Navigation Links
Women more depressed and men more impulsive with reduced serotonin functioning
Date:9/17/2007

Philadelphia, PA, September 17, 2007 Women and men appear to respond differently to the same biochemical manipulation. Major depressive disorder (MDD) is one of the most common mental disorders, and it is also one of the most studied. It is already known that reduced serotonin transmission contributes to the pathophysiology, or functional changes, associated with MDD and most of todays most popular antidepressants block the serotonin uptake site, also known as the transporter, in the brain. It is also known that people with MDD are frequently found to have impaired impulse control. A new study being published in the September 15th issue of Biological Psychiatry now reports on important sex and genetic differences in the way that men and women react to reductions in serotonin function, specifically in terms of their mood and impulsivity.

Using a technique in healthy participants called acute tryptophan depletion, which decreases serotonin levels in the brain, Walderhaug and colleagues found that men became more impulsive, but did not experience any mood changes in response to the induced chemical changes. However, women in this study reported a worsening of their mood and they became more cautious, a response commonly associated with depression. The researchers also discovered that the mood lowering effect in women was influenced by variation in the promotor region of the serotonin transporter gene (5-HTTLPR).

One of the studys authors, Dr. Espen Walderhaug, explains, We were surprised to find such a clear sex difference, as men and women normally experience the same effect when the brain chemistry is changed Although we have the same serotonergic system in the brain, it is possible that men and women utilize serotonin differently.

These findings highlight the complexity of studying and treating these disorders, as the interactive effects of gender and genetic coding impacted the outcomes in the men and women when their serotonergic functions were disrupted. Dr. Walderhaug comments that their studys findings might be relevant in understanding why women show a higher prevalence of mood and anxiety disorders compared to men, while men show a higher prevalence of alcoholism, ADHD and impulse control disorders. John H. Krystal, M.D., Editor of Biological Psychiatry and affiliated with both Yale University School of Medicine and the VA Connecticut Healthcare System, adds that the response patterns that have emerged in these findings are the beginnings of an understanding for these sex-related effects. Ultimately, it is hoped that these findings further advance the ability to quickly and more accurately treat patients.


'/>"/>

Contact: Jayne M. Dawkins
ja.dawkins@elsevier.com
215-239-3674
Elsevier
Source:Eurekalert

Related biology news :

1. Male circumcision reduces risk of HIV transmission from women to men
2. Variation in womens X chromosomes may explain differences among individuals, between sexes
3. Of mice and mens (and womens) contraceptives
4. Survey reveals women and doctors arent talking about HPV
5. Men Estimate Mens Risks Of Common Disorders Higher Than Women Do, And Vice Versa
6. Pregnant women at higher risk for HIV, Uganda study finds
7. Higher risk for cervical cancer seen among women infected with multiple HPV types
8. Women cautioned against using herbal supplements
9. Screen all at risk for HIV, plus pregnant women
10. Women feel more pain than men, research shows
11. Agreement will speed research on microbicides for women
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/1/2016)... -- Favorable Government Initiatives Coupled With Implementation ... to Boost Global Biometrics System Market Through 2021  ... " Global Biometrics Market By Type, By End ... - 2021", the global biometrics market is projected to ... growing security concerns across various end use sectors such ...
(Date:5/20/2016)... 20, 2016  VoiceIt is excited to announce ... By working together, VoiceIt and VoicePass ... and VoicePass take slightly different approaches to voice ... security and usability. ... new partnership. "This marketing and technology ...
(Date:5/12/2016)... , May 12, 2016 WearablesResearch.com ... just published the overview results from the Q1 wave ... the recent wave was consumers, receptivity to a program ... data with a health insurance company. "We ... to share," says Michael LaColla , CEO of ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... WI (PRWEB) , ... June 23, 2016 , ... ... supplements, is pleased to announce the launch of their brand, UP4™ Probiotics, into ... for over 35 years, is proud to add Target to its list of ...
(Date:6/23/2016)... ... 2016 , ... Charm Sciences, Inc. is pleased to announce ... Research Institute approval 061601. , “This is another AOAC-RI approval of the Peel ... President of Regulatory and Industrial Affairs. “The Peel Plate methods perform comparably to ...
(Date:6/23/2016)... ... ... STACS DNA Inc., the sample tracking software company, today announced that Dr. ... STACS DNA as a Field Application Specialist. , “I am thrilled that Dr. ... STACS DNA. “In further expanding our capacity as a scientific integrator, Hays brings a ...
(Date:6/23/2016)... 2016 On Wednesday, June 22, 2016, ... 0.22%; the Dow Jones Industrial Average edged 0.27% lower to ... down 0.17%. Stock-Callers.com has initiated coverage on the following equities: ... (NASDAQ: NKTR ), Aralez Pharmaceuticals Inc. (NASDAQ: ... BIND ). Learn more about these stocks by accessing their ...
Breaking Biology Technology: