Navigation Links
APS lecturer shows rare video of 'teacher-student' immune cell interactions in live animal

ne system when it fails to recognize the danger."

Technological leap makes it possible

Intravital microscopy, invented in the early 19th century, allows scientists to look at the tissues and cells of live animals. The technology has been in use for generations. But particularly advanced and powerful multi-photon microscopes using infrared beams to image fluorescent cells in living tissues became commercially available in the late 1990s.

That prompted von Andrian to embark on a project to use the technology to study the immune system. He set up his lab at the CBR Institute and developed a strain of mouse that has fluorescent T-cells.

"We are among a handful of labs which started to do this at the same time," von Andrian said of using the technology to study the immune system. The microscopes produce optical sections through solid organs, similar to a CT-scan. Hundreds, even thousands of these sections are assembled into digital time-lapse videos to generate a 3-dimensional look at an immune response in real time.

The organism remains intact, providing a live look at what is happening in the immune system. The challenge in adapting the technology was that it takes 15-30 seconds to generate the necessary series of photographs to create the 3-dimensional footage and the animal must remain perfectly still for it to work.

It took a year to figure out how to keep the anesthetized animal from moving, he said. Others have also worked to develop and advance the technology, von Andrian said. His lab's distinction was in adapting the technology for use in lymphoid organs in live animals.


'"/>

Source:American Physiological Society


Page: 1 2 3 4 5

Related biology news :

1. Genome of deadly amoeba shows surprising complexity, evidence of lateral gene transfer
2. “Nano-scissors?laser shows precise surgical capability
3. Clam embryo study shows pollutant mixture adversely affects nerve cell development
4. New imaging method gives early indication if brain cancer therapy is effective, U-M study shows
5. Study shows nanoshells ideal as chemical nanosensors
6. Gene vaccine for Alzheimers disease shows promising results
7. Flocking together: Study shows how animal groups find their way
8. New drug shows promise as powerful anticancer agent
9. Loves all in the brain: fMRI study shows strong, lateralized reward, not sex, drive
10. Test for early detection of prostate cancer shows promise
11. Mouse gene shows new mechanism behind cardiac infarction in man
Post Your Comments:
(Date:10/31/2014)... uncovered key steps involved in programmed cell death, offering ... cancers and neurodegenerative diseases. , The research teams ... to discover the three-dimensional structure of a key cell ... in how it causes cell death. Their studies were ... Proceedings of the National Academy of Sciences ...
(Date:10/31/2014)... and his team have been studying the behavior ... Austrian Alps for years. They observed that ravens ... grooming and playing. However, they also observed that ... third individual. Although in about 50 % of ... up the two affiliating ravens, intervening can be ...
(Date:10/30/2014)... help reduce or reverse soil subsidence and reduce ... Sacramento-San Joaquin River Delta by Dartmouth College researchers ... one of the first to continually measure the ... cycle through wetlands, appears in the journal by ... Worldwide, agricultural drainage of organic soils has resulted ...
Breaking Biology News(10 mins):A matter of life and death: Cell death proteins key to fighting disease 2Dartmouth study finds restoring wetlands can lessen soil sinkage, greenhouse gas emissions 2
... RIVERSIDE, Calif. Humans are conducting massive experiments on ... introducing exotic species, boosting nutrient concentrations, and altering climates. ... will give the Jane Block Distinguished Lecture in ... which he will discuss how our ability to assess ...
... May 7, 2013 /PRNewswire-iReach/ -- Glutathione is the ... oxidants and a large variety of other toxins and insults. ... enhancing glutathione levels in cells and tissues has simmered for ... oral supplementation is effective in increasing the body,s stores of ...
... For plants and animals forced to tough out harsh ... country is a refuge, a stable beneath-the-snow habitat that gives ... in a warming world, winter and spring snow cover in ... plants and animals that depend on the space beneath the ...
Cached Biology News:Public lecture at UC Riverside to discuss challenges in assessing human impact on ecosystems 2Clinical Tests Demonstrate Long-Term Effectiveness of Oral Glutathione Supplements - Kyowa Study 2Clinical Tests Demonstrate Long-Term Effectiveness of Oral Glutathione Supplements - Kyowa Study 3Decline in snow cover spells trouble for many plants, animals 2Decline in snow cover spells trouble for many plants, animals 3
(Date:10/31/2014)... Caustic soda is utilized in the production of ... China takes lead in the global caustic soda market, followed ... of facilities in the USA, Germany, Brazil and Canada, is ... in terms of output and production capacities. , The global ... 3% per year in the years ahead. The APAC region ...
(Date:10/31/2014)... Following the successful launch of On ... to introduce its new product and demonstrate its potential ... Launched in September, Formedix On Demand Services is the ... automation tools. For the first time, these market-leading tools ... introducing Formations – a revolutionary new token-based payment system ...
(Date:10/31/2014)... ENVIRON , an international ... that Dr. Harvey Clewell III has rejoined the ... closely with senior professionals in ENVIRON’s Health Sciences ... at The Hamner Institutes for Health Sciences (The ... he is Director, Center for Human Health Assessment. ...
(Date:10/30/2014)... 2014 The report “Fragrance Ingredients Market ... (Cosmetics & Toiletries, and Soaps & Detergents) & by ... defined and segmented the Fragrance Ingredients Market with analyses ... of value. The market has been segmented on the ... Asia-Pacific, Latin America, and Rest of the World (ROW); ...
Breaking Biology Technology:China to Dominate Caustic Soda Market Through 2018, Says Merchant Research & Consulting in Its New Study 2Formedix to Introduce "Revolutionary" Clinical Trial Automation Software with Learning Webinar 2Internationally recognized health scientist Dr. Harvey Clewell renews association with ENVIRON 2Internationally recognized health scientist Dr. Harvey Clewell renews association with ENVIRON 3Fragrance Ingredients Market worth $17,104.21 Million by 2019 - New Report by MarketsandMarkets 2Fragrance Ingredients Market worth $17,104.21 Million by 2019 - New Report by MarketsandMarkets 3Fragrance Ingredients Market worth $17,104.21 Million by 2019 - New Report by MarketsandMarkets 4Fragrance Ingredients Market worth $17,104.21 Million by 2019 - New Report by MarketsandMarkets 5
... SAN CARLOS, Calif., Jan. 7 Nuvelo, Inc.,(Nasdaq: ... stockholders of Nuvelo have approved,the issuance of Nuvelo ... 24, 2008, as amended, between Nuvelo, ARCA biopharma ... adjourn Nuvelo,s special,stockholder meeting until January 23, 2009, ...
... Jan. 7 Volcano Corporation,(Nasdaq: VOLC ), ... for the diagnosis and treatment of coronary and peripheral ... announced acquisition of,Axsun Technologies, Inc. , ... lasers and optical,engines used in medical Optical Coherence Tomography ...
... Jan. 7 Cold season has settled in for ... leading cause for doctor,appointments and missed days of school ... help boost your immune system. And Immunity Enhanced Beverage ... Recently introduced by Innovative Beverage Products, Immunity Enhanced,Beverage ...
Cached Biology Technology:Nuvelo Shareholders Approve Issuance of Common Stock Pursuant to Merger Agreement With ARCA biopharma 2Nuvelo Shareholders Approve Issuance of Common Stock Pursuant to Merger Agreement With ARCA biopharma 3Nuvelo Shareholders Approve Issuance of Common Stock Pursuant to Merger Agreement With ARCA biopharma 4Nuvelo Shareholders Approve Issuance of Common Stock Pursuant to Merger Agreement With ARCA biopharma 5Volcano Announces Closing of Axsun Technologies Acquisition 2Innovative Beverage Products Launches New Product Designed to Enhance the Body's Immune Defense 2
Rabbit polyclonal antibody to GluR2...
... Blocker Array II can be used ... against various proteins and sera that are ... carriers. The array contains spots for 19 ... Application: Determination of antibody crossreactivity and species ...
... Each kit contains sufficient materials for 1,464 array ... Membrane: 4 each , Blocker BSA ... Goat Anti-Mouse Antibody, HRP-conjugated: 10 g ... , 10% Tween-20: 2 x 10 ml ...
... gun system, 100-120 V, is used for ... This handheld device employs an adjustable helium ... biomaterial-coated gold microcarriers from the inner wall ... target cells. This system has a 2 ...
Biology Products: