Navigation Links
Yale scientists use nanotechnology to fight E. coli
Date:8/30/2007

New Haven, Conn. Single-walled carbon nanotubes (SWCNTs) can kill bacteria like the common pathogen E. coli by severely damaging their cell walls, according to a recent report from Yale researchers in the American Chemical Society (ACS) journal Langmuir.

We began the study out of concerns for the possible toxicity of nanotubes in aquatic environments and their presence in the food chain, said Menachem Elimelech, professor and chair of chemical and environmental engineering at Yale and senior author on the paper. While nanotubes have great promise for medical and commercial applications there is little understanding of how they interact with humans and the environment.

The nanotubes are microscopic carbon cylinders, thousands of times smaller than a human hair that can be easily taken up by human cells, said Elimelech. We wanted to find out more about where and how they are toxic.

This nanoscience version of a David-and-Goliath story was hailed in an ACS preview of the work as the first direct evidence that carbon nanotubes have powerful antimicrobial activity, a discovery that could help fight the growing problem of antibiotic resistant infections.

Using the simple E. coli as test cells, the researchers incubated cultures of the bacteria in the presence of the nanotubes for up to an hour. The microbes were killed outright but only when there was direct contact with aggregates of the SWCNTs that touched the bacteria. Elimelech speculates that the long, thin nanotubes puncture the cells and cause cellular damage.

The study ruled out metal toxicity as a source of the cell damage. To avoid metal contaminants in commercial sources, the SWCNTs were rigorously synthesized and purified in the laboratory of co-author Professor Lisa Pfefferle.

We're now studying the toxicity of multi-walled carbon nanotubes and our preliminary results show that they are less toxic than SWCNTs, Elimelech said. We are also looking at the effects of SWCNTs on a wide range of bacterial strains to better understand the mechanism of cellular damage.

Elimelech projects that SWCNTs could be used to create antimicrobial materials and surface coatings to improve hygiene, while their toxicity could be managed by embedding them to prevent their leaching into the environment.


'/>"/>
Contact: Janet Rettig Emanuel
janet.emanuel@yale.edu
203-432-2157
Yale University
Source:Eurekalert

Related biology news :

1. Wisconsin scientists grow critical nerve cells
2. Scientists ID molecular switch in liver that triggers harmful effects of saturated and trans fats
3. UCSB scientists probe sea floor venting to gain understanding of early life on Earth
4. UAB scientists discover the origin of a mysterious physical force
5. Fox Chase Cancer Center scientists identify immune-system mutation
6. Scientists Replicate Hepatitis C Virus in Laboratory
7. Scientists detect probable genetic cause of some Parkinsons disease cases
8. Scientists find missing enzyme for tuberculosis iron scavenging pathway
9. Scientists seek answers on what activates deadly anthrax spores
10. Yale Scientists Find MicroRNA Regulates Ras Cancer Gene
11. Scientists collaborate to assess health of global environment
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/12/2019)... Ore. (PRWEB) , ... November 12, 2019 , ... ... launching Cross-Channel Spend Optimizer that improves digital advertising performance up to 25% and ... Digital Advertising, Cross-Channel Spend Optimizer uses advanced multi-touch attribution (MTA) to predict best ...
(Date:11/9/2019)... ... November 08, 2019 , ... ... provider of specialized histology, pathology, biomarker development, and archiving services for the ... the mergers of Histo-Scientific Research Laboratories (HSRL), Vet Path Services (VPS) and ...
(Date:11/5/2019)... (PRWEB) , ... November 05, 2019 , ... ... and manufacturing solutions for drugs, biologics, gene therapies, and consumer health products, today ... held at Hotel Sofia, Barcelona, Spain on Nov. 12 – 14, 2019. , ...
Breaking Biology News(10 mins):
(Date:11/9/2019)... ... November 08, 2019 , ... ... pathology research, today announced the results of analyses examining the severity of ... phase 3 selonsertib studies (STELLAR). Strong correlations were demonstrated between AI-powered and ...
(Date:11/5/2019)... ... 2019 , ... Ole, a German Shepherd, was demonstrating signs of osteoarthritis in April 2019. ... energy level and his willingness to play were normal, it was clear that he was ... VCA Emergency Animal Hospital and Referral Center in San Diego, California. Dr. Mullen ...
(Date:10/30/2019)... ... 2019 , ... Western University of Health Sciences held Innovation ... in educating the next generation of health care providers. , The event, organized ... administrators and representatives of companies working with the University on a range of ...
(Date:10/22/2019)... , ... October 22, 2019 , ... nQ Medical, Inc. ... School’s 2019 Most Fundable Companies List which was announced at a showcase event yesterday ... million in annual revenue, strong business plans, and impressive near-term growth projections to be ...
Breaking Biology Technology: