Navigation Links
Why cells stick: Phenomenon extends longevity of bonds between cells
Date:2/14/2013

partment of Biomedical Engineering at Georgia Tech and Emory University and the study's corresponding author. "The cells respond to their environment, which includes many mechanical aspects. This study has extended our understanding of how connections are made and how mechanical forces regulate interactions."

The research was published online by the journal on February 14th. The work was supported by the National Institutes of Health (NIH) and the Wellcome Trust.

Cells of the body regulate adhesion in response to both internally- and externally-applied forces. This is particularly important to adhesion mediated by proteins such as integrins that connect the extracellular matrix to the cytoskeleton and provide cells with both mechanical anchorages and the means to initiate signaling.

Using delicate force measuring equipment, researchers in Zhu's lab and the laboratory of Andres Garcia a professor in the Woodruff School of Mechanical Engineering at Georgia Tech collaborated to study adhesion between integrin and fibronectin, a protein component of the extracellular matrix. What they found was that cyclic forces applied to the bond switch it from a short lived state with lifetimes of about one second to a long-lived state that can exist for more than a hundred seconds.

"Force can be very important in biology," said Zhu. "Force has direction, magnitude and duration, so in describing its effects on biological systems, you have to use a more complete language."

Zhu, Garcia and Georgia Tech graduate students Fang Kong, William Parks and David Dumbauld along with postdoctoral fellow Zenhai Li used two different mechanical techniques to study the strength of bonds between integrin and fibronectin. One technique measured the bond strengths in purified molecules, while the other studied the effects of them in their native cellular environment.

"We have very precise force
'/>"/>

Contact: John Toon
jtoon@gatech.edu
404-894-6986
Georgia Institute of Technology
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Long noncoding RNAs control development of fat cells
2. Research improving breast cancer treatment by targeting tumor initiating cells
3. Artificial atoms allow for magnetic resonance on individual cells
4. Tumor blood vessels prevent the spread of cancer cells
5. Peering into living cells -- without dye nor fluophore
6. Experimental drug combination selectively destroys lymphoma cells
7. Nanostructures with living cells
8. Changes to DNA on-off switches affect cells ability to repair breaks, respond to chemotherapy
9. Listening to cells: Scientists probe human cells with high-frequency sound
10. New methods for quantifying antisense drug delivery to target cells and tissues
11. Programming cells: The importance of the envelope
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Why cells stick: Phenomenon extends longevity of bonds between cells
(Date:11/18/2014)... The Parenteral Drug Association (PDA) today confirmed that seven officials ... least seven more will participate in the upcoming 2014 PDA ... Washington D.C. , Dec. 2-4. ... the regulatory agencies in the United States ... to help advance the use of metrics in the regulatory ...
(Date:11/10/2014)... Laundry detergent pods began appearing on U.S. store shelves ... growing numbers ever since. The small packets can be ... measure out a liquid or powder. The convenience, though, ... new study from researchers at Nationwide Children,s Hospital found ... received reports of 17,230 children younger than 6 years ...
(Date:11/6/2014)... occur because of metastasis, yet progress in preventing ... , "It,s been particularly challenging to design drugs ... fellow in systems biology at Harvard Medical School. ... after they,ve already metastasized." , Gujral and colleagues ... help researchers better understand how metastasis begins. Their ...
Breaking Biology News(10 mins):FDA's Janet Woodcock, EMA's Emer Cooke Headline PDA Quality Metrics Conference 2Study finds laundry detergent pods, serious poisoning risk for children 2Migration negation 2Migration negation 3
... 18, 2007 UT Southwestern Medical Center researchers have found ... often excludes a group of obese patients at risk of ... issue of the journal Surgery for Obesity and Related ... relationship between body mass index (BMI) and cardiovascular disease as ...
... VA (Dec. 17, 2007) New research from the University ... 1 myotonic muscular dystrophy (DM1), a well known heart ... form of muscular dystrophy in adults and affects approximately 40,000 ... is a biomarker for heart stem cells. It is ...
... pollution, like catching criminals, requires evidence and witnesses; but ... enough detectors is easier said than done. ... policy specialists at Arizona State University may soon change ... they have developed a new way to close the ...
Cached Biology News:BMI criteria for obesity surgery should be lowered, UT Southwestern researcher suggests 2UVA reports surprising findings related to myotonic muscular dystrophy 2ASU researchers use NASA satellites to improve pollution modeling 2
(Date:11/21/2014)... 2014 The science of light and ... with more than 200 primary students in a traveling ... University of Otago Physics Department and funded by an ... members of the university’s OSA/SPIE Student Chapter visited six ... giving children from small, rural schools hands-on lessons in ...
(Date:11/21/2014)... 20, 2014 The report, ... Oligos, Enzymes, Cloning kits), Technology (Bioinformatics, Nanotechnology, ... Pharmaceuticals, Biomaterials, Bioremediation) - Global Forecast to ... drivers, threats, opportunities, and challenges. , Browse ... spread through 185 pages and in-depth TOC ...
(Date:11/21/2014)... 21, 2014 2014 Deep Research ... is a professional and in-depth research report on ... information, like its definition, classification, application, and ... This report covers the international market analysis, including ... as the US, Europe, Asia, China, Japan etc. ...
(Date:11/21/2014)... DIEGO , Nov. 20, 2014  Cytori Therapeutics (NASDAQ: ... Marc Hedrick , M.D. will present live at VirtualInvestorConferences.com on ... 2014 TIME:    11:15 am PT / 2:15 pm ... URL into your browser,s address bar: http://bit.ly/1B2KGaL ... and receive event updates. This will be ...
Breaking Biology Technology:Optics and photonics outreach programs share science, spark fascination with light 2Optics and photonics outreach programs share science, spark fascination with light 3Synthetic Biology Market Expected to Reach $5,630.4 Million in 2018 - New Report by MarketsandMarkets 2Synthetic Biology Market Expected to Reach $5,630.4 Million in 2018 - New Report by MarketsandMarkets 3Synthetic Biology Market Expected to Reach $5,630.4 Million in 2018 - New Report by MarketsandMarkets 4Sodium Ferrocyanide Market: Analysis for Global & China Regions Development Trends Available at DeepResearchReports.com 2Sodium Ferrocyanide Market: Analysis for Global & China Regions Development Trends Available at DeepResearchReports.com 3Cytori Therapeutics to Provide Corporate Update and Investor Presentation on December 4 through a Live, Interactive Webcast 2Cytori Therapeutics to Provide Corporate Update and Investor Presentation on December 4 through a Live, Interactive Webcast 3Cytori Therapeutics to Provide Corporate Update and Investor Presentation on December 4 through a Live, Interactive Webcast 4
... Madison, Wis . - Every surgical operation requires proper ... complications, and a Madison start-up business has received a ... products. , , Nerites Corp ., which develops tissue ... has received a $100,000 Small Business Innovation Research ...
... initiatives continue to experience high rates of failure. As ... as a valued partner. The result stifles innovation, growth, ... to IT requires shedding the flawed processes of yesterday, ... and business by promising incremental delivery of functional software. ...
... of transforming more health research into clinical practice, the ... research entity - the Institute for Clinical and Translational ... four UW-Madison health sciences schools: Medicine and Public Health, ... the Marshfield Clinic Research Foundation, the research arm of ...
Cached Biology Technology:Agile Revolution: A new era of software delivery 2Agile Revolution: A new era of software delivery 3Agile Revolution: A new era of software delivery 4
HNF-1 Purified Anti-Mouse, Anti-Rat, Anti-Rabbit, Anti-Human clone 2, Isotype Mouse IgG 1 , 50 µg Consult technical datasheet for details....
... Immunogen KLH-conjugated, ... acids 54-75 (RRGPHRNPG-PGDDDGQRSRSSS) of mouse ... mapped to amino acids 62-75. ... Routinely evaluated by immunoblot. ...
EDG-1 Western blot control Source: Cell Lysate Application: Western Blotting Control...
Complete cell culture media with cytokines...
Biology Products: