Navigation Links
Young malaria parasites refuse to take their medicine, may explain emerging drug resistance
Date:2/19/2013

New research has revealed that immature malaria parasites are more resistant to treatment with key antimalarial drugs than older parasites, a finding that could lead to more effective treatments for a disease that kills one person every minute and is developing resistance to drugs at an alarming rate.

University of Melbourne researchers have shown for the first time that malaria parasites (Plasmodium falciparum)in the early stages of development are more than 100 times less sensitive to artemisinin-based drugs, which currently represent a last line of defense against malaria.

The study was conducted by a team led by Professor Leann Tilley and Dr Nectarios (Nick) Klonis from the Department of Biochemistry and Molecular Biology and the Bio21 Institute, and is published in the journal PNAS.

The drug artemisinin (ART) saves millions of lives each year but it is still not clear exactly how it works. Professor Tilley's team developed a novel approach to examine how the parasite responds to drugs under the conditions it encounters in the body. This is important because the malaria parasite takes two days to reach maturity in each cycle but the drug only remains in the bloodstream for a few hours.

"We were surprised to find that juvenile parasites were up to 100 times less sensitive to the drug than mature parasites, and that in some strains the juvenile parasites showed a particularly high degree of resistance. This would result in a large number of juvenile parasites surviving against clinical treatment and helps explain how resistance to drugs develops," Professor Tilley said.

In order to survive in the human body, the parasite must inhabit red blood cells for part of its life cycle, to do this it first digests the cell contents including the haemoglobin protein which carries oxygen in blood.

"We found that the parasite is most susceptible to drug treatment when it is digesting haemoglobin, sugge
'/>"/>

Contact: Nerissa Hannink
nhannink@unimelb.edu.au
61-430-588-055
University of Melbourne
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Experimental gene therapy treatment for Duchenne muscular dystrophy offers hope for youngster
2. Joslin scientists find first human iPSC from patients with maturity onset diabetes of the young
3. Wiley Prize in Biomedical Sciences awarded to Rosbash, Hall and Young
4. Damon Runyon Cancer Research Foundation grants prestigious awards to 17 young scientists
5. Giant tobacco plants that stay young forever
6. Strength training improves vascular function in young black men
7. Young Investigator Award winners announced by Anatomy Society
8. Dr. Sanjay Kumar wins STEM CELLS Young Investigator Award
9. New programs draws young artists into science
10. Young gamers offer insight to teaching new physicians robotic surgery
11. Omega-3 intake heightens working memory in healthy young adults
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Young malaria parasites refuse to take their medicine, may explain emerging drug resistance
(Date:1/22/2015)... 2015 Valid S.A. ("Company") (BM&FBOVESPA: VLID3 ON), is pleased ... State of Washington,s Department of Licensing, ... and central issuance system for driver,s licenses and identification cards ... planning and development will start in January 2015, with enrollment ...
(Date:1/22/2015)... DETROIT , Jan. 13, 2015 Technology Showcase, Hall ... iris-based identity authentication solutions, today announced it will showcase its ... and developed by the Department of Energy,s Oak Ridge ... International Auto Show . EyeLock,s iris identity authentication technology is ...
(Date:1/22/2015)... NXT-ID, Inc. (NASDAQ: NXTD and NXTDW) a biometric authentication ... success of the Wocket™ smart wallet at CES 2015 in ... as one of the "11 Hot Products at CES" in a review ... So Far" by Newseveryday.com and "The top 10 gadgets from CES 2015" ...
Breaking Biology News(10 mins):Valid USA Signs Contract For Washington Driver's License Issuance 2EyeLock Debuts First Iris Authentication Technology Embedded in 3D Printed Automobile 2EyeLock Debuts First Iris Authentication Technology Embedded in 3D Printed Automobile 3CES Response for NXT-ID's Wocket Smart Wallet Kicks Off 2015 2CES Response for NXT-ID's Wocket Smart Wallet Kicks Off 2015 3
... of newborns, blood samples stored in a Michigan bio-bank, ... practice of using the blood spots for medical research. ... public policy decisions and develop an improved consent process ... said Ann Mongoven, an assistant professor in MSU,s Center ...
... squids as different as they may look, they ... the phylum Mollusca , also called molluscs. An ... Professor Ken Halanych, USA, with the participation of Johannes ... into the relationships among different molluscs as part of ...
... 2011 SynCardia Systems, Inc. ( www.syncardia.com ), manufacturer ... announced today that University Hospital of Nantes successfully transplanted ... days of support. Mrs. Mouche is a French gypsy ... 40 km from Nantes. "We first implanted ...
Cached Biology News:MSU engages public on using newborn blood spots for research 2Research into molluscan phylogeny reveals deep animal relationship of snails and mussels 2Research into molluscan phylogeny reveals deep animal relationship of snails and mussels 3SynCardia's Total Artificial Heart Rescues LVAD Patient with Right Ventricular Failure 2SynCardia's Total Artificial Heart Rescues LVAD Patient with Right Ventricular Failure 3
(Date:2/28/2015)... AZ (PRWEB) February 28, 2015 Increasing its ... World Films launches its first three episodes of The GMO ... Mile Project this month, as it continues its mission to ... launch, the project's first phase, to “uncover the truth about ... of media. , The GMO Truth Podcast is an expansion ...
(Date:2/27/2015)... Mass. , Feb. 27, 2015 ... of the NCATS rare-diseases portfolio " in ... a new financing technique to reduce the risk ... diseases and potentially unlock new levels of funding ... The product of a unique collaboration between scientists ...
(Date:2/27/2015)... , Feb. 27, 2015 Bionomics Limited ... the DisrupTOR-1 trial of BNC105 in patients with metastatic ... Orlando, Florida . The data will ... the City of Hope Comprehensive Cancer Center in ... The new data identifies Ferritin and IL-8 ...
(Date:2/27/2015)... Calif. , Feb. 27, 2015  Steep Hill, ... the US and internationally, intends to open a full ... Albuquerque, New Mexico , bringing advanced scientific tools ... cannabis. Steep Hill is currently the only ... to conduct potency and contaminant testing in order to ...
Breaking Biology Technology:The Walk a Mile Project Launches “GMO Truth” Podcast 2New Financing Technique May Hold Key to Unlocking Funding for Rare Diseases 2New Financing Technique May Hold Key to Unlocking Funding for Rare Diseases 3New Financing Technique May Hold Key to Unlocking Funding for Rare Diseases 4New BNC105 Biomarker Data to be Presented at US Cancer Conference 2New BNC105 Biomarker Data to be Presented at US Cancer Conference 3New BNC105 Biomarker Data to be Presented at US Cancer Conference 4New BNC105 Biomarker Data to be Presented at US Cancer Conference 5Steep Hill First to Receive Provisional Approval to Establish Laboratory Services for Cannabis Testing in State of New Mexico 2
... , , , , , , For transfection ... Features and benefits , , , , , , ... siRNA for effective gene silencing , Quick and easy setup , ... of RNase activity , , , , , ...
... , , , , , , For automated purification of genomic and mitochondrial ... , Format: , ... 8), QIAamp DNA Blood MDX Protocol, , ... Fresh or frozen whole blood (with common anticoagulants , such ...
... For , HotStarTaq DNA Polymerase , HotStarTaq Master Mix Kit , ... , Kit Contents , ... Technical Assistance , Safety Information , ... , HotStarTaq DNA Polymerase , ...
Cached Biology Technology:TransMessenger Transfection Reagent 2TransMessenger Transfection Reagent 3QIAamp DNA Blood BioRobot MDx Kit 2HotStarTaq PCR Handbook 2HotStarTaq PCR Handbook 3HotStarTaq PCR Handbook 4HotStarTaq PCR Handbook 5HotStarTaq PCR Handbook 6HotStarTaq PCR Handbook 7HotStarTaq PCR Handbook 8HotStarTaq PCR Handbook 9HotStarTaq PCR Handbook 10HotStarTaq PCR Handbook 11HotStarTaq PCR Handbook 12HotStarTaq PCR Handbook 13HotStarTaq PCR Handbook 14HotStarTaq PCR Handbook 15HotStarTaq PCR Handbook 16HotStarTaq PCR Handbook 17HotStarTaq PCR Handbook 18HotStarTaq PCR Handbook 19HotStarTaq PCR Handbook 20HotStarTaq PCR Handbook 21HotStarTaq PCR Handbook 22HotStarTaq PCR Handbook 23HotStarTaq PCR Handbook 24HotStarTaq PCR Handbook 25HotStarTaq PCR Handbook 26HotStarTaq PCR Handbook 27HotStarTaq PCR Handbook 28HotStarTaq PCR Handbook 29HotStarTaq PCR Handbook 30HotStarTaq PCR Handbook 31HotStarTaq PCR Handbook 32HotStarTaq PCR Handbook 33
ABgene® supplies a 94kDa ultra-pure recombinant thermostable DNA polymerase obtained by high level expression of the Taq DNA polymerase gene in E. coli....
Heavy-duty rim. Especially recommended as a titration flask. Corning5100. capacity 250 mL Special grade: student grade...
... This CLS number ... number, created to easily ... If showing no availability ... the old Sigma-Aldrich number ...
A convenience pack containing one each of the most popular sizes of Cat. No. 4980 flask. Designed for the low volume user, a case contains one each of five sizes: 50mL, 125mL, 250mL, 500mL, and 1L....
Biology Products: