Navigation Links
Agent slows aging in mice

Aspirin didn’t pan out. Neither did two other potential anti-aging agents. But a synthetic derivative of a pungent desert shrub is now a front- runner in ongoing animal experiments to find out if certain chemicals, known to inhibit inflammation, cancer and other destructive processes, can boost the odds of living longer.

Today at the annual meeting of the American Aging Association, University of Michigan scientist Richard A. Miller reports early results from a mouse study his lab and two others are conducting for the National Institute on Aging. The study, now in its fourth year, will test as many as two dozen possible anti-aging agents in animals in the next five years. The other centers are the University of Texas Health Science Center in San Antonio, Texas, and the Jackson Laboratory in Bar Harbor, Maine.

The scientists were surprised to find so quickly that one agent showed promise: NDGA, a compound derived from creosote bushes. These common North American desert shrubs have been traditionally used by Native Americans as healing remedies.

The preliminary results, to be published in August in the journal Aging Cell, show that male mice fed a normal diet and NDGA so far have survived in significantly greater numbers than mice on a normal diet. Scientists measured the difference at a point called median lifespan, when half the control mice had died of natural causes associated with aging.

“This is the first time to my knowledge when an agent has been shown to extend median life span in three laboratories,” says Miller, professor of pathology at the U-M Medical School and associate director of the U-M Geriatrics Center. Miller is also a research scientist at the Ann Arbor VA Medical Center.

No significant difference occurred in female mice. The scientists can’t explain why at this point. “We don’t know how NDGA is having its effect on survival in this first analysis,” Miller says.

“It may be that the f
'"/>

Source:University of Michigan Health System


Page: 1 2

Related biology news :

1. Cancer drug slows poxvirus in mice
2. Stress substantially slows human bodys ability to heal
3. Cell therapy slows progression of an inherited neurological disease; Improves motor skills in mice
4. Diabetes slows nerve recovery after heart transplant
5. Protein found that slows hepatitis C growth in liver cells
6. Imaging Lymph Nodes with Nanoparticles
7. New imaging method gives early indication if brain cancer therapy is effective, U-M study shows
8. Special Imaging Study Shows Failing Hearts Are Energy Starved
9. How the environment could be damaging mens reproductive health
10. Human Cells Filmed Instantly Messaging for First Time
11. Duke engineers develop new 3-D cardiac imaging probe
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Agent slows aging mice

(Date:10/17/2014)... critical and pertinent for practicing physicians and clinicians given ... The Journal, Disaster Medicine and Public Health Preparedness ... Public Health, to surround the public, medical professionals and ... , On October 17, the journal published ... was prepared by Dr. Eric Toner, internist and emergency ...
(Date:10/17/2014)... To date, antidotes ... doctors are often limited to supportive therapy such as induced ... of drugs involved. So what can be done if a ... professor Jean-Christophe Leroux from the Institute of Pharmaceutical Sciences at ... "The task was to develop an agent that could eliminate ...
(Date:10/16/2014)... new synthesis of recent research findings to inform their ... two states. , The Ecology and Management of ... Synthesis of the Relevant Biophysical Science and Implications for ... the U.S. Forest Service,s Pacific Northwest Research Station, is ... a synthesis of the large body of scientific information ...
Breaking Biology News(10 mins):Emergency aid for overdoses 2Emergency aid for overdoses 3New report synthesizes best available science on management of moist mixed-conifer forests 2
... cells can grow new extensions when the amount of three ... , The research examined three related receptor proteins, called ... of rats. , When researchers increased the amount ... up to three times longer than those on nerve cells ...
... the detrimental loss of sea ice sheets in ... the scientific community have been saying for years. Now ... of Earth and Environmental Science are turning their attention to ... having similar effects in the frigid Antarctic region. ...
... tumor cells implanted in mice have shown that the ... breast cancer to the lungs. The new studies by ... genes work together to promote the growth of primary ... cancerous cells to escape into the bloodstream and penetrate ...
Cached Biology News:3 proteins may play important role in nerve-cell repair 2UTSA researchers examine effects of global warming on Antarctic 2A genetic 'gang of 4' drives spread of breast cancer 2A genetic 'gang of 4' drives spread of breast cancer 3A genetic 'gang of 4' drives spread of breast cancer 4
(Date:10/22/2014)... CA (PRWEB) October 22, 2014 ... from Sartorius, A & D Weighing, Rice Lake, ... CPA Semi-Micro Balance . The Sartorius CPA Semi-Micro ... an affordable high-quality, precise, and user-friendly laboratory balance. ... of laboratory equipment, their laboratory balances are well ...
(Date:10/22/2014)... --  Synthetic Biologics, Inc. (NYSE MKT: SYN), a ... and diseases, announced today that the U.S. Patent and ... a composition of matter patent application that covers the ... This is Synthetic Biologics, first allowed patent application directly ... the Company,s extensive C. difficile patent estate. ...
(Date:10/22/2014)... and HONG KONG , Oct. 22, ... therapeutics enterprise, announced today that rare disease expert ... vice president, research. Dr. McKew brings more than two ... positions at the National Institutes of Health, Wyeth Research ... Wyeth). Dr. McKew will lead aTyr,s efforts to expand and ...
(Date:10/20/2014)... , Oct. 20, 2014 Asterias ... the Company has signed a Notice of Grant ... Medicine (CIRM), effective October 1, 2014.  The NGA ... payments and the release of additional grant funds ... grant award for clinical development of Asterias, product, ...
Breaking Biology Technology:Pipette.com Launches the Addition of Sartorius CPA Semi-Micro Balance to Their Product Portfolio with Special Promotional Pricing 2Pipette.com Launches the Addition of Sartorius CPA Semi-Micro Balance to Their Product Portfolio with Special Promotional Pricing 3Synthetic Biologics Announces Allowance of Key U.S. Composition of Matter Patent for C. difficile Program 2Synthetic Biologics Announces Allowance of Key U.S. Composition of Matter Patent for C. difficile Program 3Synthetic Biologics Announces Allowance of Key U.S. Composition of Matter Patent for C. difficile Program 4aTyr Pharma Appoints John C. McKew, Ph.D., as Vice President, Research 2aTyr Pharma Appoints John C. McKew, Ph.D., as Vice President, Research 3Asterias Biotherapeutics Announces Notice of Grant Award with CIRM for Phase 1/2a Clinical Trial of AST-OPC1 in Complete Cervical Spinal Cord Injury 2Asterias Biotherapeutics Announces Notice of Grant Award with CIRM for Phase 1/2a Clinical Trial of AST-OPC1 in Complete Cervical Spinal Cord Injury 3Asterias Biotherapeutics Announces Notice of Grant Award with CIRM for Phase 1/2a Clinical Trial of AST-OPC1 in Complete Cervical Spinal Cord Injury 4
... Fla., Oct. 7 GeneWize Life Sciences ... Bulletin Board: GNLK) announced before a full house of ... targeting the teen market, adding to their current flagship ... The new nutrition and skin-clearing products, aimed ...
... BioMarin Pharmaceutical Inc. (Nasdaq: BMRN ... Executive Officer of BioMarin, will host a ... 28, at 5:00 p.m. ET to discuss ... Dial-in Number:  866.202.3048International Dial-in Number:  617.213.8843Participant Code: ...
... JOSEPH, Mich., Oct. 7 GeneGo, Inc., a leading ... and chemistry, announced today that they have integrated GenomeQuest,s ... MetaDrug. Using GenomeQuest,s interactive analysis, scientists who ... of interest (hundreds of millions of reads, to thousands ...
Cached Biology Technology:GeneWize Announces New Skin Clearing Product and Teen Nutrition at Annual Convention 2BioMarin to Host Third Quarter 2010 Financial Results Conference Call and Webcast on Thursday, October 28 at 5:00 p.m. ET 2GeneGo Announces Integration With GenomeQuest for Pathway Analysis of Next Generation Sequencing Data 2
... The product contains 5 ... coated with the monoclonal BerEP4 ... EpCAM (epithelial cell adhesion molecule). ... samples of 2 x 10e7 ...
MOUSE ANTI HUMAN FACTOR I...
Superior homology search software - in all the flavours of blast, with increased sensitivity and speed. Free windows version for academic use....
GFX PCR DNA,Gel Band Purif,100, 1 EA. Category: Nucleotide Sample Handling....
Biology Products: