Navigation Links
Why cells stick: Phenomenon extends longevity of bonds between cells
Date:2/14/2013

Research carried out by scientists at the Georgia Institute of Technology and The University of Manchester has revealed new insights into how cells stick to each other and to other bodily structures, an essential function in the formation of tissue structures and organs. It's thought that abnormalities in their ability to do so play an important role in a broad range of disorders, including cardiovascular disease and cancer.

The study's findings are outlined in the journal Molecular Cell and describe a surprising new aspect of cell adhesion involving the family of cell adhesion molecules known as integrins, which are found on the surfaces of most cells. The research uncovered a phenomenon termed "cyclic mechanical reinforcement," in which the length of time during which bonds exist is extended with repeated pulling and release between the integrins and ligands that are part of the extracellular matrix to which the cells attach.

Professor Martin Humphries, dean of the faculty of life sciences at the University of Manchester and one of the paper's co-authors, says the study suggests some new capabilities for cells: "This paper identifies a new kind of bond that is strengthened by cyclical applications of force, and which appears to be mediated by complex shape changes in integrin receptors. The findings also shed light on a possible mechanism used by cells to sense extracellular topography and to aggregate information through 'remembering' multiple interaction events."

The cyclic mechanical reinforcement allows force to prolong the lifetimes of bonds, demonstrating a mechanical regulation of receptor-ligand interactions and identifying a molecular mechanism for strengthening cell adhesion through cyclical forces.

"Many cell functions such as differentiation, growth and the expression of particular genes depend on cell interaction with the ligands of the intracellular matrix," said Cheng Zhu, a professor in the Coulter De
'/>"/>

Contact: John Toon
jtoon@gatech.edu
404-894-6986
Georgia Institute of Technology
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Long noncoding RNAs control development of fat cells
2. Research improving breast cancer treatment by targeting tumor initiating cells
3. Artificial atoms allow for magnetic resonance on individual cells
4. Tumor blood vessels prevent the spread of cancer cells
5. Peering into living cells -- without dye nor fluophore
6. Experimental drug combination selectively destroys lymphoma cells
7. Nanostructures with living cells
8. Changes to DNA on-off switches affect cells ability to repair breaks, respond to chemotherapy
9. Listening to cells: Scientists probe human cells with high-frequency sound
10. New methods for quantifying antisense drug delivery to target cells and tissues
11. Programming cells: The importance of the envelope
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Why cells stick: Phenomenon extends longevity of bonds between cells
(Date:11/7/2014)... 2014 Leading Biometric companies aim to ... revolutionizing online transactions.  Companies in focus today are: NXT-ID, Inc. ... BABA ), Google Inc. (NASDAQ: GOOG ), ... EBAY ) and MasterCard Inc. (NYSE: MA) ... a biometric authentication company focused on the growing mobile commerce ...
(Date:11/6/2014)... - Insilico Medicine, Inc, a Baltimore-based bioinformatics company ... diseases announced a research collaboration with the international ... Inc (OTC: CSBR). , "There are many companies ... Champions Oncology,s TumorGraft technology is unique in a ... experimentally generating vast amounts of valuable data. Our ...
(Date:11/4/2014)... SALT LAKE CITY, Nov. 5, 2014 – University of ... uses enzymes to help jet fuel produce electricity without ... can be used to power portable electronics, off-grid power ... appears online today in the American Chemical Society journal ... into electricity through a chemical reaction between a fuel ...
Breaking Biology News(10 mins):Universal Authentication Methods Provide More Secure Operations for Biometrics Devices - Company Joins FIDO Alliance for Consumer Protection 2Universal Authentication Methods Provide More Secure Operations for Biometrics Devices - Company Joins FIDO Alliance for Consumer Protection 3Universal Authentication Methods Provide More Secure Operations for Biometrics Devices - Company Joins FIDO Alliance for Consumer Protection 4Universal Authentication Methods Provide More Secure Operations for Biometrics Devices - Company Joins FIDO Alliance for Consumer Protection 5Universal Authentication Methods Provide More Secure Operations for Biometrics Devices - Company Joins FIDO Alliance for Consumer Protection 6Insilico Medicine, Inc announces research collaboration with Champions Oncology, Inc 2Jet-fueled electricity at room temperature 2
... at the U.S. Department of Energy,s Lawrence Berkeley National ... into wispy nanoscale ropes that approach the structural complexity ... development in the push to develop self-assembling nanoscale materials ... but which are rugged enough to withstand harsh conditions ...
... Energy,s Pacific Northwest National Laboratory has been recognized for ... The award-winning partnerships are helping analyze trace amounts of ... and more easily study live cells., The Federal Laboratory ... 2011 for Excellence in Technology Transfer. The consortium is ...
... have proven that you don,t have to travel to exotic ... distinctive species of crayfish in Tennessee and Alabama that is ... genetic relative, once thought to be the only species in ... in Kentucky, can grow almost as big as a lobster. ...
Cached Biology News:A nanoscale rope, and another step toward complex nanomaterials that assemble themselves 2A nanoscale rope, and another step toward complex nanomaterials that assemble themselves 3PNNL recognized for technology transfer 2PNNL recognized for technology transfer 3Researchers discover giant crayfish species right under their noses 2Researchers discover giant crayfish species right under their noses 3Researchers discover giant crayfish species right under their noses 4
(Date:11/27/2014)... 27, 2014 The Europe Thermal ... market to provide crucial revenue forecasts. It estimates ... growing at a CAGR of 7.5%, from 2013 ... the Europe Thermal Protective Clothing market report for ... analysis supported by various tables and figures. , ...
(Date:11/27/2014)... First articles published now ... Elsevier , a world-leading provider of scientific, technical ... announce the launch of a new journal: ... The launch of Extreme Mechanics Letters is ... of applied sciences such as micro and nanotechnologies, biotechnologies, ...
(Date:11/26/2014)... NOVEMBER 21, 2014 (PRWEB) November 26, 2014 ... health-oriented communications network, today announced the organization has won ... Rx Club Awards. Digitas Health LifeBrands was honored with ... four other PHCG agencies received eight Awards of Excellence. ... creative aspects of pharmaceutical advertising and promotion. The Awards ...
(Date:11/26/2014)... The North America Thermal Protective Clothing Market report ... of the growth trends and revenue forecasts. It ... 2018, growing at a CAGR of 7.1% from ... of the North America Thermal Protective Clothing Market ... analysis and industry segmentation supported by various tables ...
Breaking Biology Technology:The Europe Thermal Protective Clothing market is estimated to grow up to $577.9 million by 2018 - Report by MicroMarket Monitor 2The Europe Thermal Protective Clothing market is estimated to grow up to $577.9 million by 2018 - Report by MicroMarket Monitor 3Elsevier Announces the Launch of a New Journal: Extreme Mechanics Letters 2Elsevier Announces the Launch of a New Journal: Extreme Mechanics Letters 3Publicis Healthcare Wins 20 Rx Club Awards 2Publicis Healthcare Wins 20 Rx Club Awards 3The North America Thermal Protective Clothing Market is estimated to grow up to $616.3 million by 2018 - Report by MicroMarket Monitor 2The North America Thermal Protective Clothing Market is estimated to grow up to $616.3 million by 2018 - Report by MicroMarket Monitor 3
... using Adult Stem Cells drives,awareness among viewers; NeoStem ... NEW YORK, Oct. 8 NeoStem, Inc. (Amex: ... processing and long-term,storage of adult stem cells for ... adult stem cell public awareness program, a key ...
... VRUS ) management will present at the ... 13-14, 2008 at the Waldorf Astoria,in New York ... an overview of the company on Monday, October ... Pharmasset is a clinical-stage pharmaceutical company committed ...
... LS9, Inc., the,Renewable Petroleum Company(TM), today announces it ... Haywood brings over 30 years of,experience in the ... of,planning, engineering, execution and start-up of major projects ... be pivotal to LS9 as the company delivers,significant ...
Cached Biology Technology:Suzanne Somers, Renowned Author, Medical Advocate, and Official Spokesperson for NeoStem, Inc., Inspires the Audience on The Ellen Degeneres Show 2Suzanne Somers, Renowned Author, Medical Advocate, and Official Spokesperson for NeoStem, Inc., Inspires the Audience on The Ellen Degeneres Show 3Suzanne Somers, Renowned Author, Medical Advocate, and Official Spokesperson for NeoStem, Inc., Inspires the Audience on The Ellen Degeneres Show 4LS9, Inc. Appoints Bill Haywood Chief Executive Officer 2