Navigation Links
Why anandamide can increase intracellular Ca2+ concentration?
Date:7/11/2014

Evidence exists that cannabinoid receptor type 1 can inhibit voltage-gated calcium channel, decrease intracellular Ca2+ influx, and reduce neurotransmitter release. However, some scholars demonstrated that cannabinoid receptor type 1 can increase extracellular Ca2+ influx and increase neurotransmitter release. Dr. Yi Zhang and his team, Tongji Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, China used whole cell voltage-clamp and calcium imaging in cultured trigeminal ganglion neurons and found that anandamide directly caused Ca2+ influx, which then triggered an increase of intracellular Ca2+ concentration. Inhibition of voltage-gated calcium channel by anandamide and increase in intracellular Ca2+ concentration by anandamide are two independent events. The underlying mechanisms are similar, both are bidirectional. That is to say, low concentration of anandamide exerts effects by activating cannabinoid receptor type 1 and high concentration of anandamide exerts effects by activating cannabinoid receptor type 1 and vanilloid receptor type 1. The signaling pathways involved in two independent events are different. Protein kinase C signaling pathway is involved in anandamide inhibition of voltage-gated calcium channel, but it does not participate in the process during which anandamide increases intracellular Ca2+ concentration. These findings provide evidence for studying the mechanism underlying the neural excitatory effects of anandamide. Related results were published in Neural Regeneration Research (Vol. 9, No. 8, 2014).


'/>"/>

Contact: Meng Zhao
eic@nrren.org
86-138-049-98773
Neural Regeneration Research
Source:Eurekalert

Page: 1

Related biology news :

1. Increase in Arctic shipping poses risk to marine mammals
2. Columbia Engineering and Penn researchers increase speed of single-molecule measurements
3. Fertilizer use responsible for increase in nitrous oxide in atmosphere
4. NIST/UMass study finds evidence nanoparticles may increase plant DNA damage
5. Study finds soda consumption increases overall stroke risk
6. Scientists have discovered genes that increase the risk of osteoporosis and fractures
7. Family history of liver cancer increases risk of developing the disease
8. Research shows how PCBs promote dendrite growth, may increase autism risk
9. Increased fructose consumption may deplete cellular energy in patients with obesity and diabetes
10. NIH-led study finds genetic test results do not trigger increased use of health services
11. Flapping protective wings increase lift
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/17/2014)... Valencell, a leader in performance biometric data sensor technology, ... such as Intel, Jabra, Atlas, and Scosche to develop ... products will be showcased at CES 2015, taking place ... "Our partners choose PerformTek biometrics, because ...
(Date:12/11/2014)... 09, 2014 Research and Markets , ... ) has announced the addition of the "Biometrics ... offering. One major trend emerging in ... in technology, it is important to upgrade biometric solutions ...
(Date:12/10/2014)... 2014 You,ve been here before: you desperately need to sign ... key or the answer to your secret question. What,s your dog,s ... Hoyos Labs , a digital infrastructure security company, launches ... frustration that comes with usernames, passwords and PINs – 1U ...
Breaking Biology News(10 mins):Valencell PerformTek Biometrics Power the Most Accurate Wearables at CES 2015 2Biometrics Market in the APAC Region 2015-2019: Key Vendors are 3M Cogent, NEC, Safran and Suprema 2The Password is Finally Dead: Launch of 1U Mobile App Eliminates Need for All Usernames and Passwords 2The Password is Finally Dead: Launch of 1U Mobile App Eliminates Need for All Usernames and Passwords 3
... by scientists at the University of York and Yunnan ... management of cattle populations in northern China, around the ... East, over 10,000 years ago., The domestication of cattle ... researchers believed that humans started domesticating cattle around 10,000 ...
... Fortune has studied glass knifefish, a species of three-inch long ... laboratory he tries to understand how their tiny brains control ... intrigued by the special "ribbon fin" that knifefish use to ... allowing the fish to move forward or backward. Biologists have ...
... researchers says in a new paper that climate science ... practical applications for dealing with the myriad impacts of ... does much of the organizational structure, they say, to ... snowpack, to severe storms, to sea level rise. What ...
Cached Biology News:Researchers uncover origins of cattle farming in China 2A fish that pushes in the wrong direction solves a mystery of animal locomotion 2A fish that pushes in the wrong direction solves a mystery of animal locomotion 3Researchers advocate for climate adaptation science 2Researchers advocate for climate adaptation science 3
(Date:1/23/2015)... Biofertilizers stimulate microbial activities in soil. These ... through the activities in the soil or in the ... the stress on reducing environmental pollution and on reducing ... and segments the bio fertilizers market with analysis and ...
(Date:1/22/2015)... Davis, California (PRWEB) January 22, 2015 ... of Accelerator Mass Spectrometry (AMS) services to the pharmaceutical ... PhD has joined the company in the position of ... 30 years of broad and valuable experience in drug ...
(Date:1/22/2015)... 22, 2015 GEA Niro Soavi the ... laboratory homogenizer, the PandaPLUS 2000, which is ideal for ... and cell disruption . This compact laboratory homogenizer ... juices, liquid food, food additives and ingredients as well ...
(Date:1/22/2015)... January 22, 2015 The laboratory information ... has witnessed a number of technological advancements due to ... requirements, growing need to integrate healthcare systems, and increasing ... challenges in system integration. Key players in the market ...
Breaking Biology Technology:Biofertilizers Market Expected to Reach $1,649.7 Million by 2019 - New Report By MarketsandMarkets 2Biofertilizers Market Expected to Reach $1,649.7 Million by 2019 - New Report By MarketsandMarkets 3Biofertilizers Market Expected to Reach $1,649.7 Million by 2019 - New Report By MarketsandMarkets 4Eckert & Ziegler Vitalea Science appoints Mark Seymour, PhD as Director of Science & Technology 2Eckert & Ziegler Vitalea Science appoints Mark Seymour, PhD as Director of Science & Technology 3GEA Niro Soavi Announces the PandaPLUS 2000 Homogenizer for Processing New Applications for Nanoemulsions and Cell Disruption 2Laboratory Information Management Systems Market is Expected to Reach $1,323.6 Million by 2019 - New Research Report by MarketsandMarkets 2Laboratory Information Management Systems Market is Expected to Reach $1,323.6 Million by 2019 - New Research Report by MarketsandMarkets 3Laboratory Information Management Systems Market is Expected to Reach $1,323.6 Million by 2019 - New Research Report by MarketsandMarkets 4
... 2011 Cross reference:   Picture ... be downloaded free of charge at:   http://www.presseportal.de/pm/18701/eppendorf-ag?keygroup=bild ... Science from 2008, Dr. Andrew Holt and ... how chemicals used as manufacturing additives can substantially inhibit ...
... HANOVER, N.J., Dec. 2, 2011 Novartis Pharmaceuticals Corporation ... presentations on data from its robust oncology portfolio at ... for patients with cancers and hematological diseases. ... held from December 6-10, will feature data presentations from ...
... Ltd. - (OTCBB: HADSY), a publicly traded portfolio of ... owned by the Hadassah University Hospital, Israel,s foremost medical ... companies have received grant approvals from the Israeli Office ... Industry, Trade and Labor. These approvals ...
Cached Biology Technology:Eppendorf Video Features Dr Andrew Holt's Work on Bioactive Leachates From Plastic Consumables 2Novartis Highlights Advances for Patients With Breast Cancer and Hematological Diseases With Over 160 SABCS and ASH Abstracts 2Novartis Highlights Advances for Patients With Breast Cancer and Hematological Diseases With Over 160 SABCS and ASH Abstracts 3Novartis Highlights Advances for Patients With Breast Cancer and Hematological Diseases With Over 160 SABCS and ASH Abstracts 4Novartis Highlights Advances for Patients With Breast Cancer and Hematological Diseases With Over 160 SABCS and ASH Abstracts 5Novartis Highlights Advances for Patients With Breast Cancer and Hematological Diseases With Over 160 SABCS and ASH Abstracts 6Novartis Highlights Advances for Patients With Breast Cancer and Hematological Diseases With Over 160 SABCS and ASH Abstracts 7Novartis Highlights Advances for Patients With Breast Cancer and Hematological Diseases With Over 160 SABCS and ASH Abstracts 8Novartis Highlights Advances for Patients With Breast Cancer and Hematological Diseases With Over 160 SABCS and ASH Abstracts 9Novartis Highlights Advances for Patients With Breast Cancer and Hematological Diseases With Over 160 SABCS and ASH Abstracts 10Novartis Highlights Advances for Patients With Breast Cancer and Hematological Diseases With Over 160 SABCS and ASH Abstracts 11Novartis Highlights Advances for Patients With Breast Cancer and Hematological Diseases With Over 160 SABCS and ASH Abstracts 12Novartis Highlights Advances for Patients With Breast Cancer and Hematological Diseases With Over 160 SABCS and ASH Abstracts 13Novartis Highlights Advances for Patients With Breast Cancer and Hematological Diseases With Over 160 SABCS and ASH Abstracts 14Novartis Highlights Advances for Patients With Breast Cancer and Hematological Diseases With Over 160 SABCS and ASH Abstracts 15Novartis Highlights Advances for Patients With Breast Cancer and Hematological Diseases With Over 160 SABCS and ASH Abstracts 16Novartis Highlights Advances for Patients With Breast Cancer and Hematological Diseases With Over 160 SABCS and ASH Abstracts 17Novartis Highlights Advances for Patients With Breast Cancer and Hematological Diseases With Over 160 SABCS and ASH Abstracts 18Novartis Highlights Advances for Patients With Breast Cancer and Hematological Diseases With Over 160 SABCS and ASH Abstracts 19Novartis Highlights Advances for Patients With Breast Cancer and Hematological Diseases With Over 160 SABCS and ASH Abstracts 20Novartis Highlights Advances for Patients With Breast Cancer and Hematological Diseases With Over 160 SABCS and ASH Abstracts 21Hadasit Bio-Holdings Ltd. Reports Significant External Financing for Portfolio Companies 2
... from an inert polymer with a unique split ... split septum caps for use with 384-well tall-chimney ... when used in conjunction with screw or clip-down ... pipetting equipment 384 septum caps may be ...
... Bionic Buffer is a unique ... and TAE (TRIS acetate-EDTA) electrophoresis buffers. ... runs, extremely rapid running times, and ... use in gel electrophoresis after dilution ...
The Mu-End™ Protein Truncation Kit provides a convenient method for generating a library of N-terminal and C-terminal protein deletions that can be expressed in E. coli....
... The SearchLight® IR Mouse Cytokine Array ... assay) for the quantitative measurement of 12 ... plasma and culture supernatants. Each well of ... that capture specific cytokines in standards and ...
Biology Products: