Navigation Links
Zebra fish fins help Oregon researchers gain insight into bone regeneration
Date:1/30/2014

EUGENE, Ore. -- University of Oregon biologists say they have opened the window on the natural process of bone regeneration in zebra fish, and that the insights they gained could be used to advance therapies for bone fractures and disease.

In a paper placed online in advance of print in the Feb. 13 issue of the journal Cell Reports, the UO team shows that two molecular pathways work in concert to allow adult zebra fish to perfectly replace bones lost upon fin amputation.

One pathway resets existing bone cells to a developmental stem cell-like state and then supports their growth to replace lost cells. The second directs the newly formed cells to turn back into functional, organized bone. Using genetic, cellular and molecular approaches, the authors detailed how the opposing pathways cross-communicate to keep the regenerative process in balance.

Unlike humans, some vertebrates, including zebra fish, have amazing innate abilities to regenerate lost appendages and organs, said co-author Kryn Stankunas, a professor of biology and member of the UO Institute of Molecular Biology. According to the authors, a mysterious process triggers residual cells to revert to a less developed state upon tissue damage, a process known as dedifferentation. The process is unique to animals like zebra fish and could be the key to their ability to perfectly restore lost tissue. Understanding the mechanisms could support the design of regenerative therapies that direct human cells to behave similarly.

"We focused on the bones of the zebra fish tail fin," Stankunas said, "and asked how amputation induces mature bone-lining cells to go backwards in their developmental age to what's called a progenitor state."

The researchers found that cell-to-cell signaling mediated by the Wnt pathway helps existing mature bone cells become progenitor cells after fin amputation. This starts the bone regeneration process. Local Wnt production at the ti
'/>"/>

Contact: Jim Barlow
jebarlow@uoregon.edu
541-346-3481
University of Oregon
Source:Eurekalert

Page: 1 2

Related biology news :

1. New methods improve quagga and zebra mussel identification
2. Mechanisms of wound healing are clarified in MBL zebrafish study
3. Zebrafish help identify mutant gene in rare muscle disease
4. Zebrafish study suggests that vitamin B2 (riboflavin) is an antidote to cyanide poisoning
5. Zebrafish may hold the answer to repairing damaged retinas and returning eyesight to people
6. Surprising teaching tool in K-12 science education -- Zebrafish research
7. Zebrafish study explains why the circadian rhythm affects your health
8. Zebra fish point the way towards new therapies for amyotrophic lateral sclerosis
9. Study of zebra fish mouth formation may speak to Fraser syndrome hearing loss
10. Zebrafish -- the stars of biomedicine
11. Zebrafish provide insights into causes and treatment of human diseases
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/30/2014)... in almost any aquatic environment on Earth, but when ... are pushed to the limit. The amount of time ... for how different species cope in the future, reveals ... Gothenburg, published in the scientific journal Proceedings of ... apace thanks to increasing levels of greenhouse gases in ...
(Date:9/30/2014)... research, involving mice and published in the October 2014 ... , suggests that just because you can do ... team of Italian scientists have found that using marijuana ... immune system. This damage may result in autoimmune diseases ... bowel disease and rheumatoid arthritis in adulthood. , "I ...
(Date:9/30/2014)... with IVF? Here,s some hope: A new research report ... FASEB Journal , explains how scientists developed a ... which induced embryo development in human and mouse eggs ... the sperm cell during fertilization. , "We believe that ... shift in our understanding of human fertilization by providing ...
Breaking Biology News(10 mins):Shape up quickly -- applies to fish, too! 2Adolescent exposure to thc may cause immune systems to go up in smoke 2Synthetic sperm protein raises the chance for successful in vitro fertilization 2
... viruses is also involved in keeping cancer cells alive, researchers ... anti-viral molecule, called TBK-1, was found to be essential for ... a treatment for fighting cancer, the researchers report in today's ... that this mechanism is involved in cancer cell survival, even ...
... to transform into a new life, or into new cells ... in the mechanics - in how a single cell can ... this week in the Proceedings of the National Academy ... human egg. The identification opens the way to understanding these ...
... of different types of nerve cells by neural stem ... much of one kind of cell and too little ... brain malformations. In the October 6 issue of Cell, ... report discovering a new molecular pathway that influences the ...
Cached Biology News:Natural anti-viral enzyme helps keep cancer cells alive, researchers find 2Scientists crack genetic secrets of human egg 2Novel pathway regulates timing of brain cell development 2
(Date:10/1/2014)... Greifensee, Switzerland (PRWEB) October 01, 2014 ... influence the quality of the final product. However, ... most regulated, regulatory frameworks such as Good Manufacturing ... is the responsibility of the manufacturer to interpret ... ensure consistent weighing performance quality. METTLER TOLEDO experts ...
(Date:10/1/2014)... Today the National Institutes of ... for the Brain Research through Advancing Innovative Neurotechnologies ... and revolutionize new methods of understanding the complexities ... This first round of grants totaling $46 million ... to more than 100 investigators in 15 states ...
(Date:10/1/2014)... Francisco, California (PRWEB) October 01, 2014 ... from the National Science Foundation to expand their bioCAD/CAM ... to build and modify DNA. The Small Business Innovation ... commercialize the “j5” technology under exclusive license from the ... Joint BioEnergy Institute , an LBNL laboratory that ...
(Date:9/30/2014)... a well-known optical phenomenon called thin-film interference, a ... the ability to "paint" ultra-thin coatings onto a ... making future, flexible electronic devices, creating advanced solar ... ships and spacecraft with extremely lightweight decorative logos. ... it becomes iridescent, revealing a myriad of colors ...
Breaking Biology Technology:Comply with Weighing-Related Regulations in Pharma Manufacturing 2NIH Awards 15 Grants to CHI Members for BRAIN Initiative Research 2NIH Awards 15 Grants to CHI Members for BRAIN Initiative Research 3TeselaGen Receives $750k NSF SBIR Phase II Award 2TeselaGen Receives $750k NSF SBIR Phase II Award 3Taking thin films to the extreme 2
... 2011 Reaction Biology Corporation ("RBC"), a leading ... epigenetics, today announced the rollout of a new ... initial offerings will emphasize the histone methyltransferases (HMTs), ... no previous commercial source. The ...
... Fla., Oct. 24, 2011 GeneLink BioSciences, Inc. ... leading consumer genomics biotech company, today announced that it ... Deloitte,s ranking of 500 of the fastest growing technology, ... North America. GeneLink grew 4,363 percent during the period ...
... Products, Inc. (NASDAQ: CBPO, "China Biologic" or the "Company"), ... People,s Republic of China, today announced that it has ... "200 Best Under a Billion" for the year 2011. ... for the year 2009. According to Forbes ...
Cached Biology Technology:Reaction Biology Launches Recombinant Methyltransferase Line 2GeneLink BioSciences, Inc. Ranked Number 33 Fastest Growing Company in North America on Deloitte's 2011 Technology Fast 500™ 2GeneLink BioSciences, Inc. Ranked Number 33 Fastest Growing Company in North America on Deloitte's 2011 Technology Fast 500™ 3China Biologic Named to Asia's "200 Best Under a Billion" by Forbes Asia 2China Biologic Named to Asia's "200 Best Under a Billion" by Forbes Asia 3
Anti-MMP-25 (Membrane-type MMP-6, Mt6MMP), hinge region; rabbit host...
PPIF Antibody...
Rabbit polyclonal to FLIP ( Abpromise for all tested applications). entrezGeneID: 8837 SwissProtID: O15519...
Fluorescein isothiocyanate (FITC) mouse anti-human IFN-alpha2 50 ug...
Biology Products: