Navigation Links
X-ray diffraction may play key role in stopping 'kissing bug,' fungus
Date:10/19/2010

COLUMBIA, Mo. If finding the cure for a fungus and parasite that affects millions of people were the subject of a detective show, University of Missouri Chemistry Professor John Tanner would be the forensic expert in the lab, using high-tech equipment to make a model that could eventually solve the crime.

Tanner, who also teaches chemistry in the College of Arts and Science, has joined forces with Pablo Sobrado, an assistant professor of biochemistry at Virginia Tech, to study a unique enzyme found on two "crime scenes": in Aspergillus fumigatus, a fungus that causes pulmonary diseases in immuno-compromised people; and in a blood-sucking insect prevalent in South America and now being found in the southwestern U.S., called the Chagas parasite, also known as the "kissing bug" for the red welts left on the victims' faces after being bitten in his or her sleep.

"My job is to figure out what the enzyme looks like using X-ray diffraction," Tanner said. "This enzyme makes a special sugar molecule that these organisms need to survive, so if we can find a way to stop the reaction that makes that sugar, then we might find a way to kill these pathogens."

In Tanner's lab at the University of Missouri, researcher Dale Karr is in the first stages of the process growing tiny crystals of the enzyme. These crystals will eventually be used in X-ray crystallography, a technique in which diffraction patterns that are produced by bombarding crystals with intense X-ray beams are decoded to determine the atomic structure of the enzyme. With this information, and Sobrado's information on how the protein can be isolated and characterized, different drugs that may inhibit the enzyme can be designed and tested.

"The enzyme is like a lock, and if we can see what the lock looks like, we can find a key to fit in the lock and prevent the enzyme from being active," said Tanner. "This is interesting because it's a new project for us, and the collaboration with Pablo has
'/>"/>

Contact: Steven Adams
AdamsST@missouri.edu
573-882-8353
University of Missouri-Columbia
Source:Eurekalert

Page: 1 2

Related biology news :

1. An X-ray for your genes
2. LiXEdrom: Innovative measuring chamber for X-ray study of liquid jets
3. Early results from the worlds brightest X-ray source
4. First X-ray lasers early success brings approval for next-phase facility
5. Lensless imaging of whole biological cells with soft X-rays
6. E-beam and X-ray irradiation technologies
7. Scientists using X-ray vision to produce more nutritious flour
8. Researchers demonstrate nanoscale X-ray imaging of bacterial cells
9. Scientists make important step toward stopping plaque-like formations in Huntingtons disease
10. Mango effective in preventing, stopping certain colon, breast cancer cells
11. Stopping MRSA before it becomes dangerous is possible, Sandia/UNM researchers find
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/23/2014)... for providing essential fatty acids and energy to ... has been concern that soybean-based emulsions could compromise ... its composition. Combination lipid emulsions based on triglyceride ... developed to address this concern. , However, researchers ... may be unwarranted, according to a review published ...
(Date:7/22/2014)... consists of both still images and video of ... research. Forty-four still images were chosen from more ... staff, and alumni representing more than 25 different ... than 50 submissions. , Zach Donnell, a graduate ... 2014 organizers, noted that the exhibit highlights the ...
(Date:7/22/2014)... (NASDAQ: AWRE ), a leading supplier of biometrics ... quarter ended June 30, 2014. Revenue for the ... 53% compared to $4.4 million in the same quarter last ... quarter of 2014 was $1.4 million compared to $0.5 million ... and operating income was driven by higher sales of software ...
Breaking Biology News(10 mins):Art of Science 2014 2Aware, Inc. Reports Second Quarter 2014 Financial Results 2Aware, Inc. Reports Second Quarter 2014 Financial Results 3Aware, Inc. Reports Second Quarter 2014 Financial Results 4Aware, Inc. Reports Second Quarter 2014 Financial Results 5Aware, Inc. Reports Second Quarter 2014 Financial Results 6Aware, Inc. Reports Second Quarter 2014 Financial Results 7
... , June 19, 2013  Paris Air Show – ... Systems) , a leading provider of innovative test solutions ... solutions this week at the Paris Air Show ... complex armament systems with longer lifecycles, industry leaders are ...
... University, sophisticated computational models and advances in graphical processing ... genomic data, virus structure and the formation of the ... "We hope that some of what we are ... unable to replicate," says post-doctoral fellow Jason Perlmutter, first ...
... Washington, D.C. June 18, 2013 Joshua Obar, ... UniversityBozeman, has been honored with a 2013 ICAAC Young ... the regulation of immunological memory responses to infection. ... Wesleyan University in 2001 and went on to complete ...
Cached Biology News:Marvin Test Solutions Demonstrates Next-Generation Armament Test Solutions at Paris Air Show 2Marvin Test Solutions Demonstrates Next-Generation Armament Test Solutions at Paris Air Show 3Computer modeling technique goes viral at Brandeis 2The American Society for Microbiology honors Joshua Obar 2
(Date:7/22/2014)... og SHENZHEN , Kina, ... Co., LTD, (BGI Tech), et datterselskab af BGI, ... en ny human whole exome-sekvenseringstjeneste baseret på Complete ... højt anset i branchen for at levere patenterede ... af alle typer varianter, blev købt af BGI ...
(Date:7/22/2014)... China , 22 juli 2014 BGI ... BGI, ,s wereld grootste organisatie op het gebied van ... service ten behoeve van hele menselijke genoomsequentie via het ... In 2013 acquireerde BGI Complete Genomics, ... staat vanwege de in eigen beheer ontwikkelde sequentietechnologieën met ...
(Date:7/22/2014)... -- Hussey Copper , a leader in copper ... announces Pullman Regional Hospital,s conversion of more than 1,100 ... surface, at a nominal cost.  This reasonably priced surface ... bacteria within 2 hours of exposure 1 and will ... diseases in its facilities. Pullman Regional Hospital, ...
(Date:7/22/2014)... 2014  Semler Scientific, Inc. (Nasdaq: ... company that develops patented products that assist healthcare ... today announced that it will report second quarter ... financial markets on July 25, 2014. Doug Murphy-Chutorian, M.D., chief ... call at 11 a.m. EDT, July 25, 2014. ...
Breaking Biology Technology:BGI Tech lancerer Human Whole Exome-sekvenseringstjeneste på Complete Genomics avancerede platform 2BGI Tech introduceert service op gebied van hele menselijke exoomsequencing op geavanceerd Complete Genomics-platform 2Pullman Regional Hospital changes more than 1,100 touch points to Hussey Copper's MD-Cu29 antimicrobial copper to help protect against bacteria 2Pullman Regional Hospital changes more than 1,100 touch points to Hussey Copper's MD-Cu29 antimicrobial copper to help protect against bacteria 3Semler to Report Second Quarter 2014 Financial Results and Host Conference Call on July 25, 2014 2
... Bunge North America, the North American operating arm of Bunge ... which can be attributed to Soren Schroder, Bunge North America ... aware from press reports of Syngenta,s allegations.  From what we ... and disappointed that Syngenta has taken an action which could ...
... 23, 2011 MedNet Solutions, a global life sciences technology ... to announce that MedNet has once again been recognized by ... held companies in the United States.  MedNet is greatly honored ... straight year, since, as noted by Inc . magazine, ...
... FMC Corporation (NYSE: FMC ) announced today ... agreements covering global development and supply of Chr. Hansen ... begin commercialization this year of Chr. Hansen,s Nemix bacillus ... standalone and combination products in the Americas and key ...
Cached Biology Technology:Bunge Responds to Syngenta Suit 2MedNet Solutions Achieves the Inc. 5000 List Five Years in a Row 2FMC Corporation Announces Exclusive Global Development and Supply Agreements for Chr. Hansen Biological Products 2
Required to perform reference file generation, flatfield calibration and performance verification processes on the GSD-501...
... The 2.0 network client/server version of Freezerworks ... workflow in high-volume labs and facilitates the sharing ... to share sample information. ... PowerPC (100MHz, PPC 601); 13 in monitor with ...
... 500 reactions. Prepare circular DNA templates ... microgram quantities of template DNA from ... DNA directly for cycle sequencing without ... liquid cultures, colonies, plaques, or purified ...
...
Biology Products: