Navigation Links
Agent slows aging in mice

Aspirin didn’t pan out. Neither did two other potential anti-aging agents. But a synthetic derivative of a pungent desert shrub is now a front- runner in ongoing animal experiments to find out if certain chemicals, known to inhibit inflammation, cancer and other destructive processes, can boost the odds of living longer.

Today at the annual meeting of the American Aging Association, University of Michigan scientist Richard A. Miller reports early results from a mouse study his lab and two others are conducting for the National Institute on Aging. The study, now in its fourth year, will test as many as two dozen possible anti-aging agents in animals in the next five years. The other centers are the University of Texas Health Science Center in San Antonio, Texas, and the Jackson Laboratory in Bar Harbor, Maine.

The scientists were surprised to find so quickly that one agent showed promise: NDGA, a compound derived from creosote bushes. These common North American desert shrubs have been traditionally used by Native Americans as healing remedies.

The preliminary results, to be published in August in the journal Aging Cell, show that male mice fed a normal diet and NDGA so far have survived in significantly greater numbers than mice on a normal diet. Scientists measured the difference at a point called median lifespan, when half the control mice had died of natural causes associated with aging.

“This is the first time to my knowledge when an agent has been shown to extend median life span in three laboratories,” says Miller, professor of pathology at the U-M Medical School and associate director of the U-M Geriatrics Center. Miller is also a research scientist at the Ann Arbor VA Medical Center.

No significant difference occurred in female mice. The scientists can’t explain why at this point. “We don’t know how NDGA is having its effect on survival in this first analysis,” Miller says.

“It may be that the f
'"/>

Source:University of Michigan Health System


Page: 1 2

Related biology news :

1. Cancer drug slows poxvirus in mice
2. Stress substantially slows human bodys ability to heal
3. Cell therapy slows progression of an inherited neurological disease; Improves motor skills in mice
4. Diabetes slows nerve recovery after heart transplant
5. Protein found that slows hepatitis C growth in liver cells
6. Imaging Lymph Nodes with Nanoparticles
7. New imaging method gives early indication if brain cancer therapy is effective, U-M study shows
8. Special Imaging Study Shows Failing Hearts Are Energy Starved
9. How the environment could be damaging mens reproductive health
10. Human Cells Filmed Instantly Messaging for First Time
11. Duke engineers develop new 3-D cardiac imaging probe
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Agent slows aging mice

(Date:7/22/2014)... by researchers in modifying properties of nanomaterials for application ... thanks to recent innovative studies conducted by scientists from ... use of a simple, efficient and low cost technique ... led by Professor Sow Chorng Haur from the Department ... that the properties of two different types of materials ...
(Date:7/22/2014)... a cost-effectiveness analysis of commercial diet programs and pills, ... the best value for the money. The Jenny Craig ... the most expensive option tested, according to researchers at ... The findings, published in the June issue of the ... health and weight-loss benefits per dollar spent as insurance ...
(Date:7/22/2014)... multinational, collaborative effort, researchers from the Icahn School of ... locations in the human genome associated with the risk ... on any psychiatric disorder to date, conducted with 80,000 ... point to biological mechanisms and pathways that may underlie ... the disorder, which has seen little innovation in drug ...
Breaking Biology News(10 mins):NUS scientists use low cost technique to improve properties and functions of nanomaterials 2NUS scientists use low cost technique to improve properties and functions of nanomaterials 3Study compares cost-effectiveness of weight-loss programs and drugs 2Study compares cost-effectiveness of weight-loss programs and drugs 3Mount Sinai scientists and international team shed new light on schizophrenia 2Mount Sinai scientists and international team shed new light on schizophrenia 3
... have determined the fine-scale genetic structure of the first ... change. , They used a high-throughput sequencing technique called ... , Their results, which focus on the pitcher ... the journal Proceedings of the National Academy of ...
... of the High Arctic climate roughly 50 million years ago ... explain how ancient alligators and giant tortoises were able to ... as they endured six months of darkness each year. ... Eocene period 52 to 53 million years ago, also has ...
... Male infertility is a common medical problem, affecting millions ... include an inability to make productive sperm. Now, using ... of Pennsylvania School of Medicine are beginning to identify ... problem. Shelley Berger PhD, the Daniel S. ...
Cached Biology News:Genetic structure of first animal to show evolutionary response to climate change determined 2Genetic structure of first animal to show evolutionary response to climate change determined 3New study shows how giant tortoises, alligators thrived in High Arctic 50 million years ago 2New study shows how giant tortoises, alligators thrived in High Arctic 50 million years ago 3New study shows how giant tortoises, alligators thrived in High Arctic 50 million years ago 4Swimming upstream: Molecular approaches to better understand male infertility 2Swimming upstream: Molecular approaches to better understand male infertility 3
(Date:7/22/2014)... Hussey Copper , a leader in ... copper announces Pullman Regional Hospital,s conversion of more than ... touch surface, at a nominal cost.  This reasonably priced ... other bacteria within 2 hours of exposure 1 and ... infectious diseases in its facilities. Pullman Regional ...
(Date:7/22/2014)... Quorum Review IRB, the industry leader in central ... called Quick Step™ . The offering went live on ... industry’s need for seamless study start-up with a large volume ... planning 50 or more North American investigator sites, as well ... count of 80 or more. Qualifying studies may also enroll ...
(Date:7/22/2014)... July 22, 2014 Biofeedback ... disorder (ADHD) is diagnosed, selecting medication to best treat ... Analyzing brain patterns by using electroencephalography (EEG) can help ... thus lower the risk of adverse drug events. , ... Biomarkers” in the current issue of the journal ...
(Date:7/21/2014)... Hills, IL (PRWEB) July 21, 2014 ... control, and simple programming, the new Cole-Parmer® ... Head is easy to operate for automated ... cycles for hands-free dispensing. The batch count function ... cumulative volume or totalizer tracks amount dispensed across ...
Breaking Biology Technology:Pullman Regional Hospital changes more than 1,100 touch points to Hussey Copper's MD-Cu29 antimicrobial copper to help protect against bacteria 2Pullman Regional Hospital changes more than 1,100 touch points to Hussey Copper's MD-Cu29 antimicrobial copper to help protect against bacteria 3Quorum Review IRB Launches New Quick Step™ Service for Large Clinical Trials 2Quorum Review IRB Launches New Quick Step™ Service for Large Clinical Trials 3Analyzing Brain Patterns with EEG Can Help Predict Effective Use of Medication 2Analyzing Brain Patterns with EEG Can Help Predict Effective Use of Medication 3New Easy-View Cole-Parmer Digital Gear Pump Drive Makes Performance Monitoring Effortless 2
... E May Help,Prevent, Cardiovascular Events in Hp2-2 Diabetes, ... SYI ) today announced new data demonstrating that,discontinuation ... may result,in an increased risk of heart attack and ... at the Annual Scientific,Sessions of the American Heart Association, ...
... First laboratory to be certified for A1c testing using ... Heritage Labs,International LLC, a division of Hooper Holmes ... A1c testing methods by the National,Glycohemoglobin Standardization Program (NGSP)., ... hemoglobin A1c, one,for testing whole blood specimens and the ...
... 11 Amicus Therapeutics,(Nasdaq: FOLD ), today announced ... at the 5th Annual Lazard Capital Markets Healthcare,Conference in ... p.m. EST., A webcast and audio archive of ... at http://www.amicustherapeutics.com . Participants,should allow approximately five to ...
Cached Biology Technology:Synvista Therapeutics Announces Data Further Demonstrating the Value of Haptoglobin Genotyping in Diabetic Patients During AHA Meeting 2Synvista Therapeutics Announces Data Further Demonstrating the Value of Haptoglobin Genotyping in Diabetic Patients During AHA Meeting 3Synvista Therapeutics Announces Data Further Demonstrating the Value of Haptoglobin Genotyping in Diabetic Patients During AHA Meeting 4Heritage Labs Announces A1c Test Certification Milestone 2Heritage Labs Announces A1c Test Certification Milestone 3
...
... designed for two-dimensional electrophoresis (2D) and ... in this marker have been selected ... a 2D gel. The pI range ... Mol wt: 17,000-89,000 Physical Form: ...
... Serial Analysis of Gene Expression (SAGE) ... technology. Agencourt offers a cost-effective outsourcing ... and LongSAGE libraries. Agencourt's SAGE sequencing ... project turnaround and long Phred20 read ...
... Affinity Life Sciences can provide custom microplate coating using advanced ... a variety of plate formats. We can also accommodate virtually ... range of 0.5-320 L):, , ... 96 well microplate, 384 ...
Biology Products: