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Why serotonin can cause depression and anxiety
Date:2/4/2008

Mood disorders could be caused by a loss of our inherent, reflexive avoidance of aversive events, according to a study published in PLoS Computational Biology. Researchers from UCL in London and Columbia University in New York used computational modeling techniques to integrate what appeared to be blatant contradictions between serotonins roles in different states of health.

Serotonin appears to be one of the major players in mood and a variety of other disorders. But exactly how remains an open question. Imagine walking past a dark alleyway in a dangerous part of some city; although it might be a shortcut, most people wouldnt consider taking it. In healthy subjects, serotonin appears important for this automatic avoidance.

It has long been suggested that over-activity of the serotonin system may relate to mood disorders such as depression and anxiety, as these seem characterized by too much withdrawal and avoidance. However, the new modeling study simply suggests that we think about what happens when these reflexes failsuddenly you have to think hard to avoid things that used to be avoided reflexively You might for example consider walking down the dangerous alley, be robbed and thus be reminded and taught by additional experience that dark alleys are to be avoided.

In this study Prof. Peter Dayan and Dr. Quentin Huys built a reinforcement learning model of reflexive choices. Agents take actions and as a result of these move through a set of states, some of which are rewarded or punished. As agents progress through this space, they learn the value of each statehow much punishment or reward is to be expected from this state onwards.

It turns out that adding to the agents behavioural repertoire a simple reflex, which guides the agent away from an action with potential for poor consequences, does two things: it increases the rewards reaped overall, but, because bad states are now not explored any more, it also preven
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Contact: Mary Kohut
Press@plos.org
415-568-3457
Public Library of Science
Source:Eurekalert

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