Navigation Links
Why cells stick: Phenomenon extends longevity of bonds between cells
Date:2/14/2013

transducers that allow us to measure force on the scale of pico-newtons," said Zhu. "We prepare the samples in such a way that we engage only one bond, then we control the application of force and observe what happens."

The researchers first used an atomic force microscope to bring the integrin molecule together with the fibronectin, then separate the two. Instruments measured the pico-newton forces required to separate the molecules, and found that the duration of the bonds increased with the repetition of the contacts.

The second technique, known as BFP, involved the use of a fibronectin-bearing glass bead attached to a red blood cell aspirated by a micropipette. Integrin expressed on the micropipette-aspirated cell was pressed into the bead, then pulled away over repeated cycles. Lifetime measurement confirmed that repeated pulling increased the longevity of the bonds.

The researchers studied two integrins, part of a family of 24 related molecules that operate in humans. In future work, they hope to determine whether or not the cyclic mechanical reinforcement they observed is a universal property of many cellular adhesion molecules.

The researchers also hope to explore how cells use this cyclic mechanical reinforcement. Because many disease processes result from abnormal cellular adhesion mechanisms, a better understanding could provide insights into how cardiovascular disease, cancer and immune system disorders operate.

"The findings of the paper have deep implications for our understanding of force-regulated signaling," added Humphries. "There is abundant biological evidence for profound effects of extracellular tensility and elasticity in controlling processes such as cancer cell proliferation and stem cell differentiation, but the mechanisms whereby this information is transduced across the outer cell membrane are unclear."


'/>"/>

Contact: John Toon
jtoon@gatech.edu
404-894-6986
Georgia Institute of Technology
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Long noncoding RNAs control development of fat cells
2. Research improving breast cancer treatment by targeting tumor initiating cells
3. Artificial atoms allow for magnetic resonance on individual cells
4. Tumor blood vessels prevent the spread of cancer cells
5. Peering into living cells -- without dye nor fluophore
6. Experimental drug combination selectively destroys lymphoma cells
7. Nanostructures with living cells
8. Changes to DNA on-off switches affect cells ability to repair breaks, respond to chemotherapy
9. Listening to cells: Scientists probe human cells with high-frequency sound
10. New methods for quantifying antisense drug delivery to target cells and tissues
11. Programming cells: The importance of the envelope
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Why cells stick: Phenomenon extends longevity of bonds between cells
(Date:4/17/2015)... Canada , April 17, 2015 ... growing security concerns, and technological advancement to drive ... until 2020   According ... Saudi Arabia Biometric Systems Market Forecast &  Opportunities, 2020 ", biometric systems ... is projected to register growth at CAGR of ...
(Date:4/14/2015)... OXFORD, Conn. , April 14, 2015 ... "Company"), a biometric authentication company focused on the growing ... has been nominated for the 2015 New York Design ... The Design100, New York City Design Awards are ... are based on over 2,500 ratings from the marketplace, ...
(Date:4/13/2015)... , April 13, 2015  higi, a leading cloud-based ... to more fully engage with their communities around health ... privacy protected and secure API.  ... the most accessible, affordable, and convenient vehicle to receive ... The API will allow higi,s ...
Breaking Biology News(10 mins):Saudi Arabia Biometric Systems Market to Grow at 22% Through 2020, Says TechSci Research 2Saudi Arabia Biometric Systems Market to Grow at 22% Through 2020, Says TechSci Research 3NXT-ID's Wocket Smart Wallet Nominated for 2015 New York Design Awards in 'Product Design- Technology' 2NXT-ID's Wocket Smart Wallet Nominated for 2015 New York Design Awards in 'Product Design- Technology' 3higi Launches Seamless Access to HIPAA-Compliant Health Outcomes and Activity Data 2higi Launches Seamless Access to HIPAA-Compliant Health Outcomes and Activity Data 3
... Greenland ice sheet can experience extreme melting even when temperatures ... Dr. Marco Tedesco, assistant professor in the Department of Earth ... His findings suggest that glaciers could undergo a self-amplifying ... halt. "We are finding that even if you don,t ...
... of us would love nothing more than to trick ourselves into ... a new brain imaging study reported in the November issue of ... just be a way. The key is to go with our ... findings suggest that a simple hormone-inspired pill could be the long-sought ...
... -- With salmonella-tainted ground turkey sickening more than 100 ... ability to detect outbreaks of food-borne illness and determine ... A new approach, reported online Oct. 14 in the ... collaborative team led by Cornell University scientists, will enable ...
Cached Biology News:Extreme melting on Greenland ice sheet, reports CCNY team 2Extreme melting on Greenland ice sheet, reports CCNY team 3Simple gut hormone combo makes our brains think we're full 2New test can precisely pinpoint food pathogens 2
(Date:5/21/2015)... - SQI Diagnostics Inc. ("SQI" or the "Company") (TSX-V: ... commercializes proprietary technologies and products for advanced microarray diagnostics, ... second fiscal quarter ended March 31, 2015. ... business with our existing customers and to develop new ... of SQI. "The delivery of a fully automated sqidlite™ ...
(Date:5/21/2015)... 2015 Specialty Pharmacy Times has ... admitted to BPA Worldwide as a business publication ... audience data for Specialty Pharmacy Times based on ... becoming a member of BPA Worldwide, Specialty Pharmacy ... clients with the most reliable, unequaled data,” said ...
(Date:5/21/2015)... 21, 2015  Prima Biomed Ltd. (NASDAQ: PBMD ... to become a leader in the development of immunotherapeutic ... the final CVac data from the Phase II CAN-003 ... for a clinically meaningful improvement in Overall Survival ("OS") ... In the group of second remission patients ...
(Date:5/21/2015)... , May 21, 2015  The EveryLife ... Hatch (R-UT) and Amy Klobuchar ... Now Accelerating Cures & Treatments, or OPEN ACT. ... disease patient advocacy organizations, this bipartisan legislation promises ... affordable medicines to rare disease patients by incentivizing ...
Breaking Biology Technology:SQI Diagnostics Reports Second Quarter Financial Results 2SQI Diagnostics Reports Second Quarter Financial Results 3SQI Diagnostics Reports Second Quarter Financial Results 4SQI Diagnostics Reports Second Quarter Financial Results 5SQI Diagnostics Reports Second Quarter Financial Results 6SQI Diagnostics Reports Second Quarter Financial Results 7SQI Diagnostics Reports Second Quarter Financial Results 8Specialty Pharmacy Times Joins BPA Worldwide 2Correction Continues after Big Move - BrokerBank Securities, Inc. 2Advocates Cheer Senate Leaders for Introducing Bipartisan Bill to Increase Number of Rare Disease Treatments 2
... Thoratec Corporation,(Nasdaq: THOR ), a world ... and restore failing hearts, said today that it will,be ... on,Wednesday, January 14. , Gary ... on the company, beginning at 9 a.m., Pacific Standard ...
... 6 Halozyme Therapeutics, Inc. (Nasdaq: ... products targeting the extracellular matrix for the endocrinology, ... receipt of $5.5 million from Baxter Healthcare Corporation ... the terms of its HYLENEX licensing agreement, which ...
... 6 The Susan G. Komen for the ... in Indianapolis has partnered with,BioStorage Technologies, Inc. (BST) ... will store a third of the tissue bank,s ... including,samples being collected during the tissue bank,s upcoming ...
Cached Biology Technology:BioStorage Technologies Partners with Susan G. Komen for the Cure(R) Tissue Bank at the IU Simon Cancer Center in Breast Cancer Research Initiative 2BioStorage Technologies Partners with Susan G. Komen for the Cure(R) Tissue Bank at the IU Simon Cancer Center in Breast Cancer Research Initiative 3
Fast, sensitive quantitation of Mouse IgM concentration....
Request Info...
... anti-rabbit IgG FITC is used as ... staining on tissues or culture cells ... in rabbits. It is highly recommended ... omitting the primary antibody, be included ...
1000X solution used for inducing CopyControl™ based vectors to high copy numbers...
Biology Products: