Navigation Links
APS lecturer shows rare video of 'teacher-student' immune cell interactions in live animal

ne system when it fails to recognize the danger."

Technological leap makes it possible

Intravital microscopy, invented in the early 19th century, allows scientists to look at the tissues and cells of live animals. The technology has been in use for generations. But particularly advanced and powerful multi-photon microscopes using infrared beams to image fluorescent cells in living tissues became commercially available in the late 1990s.

That prompted von Andrian to embark on a project to use the technology to study the immune system. He set up his lab at the CBR Institute and developed a strain of mouse that has fluorescent T-cells.

"We are among a handful of labs which started to do this at the same time," von Andrian said of using the technology to study the immune system. The microscopes produce optical sections through solid organs, similar to a CT-scan. Hundreds, even thousands of these sections are assembled into digital time-lapse videos to generate a 3-dimensional look at an immune response in real time.

The organism remains intact, providing a live look at what is happening in the immune system. The challenge in adapting the technology was that it takes 15-30 seconds to generate the necessary series of photographs to create the 3-dimensional footage and the animal must remain perfectly still for it to work.

It took a year to figure out how to keep the anesthetized animal from moving, he said. Others have also worked to develop and advance the technology, von Andrian said. His lab's distinction was in adapting the technology for use in lymphoid organs in live animals.


'"/>

Source:American Physiological Society


Page: 1 2 3 4 5

Related biology news :

1. Genome of deadly amoeba shows surprising complexity, evidence of lateral gene transfer
2. “Nano-scissors?laser shows precise surgical capability
3. Clam embryo study shows pollutant mixture adversely affects nerve cell development
4. New imaging method gives early indication if brain cancer therapy is effective, U-M study shows
5. Study shows nanoshells ideal as chemical nanosensors
6. Gene vaccine for Alzheimers disease shows promising results
7. Flocking together: Study shows how animal groups find their way
8. New drug shows promise as powerful anticancer agent
9. Loves all in the brain: fMRI study shows strong, lateralized reward, not sex, drive
10. Test for early detection of prostate cancer shows promise
11. Mouse gene shows new mechanism behind cardiac infarction in man
Post Your Comments:
(Date:9/18/2014)... tonight at the third annual Golden Goose Award ceremony ... infants and in paving the way for the telecommunications ... by the National Science Foundation, the National Institutes of ... honored at a ceremony at the Library of Congress ... Congress will be on hand to help present their ...
(Date:9/18/2014)... of the fish world, are the ideal animal in ... They,ve moved from the ocean into tens of thousands ... time changing their skeleton to adapt to the new ... of sticklebacks now have turned up one of the ... simple change in that gene,s regulation in a freshwater ...
(Date:9/17/2014)... were instrumental in the creation of the Santa Ana ... the fire threat potential of the powerful, hot, dry ... an inferno. The index was introduced Sept. 17 by ... San Diego Gas and Electric. , The index includes ... will be used to help fire agencies and other ...
Breaking Biology News(10 mins):3rd annual Golden Goose award ceremony honors 8 researchers; Unusual work had big results 2Counting fish teeth reveals regulatory DNA changes behind rapid evolution, adaptation 2Counting fish teeth reveals regulatory DNA changes behind rapid evolution, adaptation 3UCLA scientists play key role in developing new Santa Ana Wildfire Threat Index 2
... December 12, 2012 Cell aging, or cellular senescence, ... to tumor development. Activated oncogenes are able to induce ... (OIS) could play a key role in future cancer ... in the regulation of OIS. This study is published ...
... plant dye once prized throughout the Old World to make fiery ... for a new "green" battery. Chemists from The ... and the U.S. Army Research Laboratory to develop a non-toxic and ... roots of the madder plant ( Rubia species). More ...
... engineering researchers at Rensselaer Polytechnic Institute shows, for the ... significant role in the strength of our bones. The ... fighting osteoporosis and lowering the risk of bone fracture. ... the study details how fractures in healthy bones begin ...
Cached Biology News:Previously unknown mechanism identified in oncogene-induced senescence 2Ancient red dye powers new 'green' battery 2Ancient red dye powers new 'green' battery 3Battling brittle bones... with broccoli and spinach? 2
(Date:9/18/2014)... 18, 2014 ... ) has announced the addition of ... Strategic Business Report" report to ... report analyzes the worldwide markets for ... the following Product Segments: Polymeric Materials, ...
(Date:9/18/2014)... Washington, D.C. (PRWEB) September 18, 2014 ... Dick Durbin and Sen. Jim Risch for National Lab ... research projects from across the national laboratory system. Durbin ... Caucus, which aims to increase awareness of the reach ... breakthrough technologies and discoveries to address some of our ...
(Date:9/18/2014)... , Sept. 18, 2014 Research ... the "Global N-acetylcysteine Industry Report 2014" ... Global N-acetylcysteine Industry Report 2014 is a professional ... the global N-acetylcysteine industry. The report ... definitions, classifications, applications and industry chain structure. The ...
(Date:9/18/2014)... 2014 Research and Markets has ... (Polymerase Chain Reaction, In-situ hybridization, Immunohistochemistry) Market - Trends ... The global companion diagnostics market is ... 2014 to 2019. Factors such as rising need for ... diagnostics by the pharmaceutical industry, support from regulatory authorities, ...
Breaking Biology Technology:Biocompatible Materials - Global Strategic Business Report 2014 2Biocompatible Materials - Global Strategic Business Report 2014 3Lab Day Highlight Labs' Contribution to U.S. Competitiveness and Innovation 2Lab Day Highlight Labs' Contribution to U.S. Competitiveness and Innovation 3Global N-acetylcysteine Industry Report 2014 2Global Companion Diagnostics (Polymerase Chain Reaction, In-situ hybridization, Immunohistochemistry) Market - Trends & Forecasts to 2019 2Global Companion Diagnostics (Polymerase Chain Reaction, In-situ hybridization, Immunohistochemistry) Market - Trends & Forecasts to 2019 3
... Oramed Pharmaceuticals Inc. (OTCBB: ORMP.OB) ( http://www.oramed.com ... today that its work entitled "Evaluation of the Safety ... Volunteers" will be presented at the Eleventh Annual Meeting ... San Francisco, California. "The selection of Oramed ...
... 25, 2011 Reportlinker.com announces that a ... its catalogue: Global Automated ... http://www.reportlinker.com/p092467/Global-Automated-And-Rapid-Microbiological-Tests-Industry.html#utm_source=prnewswire&utm_medium=pr&utm_campaign=In_Vitro_Diagnostic This ... and Rapid Microbiological Tests in US$ Million ...
... some patients develop a potentially deadly blood infection from ... bodies have gene mutations that allow them to stick ... infections because of a biofilm of persistent bacterial bugs ... some strains of the bacteria, Staphylococcus aureus, have just ...
Cached Biology Technology:Oramed Pharmaceuticals Chosen to Present at the Diabetes Technology Meeting (October 27-29, 2011; San Francisco, CA) 2Global Automated And Rapid Microbiological Tests Industry 2Global Automated And Rapid Microbiological Tests Industry 3Global Automated And Rapid Microbiological Tests Industry 4Global Automated And Rapid Microbiological Tests Industry 5Global Automated And Rapid Microbiological Tests Industry 6Global Automated And Rapid Microbiological Tests Industry 7Global Automated And Rapid Microbiological Tests Industry 8Global Automated And Rapid Microbiological Tests Industry 9Global Automated And Rapid Microbiological Tests Industry 10Global Automated And Rapid Microbiological Tests Industry 11Global Automated And Rapid Microbiological Tests Industry 12Global Automated And Rapid Microbiological Tests Industry 13Global Automated And Rapid Microbiological Tests Industry 14Global Automated And Rapid Microbiological Tests Industry 15Global Automated And Rapid Microbiological Tests Industry 16Global Automated And Rapid Microbiological Tests Industry 17Global Automated And Rapid Microbiological Tests Industry 18Global Automated And Rapid Microbiological Tests Industry 19Global Automated And Rapid Microbiological Tests Industry 20Global Automated And Rapid Microbiological Tests Industry 21Global Automated And Rapid Microbiological Tests Industry 22Global Automated And Rapid Microbiological Tests Industry 23Global Automated And Rapid Microbiological Tests Industry 24Global Automated And Rapid Microbiological Tests Industry 25Global Automated And Rapid Microbiological Tests Industry 26Study offers clues as to why some patients get infections from cardiac implants 2Study offers clues as to why some patients get infections from cardiac implants 3Study offers clues as to why some patients get infections from cardiac implants 4Study offers clues as to why some patients get infections from cardiac implants 5
... DIGIVIEW line of digital x-ray detectors from ... device complete with 12 to 16 bit ... of a photodiode array sensor with pixel ... are available in low x-ray energies (10-50 ...
The Odyssey Infrared Imaging System is a complete family of products that includes the Odyssey Imager, IRDye labeling reagents and Odyssey software for scan control and data analysis....
... System from KUBTEC is a dual capability system ... dimensional representation of the specimen under test. While ... X-ray images, the micro focus source also allows ... in standard 2D images. The 50 mm x ...
... the condition in which a lack of ... the various antioxidants. Oxidative stress appears ... several diseases, including artherosclerosis, chronic inflammatory diseases, ... antioxidant systems that are very important for ...
Biology Products: