Navigation Links
When our protective armor shows weakness
Date:8/1/2008

New knowledge points to the fact that a genetically induced lack of filaggrin, a key protein of the skin barrier, plays a decisive role in the origin of allergies. In a large study on more than 3000 school-children scientists of the Helmholtz Zentrum Mnchen and the Technische Universitt Mnchen found that about 8% of the German population carry variations of the filaggrin gene, which raise the risk to develop atopic dermatitis more than threefold. In addition, these genetic variations predispose to hay fever and asthma in those with atopic dermatitis.

Allergic diseases have increased considerably in the past decades in most industrial countries. A combination of genetic and environmentally related factors is said to be the cause. In recent years, several genes were examined for a role in allergic diseases, and one of them actually turned out to be a key player. This gene encodes filaggrin, an essential protein in the horny layer of the skin. If this protein is reduced or lacking due to a genetic defect, the natural cornification is impeded and the natural barrier function of the skin is limited.

In 2006 filaggrin mutations could be identified as cause of the so-called fish scale disease or ichthyosis vulgaris, and as risk factors for the development of atopic dermatitis, a genetic breakthrough made by the Irish research team around Irwin McLean and Alan Irvine.

In an international collaboration, Dr. Stephan Weidinger from the Technische Universitt Mnchen and Dr. Thomas Illig from the Helmholtz Zentrum Mnchen now investigated 3,000 school children, representing the population as a whole. The study was carried out together with Dr. Michael Kabesch of the Children's Hospital of the Kudwig-Maximilians-University Munich. The Munich scientists found that almost 8% of the children in Germany suffer from a genetically determined deficiency of filaggrin protein in the skin. These children have a more than threefold increased risk to develop ato
'/>"/>

Contact: Thomas Illig
illig@helmholtz-muenchen.de
0049-893-187-4249
Helmholtz Zentrum Mnchen - German Research Center for Environmental Health
Source:Eurekalert

Page: 1 2

Related biology news :

1. Boston University biomedical engineers find chink in bacterias armor
2. Lab study shows methadone breaks resistance in untreatable forms of leukemia
3. Immunotherapy in high-risk pediatric sarcomas shows promising response
4. New study shows compounds from soy affect brain and reproductive development
5. OSU study shows exposure to bad air raises blood pressure
6. Study shows parasites outweigh predators
7. Study shows increased education on nanotech, human enhancement increases public concerns
8. Sociological research shows combined impact of genetics, social factors on delinquency
9. Revolutionary chefs? Not likely, shows physics research
10. Study shows rise in Cornwalls dolphin, whale and porpoise deaths
11. Long-term study of middle-aged mice shows
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/17/2014)... . Our eyes ... us with a continuous stream of information about our own ... in a car the world glides by us and ... effort, our brain calculates self-motion from this "optic flow". This ... gaze during our own movements. Together with biologists from the ...
(Date:4/17/2014)... years ago, Katia Silvera , a postdoctoral scholar at ... a field trip in a mountainous area in central Panama ... before. , Unable to identify it, they contacted German Carnevali, ... to be an unnamed species. So Carnevali recently named it ... the genus name, comprising about 40 species in the world. ...
(Date:4/17/2014)... devastate honeybees in Europe, Asia and the United States ... to be impacting native honeybee populations at this time, ... pests include including Nosema microsporidia and ... be resilient to these invasive pests, which suggests to ... Europe, Asia and the United States currently are not ...
Breaking Biology News(10 mins):How vision makes sure that little fish do not get carried away 2How vision makes sure that little fish do not get carried away 3How vision makes sure that little fish do not get carried away 4Orchid named after UC Riverside researcher 2Orchid named after UC Riverside researcher 3East African honeybees are safe from invasive pests… for now 2East African honeybees are safe from invasive pests… for now 3
... one sex from another may depend on the number ... the number of receptors is controlled by levels of ... researchers have found. , Everything from the ability to ... amyotrophic lateral sclerosis, muscular dystrophy, post-traumatic stress syndrome and ...
... human tumor cells implanted in mice have shown that ... of breast cancer to the lungs. The new studies ... aberrant genes work together to promote the growth of ... enables cancerous cells to escape into the bloodstream and ...
... learns to perceive objects is one of the ultimate challenges ... the Massachusetts Institute of Technology, launched an initiative with the ... skills. The goal of his "Project Prakash" is to find, ... unique case study that resulted from this project appears in ...
Cached Biology News:Bisexual fruit flies show new role for neurochemical 2A genetic 'gang of 4' drives spread of breast cancer 2A genetic 'gang of 4' drives spread of breast cancer 3A genetic 'gang of 4' drives spread of breast cancer 4
(Date:1/15/2014)... interface is the device," Nobel laureate Herbert Kroemer ... be found at the junctures where layers of ... nanotechnology, the interfaces between layers of metal oxides ... high-tech favorites as spintronics, high-temperature superconductors, ferroelectrics and ...
(Date:1/15/2014)... 15, 2014   Niagara Thermal Products is proud ... BioBlower Technologies LLC ("B3") as the critical thermal component ... from the Army Corps of Engineers.  B3 has developed ... biological contaminants and destroys VOCs and other chemical pollutants, ...
(Date:1/15/2014)... JOSE, California , January 15, 2014 ... cancer, today announced the appointment of Thomas C Reynolds MD, ... 20 years, development experience gained in the biotechnology industry, most ... "I am delighted to welcome Tom at this transformative time ...
(Date:1/15/2014)... January 15, 2014 A study has been ... the Formula 1 track could help to tackle the problem ... (MAT), Stowhealth (a GP surgery based in Stowmarket) and academics ... Simplyhealth. Telemetry technology, which is inspired by equipment ...
Breaking Biology Technology:A deeper look at interfaces 2Niagara Thermal Products LLC Selected as Critical Supplier for Buffalo BioBlower Air Purification Systems 2Oxford BioTherapeutics Appoints Thomas C Reynolds MD, PhD to its Board of Directors 2Oxford BioTherapeutics Appoints Thomas C Reynolds MD, PhD to its Board of Directors 3Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 2Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 3Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 4
... April 23 STAAR Surgical,Company (Nasdaq: STAA ... invasive ophthalmic products, today announced very strong,participation in ... the Company,s,Visian ICL(TM) (Implantable Collamer Lens). The first ... My Website Compels Patients to Call,Me," is part ...
... FORT LAUDERDALE, Fla., April 23 Imaging,Diagnostic ... on,April 16, 2008, the Company received and accepted ... Patrick Gorman, and Sherman Lazrus.,These resignations were tendered ... as a condition to such funding. In connection ...
... conference call Wednesday, April 30, at 1:00 p.m. ... Avigen, Inc.,(Nasdaq: AVGN ), a biopharmaceutical company ... conference call to discuss first,quarter results on Wednesday, ... a.m.,PT). Kenneth Chahine, Chief Executive Officer, and Michael ...
Cached Biology Technology:More Than 700 Physicians and Administrators Participate in the Visian ICL Growth Program(TM) Launch 2More Than 700 Physicians and Administrators Participate in the Visian ICL Growth Program(TM) Launch 3Imaging Diagnostic Systems Accepts Resignations of Outside Directors 2Imaging Diagnostic Systems Accepts Resignations of Outside Directors 3Avigen, Inc. Announces First Quarter 2008 Earnings Conference Call 2
... 301 Power Supply, 1. 300 V, ... or constant current modes.Single-unit increments in ... reproducibility.Suitable for submarine, mini vertical, and ... as semidry and mini tank blotting ...
Mouse monoclonal [PRMT5-21] to PRMT5 ( Abpromise for all tested applications). entrezGeneID: 10419 SwissProtID: O14744...
B3-1...
Mouse TrkC Affinity Purified Polyclonal Ab...
Biology Products: