Navigation Links
APS lecturer shows rare video of 'teacher-student' immune cell interactions in live animal

months, repeating this process and then passing the information on to their successors. The interaction between T cells and dendritic cells in the lymph node changes over time, von Andrian said.

"It's nice that the T cell learns to recognize the antigen, but that doesn't get rid of the microbe that has entered the body," von Andrian said. He traced the path of the educated T cells leaving the lymph node, when they become known as effector cells. In addition, von Andrian addressed how these T cells kill those cells they identified as harboring a pathogen without going on a rampage and annihilating everything in sight.

"There must be a control mechanism that can keep these cytotoxic cells in check," von Andrian noted. The immune system does this by creating regulatory T cells to control the effector cells, he said. Previous research had shown that the regulatory T cells can also receive their education in the lymph node before proliferating and entering the blood stream.

May lead to vaccines

"The events I have described are at the heart of any vaccination," von Andrian said. Many pathogens take advantage of the lymph system to gain access to the body, he noted, including pathogens used in biological warfare, such as anthrax, or yersinia pestis, the agent that causes the plague.

Bubonic plague, for instance, starts with a flea that deposits a few bacteria, which travel via the lymphatic system to the lymph node and proliferate to huge numbers. One of the puzzles von Andrian has been working on, is how foreign invaders manage to proliferate in the very area, the lymph node, where the immune system is marshaling its troops.

"So understanding how these (foreign) cells survive in the lion's den of the lymph node might allow us to develop strategies to combat infections," von Andrian said. "Somehow, they do this without ringing the alarm bells. Possibly we could manipulate the process to ring the alarm bell for the immu
'"/>

Source:American Physiological Society


Page: 1 2 3 4 5

Related biology news :

1. Genome of deadly amoeba shows surprising complexity, evidence of lateral gene transfer
2. “Nano-scissors?laser shows precise surgical capability
3. Clam embryo study shows pollutant mixture adversely affects nerve cell development
4. New imaging method gives early indication if brain cancer therapy is effective, U-M study shows
5. Study shows nanoshells ideal as chemical nanosensors
6. Gene vaccine for Alzheimers disease shows promising results
7. Flocking together: Study shows how animal groups find their way
8. New drug shows promise as powerful anticancer agent
9. Loves all in the brain: fMRI study shows strong, lateralized reward, not sex, drive
10. Test for early detection of prostate cancer shows promise
11. Mouse gene shows new mechanism behind cardiac infarction in man
Post Your Comments:
(Date:5/22/2013)... Early screening for prostate cancer could become as ... women, thanks to UC Irvine research published today in ... , After more than a decade of work, UC ... clinically usable markers for prostate cancer in urine, meaning ... greater accuracy and at dramatically lower cost. The same ...
(Date:5/21/2013)... monitoring" device attached to a whale entangled in fishing ... lines changed a whale,s diving and swimming behavior. The ... eat and migrate, depletes their energy as they drag ... a slow death. , The scientists in this entanglement ... a two-year-old female North Atlantic right whale called Eg ...
(Date:5/21/2013)... have found that a class of pharmaceuticals can both ... The drugs, known as "TSPO ligands," are currently used ... the effects of TSPO ligand in young adult mice ... aged mice when pathology was quite severe," said lead ... Gerontology. "TSPO ligand reduced measures of pathology and improved ...
Breaking Biology News(10 mins):UCI chemists devise inexpensive, accurate way to detect prostate cancer 2UCI chemists devise inexpensive, accurate way to detect prostate cancer 3Study reveals how fishing gear can cause slow death of whales 2Study reveals how fishing gear can cause slow death of whales 3Drugs found to both prevent and treat Alzheimer's disease in mice 2
... China - A group of scientists from United Kingdom (UK), ... sequencing of peregrine and saker falcons genomes at the 2nd ... study is a part of Falcon Genome Project, launched and ... this January. The results will enable biologists to better study ...
... BioInnovation Institute in Akron (ABIA) and the U.S. Food ... collaboration to support and develop regulatory science for the ... Effective today, the FDA and ABIA executed a ... draw upon ABIA resourcesincluding a library of test methods ...
... -- Believed critical for determining which individuals can -- or ... figure prominently in the origin of new species, but are ... new species form. Today, new international research led ... the exact shape and fit of genitalia steals the show ...
Cached Biology News:Genomic sequences of 2 iconic falconry birds - Peregrine and Saker Falcons- successfully decoded 2FDA, ABIA to collaborate on safety and performance of materials used in medical devices 2Shape, fit of reproductive organs evolve quickly and in concert, leaving size behind 2Shape, fit of reproductive organs evolve quickly and in concert, leaving size behind 3
(Date:5/22/2013)... A recent study from researchers in Tasmania ... that those who took probiotics were able to run for ... showed that in extreme heat conditions, probiotics were able to ... acne treatment explains what this new discovery means for ... skin condition. , While researchers tote the benefits of ...
(Date:5/22/2013)... Mass. , May 22, 2013  Moderna Therapeutics, ... new treatment modality to enable the in vivo ... John Reynders will join Moderna in ... Reynders is a proven leader in the ... of drug development, from discovery to translation, clinical operations ...
(Date:5/21/2013)... , May 21, 2013  On May 9, ... ), the global business advisory firm dedicated to ... (the "Company"), announced that it has combined the ... formerly included within the Corporate Finance/Restructuring segment with ... to form a single integrated practice whose financial ...
(Date:5/21/2013)... (PRWEB) May 21, 2013 Custom ... to reporting eLearning solution using Tin Can API ... dashboard tool. CLD is a leading developer of ... medical device companies worldwide. , Tin Can ... that helps learners and trainers more accurately measure ...
Breaking Biology Technology:Adult Acne Treatment, Probiotic Action Shares Insight on New Findings Between Probiotics and Heat Tolerance, and What It Means for Acne Sufferers 2Industry Leader John Reynders Joins Moderna Therapeutics as Chief Information Officer 2Industry Leader John Reynders Joins Moderna Therapeutics as Chief Information Officer 3FTI Consulting Releases Realigned Segment Information Reflecting Newly Combined Health Solutions Practice 2CLD Integrates Tin CAN API with its eLearning Solutions and Launches its Excelerometer Tracking Statement Dashboard 2CLD Integrates Tin CAN API with its eLearning Solutions and Launches its Excelerometer Tracking Statement Dashboard 3
... June 29 Kornberg Associates | Architects ( www.kornberg.com ... to design a new Cognitive & Neurobiological Imaging Center. ... firm has worked with Stanford University since 1980 ... one of which is the two-story, 32,000 square-foot office building ...
... ... odor elimination, exterior plastic trim and headlight restoration products to the Automotive, RV and ... a myriad of industries, to introduce these innovative and eco-friendly products to the pan-national ... ...
... ... 30-Friday, October 2, 2009. , ... Portland, Maine (PRWEB) June 26, 2009 -- IntertechPira, in conjunction with the ... an International conference bringing together hydrogen producers, developers and users to discuss the future ...
Cached Biology Technology:Kornberg Associates Architects Selected to Develop Design for New Stanford University Imaging Center 2MEDS World, LLC Provides Multiple Environments with Designed Solutions - Wherever People Congregate, MEDS Odor Elimination Solutions Offer Eco-Friendly, Odor-Free Air 2MEDS World, LLC Provides Multiple Environments with Designed Solutions - Wherever People Congregate, MEDS Odor Elimination Solutions Offer Eco-Friendly, Odor-Free Air 3Industry Leaders Will Gather to Discuss the Future of the "Hydrogen Economy" in Washington DC 2
... 2000 Capillary Electrophoresis System uses revolutionary ... electrophoresis (SPE), urine protein electrophoresis and ... accurate analysis. The system is truly ... and no staining to process patient ...
The filter 695RDF55 Reflect 635 for the Molecular Imager FX is a band pass filter for Cy5 and Alexa Fluor 635 dyes....
... UltraClean Plant DNA Kit is designed for ... DNA from plant cells and tissues. The ... replaces cumbersome DNA isolation procedures such as ... UltraClean procedure, alcohol precipitation is not necessary ...
... The ApopTag Red In Situ Apoptosis ... by the indirect TUNEL method, utilizing ... fluorochrome. The kit provides indirect immunofluorescence ... analyzed using either fluorescence microscopy or ...
Biology Products: