Navigation Links
APS lecturer shows rare video of 'teacher-student' immune cell interactions in live animal

ne system when it fails to recognize the danger."

Technological leap makes it possible

Intravital microscopy, invented in the early 19th century, allows scientists to look at the tissues and cells of live animals. The technology has been in use for generations. But particularly advanced and powerful multi-photon microscopes using infrared beams to image fluorescent cells in living tissues became commercially available in the late 1990s.

That prompted von Andrian to embark on a project to use the technology to study the immune system. He set up his lab at the CBR Institute and developed a strain of mouse that has fluorescent T-cells.

"We are among a handful of labs which started to do this at the same time," von Andrian said of using the technology to study the immune system. The microscopes produce optical sections through solid organs, similar to a CT-scan. Hundreds, even thousands of these sections are assembled into digital time-lapse videos to generate a 3-dimensional look at an immune response in real time.

The organism remains intact, providing a live look at what is happening in the immune system. The challenge in adapting the technology was that it takes 15-30 seconds to generate the necessary series of photographs to create the 3-dimensional footage and the animal must remain perfectly still for it to work.

It took a year to figure out how to keep the anesthetized animal from moving, he said. Others have also worked to develop and advance the technology, von Andrian said. His lab's distinction was in adapting the technology for use in lymphoid organs in live animals.


'"/>

Source:American Physiological Society


Page: 1 2 3 4 5

Related biology news :

1. Genome of deadly amoeba shows surprising complexity, evidence of lateral gene transfer
2. “Nano-scissors?laser shows precise surgical capability
3. Clam embryo study shows pollutant mixture adversely affects nerve cell development
4. New imaging method gives early indication if brain cancer therapy is effective, U-M study shows
5. Study shows nanoshells ideal as chemical nanosensors
6. Gene vaccine for Alzheimers disease shows promising results
7. Flocking together: Study shows how animal groups find their way
8. New drug shows promise as powerful anticancer agent
9. Loves all in the brain: fMRI study shows strong, lateralized reward, not sex, drive
10. Test for early detection of prostate cancer shows promise
11. Mouse gene shows new mechanism behind cardiac infarction in man
Post Your Comments:
(Date:12/10/2014)... --Research and Markets ( http://www.researchandmarkets.com/research/xclcvw/biometrics_market ) ... Market in Japan 2014-2018" report to their ... The integration of biometrics and smart ... upgradation of the driver,s license is one of ... the aforementioned projects, biometrics is being used as ...
(Date:12/4/2014)... , Dec. 3, 2014  Crossmatch™, a ... announced that its DigitalPersona ® Pro Enterprise ... have been deployed throughout First Bank branch locations ... South Carolina and Virginia. First Bank, ... Southern Pines, North Carolina , selected ...
(Date:11/21/2014)... -- Earlier this year Donald Spector , Chairman of ... the most prolific inventors in the world, got a ... to third party agencies. Spector envisioned this technology even ... earliest known patents in this area. Now major technology ... care, elder care and hospital applications. This technology has ...
Breaking Biology News(10 mins):Biometrics Market in Japan 2014-2018: Key Vendors are DDS, Fujitsu, Hitachi and NEC 2First Bank Partners with Crossmatch to Increase Log In Security 2First Bank Partners with Crossmatch to Increase Log In Security 3Patented Biosensor Wearable Technology Provides a More Civilized Method of Quarantine 2Patented Biosensor Wearable Technology Provides a More Civilized Method of Quarantine 3Patented Biosensor Wearable Technology Provides a More Civilized Method of Quarantine 4
... inferences about the intentions of other individuals in order ... of everyday life that we humans take for granted. ... Max Planck Institute in Germany, this ability is present ... in the April issue of Current Directions in Psychological ...
... the National Institute on Drug Abuse (NIDA), part of ... time identified genes that might increase a person’s ability ... by Dr. George Uhl at NIDA’s Intramural Research Program ... the Center for Nicotine and Smoking Cessation Research at ...
... international team of 19 researchers calls for better forecasting ... The researchers, led by Daniel B. Botkin, note that ... be at risk from global warming, surprisingly few species ... period encompassing several ice ages. They suggest that this ...
Cached Biology News:Man's best friend lends insight into human evolution 2NIDA study identifies genes that might help some people abstain from smoking 2
(Date:12/19/2014)... -- Relmada Therapeutics, Inc. (OTCQB: RLMD), a clinical-stage company ... announced the results of its annual general meeting of ... year in Relmada,s history and it set the stage ... Sergio Traversa , chief executive officer of Relmada. "Over ... human resource and clinical development objectives that position Relmada ...
(Date:12/17/2014)... 17, 2014 Achim Noack has been ... Stoller Group. In this position, Noack will assist Jerry ... matters, develop marketing strategy and supervise global marketing management ... “Achim has tremendous knowledge and experience in the crop ... “His experience and innovative thinking will be a great ...
(Date:12/17/2014)... Xeno Diagnostics has again received ... recent COLA inspection. Xeno has met all criteria ... accreditation organization. Accreditation is earned only by laboratories ... operations, demonstrate continued accuracy in the performance of ... survey. , While the Laboratory Excellence ...
(Date:12/17/2014)... 2014  United Therapeutics Corporation (NASDAQ: UTHR ... as changes to Martine Rothblatt , Ph.D,s compensation ... United Therapeutics announced the promotion of Roger ... and David Zaccardelli , Pharm.D. to Executive Vice ... promotions, Dr. Rothblatt,s title will change from Chairman and ...
Breaking Biology Technology:Relmada Therapeutics Announces Results of Annual Shareholders Meeting 2Achim Noack Joins Stoller Group as Global Vice President of Marketing and Administration 2Xeno Diagnostics Receives 3rd Award for Laboratory Excellence 2United Therapeutics Corporation Announces Executive Promotions and CEO Compensation Change 2United Therapeutics Corporation Announces Executive Promotions and CEO Compensation Change 3United Therapeutics Corporation Announces Executive Promotions and CEO Compensation Change 4
... The 2nd Aesthetic Plastic Surgery and Anti Aging Medicine: The ... in New York on June 10-12, 2011. This three day ... medicine, the science of stem cells, and fat grafting applications ... plastic surgeons Drs. Sydney Coleman and J. Peter Rubin, among ...
... American Regent is conducting a nationwide voluntary recall ... mL Single Dose VialsNDC # 0517-4901-25;andDexamethasone Sodium Phosphate Injection, ... Sodium Phosphate Injection, 4 mg/mL, 30 mL Multiple Dose ... voluntary recall, initiated on March 16, 2011 to the ...
... NEW YORK, March 16, 2011 Reportlinker.com announces ... in its catalogue: Global Specialty ... This report analyzes the worldwide markets ... following product segments - Specialty Medical Enzymes, Polymerases, ...
Cached Biology Technology:Aesthetic Plastic Surgery and Anti Aging Medicine Symposium Features New Developments in the Science of Stem Cells and Fat Grafting 2American Regent Initiates Voluntary Nationwide Recall of Dexamethasone Sodium Phosphate Injection, USP, 4 mg/mL, 1 mL Single Dose Vials; 5 mL and 30 mL Multiple Dose Vials 2American Regent Initiates Voluntary Nationwide Recall of Dexamethasone Sodium Phosphate Injection, USP, 4 mg/mL, 1 mL Single Dose Vials; 5 mL and 30 mL Multiple Dose Vials 3American Regent Initiates Voluntary Nationwide Recall of Dexamethasone Sodium Phosphate Injection, USP, 4 mg/mL, 1 mL Single Dose Vials; 5 mL and 30 mL Multiple Dose Vials 4American Regent Initiates Voluntary Nationwide Recall of Dexamethasone Sodium Phosphate Injection, USP, 4 mg/mL, 1 mL Single Dose Vials; 5 mL and 30 mL Multiple Dose Vials 5Global Specialty Enzymes Industry 2Global Specialty Enzymes Industry 3Global Specialty Enzymes Industry 4Global Specialty Enzymes Industry 5Global Specialty Enzymes Industry 6Global Specialty Enzymes Industry 7Global Specialty Enzymes Industry 8Global Specialty Enzymes Industry 9Global Specialty Enzymes Industry 10Global Specialty Enzymes Industry 11Global Specialty Enzymes Industry 12Global Specialty Enzymes Industry 13Global Specialty Enzymes Industry 14Global Specialty Enzymes Industry 15Global Specialty Enzymes Industry 16Global Specialty Enzymes Industry 17Global Specialty Enzymes Industry 18Global Specialty Enzymes Industry 19Global Specialty Enzymes Industry 20Global Specialty Enzymes Industry 21Global Specialty Enzymes Industry 22Global Specialty Enzymes Industry 23Global Specialty Enzymes Industry 24
Immunogen: Peptide corresponding to amino acid residues from the N-terminal region of human thyroid hormone receptor, alpha1/alpha2-isotype. Storage: -20 C, Avoid Freeze/Thaw Cycles...
Antibodies were affinity purified using epitopes specific to QKI immobilized on solid support....
Direct ELISA Assay Diluent, 10 L...
SpectroQuest single beam 1.8nm UV/Vis spectrophotometer; stand-alone unit...
Biology Products: