Navigation Links
Yale researchers identify targets for immunotherapy in early-stage breast cancer
Date:7/18/2014

July 17, 2014, New Haven, CT Yale Cancer Center researchers used a new molecular analysis tool to accurately detect the level of an important target for immunotherapy in early-stage breast cancers. The diagnostic test, using RNAScope, measures the amount of PD-L1 (programmed death ligand 1) mRNA in routine formalin-fixed cancer tissues and is devoid of many of the technical issues that plague antibody-based detection methods that have yielded conflicting results in the past. PD-L1 is the target of several novel immune stimulatory therapies in clinical trials. The findings were published in the Journal of Clinical Cancer Research in May.

PD-L1 is a protein that plays an important role in suppressing immune response, and in cancer, it may allow tumors to evade immune attack. The study demonstrated that about 60 percent of early-stage breast cancers have PD-L1 expression, and a subset of these cancers also have large numbers of tumor infiltrating lymphocytes. High levels of lymphocytes and PD-L1 predicted for better survival, suggesting a beneficial role for the immune system in at least partially controlling these cancers.

"This is exciting because these findings provide the rationale to test PD-L1 targeted therapies in breast cancer with the hope of further improving cure rates in early stage breast cancer," said Lajos Pusztai, MD, DPhil, professor of Medical Oncology and chief of Breast Medical Oncology at Smilow Cancer Hospital, Yale Cancer Center, and an author on the study. "Patients with many tumor infiltrating lymphocytes and high PD-L1 expression may be the ideal candidates for these therapies."

The in situ mRNA detection method used in the study, eliminates many of the technical problems that older immunohistochemistry assays had, Pusztai added.


'/>"/>

Contact: Vicky Agnew
vicky.agnew@yale.edu
203-785-7001
Yale University
Source:Eurekalert

Page: 1

Related biology news :

1. CNIO researchers discover a gene that links stem cells, aging and cancer
2. Duck migration study reveals importance of conserving wetlands, MU researchers find
3. Researchers advance understanding in immune response to infectious disease
4. Researchers find organic pollutants not factor in turtle tumor disease
5. Largest International Meeting for the Study of Reproductive Biology Attracts Researchers from 36 Countries in Grand Rapids, Michigan
6. Little too late: Researchers identify disease that may have plagued 700-year-old skeleton
7. Researchers declassify dinosaurs as being the great-great-grandparents of birds
8. IPCC must consider alternate policy views, researchers say
9. Science and cookies: Researchers tap into citizen science to shed light on ant diversity
10. Researchers receive $12.6 million NIH grant to study genetics of Alzheimers
11. Researchers uncover new knowledge about our intestines
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/21/2014)... JOSE, Calif. , Nov. 20, 2014   ... global leader in microcontroller (MCU) and touch technology solutions, ... digital temperature sensors with the widest V cc ... delivers higher temperature accuracy and faster I 2 C ... registers and serial EEPROM memory making them ideal for ...
(Date:11/15/2014)... we may still be a few years away from the ... gain instant access to all that ailed his patients, mobile ... for monitoring and measuring our health are cropping up in ... tad Orwellian to some, but a new survey suggests that ... into their healthcare regime. These are some of ...
(Date:11/7/2014)... Nov. 7, 2014  In conjunction with the ... Departments, The Community Foundation of the Verdugos has announced the ... JUSTICE PROJECT," a $250,000 initiative to keep the Verdugo Regional ... its first six months of existence, the Lab has processed ... for local law enforcement. "Because our number one ...
Breaking Biology News(10 mins):Atmel Launches Industry's First Wide-V(cc) Low-Power Temperature Sensor Family 2Atmel Launches Industry's First Wide-V(cc) Low-Power Temperature Sensor Family 3Atmel Launches Industry's First Wide-V(cc) Low-Power Temperature Sensor Family 4Americans May Be Ready for a Brave New World of Healthcare 2Americans May Be Ready for a Brave New World of Healthcare 3Americans May Be Ready for a Brave New World of Healthcare 4Community Foundation Of The Verdugos Unveils Campaign To Fund Glendale-Burbank DNA Justice Project 2
... at the University of North Carolina at Chapel Hill have ... programmed cell death or apoptosis. This molecule, a tiny ... shown to be in short supply in certain neurodegenerative illnesses ... could herald a new treatment to prompt brain cells to ...
... lower total and LDL (low-density lipoprotein or "the ... mechanism whereby soy protein lowers cholesterol remains unresolved. ... of Clinical Lipidology last month shows that ... lipoprotein) cholesterol significantly more than milk protein in ...
... even though their close relatives rays and chimaeras have ... Nathan Scott Hart and colleagues from the University of ... Their study shows that although the eyes of sharks ... only have a single long-wavelength-sensitive cone* type in the ...
Cached Biology News:New molecule could save brain cells from neurodegeneration, stroke 2New molecule could save brain cells from neurodegeneration, stroke 3New study shows soy protein lowers non-HDL cholesterol significantly more than milk protein 2Are sharks color blind? 2
(Date:11/22/2014)... The “Chiral Chromatography Columns Market by type (Empty, ... by Application [GC, LC (HPLC, UHPLC, Flash Chromatography, ... and studies the major market drivers, restraints, opportunities, ... Rest of the World. , Browse 90 market ... pages and in-depth TOC on “Chiral Chromatography Columns ...
(Date:11/22/2014)... , November 21, 2014   ... als Chief Commercial Officer zu KLOX    ... Unternehmensentwicklung und Chief Financial Officer bestellt    ... der Vermarktung seines jüngst zugelassenen Behandlungssystems zur Wundheilung zu ... bzw. das "Unternehmen") ist sehr erfreut, die folgenden personellen ...
(Date:11/21/2014)... The science of light and how it ... than 200 primary students in a traveling program organized ... Otago Physics Department and funded by an SPIE ... the university’s OSA/SPIE Student Chapter visited six primary schools ... from small, rural schools hands-on lessons in optics and ...
(Date:11/21/2014)... Palo Alto, Calif. (PRWEB) November 20, 2014 ... (CHI), a nonprofit, public policy research organization representing ... and pharmaceutical firms, and PwC US ... other states in life sciences industry growth. The ... and 2013. The 2015 California Biomedical Industry ...
Breaking Biology Technology:Chiral Chromatography Columns Market worth $87.8 Million by 2018 - New Research Report by MarketsandMarkets 2Chiral Chromatography Columns Market worth $87.8 Million by 2018 - New Research Report by MarketsandMarkets 3Chiral Chromatography Columns Market worth $87.8 Million by 2018 - New Research Report by MarketsandMarkets 4Chiral Chromatography Columns Market worth $87.8 Million by 2018 - New Research Report by MarketsandMarkets 5KLOX Technologies meldet Neubesetzung von Führungspositionen 2KLOX Technologies meldet Neubesetzung von Führungspositionen 3KLOX Technologies meldet Neubesetzung von Führungspositionen 4KLOX Technologies meldet Neubesetzung von Führungspositionen 5Optics and photonics outreach programs share science, spark fascination with light 2Optics and photonics outreach programs share science, spark fascination with light 3California Healthcare Institute and PwC Report Boom in California’s Biomedical Industry 2California Healthcare Institute and PwC Report Boom in California’s Biomedical Industry 3California Healthcare Institute and PwC Report Boom in California’s Biomedical Industry 4
... Co., Ltd., and its parent company, Otsuka Holdings Co., ... for Human Use (CHMP), a division of the European ... of Teysuno™ (S-1), a novel oral anti-cancer agent, intended ... when given in combination with cisplatin. The Committee will ...
... Catal de Nanotecnologia (ICN), in Barcelona, has demonstrated a device ... key step in developing the spin computers of the future. ... the journal Science. The authors are Marius V. Costache and ... the Physics and Engineering of Nanodevices Group at ICN. ...
... Quest Diagnostics (NYSE: DGX ), the ... services, today announced that its Care360™ Electronic Health ... was certified as a Complete EHR on Wednesday, ... eligible Health Information Technology (CCHIT®), an ONC-ATCB, in ...
Cached Biology Technology:Teysuno™ (S-1) Receives CHMP Positive Opinion for Approval as First-Line Therapy for Advanced Gastric Cancer 2Teysuno™ (S-1) Receives CHMP Positive Opinion for Approval as First-Line Therapy for Advanced Gastric Cancer 3Teysuno™ (S-1) Receives CHMP Positive Opinion for Approval as First-Line Therapy for Advanced Gastric Cancer 4A 'spin ratchet': A new electronic structure for generating spin current 2Quest Diagnostics® Care360™ EHR Receives ONC-ATCB 2011/2012 Certification 2Quest Diagnostics® Care360™ EHR Receives ONC-ATCB 2011/2012 Certification 3Quest Diagnostics® Care360™ EHR Receives ONC-ATCB 2011/2012 Certification 4
Anti-Kusabira Orange Monoclonal Antibody Description: 100 g Research Focus: tag Storage: -20C Shipping Temperature: 4C...
TXNL2 Antibody...
Mouse monoclonal [3F8 ] to smooth muscle Myosin heavy chain I ( Abpromise for all tested applications). entrezGeneID: 4629 SwissProtID: P35749...
Request Info...
Biology Products: