Navigation Links
Why cells stick: Phenomenon extends longevity of bonds between cells
Date:2/14/2013

Research carried out by scientists at the Georgia Institute of Technology and The University of Manchester has revealed new insights into how cells stick to each other and to other bodily structures, an essential function in the formation of tissue structures and organs. It's thought that abnormalities in their ability to do so play an important role in a broad range of disorders, including cardiovascular disease and cancer.

The study's findings are outlined in the journal Molecular Cell and describe a surprising new aspect of cell adhesion involving the family of cell adhesion molecules known as integrins, which are found on the surfaces of most cells. The research uncovered a phenomenon termed "cyclic mechanical reinforcement," in which the length of time during which bonds exist is extended with repeated pulling and release between the integrins and ligands that are part of the extracellular matrix to which the cells attach.

Professor Martin Humphries, dean of the faculty of life sciences at the University of Manchester and one of the paper's co-authors, says the study suggests some new capabilities for cells: "This paper identifies a new kind of bond that is strengthened by cyclical applications of force, and which appears to be mediated by complex shape changes in integrin receptors. The findings also shed light on a possible mechanism used by cells to sense extracellular topography and to aggregate information through 'remembering' multiple interaction events."

The cyclic mechanical reinforcement allows force to prolong the lifetimes of bonds, demonstrating a mechanical regulation of receptor-ligand interactions and identifying a molecular mechanism for strengthening cell adhesion through cyclical forces.

"Many cell functions such as differentiation, growth and the expression of particular genes depend on cell interaction with the ligands of the intracellular matrix," said Cheng Zhu, a professor in the Coulter De
'/>"/>

Contact: John Toon
jtoon@gatech.edu
404-894-6986
Georgia Institute of Technology
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Long noncoding RNAs control development of fat cells
2. Research improving breast cancer treatment by targeting tumor initiating cells
3. Artificial atoms allow for magnetic resonance on individual cells
4. Tumor blood vessels prevent the spread of cancer cells
5. Peering into living cells -- without dye nor fluophore
6. Experimental drug combination selectively destroys lymphoma cells
7. Nanostructures with living cells
8. Changes to DNA on-off switches affect cells ability to repair breaks, respond to chemotherapy
9. Listening to cells: Scientists probe human cells with high-frequency sound
10. New methods for quantifying antisense drug delivery to target cells and tissues
11. Programming cells: The importance of the envelope
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Why cells stick: Phenomenon extends longevity of bonds between cells
(Date:6/25/2015)... 25, 2015  TAKE Solutions Ltd., a global business ... United States Patent and Trademark Office (USPTO) for its ... TAKE Solutions, Clinical Accelerators to reduce the time taken ... to standardization without the accelerators), thus reducing time to ... At the heart of the patented Clinical Data ...
(Date:6/24/2015)... 2015  Synaptics Inc. (NASDAQ: SYNA ), ... announced that Sharp has selected its industry-leading Natural ... its latest flagship smartphone device, the AQUOS ZETA ... shipments of its fingerprint ID sensor technology, this ... and leadership in the biometrics market through its ...
(Date:6/23/2015)... Minn. , June 23, 2015   ... company that supports the entire spectrum of clinical ... iMedNet ™ , the company,s intuitive, ... been awarded a Silver 2015 Stevie® Award by ... Health Products & Services Website category.  The American ...
Breaking Biology News(10 mins):TAKE Solutions Awarded Patent By USPTO 2Synaptics Brings Natural ID Technology to Sharp's Newest Flagship Smartphone 2MedNet Solutions' iMedNet eClinical Wins Silver Stevie Award 2
... URBANA - A tool commonly used by financial strategists ... stock portfolio was used to develop a diversified portfolio of ... purposes given the uncertainty about climate change. Instead of ... a stock, University of Illinois environmental economist Amy Ando and ...
... WEST LAFAYETTE, Ind. - The brown tissue that signals ... large producers and home gardeners, but a Purdue University researcher ... the disease sitting on a shelf for 20 years. ... transgenic tomato with a thicker juice that yields 10 percent ...
... A new initiative aims to build a grand tree of ... living things are related, from the tiniest bacteria to the ... for more than 150 years, ever since Charles Darwin drew ... in fleshing out the major branches of the tree of ...
Cached Biology News:Financial tool considered climate change uncertainty to select land for conservation 2Financial tool considered climate change uncertainty to select land for conservation 3Blossom end rot plummets in Purdue-developed transgenic tomato 2Researchers aim to assemble the tree of life for all 2 million named species 2Researchers aim to assemble the tree of life for all 2 million named species 3
(Date:7/27/2015)... 2015   Inocucor Technologies Inc ., the ... for farmers, has received a notice of allowance ... its patent application to protect Inocucor consortia and ... enhance yields on farms and in greenhouses. ... IN-M1 microbial consortium and its fermentation byproducts, which ...
(Date:7/27/2015)... , July 27, 2015 According ... by Type (Home-brew Media, Pre-formulated Media), by Application (Biobanking, Regenerative ... , Europe , Asia-Pacific ... 2019", The global biopreservation media market was valued at $247.7 ... $571.5 million by 2019, at a CAGR of 18.2% between ...
(Date:7/27/2015)... 27, 2015 IDEXX Laboratories, Inc. (NASDAQ: ... have submitted over 100,000 specimens to IDEXX Reference Laboratories ... first 10 days since the breakthrough kidney function test ... a leading cause of suffering and death in cats ... consistent with generally accepted kidney disease prevalence data showing ...
(Date:7/25/2015)... ... 2015 , ... Technology leader Anton Paar offers the ... surface temperature of the measuring prism. This is required to achieve the most ... are key requirements. It is likely that no refractometer manufacturers on the market ...
Breaking Biology Technology:Inocucor Technologies Receives Groundbreaking U.S. Patent for Proprietary Biological Processes that Stimulate Plant Growth 2Inocucor Technologies Receives Groundbreaking U.S. Patent for Proprietary Biological Processes that Stimulate Plant Growth 3Global Biopreservation Media Market to be Worth $571.5 Million by 2019 2Global Biopreservation Media Market to be Worth $571.5 Million by 2019 3Over 100,000 Pets Tested with New IDEXX SDMA Kidney Function Test Since Product Launch on July 13 2Over 100,000 Pets Tested with New IDEXX SDMA Kidney Function Test Since Product Launch on July 13 3Over 100,000 Pets Tested with New IDEXX SDMA Kidney Function Test Since Product Launch on July 13 4Over 100,000 Pets Tested with New IDEXX SDMA Kidney Function Test Since Product Launch on July 13 5It’s T-Time for Refractometers: On-site Temperature Check Now Available 2
... , , INCLINE VILLAGE, Nev., Sept. 18 ... an adjustment to the conversion rate for its 2.00% Convertible Senior Notes ... 94.447 shares of common stock per $1,000 principal amount of the Notes, ... 89.165 shares of common stock per $1,000 principal amount of the Notes. ...
... , 10 Years of Planning for Unique Reefs ... CHARLESTON, S.C., Sept. 18 Environmental Defense Fund saluted the ... protect what may be Earth,s largest deepwater coral ecosystem off the ... A veritable wonderland of marine life, the 25,000-square-mile area is among ...
... , TUSTIN, Calif., Sept. 18 AMDL ... in China, announced today its stockholders have approved by verbal consent the ... Corporation" . The new ticker symbol on the New York ... Company has filed an amendment to its ,Articles of Incorporation, to implement ...
Cached Biology Technology:PDL BioPharma Announces Conversion Rate Adjustment for Its 2.00% Convertible Senior Notes Due February 15, 2012 2Big Win for Huge Coral Reefs off NC, SC, Georgia, Florida 2AMDL Inc. Announces Stockholder Approval of Name Change and Issuance of a New Trading Symbol on the NYSE Alternext US 2AMDL Inc. Announces Stockholder Approval of Name Change and Issuance of a New Trading Symbol on the NYSE Alternext US 3AMDL Inc. Announces Stockholder Approval of Name Change and Issuance of a New Trading Symbol on the NYSE Alternext US 4AMDL Inc. Announces Stockholder Approval of Name Change and Issuance of a New Trading Symbol on the NYSE Alternext US 5
...
...
D.R. Harper and C. Grose (1994) • Includes: virus structure & replication, fundamental virology, immunology and pathogenesis, vaccines and antiviral drugs, novel diagnostic techniques, cloning a...
IHC Polymer Detection Kit (Rabbit DAB)150 slides...
Biology Products: