Navigation Links
APS lecturer shows rare video of 'teacher-student' immune cell interactions in live animal

ne system when it fails to recognize the danger."

Technological leap makes it possible

Intravital microscopy, invented in the early 19th century, allows scientists to look at the tissues and cells of live animals. The technology has been in use for generations. But particularly advanced and powerful multi-photon microscopes using infrared beams to image fluorescent cells in living tissues became commercially available in the late 1990s.

That prompted von Andrian to embark on a project to use the technology to study the immune system. He set up his lab at the CBR Institute and developed a strain of mouse that has fluorescent T-cells.

"We are among a handful of labs which started to do this at the same time," von Andrian said of using the technology to study the immune system. The microscopes produce optical sections through solid organs, similar to a CT-scan. Hundreds, even thousands of these sections are assembled into digital time-lapse videos to generate a 3-dimensional look at an immune response in real time.

The organism remains intact, providing a live look at what is happening in the immune system. The challenge in adapting the technology was that it takes 15-30 seconds to generate the necessary series of photographs to create the 3-dimensional footage and the animal must remain perfectly still for it to work.

It took a year to figure out how to keep the anesthetized animal from moving, he said. Others have also worked to develop and advance the technology, von Andrian said. His lab's distinction was in adapting the technology for use in lymphoid organs in live animals.


'"/>

Source:American Physiological Society


Page: 1 2 3 4 5

Related biology news :

1. Genome of deadly amoeba shows surprising complexity, evidence of lateral gene transfer
2. “Nano-scissors?laser shows precise surgical capability
3. Clam embryo study shows pollutant mixture adversely affects nerve cell development
4. New imaging method gives early indication if brain cancer therapy is effective, U-M study shows
5. Study shows nanoshells ideal as chemical nanosensors
6. Gene vaccine for Alzheimers disease shows promising results
7. Flocking together: Study shows how animal groups find their way
8. New drug shows promise as powerful anticancer agent
9. Loves all in the brain: fMRI study shows strong, lateralized reward, not sex, drive
10. Test for early detection of prostate cancer shows promise
11. Mouse gene shows new mechanism behind cardiac infarction in man
Post Your Comments:
(Date:7/23/2014)... grip is affecting more than the color of people,s lawns. ... heat-loving amoeba commonly found in warm freshwater bodies, such as ... warmer than usual this year. , A 9-year-old Kansas girl ... swimming in several area lakes. The amoeba enters the body ... brain. Nose plugs can lower the odds of this rare ...
(Date:7/23/2014)... commonly found in dead bodies and is used in ... to as the post mortem interval. A report of ... Tamil Nadu is provided for the first time based ... DNA barcoding. This study, significant in forensic investigations was ... . , Chrysomya megacephala is commonly found ...
(Date:7/23/2014)... around the world by 2050, according to one of ... Change (IPCC), may be advantageous to the physiology and ... of forage plants such as Stylosanthes capitata Vogel ... countries such as Brazil., The conclusion is from a ... Biology at the Ribeiro Preto Faculty of Philosophy, Sciences ...
Breaking Biology News(10 mins):Diseases of another kind 2Dead body feeding larvae useful in forensic investigations 2An increase in temperature by 2050 may be advantageous to the growth of forage plants 2An increase in temperature by 2050 may be advantageous to the growth of forage plants 3An increase in temperature by 2050 may be advantageous to the growth of forage plants 4
... Davis researchers in nanotechnology, chemistry and biology now have access ... in the world. The new Spectral Imaging Facility, opened this ... a laser scanning confocal microscope, the first commercial machine of ... Asylum Research of Santa Barbara and the confocal microscope system ...
... gained new insights into how neurons control growth ... that enable them to connect with their neighbors. ... which neurons form the signaling networks that constitute ... neuronal growth will help researchers better understand brain ...
... preliminary results from a study in Botswana, Harvard School ... HIV-1 subtype C in resource-poor settings, who receive antiretroviral ... the developed world. A fully supported health care delivery ... data published in November 2005 issue of the Journal ...
Cached Biology News:How the neuron sprouts its branches 2How the neuron sprouts its branches 3Largest computational biology simulation mimics life’s most essential nanomachine 2
(Date:7/22/2014)... 22, 2014 Nuclear reactors are used ... by controlled fission chain reaction in nuclear reactors is ... used to drive a power- generating turbine. Currently nuclear ... world’s total electricity production. Nuclear reactor market is expected ... planned and proposed nuclear reactor projects. , Early buyers ...
(Date:7/22/2014)... Automated cell culture systems are instruments that mechanically ... allow production of optimum cells at a large scale ... and industries and biopharmaceutical companies. Cell culture automation systems ... cell-based assays, and cellular expression systems as they save ... Global Cell Culture market will grow at ...
(Date:7/22/2014)... (PRWEB) July 22, 2014 The ... clear and concise visual representation of history, migration, and ... was always regaled by family history stories stemming from ... as the "old country." Pictures and 8mm home movies ... side of the family, and Steve ordered a test ...
(Date:7/22/2014)... 2014 OHAUS Corporation, a leading ... balances and scales, proudly announces its Explorer line ... Equipment magazine’s 2014 “Readers' Choice” Award for ... the Explorer was voted the best laboratory balance ... Awards celebrates “excellence in product design and performance ...
Breaking Biology Technology:Nuclear Energy Market: Global Industry Analysis, Size, Share, Analysis, Growth and Forecast 2013 - 2019 2Nuclear Energy Market: Global Industry Analysis, Size, Share, Analysis, Growth and Forecast 2013 - 2019 3Global Cell Culture Market to Grow at 10.27% CAGR by 2018 Forecasts a New Research Report ReportsnReports.com 2Global Cell Culture Market to Grow at 10.27% CAGR by 2018 Forecasts a New Research Report ReportsnReports.com 3Global Cell Culture Market to Grow at 10.27% CAGR by 2018 Forecasts a New Research Report ReportsnReports.com 4DNA Test from DNA Spectrum Shows Heritage Like a Map of the Past 2DNA Test from DNA Spectrum Shows Heritage Like a Map of the Past 3DNA Test from DNA Spectrum Shows Heritage Like a Map of the Past 4OHAUS Explorer Voted “Best Balance” in Laboratory Equipment’s 2014 Readers’ Choice Awards 2
... Building the Merge Healthcare of tomorrow, as ... offshoring 150 jobs to a "more cost effective workforce" ... of the financially troubled medical imaging software company's workforce ... the competitive edge marks the centerpiece of a broader ...
... - TeraMedica , a medical informatics company, has ... the VisLite Information Manager , an ... , ,The product integrates and manages advanced and traditional ... records and health records. , ,It also uses open ...
... spend the most on research and development in the life ... University of Wisconsin-Madison ($764 million) is perennially among the ... the list is the Medical College of Wisconsin ... research centers. Next up is the University of Wisconsin-Milwaukee ...
Cached Biology Technology:Merge offshoring jobs to "more cost-effective" workforce 2Merge offshoring jobs to "more cost-effective" workforce 3Marshfield Clinic and UW combine to speed tech growth 2Marshfield Clinic and UW combine to speed tech growth 3Marshfield Clinic and UW combine to speed tech growth 4
Nuclear/Cytosol Fractionation Kit Research Focus: other Storage Temperature: 4C Shipping Temperature: 4C...
Peptide-affinity Purified Polyclonal Antibody to MTR...
Polyclonal Antibody to AGAP1 / Centaurin, gamma 2...
Polyclonal Antibody to PRG3...
Biology Products: