Navigation Links
Zebrafish study suggests that vitamin B2 (riboflavin) is an antidote to cyanide poisoning
Date:4/30/2013

With the remains of a recent lottery winner having been exhumed for foul play related to cyanide poisoning, future winners might wonder what they can do to avoid the same fate. A new report in The FASEB Journal involving zebrafish suggests that riboflavin, also known as vitamin B2, may mitigate the toxic effects of this infamous poison. In addition, the report shows that zebrafish are a viable model for investigating the effects of cyanide on humans. As with any research involving animal models, these findings are preliminary until thoroughly tested in clinical trials. Anyone who suspects cyanide poisoning should not attempt to use riboflavin as an antidote, and instead contact local poison control centers or emergency health services immediately.

"We are encouraged to see that many of the effects of cyanide on zebrafish mirror the effects on humans," said Randall Peterson, Ph.D., a researcher involved in the work from the Harvard Medical School in Boston, Massachusetts. "Hopefully, the cyanide biomarkers and antidotes we discover with the help of zebrafish can one day improve our ability to diagnose and treat humans affected by cyanide poisoning."

To make this discovery, scientists exposed zebrafish to cyanide and measured the effects on their behavior, heart rate and survival. The chemical changes that occurred were measured using a mass spectrometer. The effects in zebrafish were then compared to the effects of cyanide on rabbits and humans. Many of the effects in zebrafish matched those seen in rabbits and humans, confirming that the zebrafish could be used as a model of human cyanide exposure. From there, researchers systematically tested thousands of known drugs to see if any of them could protect the zebrafish from cyanide toxicity and found four drugs, including riboflavin. The study also identified new biomarkers that indicate cyanide exposure and may be clinically useful for the diagno
'/>"/>

Contact: Cody Mooneyhan
cmooneyhan@faseb.org
301-634-7104
Federation of American Societies for Experimental Biology
Source:Eurekalert

Page: 1 2

Related biology news :

1. Zebrafish may hold the answer to repairing damaged retinas and returning eyesight to people
2. Surprising teaching tool in K-12 science education -- Zebrafish research
3. Zebrafish study explains why the circadian rhythm affects your health
4. Zebrafish -- the stars of biomedicine
5. Zebrafish provide insights into causes and treatment of human diseases
6. Zebrafish research shows how dietary fat regulates cholesterol absorption
7. Versatility of zebrafish research highlighted at international conference
8. Environmental estrogens affect early developmental activity in zebrafish
9. Zebrafish could hold the key to understanding psychiatric disorders
10. Better housing conditions for zebrafish could improve research results
11. Study examines effects of genetic variants for infants with neonatal abstinence syndrome
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/22/2014)... habitats and trees and not just asphalt and recreation ... University of Colorado Boulder study. , Working on class ... benefits for youth, according to a paper published in ... is one of the first of its kind to ... settings and stress. , "Many schools already offer stress ...
(Date:7/22/2014)... immune cell widely believed to exacerbate chronic adult ... sclerosis (MS), can actually protect the brain from ... progression of neurodegenerative diseases, according to Cleveland Clinic ... Nature Communications . , The research team, led ... of Neurosciences at Cleveland Clinic,s Lerner Research Institute, ...
(Date:7/21/2014)... ROUGE LSU,s Mark Batzer, Boyd Professor and Dr. ... Sciences in the College of Science, contributed to an ... titled "The Common Marmoset Genome Provides Insight into Primate ... Batzer contributed analysis of "jumping genes," or mobile elements ... mechanism in the genome. The marmoset is important because ...
Breaking Biology News(10 mins):Natural-terrain schoolyards reduce children's stress, says Colorado University-Boulder study 2Natural-terrain schoolyards reduce children's stress, says Colorado University-Boulder study 3Cleveland Clinic researchers discover neuroprotective role of immune cell 2LSU's Mark Batzer contributes to Nature Genetics article on marmoset genome 2
... a fresh water supply is discussed in a special ... Desalination. With predictions that more than 3.5 billion people ... the year 2025, the challenge is to find an ... Global climate change, desertification, and over-population are already taking ...
... of mentoring in developing the scientists of the future ... Awards for Excellence in Science, Mathematics and Engineering Mentoring ... Science Foundation (NSF).The winners of the 2006 competition -- ... number of scientific disciplines -- were announced at the ...
... (LRI) strategy of backing innovative investigations into systemic lupus, ... million in large-scale funding from the National Institutes of ... progress report has determined. To date, ... the 7-year-old LRIan Institute investment of $9 million. A ...
Cached Biology News:Nuclear desalination 2Nuclear desalination 3President honors mentors of scientists and engineers 2President honors mentors of scientists and engineers 3President honors mentors of scientists and engineers 4President honors mentors of scientists and engineers 5President honors mentors of scientists and engineers 6President honors mentors of scientists and engineers 7Lupus Research Institute strategy delivers $30 million in national funding 2
(Date:7/22/2014)... Angeles, CA (PRWEB) July 22, 2014 ... test solutions with the debut of its fluorescent ... of Clinical Chemistry (AACC) meeting in Chicago, July ... or bench top versions, the HRDR-300 is a ... pending technology to analyze fluorescent lateral flow immunoassays ...
(Date:7/22/2014)... SC (PRWEB) July 22, 2014 Dr. ... of those who have recognized that the greatest health ... and far too often needlessly deadly while trying to ... multitude of quasi-experts seeking to transform an enormous system ... , Dr. Williams, in his continuing series of Open ...
(Date:7/21/2014)... in Syracuse University,s College of Arts and Sciences ... synthesis of stainless nanoparticles. , Mathew M. Maye, ... three-year, $360,000 grant from the National Science Foundation ... metal stainless alloy nanostructures, the results of which ... lithium-ion batteries. , Maye,s approach is ...
(Date:7/21/2014)... LA (PRWEB) July 21, 2014 ... sleep quality are closely correlated with depression. According ... of Health: "About three quarters of depressed ... in about 40% of young depressed adults and ... females. The symptoms cause huge distress, have a ...
Breaking Biology Technology:Holomic to Debut HRDR-300 Fluorescent Immunoassay Reader at the AACC 2014 2Dr. Ira Williams Asks What’s Wrong With Jonathan Bush’s Book, Where Does It Hurt? 2Syracuse University chemist to use NSF grant to study materials chemistry, nanoscience 2Open Label Data on Enhanced Sleep Released by JayMac Pharmaceuticals, LLC 2Open Label Data on Enhanced Sleep Released by JayMac Pharmaceuticals, LLC 3
... Ohio and LOD, Israel, November 3 Simbionix,USA ... hands-on,curriculum for training medical professionals, today announced that ... US Marketing Director on,November 10th, 2008. Gary Zamler, ... Simbionix has enjoyed double digit revenue growth in,both ...
... Telomolecular CEO, Matthew Sarad, clarifies the scope and terms of his ... ... (PRWEB) November 3, 2008 -- Telomolecular, a Rancho Cordova, California Corporation, ... therapeutics to treat diseases of aging and cancer, particularly diseases related ...
... compound in sufficient and rapidly produced yields, potentially ... could boost semiconductor capabilities for large-area applications. , ... the first heterometallic gallium-indium hydroxide nanocluster was the ... of nitrosobenzene. , The substitute was identified during ...
Cached Biology Technology:William E. Lewandowski to Lead Simbionix US Marketing Team in Simbionix's Strategic Expansion in the US Market 2Former Telomolecular CEO Clarifies SEC Settlement 2Former Telomolecular CEO Clarifies SEC Settlement 3New nanocluster to boost thin films for semiconductors 2
...
...
... Experion software, PC, is used ... the data obtained from the Experion ... data in electropherogram and simulated gel ... other calculations in a Results table. ...
... for use in the Microsart e.motion are sterile-sealed, ... in a specially designed individual package on a ... band of membrane filter units ensures that they ... the sealed band guarantees uniform dispensing of the ...
Biology Products: