Navigation Links
Wide range of differences, mostly unseen, among humans
Date:9/5/2013

No two human beings are the same. Although we all possess the same genes, our genetic code varies in many places. And since genes provide the blueprint for all proteins, these variants usually result in numerous differences in protein function. But what impact does this diversity have? Bioinformatics researchers at Rutgers University and the Technische Universitaet Muenchen (TUM) have investigated how protein function is affected by changes at the DNA level. Their findings bring new clarity to the wide range of variants, many of which disturb protein function but have no discernible health effect, and highlight especially the role of rare variants in differentiating individuals from their neighbors.

The slightest changes in human DNA can result in an incorrect amino acid being incorporated into a protein. In some cases, all it takes is for a single base to be substituted in a person's DNA, a variant known as a single nucleotide polymorphism (SNP). "Many of these point mutations have no impact on human health. However, of the roughly 10,000 'missense' SNPs in the human genome that is, SNPs affecting the protein sequence at least a fifth can change the function of the protein," explains Prof. Yana Bromberg of the Department of Biochemistry and Microbiology at Rutgers University. "And in some cases, the affected protein is so important and the change so large that we have to wonder why the person with this mutation is still healthy."

Furthermore, two unrelated individuals have thousands of different mutations that affect proteins. Previously, scientists did not fully understand how this large number of mutations affects the coding sequences of DNA. To investigate these "silent" mutations, Bromberg joined forces with Rutgers colleague Prof. Peter Kahn and Prof. Burkhard Rost at TUM.

Silent mutations more significant than previously thought

"We found that many of the mutations are anything but silent," declares Rost, he
'/>"/>

Contact: Patrick Regan
patrick.regan@tum.de
49-016-242-79876
Technische Universitaet Muenchen
Source:Eurekalert

Page: 1 2

Related biology news :

1. How chewing gum or a shed hair can let strangers read your Book of Life
2. Immunohistochemistry effectively detects ALK rearrangement
3. Stem cell study could aid quest to combat range of diseases
4. Wireless, implanted sensor broadens range of brain research
5. Strange phallus-shaped creature provides crucial missing link
6. A European invader outcompetes Canadian plants even outside its usual temperature range
7. Wake Forest Innovations Launches New Dot-Com Companies Offering Industry and Business Easy Access to Broad Range of Scientific Services
8. March of the pathogens: Parasite metabolism can foretell disease ranges under climate change
9. FASEB SRC announces conference registration open for: Genetic Recombination & Genome Rearrangements
10. Climate change projected to alter Indiana bat maternity range
11. Study shows immunohistochemistry is reliable screening tool for ALK rearrangement
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/10/2015)... , March 10, 2015  NXT-ID, Inc. (NASDAQ: ... the "Company"), a biometric authentication company focused on ... Wocket™ smart wallet has been named the "Number ... Modern. Rethink Modern ( http://www.rethinkmodern.com/ ) ... for your home and lifestyle that have a unique ...
(Date:3/3/2015)... Calif. , March 3, 2015 /PRNewswire/ ... leading provider of advanced cryogenic logistics solutions ... including immunotherapies, stem cells, cell lines, clinical ... reproductive medicine, today announced the expansion of ... Research Centers, ("Fred Hutch") Clinical Research ...
(Date:3/2/2015)...   Neurotechnology , a provider of high-precision biometric, ... Software Development Kit (SDK). The SentiGaze algorithm enables ... webcams to track eye movements and generate heatmaps based ... can be used for applications such as analysis of ... SDK can also be used to develop interfaces for ...
Breaking Biology News(10 mins):NXT-ID's Wocket Smart Wallet Named Number One Best Tech Gift for 2015 by Rethink Modern 2NXT-ID's Wocket Smart Wallet Named Number One Best Tech Gift for 2015 by Rethink Modern 3NXT-ID's Wocket Smart Wallet Named Number One Best Tech Gift for 2015 by Rethink Modern 4Cryoport, Inc. Expands Support of Fred Hutchinson Cancer Research Center's Clinical Research Division 2Cryoport, Inc. Expands Support of Fred Hutchinson Cancer Research Center's Clinical Research Division 3Neurotechnology Releases SentiGaze SDK for Eye Movement Tracking Using Ordinary Webcams 2Neurotechnology Releases SentiGaze SDK for Eye Movement Tracking Using Ordinary Webcams 3
... --- How do the French get away with a clean ... fats? Scientists have long suspected that the answer to the ... of a new study bring them closer to understanding why. ... Public Library of Science (PLoS) ONE, researchers from industry and ...
... York next week to discuss new approaches to one ... weather. Five years ago, Professor Peter Bernath, of ... the Atmospheric Chemistry Experiment (ACE) satellite mission. To ... University at the King,s Manor in York will review ...
... release is available in German . ... cormorants in order to reconcile nature conservation and fishing ... work at the European level, researchers from the Helmholtz ... journal Environmental Conservation. Furthermore, they suggest a five-step action ...
Cached Biology News:Substance in red wine found to keep hearts young 2Substance in red wine found to keep hearts young 3York symposium puts focus on chemical 'weather' 2The cormorant -- the 'black plague' or an example of successful species conservation? 2The cormorant -- the 'black plague' or an example of successful species conservation? 3The cormorant -- the 'black plague' or an example of successful species conservation? 4The cormorant -- the 'black plague' or an example of successful species conservation? 5
(Date:3/26/2015)... 2015 Neogen Corporation (NASDAQ: NEOG ) ... quarter of fiscal 2015, which ended Feb. 28, increased ... $6,575,000. Earnings per share in the current quarter were ... net income increased 17% over prior year to $24,142,000, ... per share, for the same period a year ago. ...
(Date:3/26/2015)... 26, 2015 WriteResult, a premier provider ... from Yale University’s School of Public Health and New ... during a 4 month-long project. The goal of the ... income families with free access to fresh produce and ... health concerns like high blood pressure, diabetes and weight ...
(Date:3/25/2015)... 2015 The surging prevalence of ... fuelled social media growth, with over 50% of ... social networking. Insurance companies are making use of ... and promote a diversity of their services and ... exploiting social networking services as part of sales ...
(Date:3/25/2015)... (PRWEB) March 25, 2015 An increase ... ingredients in all forms of food nutrients, regulatory changes ... a substantial rise in demand for natural astaxanthin over ... started to ramp up their capacities to satisfy the ... natural and synthetic source astaxanthin (used in nutraceuticals, aqua ...
Breaking Biology Technology:Neogen reports 13% increase in net income 2Neogen reports 13% increase in net income 3Neogen reports 13% increase in net income 4Neogen reports 13% increase in net income 5Neogen reports 13% increase in net income 6Neogen reports 13% increase in net income 7Neogen reports 13% increase in net income 8Yale and New Haven Farms Improving Patient Health with WriteResult's myPROpad™ 2Yale and New Haven Farms Improving Patient Health with WriteResult's myPROpad™ 3Social Media Role in Global Insurance Industry Examined by Timetric in New Market Research Report Published at MarketPublishers.com 2Social Media Role in Global Insurance Industry Examined by Timetric in New Market Research Report Published at MarketPublishers.com 3Global Astaxanthin Market to Reach Value of USD 1.1 billion by 2020, Expects Industry Experts in New Report Available at MarketPublishers.com 2
... measures urinary 11dhTxB2 to assess aspirin effectDENVER, March ... CONX), a worldwide developer and marketer of diagnostic ... its AspirinWorks(R) Test March 29 - 31 at ... Scientific Session. The annual meeting will take place ...
... regulatory hiccups, the number of biosimilars in the ... patent expiry of key biopharmaceuticals has opened up ... of biosimilars. In addition, payers, perception of biosimilars, ... their safety, efficacy and affordability, will further bolster ...
... 18 , - ... and Compliance Challenges of Radiologic Technologists, Managers , ... Mosby,s Imaging Suite,( http://www.mosbysimagingsuite.com ), the first fully ... education, communication and,compliance challenges of radiologic technologists and ...
Cached Biology Technology:Corgenix to Exhibit AspirinWorks(R) Test at ACC.09 2Corgenix to Exhibit AspirinWorks(R) Test at ACC.09 3The Need for Safe and Affordable Biopharmaceuticals Drives the Development of the European Biosimilars Market, Says Frost & Sullivan 2The Need for Safe and Affordable Biopharmaceuticals Drives the Development of the European Biosimilars Market, Says Frost & Sullivan 3The Need for Safe and Affordable Biopharmaceuticals Drives the Development of the European Biosimilars Market, Says Frost & Sullivan 4New Online Imaging Suite Boosts Healthcare Imaging Efficiency, Productivity, and Revenues 2New Online Imaging Suite Boosts Healthcare Imaging Efficiency, Productivity, and Revenues 3New Online Imaging Suite Boosts Healthcare Imaging Efficiency, Productivity, and Revenues 4
Use as the souce of CETP enzyme for screening CETP inhibitors. Use in conjunction with the CETP activity assay kit (K601-100)....
...
... Cloning Kit includes the pZErO-1 vector with ... The pZErO-1 vector utilizes positive selection to ... the Zeocin resistance gene reduces the overall ... efficiencies. The kit contains all of the ...
22 x 50 mm; No. 1 thickness range: 0.13 to 0.17 mm, suitable for work in histology, cytology, urinalysis and microbiology, precleaned, store at room temperature ...
Biology Products: