Navigation Links
Zebrafish study suggests that vitamin B2 (riboflavin) is an antidote to cyanide poisoning
Date:4/30/2013

With the remains of a recent lottery winner having been exhumed for foul play related to cyanide poisoning, future winners might wonder what they can do to avoid the same fate. A new report in The FASEB Journal involving zebrafish suggests that riboflavin, also known as vitamin B2, may mitigate the toxic effects of this infamous poison. In addition, the report shows that zebrafish are a viable model for investigating the effects of cyanide on humans. As with any research involving animal models, these findings are preliminary until thoroughly tested in clinical trials. Anyone who suspects cyanide poisoning should not attempt to use riboflavin as an antidote, and instead contact local poison control centers or emergency health services immediately.

"We are encouraged to see that many of the effects of cyanide on zebrafish mirror the effects on humans," said Randall Peterson, Ph.D., a researcher involved in the work from the Harvard Medical School in Boston, Massachusetts. "Hopefully, the cyanide biomarkers and antidotes we discover with the help of zebrafish can one day improve our ability to diagnose and treat humans affected by cyanide poisoning."

To make this discovery, scientists exposed zebrafish to cyanide and measured the effects on their behavior, heart rate and survival. The chemical changes that occurred were measured using a mass spectrometer. The effects in zebrafish were then compared to the effects of cyanide on rabbits and humans. Many of the effects in zebrafish matched those seen in rabbits and humans, confirming that the zebrafish could be used as a model of human cyanide exposure. From there, researchers systematically tested thousands of known drugs to see if any of them could protect the zebrafish from cyanide toxicity and found four drugs, including riboflavin. The study also identified new biomarkers that indicate cyanide exposure and may be clinically useful for the diagnosis of cyanide exposure and the development of antidotes.

"Lottery winners are not the only ones who have to worry about cyanide poisoning," said Gerald Weissmann, M.D., Editor-in-Chief of The FASEB Journal. "Cyanide exposure also occurs through smoke inhalation, industrial accidents, acts of war, and even as an unwanted byproduct of useful drugs. Therefore, the development of antidotes is crucial, and it's nice to know that a likely candidate is already on the drugstore shelf."


'/>"/>

Contact: Cody Mooneyhan
cmooneyhan@faseb.org
301-634-7104
Federation of American Societies for Experimental Biology
Source:Eurekalert

Related biology news :

1. Zebrafish may hold the answer to repairing damaged retinas and returning eyesight to people
2. Surprising teaching tool in K-12 science education -- Zebrafish research
3. Zebrafish study explains why the circadian rhythm affects your health
4. Zebrafish -- the stars of biomedicine
5. Zebrafish provide insights into causes and treatment of human diseases
6. Zebrafish research shows how dietary fat regulates cholesterol absorption
7. Versatility of zebrafish research highlighted at international conference
8. Environmental estrogens affect early developmental activity in zebrafish
9. Zebrafish could hold the key to understanding psychiatric disorders
10. Better housing conditions for zebrafish could improve research results
11. Study examines effects of genetic variants for infants with neonatal abstinence syndrome
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/9/2016)... leader in attendance control systems is proud to announce the introduction of fingerprint attendance ... the right employees are actually signing in, and to even control the opening of ... ... ... Photo - ...
(Date:6/3/2016)... , June 3, 2016 ... Management) von Nepal ... und Lieferung hochsicherer geprägter Kennzeichen, einschließlich Personalisierung, ... führend in der Produktion und Implementierung von ... der Ausschreibung im Januar teilgenommen, aber Decatur ...
(Date:6/2/2016)... LONDON , June 2, 2016 ... Systems, Manned Platforms, Unmanned Systems, Physical Infrastructure, Support & ... intelligence provider visiongain offers comprehensive analysis of ... that this market will generate revenues of $17.98 billion ... Systems acquired DVTEL Inc, a leader in software and ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... 2016   Boston Biomedical , an industry ... to target cancer stemness pathways, announced that its ... Drug Designation from the U.S. Food and Drug ... including gastroesophageal junction (GEJ) cancer. Napabucasin is an ... cancer stemness pathways by targeting STAT3, and is ...
(Date:6/23/2016)... ... June 23, 2016 , ... Charm Sciences, Inc. is pleased ... received AOAC Research Institute approval 061601. , “This is another AOAC-RI approval of ... Salter, Vice President of Regulatory and Industrial Affairs. “The Peel Plate methods perform ...
(Date:6/23/2016)... ... 23, 2016 , ... Supplyframe, the Industry Network for electronics ... Lab . Located in Pasadena, Calif., the Design Lab’s mission is to bring ... designed, built and brought to market. , The Design Lab is Supplyframe’s physical ...
(Date:6/23/2016)... Calif. , June 23, 2016  Blueprint Bio, ... biological discoveries to the medical community, has closed its ... Matthew Nunez . "We have received ... with the capital we need to meet our current ... essentially provide us the runway to complete validation on ...
Breaking Biology Technology: