Navigation Links
Whole-genome sequencing of bulls in key beef and dairy breeds
Date:7/22/2014

An international collaboration known as the '1000 Bull Genomes Project' aims to accelerate breeding for desired traits in beef and dairy cattle while also improving animal health and welfare. Results of the project's first phase -- based on sequencing the whole genomes of 234 individual bulls whose direct descendants number in the tens of millions -- are reported in the journal Nature Genetics.

According to the researchers, breeding programs could use this information to reduce or eliminate hereditary diseases and to improve the efficency of milk and beef production.

The bulls whose genomes have been sequenced and analyzed represent four of the most commercially important cattle breeds. Scientists from the Technische Universitt Mnchen (TUM) contributed data on 43 sires of the Fleckvieh breed, which has spread to every continent from its origin in the Bavarian Alps. The estimated worldwide population of Fleckvieh dairy cows is 40 million. From the widely distributed Holstein-Friesian population, the collaborators obtained whole-genome sequences for 129 bulls with more than six million daughters on dairy farms. The Jersey breed was represented by data from 15 bulls. Previously published genome sequences for 47 Angus cattle were also integrated into the analysis.

Modern breeding practices, together with advances in genome sequencing technology and bioinformatics, have made better prediction of inherited traits not only attainable but also cost-effective on the basis of a relatively small number of individuals. Selection of sires in cattle breeding is intense, and widespread use of artificial insemination means it's not unusual for a hundred thousand animals to be descendants of a single bull. With the ancestors' sequences , breeders now have a leverage tool in hand that allows them to extrapolate the sequence information to the numerous descendants using readily available chip-based DNA microarrays.

Personal Genomics for the Animal Farm

From whole-genome sequencing of the selected bulls with a total of 28.3 million variants identified the researchers began building a database of genotypes. This in turn enables sequence-based genome-wide association studies as well as genomic prediction. As a result, mutations that have a negative impact on animal health, welfare, and productivity can be rapidly identified.

Already in the first phase of the 1000 bull genome project, the researchers see evidence that this approach could help dairy and beef farmers to meet an increasing demand for their products. They tested the usefulness of the database by flagging recessive mutations associated with embryonic death and a lethal skeletal disorder. In addition, genome-wide association studies identified variants associated with specific phenotypes, such as high fat content in milk and the curly coat inherited by some Fleckvieh cattle.

In the 10,000 years of cattle breeding, this really is something new. "Whole-genome sequencing of founder animals on this scale is unprecedented for a livestock species," says Prof. Ruedi Fries, Chair of Animal Breeding at TUM. "Our results provide the basis for individualized cattle genetics, one might say 'personal genomics' for cows."

Global demand, International Collaboration

Around the world, consumer demand for beef and dairy products is changing but not diminishing. In a drive to meet cattle breeders' future needs, the 1000 bull genome project has enlisted scientists from Australia, Canada, Denmark, France, Germany, the Netherlands, and the United States.


'/>"/>
Contact: Ruedi Fries
ruedi.fries@tum.de
49-816-171-3228
Technische Universitaet Muenchen
Source:Eurekalert  

Related biology news :

1. Whole-genome sequencing uncovers the mysteries of the endangered Chinese alligator
2. BGI Tech launches human whole exome sequencing service on complete genomics advanced platform
3. Pioneer in next generation sequencing receives 2014 HudsonAlpha Life Sciences Prize
4. Sequencing electric eel genome unlocks shocking secrets
5. Sequencing efforts miss DNA crucial to bacterias disease causing power
6. Sequencing of citrus genomes points to need for more genetic diversity to fight disease
7. Poor coverage of specific gene sets in exome sequencing gives cause for concern
8. Sequencing hundreds of nuclear genes in the sunflower family now possible
9. Research team establishes benchmark set of human genotypes for sequencing
10. CHOP introduces HLA typing by next-generation sequencing to its clinical services
11. RNA sequencing of 750-year-old barley virus sheds new light on the Crusades
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Whole-genome sequencing of bulls in key beef and dairy breeds
(Date:1/28/2016)... SYNA ), a leading developer of human interface solutions, today ... --> --> Net revenue ... to the comparable quarter last year to $470.5 million. Net income ... $0.93 per diluted share. --> ... 2016 grew 9 percent over the prior year period to $60.3 ...
(Date:1/22/2016)... DUBLIN , Jan. 22, 2016 /PRNewswire/ ... announced the addition of the "Global ... report to their offering. --> ... of the "Global Biometrics Market in ... offering. --> Research and ...
(Date:1/18/2016)... SAN JOSE, Calif. , Jan. 18, 2016 ... storage security software that simplifies the use and ... a technology and go-to-market partnership with American Cyber.  ... "American Cyber brings extensive experience leading transformational C4ISR ... missions implementing and integrating the latest proven technology ...
Breaking Biology News(10 mins):
(Date:2/10/2016)... ... February 09, 2016 , ... ... current winner of the Highest Overall Customer Rating Award from Circuits Assembly ... its business units across the USA, Canada, Mexico and China. , The EMS ...
(Date:2/9/2016)... , ... February 08, 2016 , ... ... testing services, announced today the launch of its revamped and improved website. In ... language service solutions, the redesigned website will better communicate how the company designs ...
(Date:2/9/2016)... ... February 09, 2016 , ... The publishing ... Open Access publishing is one of the popular publication models that has received ... journals and 3000+ International Conferences across the globe, OMICS International ...
(Date:2/9/2016)... and LONDON , February 9, ... leading bio tech replace paper and protect ... web-based electronic laboratory notebook (ELN) will be rolled out in ... paper-based research and development (R&D) and protect valuable IP. Users ... and follow a specific researcher or experiment as part of ...
Breaking Biology Technology: