Navigation Links
Why serotonin can cause depression and anxiety
Date:2/4/2008

Mood disorders could be caused by a loss of our inherent, reflexive avoidance of aversive events, according to a study published in PLoS Computational Biology. Researchers from UCL in London and Columbia University in New York used computational modeling techniques to integrate what appeared to be blatant contradictions between serotonins roles in different states of health.

Serotonin appears to be one of the major players in mood and a variety of other disorders. But exactly how remains an open question. Imagine walking past a dark alleyway in a dangerous part of some city; although it might be a shortcut, most people wouldnt consider taking it. In healthy subjects, serotonin appears important for this automatic avoidance.

It has long been suggested that over-activity of the serotonin system may relate to mood disorders such as depression and anxiety, as these seem characterized by too much withdrawal and avoidance. However, the new modeling study simply suggests that we think about what happens when these reflexes failsuddenly you have to think hard to avoid things that used to be avoided reflexively You might for example consider walking down the dangerous alley, be robbed and thus be reminded and taught by additional experience that dark alleys are to be avoided.

In this study Prof. Peter Dayan and Dr. Quentin Huys built a reinforcement learning model of reflexive choices. Agents take actions and as a result of these move through a set of states, some of which are rewarded or punished. As agents progress through this space, they learn the value of each statehow much punishment or reward is to be expected from this state onwards.

It turns out that adding to the agents behavioural repertoire a simple reflex, which guides the agent away from an action with potential for poor consequences, does two things: it increases the rewards reaped overall, but, because bad states are now not explored any more, it also preven
'/>"/>

Contact: Mary Kohut
Press@plos.org
415-568-3457
Public Library of Science
Source:Eurekalert

Page: 1 2

Related biology news :

1. Women more depressed and men more impulsive with reduced serotonin functioning
2. deCODE discovers cause of major subtype of glaucoma
3. Study begins to reveal clues to the cause and progression of sepsis
4. Bleeding, not inflammation, is major cause of early lung infection death
5. Gamma globulin effective in treating eye infections caused by adenoviruses
6. Hidden interactions between predators and prey: evolution causes cryptic dynamics in ecology
7. Spaceflight shown to alter ability of bacteria to cause disease
8. Grubs passion for plastic causes water loss
9. Human embryonic stem cells remain embryonic because of epigenetic factors
10. Salmonid hatcheries cause stunning loss of reproduction
11. Researchers find evidence linking stress caused by the Sept. 11 disaster with low birth weights
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/29/2014)... been blamed for increasing the risk of a ... history of schizophrenia, are widely accepted. Others, such ... parasite transmitted by soil, undercooked meat and cat ... new study by Gary Smith, professor of population ... School of Veterinary Medicine, used epidemiological modeling methods ...
(Date:10/29/2014)... York City on September 19, 2014, leading geneticist and ... of Genome Sciences and Medicine at the University of ... of Tel Aviv University, was awarded the 2014 Lasker-Koshland ... to her honorary degree from TAU, Prof. King was ... Medicine, and for the past 18 years she has ...
(Date:10/29/2014)... An innovative workflow reveals new research potential of the ... recently published article in the Biodiversity Data ... BOLD in tabular format and imported these into a ... Writting Tool (PWT). Data were used to study ... wasps from the Microgastrinae subfamily. , BOLD is originally ...
Breaking Biology News(10 mins):Penn vet professor investigates parasite-schizophrenia connection 2Penn vet professor investigates parasite-schizophrenia connection 3Geneticist and humanitarian: Prof. Mary-Claire King receives Lasker Award 2Go straight and publish: From Barcode of Life Data Systems to scholarly publishing systems 2
... latest-generation DNA sequencing technology to become the first explorers ... "This project is one of the first attempts to ... than a single organism," says Nicole Gerardo, assistant professor ... we can understand how these ants have evolved to ...
... the Centers for Disease Control and Prevention (CDC) found ... by age of menarche and total number of lifetime ... over the course of a woman,s lifetime may influence ... this study are published in Cancer Epidemiology, Biomarkers ...
... We see the face of the Virgin Mary staring up ... portion of our meal for $37,000 on eBay. We believe in ... science offers a wealth of rational explanations for natural phenomena, we ... And we,ll even go to war to protect our delusions against ...
Cached Biology News:Landmark project to map genomics of complex ant systems 22 reproductive factors are important predictors of death from ovarian cancer 22 reproductive factors are important predictors of death from ovarian cancer 3Our 'caveman logic' embraces ESP over evolution 2
(Date:10/30/2014)... Oct. 30, 2014  Ardelyx, Inc. (NASDAQ: ... on cardio-renal, gastrointestinal and metabolic diseases, today announced ... results on Thursday, November 6, 2014. Following the ... live conference call and webcast at 4:30pm ET ... a business update. The live webcast ...
(Date:10/30/2014)... On October 26th at the Mid ... leading applied stem cell research scientist Neil Riordan, ... talks on New Techniques for Enhancing Stem Cell ... Cells. , Dr. Riordan focused on historical medical ... AlphaGEMS that include: wound healing; inflammation and pain ...
(Date:10/30/2014)... 30, 2014 James Sherley says he has ... tissue stem cell technology since his days as a principal ... in the late 1990’s. Sherley founded the ASCTC as ... holds all the intellectual property developed in Sherley’s research over ... Massachusetts Institute of Technology (MIT), and more recently as a ...
(Date:10/30/2014)... 30, 2014 Avure Technologies celebrates a year ... newest member of its fleet of high volume High Pressure ... anniversary as we return to PackExpo this year, which is ... Las Vegas,” said Jeff Williams, CEO at Avure. “Sales of ... pleased to be meeting the challenges of market demand for ...
Breaking Biology Technology:Ardelyx to Report Third Quarter 2014 Financial Results on November 6, 2014 2Riordan-McKenna Institute Founders, Neil Riordan, PhD and Orthopedic Surgeon, Dr. Wade McKenna Present at the Mid American Regenerative and Cellular Medicine Showcase 2Riordan-McKenna Institute Founders, Neil Riordan, PhD and Orthopedic Surgeon, Dr. Wade McKenna Present at the Mid American Regenerative and Cellular Medicine Showcase 3Riordan-McKenna Institute Founders, Neil Riordan, PhD and Orthopedic Surgeon, Dr. Wade McKenna Present at the Mid American Regenerative and Cellular Medicine Showcase 4Boston’s Adult Stem Cell Technology Center, LLC Introduces A New Technology for Monitoring Previously Elusive Adult Stem Cells 2Boston’s Adult Stem Cell Technology Center, LLC Introduces A New Technology for Monitoring Previously Elusive Adult Stem Cells 3Boston’s Adult Stem Cell Technology Center, LLC Introduces A New Technology for Monitoring Previously Elusive Adult Stem Cells 4In High Demand: New High Pressure Processing (HPP) System with Maximum Throughput Drives Strong Sales 2In High Demand: New High Pressure Processing (HPP) System with Maximum Throughput Drives Strong Sales 3
... VEGAS, Oct. 21 Altogen Biosystems announced the release ... reagent ( http://www.altogen.com/mirna.php ) in the company,s popular in ... Kit. This reagent is also compatible for in vivo ... and small proteins. The company also offers custom encapsulation ...
... Mass., Oct. 21 Sermo ( http://www.sermo.com ), the ... Sermo Report titled, " Physician Participation in the ESA ... participation rates in the FDA-required Erythropoiesis-Stimulating Agents (ESAs) risk ... to the results, 83% of Hematologists/Oncologists view the ESA ...
... Oct. 21 Cord Blood America, Inc . ( ... umbilical cord blood stem cell preservation company focused ... nationwide and internationally, is pleased to announce that Chairman, CEO ... Operations, will appear for one hour live on "Go Rogue ...
Cached Biology Technology:PEG-Liposome siRNA In Vivo Transfection Kit From Altogen Biosystems 2Sermo Report Indicates Possible Decline in Prescribing of Erythropoiesis-Stimulating Agents 2Cord Blood America Management Team to Appear on National VoiceAmerica Radio Network 2
This issue concentrated on the purification of proteins for specific purposes (i.e. large-scale purification, purification for therapeutic use, etc.)...
... Dunbar (1994) • This book describes ... methods for preparing samples for protein ... radiometric and bioluminescence-enhanced detection systems are ... the detection and characterization of glycoprotein ...
All serum is collected from U.S.D.A. fryers and broilers. Pricing: $15/unit for 1 - 10 units; $12/unit for 11 - 50 units...
Human HAPLN1 MAb (Clone 316119) Protein Family: Hyaluronan (HA) & HA Binding Proteins, Proteoglycan Regulators...
Biology Products: