Navigation Links
Young malaria parasites refuse to take their medicine, may explain emerging drug resistance
Date:2/19/2013

New research has revealed that immature malaria parasites are more resistant to treatment with key antimalarial drugs than older parasites, a finding that could lead to more effective treatments for a disease that kills one person every minute and is developing resistance to drugs at an alarming rate.

University of Melbourne researchers have shown for the first time that malaria parasites (Plasmodium falciparum)in the early stages of development are more than 100 times less sensitive to artemisinin-based drugs, which currently represent a last line of defense against malaria.

The study was conducted by a team led by Professor Leann Tilley and Dr Nectarios (Nick) Klonis from the Department of Biochemistry and Molecular Biology and the Bio21 Institute, and is published in the journal PNAS.

The drug artemisinin (ART) saves millions of lives each year but it is still not clear exactly how it works. Professor Tilley's team developed a novel approach to examine how the parasite responds to drugs under the conditions it encounters in the body. This is important because the malaria parasite takes two days to reach maturity in each cycle but the drug only remains in the bloodstream for a few hours.

"We were surprised to find that juvenile parasites were up to 100 times less sensitive to the drug than mature parasites, and that in some strains the juvenile parasites showed a particularly high degree of resistance. This would result in a large number of juvenile parasites surviving against clinical treatment and helps explain how resistance to drugs develops," Professor Tilley said.

In order to survive in the human body, the parasite must inhabit red blood cells for part of its life cycle, to do this it first digests the cell contents including the haemoglobin protein which carries oxygen in blood.

"We found that the parasite is most susceptible to drug treatment when it is digesting haemoglobin, sugge
'/>"/>

Contact: Nerissa Hannink
nhannink@unimelb.edu.au
61-430-588-055
University of Melbourne
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Experimental gene therapy treatment for Duchenne muscular dystrophy offers hope for youngster
2. Joslin scientists find first human iPSC from patients with maturity onset diabetes of the young
3. Wiley Prize in Biomedical Sciences awarded to Rosbash, Hall and Young
4. Damon Runyon Cancer Research Foundation grants prestigious awards to 17 young scientists
5. Giant tobacco plants that stay young forever
6. Strength training improves vascular function in young black men
7. Young Investigator Award winners announced by Anatomy Society
8. Dr. Sanjay Kumar wins STEM CELLS Young Investigator Award
9. New programs draws young artists into science
10. Young gamers offer insight to teaching new physicians robotic surgery
11. Omega-3 intake heightens working memory in healthy young adults
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Young malaria parasites refuse to take their medicine, may explain emerging drug resistance
(Date:7/8/2015)... DIEGO , July 8, 2015  Trovagene, ... cell-free molecular diagnostics, today announced the launch of ... the Company,s Precision Cancer Monitoring℠ (PCM) technology for ... receiving one or a combination of the novel ... Opdivo® (nivolumab), a PD-1 inhibitor. The 50-patient study ...
(Date:7/7/2015)... , July 7, 2015  Based on ... Frost & Sullivan recognizes Credence ID, LLC with ... Entrepreneurial Company of the Year Award. Credence ID ... aid in its mission of offering enrollment and ... globally. As Credence ID was formed by experts ...
(Date:7/2/2015)... Research and Markets( http://www.researchandmarkets.com/research/jvft55/next_generation ) has ... Market by Application, Technology, Function & Geography - Global ... The next generation biometrics market is expected to ... 17.9% between 2015 and 2020 Travel & ... Safran SA ( France ), NEC ...
Breaking Biology News(10 mins):Trovagene Initiates Study to Monitor Response to Immunotherapy in Melanoma Patients Using its Precision Cancer Monitoring Platform 2Trovagene Initiates Study to Monitor Response to Immunotherapy in Melanoma Patients Using its Precision Cancer Monitoring Platform 3Trovagene Initiates Study to Monitor Response to Immunotherapy in Melanoma Patients Using its Precision Cancer Monitoring Platform 4Frost & Sullivan Acknowledges the Distinctive Customer-focused Attributes of Credence ID's Mobile Biometric Product Suite 2Frost & Sullivan Acknowledges the Distinctive Customer-focused Attributes of Credence ID's Mobile Biometric Product Suite 3Frost & Sullivan Acknowledges the Distinctive Customer-focused Attributes of Credence ID's Mobile Biometric Product Suite 4Frost & Sullivan Acknowledges the Distinctive Customer-focused Attributes of Credence ID's Mobile Biometric Product Suite 5Next Generation Biometrics Market 2015 - Global Forecast to 2020 with Safran, NEC, 3M Cogent, Fujitsu & Suprema Dominating the $24 Billion Market 2Next Generation Biometrics Market 2015 - Global Forecast to 2020 with Safran, NEC, 3M Cogent, Fujitsu & Suprema Dominating the $24 Billion Market 3
... particularly carbon dioxide (CO2), have been associated with ... grasslands, drainage of the land, and land use ... have led scientists to measure soil organic carbon ... to evaluate how changes in tillage practices affect ...
... major challenges facing the international community in the coming century. ... the distribution of the sea ice, and has led to ... close connection between the Arctic climate and our own. The ... to the polar front extending south, for example. Researchers ...
... tympanoplasty can be performed successfully in 95 percent of ... study in the February 2013 issue of OtolaryngologyHead ... frequently performed procedure with varying reported success rates ranging ... membrane repair success in children is often perceived as ...
Cached Biology News:New protocol recommendations for measuring soil organic carbon sequestration 2New protocol recommendations for measuring soil organic carbon sequestration 3New protocol recommendations for measuring soil organic carbon sequestration 4Aarhus University builds research station in North Greenland 2Aarhus University builds research station in North Greenland 3
(Date:8/5/2015)... 5, 2015 The Biosimilars Forum ... members Reps. Joe Barton (R-TX) and ... of 33 House members, for their leadership in sending ... for the Centers for Medicare & Medicaid Services (CMS), ... CMS,s 2016 Medicare Physician Fee Schedule proposed rule. As ...
(Date:8/5/2015)... 2015  MabVax Therapeutics Holdings, Inc. (OTCQB: MBVX) ("MabVax" ... company, announces the posting of the following Letter to ... Hansen to the Company,s website at www.mabvax.com ... have invested in MabVax Therapeutics because you share our ... difficult cancers.  You also share our excitement about our ...
(Date:8/5/2015)... , Aug. 5, 2015 GenomeDx Biosciences announced ... at 9:45 a.m. ET on Wednesday, August 12, in ... GenomeDx, will provide an update about the company,s Decipher ® ... About Decipher ® The Decipher ®  Prostate ... test for men with intermediate and high risk prostate cancer. ...
(Date:8/5/2015)... Switzerland (PRWEB) , ... August 05, 2015 , ... ... solutions for production, culture, and assessment of more organotypic 3D cell culture models, ... GravityTRAP™ Ultra-Low Attachment (ULA) Plates are now available for purchase exclusively ...
Breaking Biology Technology:Biosimilars Forum Applauds Reps. Barton, Eshoo for Leadership on Proposed Medicare Rule on Biosimilar Coding 2Biosimilars Forum Applauds Reps. Barton, Eshoo for Leadership on Proposed Medicare Rule on Biosimilar Coding 3MabVax Therapeutics Issues Letter to Stockholders 2MabVax Therapeutics Issues Letter to Stockholders 3MabVax Therapeutics Issues Letter to Stockholders 4MabVax Therapeutics Issues Letter to Stockholders 5MabVax Therapeutics Issues Letter to Stockholders 6MabVax Therapeutics Issues Letter to Stockholders 7MabVax Therapeutics Issues Letter to Stockholders 8MabVax Therapeutics Issues Letter to Stockholders 9MabVax Therapeutics Issues Letter to Stockholders 10MabVax Therapeutics Issues Letter to Stockholders 11MabVax Therapeutics Issues Letter to Stockholders 12MabVax Therapeutics Issues Letter to Stockholders 13GenomeDx Biosciences to Present at 2015 Wedbush PacGrow Healthcare Conference 2GenomeDx Biosciences to Present at 2015 Wedbush PacGrow Healthcare Conference 3InSphero Expands Global Availability of its Patented 3D Cell Culture Platforms 2InSphero Expands Global Availability of its Patented 3D Cell Culture Platforms 3
... ARBOR, Mich.---A delicate balance of atomic forces can be ... size---an attribute that,s important for many nanotech applications but ... The same type of forces are at work ... inorganic supercluster structures in this research are in many ...
... announced today they have been named to the prestigious 30th ... entrepreneurial and fastest growing companies in America. The 2011 Inc. ... past three years.  HumanTouch is ranked 203 on this list. ... representatives of the Inc. 500 such as Zappos, Patagonia, Intuit ...
... 2011 Biotechnology leader Divine Skin Inc. (DSKX) posted ... quarter. The expanding innovator of personal care solutions credits ... sales, which are 79 percent ahead of the same ... has been keeping up with demand," said Divine Skin ...
Cached Biology Technology:Engineers discover nanoscale balancing act that mirrors forces at work in living systems 2Divine Skin Posts Record Q2 Revenue of $2.33 Million, up 79 Percent From 2010 2Divine Skin Posts Record Q2 Revenue of $2.33 Million, up 79 Percent From 2010 3
... a clone of the human Topoisomerase II gene. ... the topological state of nucleic acids by passing ... which generates a separate DNA helix (1,2) . ... mechanism, the enzyme can relax negatively or positively ...
RNase-Free DNase 50 l...
supplied with 10x reaction buffer...
... RNase H degrades, as an endoribonuclease, ... DNA hybrids of natural origin, e.g. ... synthetic complexes, e.g. poly(A) x poly(dT). ... and 3-OH termini. Nearly no activity ...
Biology Products: