Navigation Links
X-ray diffraction may play key role in stopping 'kissing bug,' fungus
Date:10/19/2010

COLUMBIA, Mo. If finding the cure for a fungus and parasite that affects millions of people were the subject of a detective show, University of Missouri Chemistry Professor John Tanner would be the forensic expert in the lab, using high-tech equipment to make a model that could eventually solve the crime.

Tanner, who also teaches chemistry in the College of Arts and Science, has joined forces with Pablo Sobrado, an assistant professor of biochemistry at Virginia Tech, to study a unique enzyme found on two "crime scenes": in Aspergillus fumigatus, a fungus that causes pulmonary diseases in immuno-compromised people; and in a blood-sucking insect prevalent in South America and now being found in the southwestern U.S., called the Chagas parasite, also known as the "kissing bug" for the red welts left on the victims' faces after being bitten in his or her sleep.

"My job is to figure out what the enzyme looks like using X-ray diffraction," Tanner said. "This enzyme makes a special sugar molecule that these organisms need to survive, so if we can find a way to stop the reaction that makes that sugar, then we might find a way to kill these pathogens."

In Tanner's lab at the University of Missouri, researcher Dale Karr is in the first stages of the process growing tiny crystals of the enzyme. These crystals will eventually be used in X-ray crystallography, a technique in which diffraction patterns that are produced by bombarding crystals with intense X-ray beams are decoded to determine the atomic structure of the enzyme. With this information, and Sobrado's information on how the protein can be isolated and characterized, different drugs that may inhibit the enzyme can be designed and tested.

"The enzyme is like a lock, and if we can see what the lock looks like, we can find a key to fit in the lock and prevent the enzyme from being active," said Tanner. "This is interesting because it's a new project for us, and the collaboration with Pablo has
'/>"/>

Contact: Steven Adams
AdamsST@missouri.edu
573-882-8353
University of Missouri-Columbia
Source:Eurekalert

Page: 1 2

Related biology news :

1. An X-ray for your genes
2. LiXEdrom: Innovative measuring chamber for X-ray study of liquid jets
3. Early results from the worlds brightest X-ray source
4. First X-ray lasers early success brings approval for next-phase facility
5. Lensless imaging of whole biological cells with soft X-rays
6. E-beam and X-ray irradiation technologies
7. Scientists using X-ray vision to produce more nutritious flour
8. Researchers demonstrate nanoscale X-ray imaging of bacterial cells
9. Scientists make important step toward stopping plaque-like formations in Huntingtons disease
10. Mango effective in preventing, stopping certain colon, breast cancer cells
11. Stopping MRSA before it becomes dangerous is possible, Sandia/UNM researchers find
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/11/2014)... CHICAGO , Nov. 11, 2014  Forensicon, Inc., ... eDiscovery firm, is pleased to announce the promotion of ... to Director of Digital Forensics. In Schiff,s new role ... out the team of digital forensics examiners and provide ... Photo - http://photos.prnewswire.com/prnh/20141110/157719 ...
(Date:11/7/2014)... Researchers led by Dr. Debra Auguste, associate professor, ... at The City College of New York, have ... treatment for one of the most aggressive forms ... (TNBCs) have a high mortality rate owing to ... effective therapeutic options. However, Professor Auguste,s team, discovered ...
(Date:11/7/2014)... , November 6, 2014 Leading ... for better mobile security revolutionizing online transactions.  Companies in focus ... Holdings Ltd. (NYSE: BABA ), Google Inc. (NASDAQ: ... ), eBay Inc. (NASDAQ: EBAY ) and MasterCard ... NXTD and NXTDW), a biometric authentication company focused on ...
Breaking Biology News(10 mins):Yaniv Schiff Promoted to Director of Digital Forensics at Forensicon, Inc. 2Universal Authentication Methods Provide More Secure Operations for Biometrics Devices - Company Joins FIDO Alliance for Consumer Protection 2Universal Authentication Methods Provide More Secure Operations for Biometrics Devices - Company Joins FIDO Alliance for Consumer Protection 3Universal Authentication Methods Provide More Secure Operations for Biometrics Devices - Company Joins FIDO Alliance for Consumer Protection 4Universal Authentication Methods Provide More Secure Operations for Biometrics Devices - Company Joins FIDO Alliance for Consumer Protection 5Universal Authentication Methods Provide More Secure Operations for Biometrics Devices - Company Joins FIDO Alliance for Consumer Protection 6
... molecules of membranes, also known as phospholipids, are composed of ... The molecules form a bilayer in the membrane, with all ... hanging in a zip-like interlay position. Biomembranes are ... cell is constantly creating new phospholipids that have to align ...
... JUPITER, FL, January 29, 2013 While the wooly musk ox ... it hot, or at least warm. In fact, their preferred optimum ... Scientists have known that a type of brain cell circuit helps ... their temperature preferences. What has been a mystery is whether or ...
... Trees in the continental U.S. could send out new spring ... than they did before global temperatures started to rise, according ... changes could lead to changes in the composition of northeastern ... up carbon dioxide. Trees play an important role in ...
Cached Biology News:Pathway for membrane building blocks 2Scripps Research Institute study shows how brain cells shape temperature preferences 2Spring may come earlier to North American forests 2Spring may come earlier to North American forests 3
(Date:11/21/2014)... , Nov. 21, 2014   TRU-D SmartUVC LLC ... their superbug-killing UVC automated disinfection robot, TRU-D SmartUVC, at FIS ... from Nov. 23 to 26 at Stand 23. ... United Kingdom,s largest infection-related event of ... societies to one of the leading events of its type ...
(Date:11/21/2014)... 2014 Offering a complete line of ... Balance promotion . The Sartorius Entris Balance is the ... accuracy, and easy-to-maintain balance entry level balance. , The ... designed to help customer’s bridge the gap between a ... is very durable. Sartorius is the second biggest balance ...
(Date:11/21/2014)... November 20, 2014 The ... policy research organization representing leading California academic institutions, ... PwC US today released a report ... sciences industry growth. The trend shows a 4 ... 2015 California Biomedical Industry Report indicates that, ...
(Date:11/21/2014)... York, NY (PRWEB) November 20, 2014 ... is now available as an open access journal featuring ... with infrared fluorescent proteins to preserve photoresponsiveness in the ... Two-color fluorescent in situ hybridization using chromogenic substrates ... chips for DNA, RNA, and protein electrophoresis , ...
Breaking Biology Technology:TRU-D SmartUVC to Showcase Superbug-Killing Robot at FIS 2014 2TRU-D SmartUVC to Showcase Superbug-Killing Robot at FIS 2014 3Pipette.com Announces an Extension on the Sartorius Entris Balance Promotion to the End of 2014 2California Healthcare Institute and PwC Report Boom in California’s Biomedical Industry 2California Healthcare Institute and PwC Report Boom in California’s Biomedical Industry 3California Healthcare Institute and PwC Report Boom in California’s Biomedical Industry 4BioTechniques: The International Journal of Life Science Methods Announces the Publication of the November 2014 Issue—Available in Print and Online 2BioTechniques: The International Journal of Life Science Methods Announces the Publication of the November 2014 Issue—Available in Print and Online 3
... government-mandated change as a result of the Sarbanes-Oxley ... reporting and companies to continually evaluate their financial ... as to the technology requirements and information technology ... any technology; however, it is difficult to envision ...
... Wednesday it will support American Musical Supplys (AMS) ... chain execution solutions. AMS , a supplier ... distribution network next year and develop business-to-business sales ... vision products. , ,AMS was driven to ...
... Act went info effect Jan. 1 and, although its enforceability ... to come. , ,CAN-SPAM (controlling the assault of non-solicited pornography ... reduce the flow of unsolicited e-mail (SPAM). According to the ... , , Clearly label commercial e-mail as advertising , Use ...
Cached Biology Technology:Technology Implications of Sarbanes-Oxley 2Technology Implications of Sarbanes-Oxley 3CAN-SPAM: Wheres the Meat? 2
... Zyagen tissue microarrays are derived from frozen ... rigorous quality control procedures to ensure the ... manually assembled in one block, sectioned at ... coated slides. Sections are large (3-5mm in ...
... Opticon real-time PCR detection system uses a ... (450-495 nm) and a photomultiplier tube for ... is built on an DNA Engine thermal ... feature. This item includes the thermal cycler, ...
... Precision-designed for Optimal Microdissection , CapSure ... the precise and rapid extraction of populations ... cytology samples with Laser Capture Microdissection., ... Downstream Molecular Analysis , All CapSure LCM ...
... are highly sensitive laser confocal systems designed ... advanced scanners that meet your expectations, differentiating ... and optimizing the signal on the bottom ... the range for increased sensitivity. Results with ...
Biology Products: