed a nanoscale assembly of molecules that successfully counteracts and inhibits anthrax toxin in animal and laboratory experiments. The novel approach used to neutralize anthrax toxin could be applied in designing potent therapeutics for a variety of pathogens and toxins, according to the researchers.

Anthrax toxin, secreted by the anthrax bacterium, is made of proteins and toxic enzymes that bind together to inflict damage on a host organism. The inhibitor, which is described by the Rensselaer-Toronto team in the April 23 online edition of the journal Nature Biotechnology, works by preventing the assembly of toxic enzyme components, thereby blocking the formation of fully assembled anthrax toxin and neutralizing its activity.

The inhibitor protected rats from anthrax toxin in the study.

"Our eventual goal is to use the inhibitor as a human therapeutic for anthrax exposure, one that can stop the toxin from functioning inside the body," says Ravi Kane, the Merck Associate Professor of Chemical and Biological Engineering at Rensselaer and a principal investigator of the project. "Combining the inhibitor with antibiotic therapy may increase the likelihood of survival for an infected person."

The 2001 intentional release of anthrax spores via postal mail in the United States led to increased research on possible therapeutics and vaccines to treat toxins that could be used as biological weapons. The current treatment for anthrax exposure is antibiotics, but inhalation anthrax still has a fatality rate of 75 percent even after antibiotics are given, according to the Centers for Disease Control and Prevention. Antibiotics slow the progression of infection by targeting the bacteria, but do not counter the advanced destructive effects of anthrax toxin in the body.

Anthrax toxin is a polyvalent protein complex in that it displays multiple copies of
'"/>

Source:Rensselaer Polytechnic Institute


Page: 1 2 3

Related biology news :

1. Study Models Impact Of Anthrax Vaccine
2. Anthrax test, developed by army and CDC, receives FDA approval
3. Anthrax inhibitors identified by Burnham team
4. Anthrax stops body from fighting back, study shows
5. Anthrax spores may survive water treatment
6. Anthrax attack posed greater potential threat than thought
7. Anthrax paralyzes immune cells with lethal toxin, UF research shows
8. Protease inhibitors reach beyond HIV
9. UNC scientists discover new role for protein as fundamental inhibitor of cell movement
10. Small molecule inhibitor of cholera discovered
11. Enzyme inhibitors block replication of SARS virus
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Anthrax inhibitor counteracts toxin may lead new therapeutics

(Date:4/22/2014)... Analyzing thousands of breeding bird surveys sent in by ... over 35 years, wildlife researchers report that most of ... or toward higher elevation in response to climate change, ... that most previous studies of potential climate change impacts ... the other have likely underestimated the effects of environmental ...
(Date:4/22/2014)... . , Performed ... genome and subsequent phylogenetic analysis show that the virus ... distinct from strains previously identified in the Democratic Republic ... the laboratory confirmed cases with the initial deaths recorded ... a lethal, highly contagious virus for which there is ...
(Date:4/22/2014)... in two Minnesota cities demonstrate how communities can ... a ten year program in New England and ... to local conditions. , "Our goal is to ... said program co-leader Latham Stack, of Syntectic International, ... worsened. We help communities move beyond feeling paralyzed ...
Breaking Biology News(10 mins):Wildlife response to climate change is likely underestimated, experts warn 2Inserm and the Institut Pasteur identify a new variant of Ebola virus in Guinea 2Minnesota projects offer hope and practical help to communities facing more extreme storms 2
... Tests on the influence that a stress-related hormone has ... on understanding how it influences human learning, according to ... Professor in Comparative Human Development, has found that when ... quickly if they have a modest amount of cortisol, ...
... been lifted at the request of the PIO. , Without ... sideways, even though they lack flippers or fins. University of ... pelvic, abdominal and rib muscles to shift their lungs like ... the head when they surface and sideways when they roll. ...
... the Genome Sequencing Center (GSC) at Washington University in St. ... of the corn genome. In the fall of ... Agriculture (USDA) and the Department of Energy (DOE), awarded $32 ... goal of the project led by the Washington University GSC ...
Cached Biology News:Research with squirrels provides clues on hormone's role in human learning 2How alligators rock and roll 2How alligators rock and roll 3How alligators rock and roll 4How alligators rock and roll 5All eyes and ears on the corn genome 2All eyes and ears on the corn genome 3
(Date:1/15/2014)... Niagara Thermal Products is proud to announce that ... ("B3") as the critical thermal component supplier in support ... Corps of Engineers.  B3 has developed the only comprehensive ... destroys VOCs and other chemical pollutants, allergens and organic ...
(Date:1/15/2014)... 15, 2014 Cynvenio, a cancer diagnostics ... the genomic analysis of tumor cells in the bloodstream, ... web-based cancer decision support application powered by CollabRx, Inc. ... ClearID™ genomic test, Therapy Finder will provide breast cancer ...
(Date:1/15/2014)... Jan. 15, 2014 ­ RedBrick Health , a ... technology, today announces that EmblemHealth , the ... company, is now providing the RedBrick Compass health assessment, ... to all of its members. EmblemHealth is among the ...
(Date:1/15/2014)... January 15, 2014 A study has been ... the Formula 1 track could help to tackle the problem ... (MAT), Stowhealth (a GP surgery based in Stowmarket) and academics ... Simplyhealth. Telemetry technology, which is inspired by equipment ...
Breaking Biology Technology:Niagara Thermal Products LLC Selected as Critical Supplier for Buffalo BioBlower Air Purification Systems 2Cynvenio Offers New Breast Cancer Therapy Finder Application for its ClearID Breast Cancer Genomic Test 2Cynvenio Offers New Breast Cancer Therapy Finder Application for its ClearID Breast Cancer Genomic Test 3EmblemHealth Selects RedBrick Health to Power its Next-Generation Health Engagement and Behavior Change System 2EmblemHealth Selects RedBrick Health to Power its Next-Generation Health Engagement and Behavior Change System 3Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 2Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 3Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 4
... EAU CLAIRE -- In the latest of a string of ... has announced a fiber-optic gigabit Ethernet adapter compatible with Mac ... Adapters with Small Tree's OS X drivers means Apple-based ... can now take advantage of optical fiber's greater range than ...
... funding in the U.S. during the first quarter of ... small companies. , ,While promising, this level was lower ... of 2003, according to PricewaterhouseCooper's MoneyTree analysis. ... were a bit of a positive shocker as venture ...
... world today are WWWno further explanation is required , ,There ... the alphabet, W, as in WWI or WWII, ... there's the WWF and WWF. The match between the World ... muscles losing to cuddly pandas, and the wrestlers became the ...
Cached Biology Technology:Midwest life science companies capture 3% of VC investments in Q.2 2The global power of WWW 2The global power of WWW 3
Mouse monoclonal [1.T.4] to WAVE 1 ( Abpromise for all tested applications). Antigen: His6 fusion protein corresponding to full-length rat WAVE1. Entrez Gene ID: 8936...
For the differentiation of mouse embryonic stem cells tooligodendrocytes....
VAP-1 (S-13)...
... atoms at the 3, 3', 4, and ... as an internal standard for the quantification ... LC-mass spectrometry. PGE2 is one of the ... one of the most widely investigated prostaglandins. ...
Biology Products: