BUFFALO, N.Y. A genetic mutation that alters the kinetics of an ion channel in red blood cells has been identified as the cause behind a hereditary anemia, according to a paper (http://bit.ly/13LgCzc) published this month in the Proceedings of the National Academy of Sciences by University at Buffalo scientists and colleagues.
The research team was led by Frederick Sachs, PhD, SUNY Distinguished Professor in the UB Department of Physiology and Biophysics, who discovered in the 1980s that some ion channels are mechanosensitive, that is, they convert mechanical stress into electrical or biochemical signals.
The findings of the new study are significant, Sachs says, because it is the first time defects in a mechanosensitive ion channel have been implicated as the cause of a disease.
"We found that the mutations in the gene that codes for the ion channel called PIEZO1 causes the channel to stay open too long, causing an ion leak in red cells," explains Sachs. "Calcium and sodium enter, and potassium leaves, and that affects the ability of the red cell to regulate its volume. The cells become dehydrated and can break open, releasing their hemoglobin into the blood, and causing symptoms, such as the shortness of breath seen in anemic patients."
The anemia that results from the mutations in PIEZO1 is called familial xerocytosis, a mild to moderate form of anemia. The ion channel, PIEZO1, is about 10 nanometers across, and it increases its dimensions significantly upon opening; that change in dimensions is what is responsible for its mechanical sensitivity.
Mechanosensitive ion channels are likely to play a role in many diseases, since all cells are mechanically sensitive. Sachs and his colleagues have worked on activation of these channels in Duchenne muscular dystrophy, which is caused by errors in a gene coding for a fibrous protein that reinforces the cell membrane
'/>"/>
| Contact: Ellen Goldbaum goldbaum@buffalo.edu 716-645-4605 University at Buffalo Source:Eurekalert |
Related biology news :
1. Nature study reveals loss of essential blood cell gene leads to anemia
2. Dinosaur bends caused by prolonged diving
3. Insecticide resistance caused by recombination of 2 genes
4. Einstein researcher receives $10.8 million grant to study toxic blood reactions caused by hemoglobin
5. Tsunami caused long-term ecosystem change in the Caribbean
6. Evidence contradicts idea that starvation caused saber-tooth cat extinction
7. A neurosteroid found to prevent brain injury caused by HIV/AIDS
8. Nearby chimpanzee populations show much greater genetic diversity than distant human populations
9. Will a genetic mutation cause trouble? Ask Spliceman
10. UC Santa Barbara researchers discover genetic link between visual pathways of hydras and humans
11. Perception and preference may have genetic link to obesity
| Copyright © 2003-2012 Bio-Medicine. All rights reserved. ABOUT | CONTACT US | DISCLAIMER | PRIVACY POLICY | TERMS AND CONDITIONS |  |