Navigation Links
Young malaria parasites refuse to take their medicine, may explain emerging drug resistance
Date:2/19/2013

New research has revealed that immature malaria parasites are more resistant to treatment with key antimalarial drugs than older parasites, a finding that could lead to more effective treatments for a disease that kills one person every minute and is developing resistance to drugs at an alarming rate.

University of Melbourne researchers have shown for the first time that malaria parasites (Plasmodium falciparum)in the early stages of development are more than 100 times less sensitive to artemisinin-based drugs, which currently represent a last line of defense against malaria.

The study was conducted by a team led by Professor Leann Tilley and Dr Nectarios (Nick) Klonis from the Department of Biochemistry and Molecular Biology and the Bio21 Institute, and is published in the journal PNAS.

The drug artemisinin (ART) saves millions of lives each year but it is still not clear exactly how it works. Professor Tilley's team developed a novel approach to examine how the parasite responds to drugs under the conditions it encounters in the body. This is important because the malaria parasite takes two days to reach maturity in each cycle but the drug only remains in the bloodstream for a few hours.

"We were surprised to find that juvenile parasites were up to 100 times less sensitive to the drug than mature parasites, and that in some strains the juvenile parasites showed a particularly high degree of resistance. This would result in a large number of juvenile parasites surviving against clinical treatment and helps explain how resistance to drugs develops," Professor Tilley said.

In order to survive in the human body, the parasite must inhabit red blood cells for part of its life cycle, to do this it first digests the cell contents including the haemoglobin protein which carries oxygen in blood.

"We found that the parasite is most susceptible to drug treatment when it is digesting haemoglobin, sugge
'/>"/>

Contact: Nerissa Hannink
nhannink@unimelb.edu.au
61-430-588-055
University of Melbourne
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Experimental gene therapy treatment for Duchenne muscular dystrophy offers hope for youngster
2. Joslin scientists find first human iPSC from patients with maturity onset diabetes of the young
3. Wiley Prize in Biomedical Sciences awarded to Rosbash, Hall and Young
4. Damon Runyon Cancer Research Foundation grants prestigious awards to 17 young scientists
5. Giant tobacco plants that stay young forever
6. Strength training improves vascular function in young black men
7. Young Investigator Award winners announced by Anatomy Society
8. Dr. Sanjay Kumar wins STEM CELLS Young Investigator Award
9. New programs draws young artists into science
10. Young gamers offer insight to teaching new physicians robotic surgery
11. Omega-3 intake heightens working memory in healthy young adults
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Young malaria parasites refuse to take their medicine, may explain emerging drug resistance
(Date:9/15/2014)... When this week,s print issue of the journal ... up from New Mexico, Montana and even the Netherlands, ... more and more the norm in these connected times. ... it will produce innovations in biology, medicine, biotechnology and ... this scientist talked with that one, that one knew ...
(Date:9/15/2014)... Sonja Schmid, an assistant professor in the Department of ... Liberal Arts and Human Sciences at Virginia Tech, has ... (CAREER) Award to study the prospects and problems of ... catastrophic failure of Japan,s Fukushima I Nuclear Power Plant ... the scientific community viewed nuclear emergencies, Schmid said. Three ...
(Date:9/15/2014)... wild, domesticated, and domesticated-wild hybridized populations of ... that within 5 to 11 generations, selection ... populations that hybridized with domesticated populations. , ... evidence that natural selection, over time, removes ... as a result of increased genetic diversity. ...
Breaking Biology News(10 mins):Collaboration drives achievement in protein structure research 2'Nuclear disasters don't respect national boundaries' 2
... to local climates -- and potentially to climate change -- may ... to new research published in Science by UBC evolutionary ... resistance to local pests -- that has helped purple loosestrife to ... species to rapidly adapt to local climate has not generally been ...
... been invading Europe,s rivers and lakes for several decades, but ... and problematic, like so many other invaders - such as ... European shrimps have something to do with this? Jaimie ... and found it only existed where native shrimps were absent ...
... body of water, from a puddle or a pond to ... rocks, plants, and animals. These so-called sessile suspension feeders are ... cleaning up environmental contaminants by consuming bacteria. A study published ... Journal reveals that by actively changing the angle of ...
Cached Biology News:Adaptability to local climate helps invasive species thrive 2Predators vs. alien: European shrimps win predatory battles with an American invader 2How tiny organisms make a big impact on clean water 2
(Date:9/13/2014)... Boehringer Laboratories Inc., with a forty year history ... successful broadcast of a live surgery by St. Luke’s ... FAMBS, and Maher El Chaar, MD, FACS, FAMBS, using ... This sleeve gastrectomy surgery was performed and broadcast live ... surgeons from around the world during the 5th International ...
(Date:9/12/2014)... Sept. 12, 2014   Arthur Kay , the ... won the Postcode Lottery Green Challenge 2014. The jury, ... 500,000 ($680,000 USD) at the final in ... Kay,s company uses a patented process ... namely biodiesel and biomass pellets, used for powering buildings ...
(Date:9/12/2014)... DUBLIN , Sept. 12, 2014 ... the "Global Dry Film Photoresist Industry Report 2014" ... Global Dry Film Photoresist Industry Report 2014 is a ... the global dry film photoresist industry . ... including definitions, classifications, applications and industry chain structure. The ...
(Date:9/12/2014)... , September 12, 2014 On Thursday, ... 0.12%, the Dow Jones Industrial Average finished the day 0.12% ... up 0.09%. The gains were broad based as seven out ... 500 Health Care Sector Index ended the day at 741.83, ... last one month. Investor-Edge has initiated coverage on the following ...
Breaking Biology Technology:Boehringer Laboratories, Inc. Announces Live Surgery Using Innovative System to Calibrate Sleeve Gastrectomy 2Green Startup Bio-Bean Wins $680,000 in Postcode Lottery Green Challenge 2Green Startup Bio-Bean Wins $680,000 in Postcode Lottery Green Challenge 3Global Dry Film Photoresist Industry Report 2014 2Technical Coverage on Biotech Stocks - Exelixis, Arena Pharma, Novavax, Dendreon, and Amicus Therapeutics 2Technical Coverage on Biotech Stocks - Exelixis, Arena Pharma, Novavax, Dendreon, and Amicus Therapeutics 3Technical Coverage on Biotech Stocks - Exelixis, Arena Pharma, Novavax, Dendreon, and Amicus Therapeutics 4Technical Coverage on Biotech Stocks - Exelixis, Arena Pharma, Novavax, Dendreon, and Amicus Therapeutics 5
... A key lawmaker who often disagrees with Governor ... he saw nothing inappropriate about the governor's use of an ... stem cell companies. , ,Meanwhile, the executive order, signed Tuesday ... from the director of Pro Life Wisconsin. , ,Ted Kanavas, ...
... - The Wisconsin Department of Motor Vehicles has deployed ... out of crime. , ,Preventing mischief in the issuance of ... Alioto, a fraud prevention specialist with the DMV , ... like a Social Security card or a birth certificate, a ...
... you're not reading this column, at least not today. May ... on the planet of the contributions to society and economy ... thousands of people will take to the streets in support ... will stay home from work. Some plan to keep their ...
Cached Biology Technology:Republican sees nothing wrong with Doyle's use of executive order 2New DMV tool never forgets a face 2New DMV tool never forgets a face 3Technology and the "American" dream 2
... a simple and convenient method for the rapid, ... been optimized for use with S. cerevisiae and ... fungus species that is susceptible to yeast lytic ... spheroplasts of yeast cells that are ideal for ...
Four siRNAs targeting your gene of interest, providing gene silencing with 100% satisfaction guaranteed High knockdown potency , High specificity for minimal off-target effects , Flexible siR...
... PHD2000 syringe pump series combines Harvard Apparatuss best ... and a wide range of configuration options. A ... dimensions of syringes from all the major manufacturers. ... all the pertinent information from across the lab. ...
... Drosophila S2 cells are used for heterologous ... System (DES). The S2 cell line was ... (20-24 hours old) Drosophila melanogaster embryos ... at room temperature without CO2 and is easily ...
Biology Products: