Navigation Links
Zebrafish study suggests that vitamin B2 (riboflavin) is an antidote to cyanide poisoning
Date:4/30/2013

With the remains of a recent lottery winner having been exhumed for foul play related to cyanide poisoning, future winners might wonder what they can do to avoid the same fate. A new report in The FASEB Journal involving zebrafish suggests that riboflavin, also known as vitamin B2, may mitigate the toxic effects of this infamous poison. In addition, the report shows that zebrafish are a viable model for investigating the effects of cyanide on humans. As with any research involving animal models, these findings are preliminary until thoroughly tested in clinical trials. Anyone who suspects cyanide poisoning should not attempt to use riboflavin as an antidote, and instead contact local poison control centers or emergency health services immediately.

"We are encouraged to see that many of the effects of cyanide on zebrafish mirror the effects on humans," said Randall Peterson, Ph.D., a researcher involved in the work from the Harvard Medical School in Boston, Massachusetts. "Hopefully, the cyanide biomarkers and antidotes we discover with the help of zebrafish can one day improve our ability to diagnose and treat humans affected by cyanide poisoning."

To make this discovery, scientists exposed zebrafish to cyanide and measured the effects on their behavior, heart rate and survival. The chemical changes that occurred were measured using a mass spectrometer. The effects in zebrafish were then compared to the effects of cyanide on rabbits and humans. Many of the effects in zebrafish matched those seen in rabbits and humans, confirming that the zebrafish could be used as a model of human cyanide exposure. From there, researchers systematically tested thousands of known drugs to see if any of them could protect the zebrafish from cyanide toxicity and found four drugs, including riboflavin. The study also identified new biomarkers that indicate cyanide exposure and may be clinically useful for the diagno
'/>"/>

Contact: Cody Mooneyhan
cmooneyhan@faseb.org
301-634-7104
Federation of American Societies for Experimental Biology
Source:Eurekalert

Page: 1 2

Related biology news :

1. Zebrafish may hold the answer to repairing damaged retinas and returning eyesight to people
2. Surprising teaching tool in K-12 science education -- Zebrafish research
3. Zebrafish study explains why the circadian rhythm affects your health
4. Zebrafish -- the stars of biomedicine
5. Zebrafish provide insights into causes and treatment of human diseases
6. Zebrafish research shows how dietary fat regulates cholesterol absorption
7. Versatility of zebrafish research highlighted at international conference
8. Environmental estrogens affect early developmental activity in zebrafish
9. Zebrafish could hold the key to understanding psychiatric disorders
10. Better housing conditions for zebrafish could improve research results
11. Study examines effects of genetic variants for infants with neonatal abstinence syndrome
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/23/2014)... Alzheimer,s disease is the first cause of dementia and ... effective cure has yet been found. One of the ... the cellular mechanisms which cause alterations in nerve transmissions ... of the disease., Researchers from the Institute of Neuroscience ... cellular mechanism involved in memory consolidation and were able ...
(Date:4/23/2014)... University of Liverpool is leading a 2 million Food ... norovirus in food premises and industry workers. , ... In 2012 a batch of frozen strawberries infected ... in the authorities, understanding of which strains cause infection ... the bacteria. , Researchers will produce data ...
(Date:4/22/2014)... the University of Montana,s Wildlife Biology Program, co-wrote a research ... National Academy of Sciences on how streamwater chemistry varies ... Lowe and ... of Washington, the Cary Institute of Ecosystem Studies, the University ... examined 664 water samples collected every 10 meters along 32 ...
Breaking Biology News(10 mins):Loss of memory in Alzheimer's mice models reversed through gene therapy 2New research focuses on streamwater chemistry, landscape variation 2
... on a unique vertebrate called the sea lamprey shows that ... development. These genes are paradoxically lost all throughout the developing ... or PGCs. The PGCs can be thought of as embryonic ... generation of lampreys. Based on computational analysis, a significant number ...
... An inexpensive antifungal drug, thiabendazole, slows tumor growth and shows ... of Natural Sciences at The University of Texas at Austin ... frogs, mice and humans. Thiabendazole is an FDA-approved, generic ... 40 years as an antifungal. It is not currently used ...
... 2012) What comes naturally to most people to ... who have lost the full use of their limbs. New ... TIRR Memorial Hermann aims to help victims recover that ability ... from the National Institutes of Health (NIH) and the President,s ...
Cached Biology News:Research reveals unique solution to gene regulation 2Common antifungal drug decreases tumor growth and shows promise as cancer therapy 2Brain-wave-reading robot might help stroke patients 2Brain-wave-reading robot might help stroke patients 3
(Date:1/15/2014)... , Jan. 15, 2014  Bill Jacobs Automotive, a group of ... teaming up with the Heartland Blood Center and offering free ... The drive takes place Saturday, Jan. 18 at the Bill ... p.m. (Photo: http://photos.prnewswire.com/prnh/20140115/MN46637 )  The ...
(Date:1/15/2014)... FALLS, N.Y., Jan. 15, 2014   Niagara Thermal Products ... selected by Buffalo BioBlower Technologies LLC ("B3") as the ... Phase 2 award from the Army Corps of Engineers.  ... that kills all biological contaminants and destroys VOCs and ...
(Date:1/15/2014)... (PRWEB) January 15, 2014 Cynvenio, a ... management through the genomic analysis of tumor cells in ... Finder™, a web-based cancer decision support application powered by ... with Cynvenio’s ClearID™ genomic test, Therapy Finder will provide ...
(Date:1/15/2014)... Jan. 15, 2014 ­ RedBrick Health , a ... technology, today announces that EmblemHealth , the ... company, is now providing the RedBrick Compass health assessment, ... to all of its members. EmblemHealth is among the ...
Breaking Biology Technology:Join the Bill Jacobs Auto blood drive and receive a free oil change 2Niagara Thermal Products LLC Selected as Critical Supplier for Buffalo BioBlower Air Purification Systems 2Cynvenio Offers New Breast Cancer Therapy Finder Application for its ClearID Breast Cancer Genomic Test 2Cynvenio Offers New Breast Cancer Therapy Finder Application for its ClearID Breast Cancer Genomic Test 3EmblemHealth Selects RedBrick Health to Power its Next-Generation Health Engagement and Behavior Change System 2EmblemHealth Selects RedBrick Health to Power its Next-Generation Health Engagement and Behavior Change System 3
... not just because they sparkle. Engineers and physicists ... is as hard as an ice ball to the ... making it an ideal material or coating for seals, ... Carpick, associate professor in the Department of Mechanical Engineering ...
... Physicists at UC Riverside have made an accidental ... change how information in computers can be transported ... a property electrons possess that makes them behave ... the development of spin-based semiconductor technology such as ...
... Inc.,(Nasdaq: RDYN ) today announced that it has ... Ltd. for faropenem medoxomil (faropenem).,In conjunction with this decision, ... agreement with Asubio Pharma Co., Ltd. and Nippon,Soda Co. ... as a,result of the Company being unable to secure ...
Cached Biology Technology:University of Pennsylvania engineers reveal what makes diamonds slippery at the nanoscale 2Discovery by UC Riverside physicists could enable development of faster computers 2Discovery by UC Riverside physicists could enable development of faster computers 3Replidyne Terminates Faropenem Agreements 2Replidyne Terminates Faropenem Agreements 3
Rabbit polyclonal to HMGB1 (rating: ****) ( Abpromise for all tested applications). entrezGeneID: 3146 SwissProtID: P09429...
Pooled normal sreum with 0.1% sodium azide as preservative...
Mouse CXCR3 Allophycocyanin MAb (Clone 220803)...
Mouse P-Selectin/CD62P MAb (Clone 127933)...
Biology Products: