Navigation Links
When our protective armor shows weakness
Date:8/1/2008

New knowledge points to the fact that a genetically induced lack of filaggrin, a key protein of the skin barrier, plays a decisive role in the origin of allergies. In a large study on more than 3000 school-children scientists of the Helmholtz Zentrum Mnchen and the Technische Universitt Mnchen found that about 8% of the German population carry variations of the filaggrin gene, which raise the risk to develop atopic dermatitis more than threefold. In addition, these genetic variations predispose to hay fever and asthma in those with atopic dermatitis.

Allergic diseases have increased considerably in the past decades in most industrial countries. A combination of genetic and environmentally related factors is said to be the cause. In recent years, several genes were examined for a role in allergic diseases, and one of them actually turned out to be a key player. This gene encodes filaggrin, an essential protein in the horny layer of the skin. If this protein is reduced or lacking due to a genetic defect, the natural cornification is impeded and the natural barrier function of the skin is limited.

In 2006 filaggrin mutations could be identified as cause of the so-called fish scale disease or ichthyosis vulgaris, and as risk factors for the development of atopic dermatitis, a genetic breakthrough made by the Irish research team around Irwin McLean and Alan Irvine.

In an international collaboration, Dr. Stephan Weidinger from the Technische Universitt Mnchen and Dr. Thomas Illig from the Helmholtz Zentrum Mnchen now investigated 3,000 school children, representing the population as a whole. The study was carried out together with Dr. Michael Kabesch of the Children's Hospital of the Kudwig-Maximilians-University Munich. The Munich scientists found that almost 8% of the children in Germany suffer from a genetically determined deficiency of filaggrin protein in the skin. These children have a more than threefold increased risk to develop ato
'/>"/>

Contact: Thomas Illig
illig@helmholtz-muenchen.de
0049-893-187-4249
Helmholtz Zentrum Mnchen - German Research Center for Environmental Health
Source:Eurekalert

Page: 1 2

Related biology news :

1. Boston University biomedical engineers find chink in bacterias armor
2. Lab study shows methadone breaks resistance in untreatable forms of leukemia
3. Immunotherapy in high-risk pediatric sarcomas shows promising response
4. New study shows compounds from soy affect brain and reproductive development
5. OSU study shows exposure to bad air raises blood pressure
6. Study shows parasites outweigh predators
7. Study shows increased education on nanotech, human enhancement increases public concerns
8. Sociological research shows combined impact of genetics, social factors on delinquency
9. Revolutionary chefs? Not likely, shows physics research
10. Study shows rise in Cornwalls dolphin, whale and porpoise deaths
11. Long-term study of middle-aged mice shows
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/29/2014)... Texas Medical Branch at Galveston has gone on record stating ... monkeys against a lethal dose of Ebola virus up to ... is severe. , Thomas Geisbert, professor of microbiology and immunology, ... in Ebola treatment research. The filoviruses known as Ebola virus ... with fatality rates of up to 90 percent. ...
(Date:8/29/2014)... German . ... the oldest form of communication. Acting as messenger molecules, ... sexual attraction between males and females. Fish rely on ... behavior in males and females. Scientists at the Marine ... Faro, Portugal, and at the Max Planck Institute for ...
(Date:8/29/2014)... USA - The rise of the Tibetan plateau -- ... -- is important for both its profound effect on ... study published in GSA Bulletin , Katharine Huntington ... isotope thermometry -- using modern and fossil snail shells ... in southwestern Tibet. , Views range widely on ...
Breaking Biology News(10 mins):Leading Ebola researcher at UTMB says there's an effective treatment for Ebola 2Ready for mating at the right time 2Ready for mating at the right time 3Snails tell of the rise and fall of the Tibetan Plateau 2Snails tell of the rise and fall of the Tibetan Plateau 3Snails tell of the rise and fall of the Tibetan Plateau 4Snails tell of the rise and fall of the Tibetan Plateau 5Snails tell of the rise and fall of the Tibetan Plateau 6Snails tell of the rise and fall of the Tibetan Plateau 7
... Whip spiders, considered by many to be creepy-crawly, are ... In two species of whip spiders, or amblypygids, mothers ... until they reach sexual maturity, and all mix in ... long-thought to be purely aggressive and anti-social, according to ...
... at the Carnegie Institution's Department of Plant Biology ... govern nutrient regulation—neighboring pore-like structures at the cell's ... a vital nutrient, nitrogen. It is the first ... neighboring molecules is essential to this regulation. Since ...
... syndrome are often seen laughing and smiling, but this ... problems and seizures. , ,ew research in ... be alleviated. , Edwin Weeber, Ph.D., and colleagues ... Angelman syndrome by preventing the inhibition of CaMKII, an ...
Cached Biology News:A rarity among arachnids, whip spiders have a sociable family life 2A rarity among arachnids, whip spiders have a sociable family life 3New mechanism for nutrient uptake discovered 2New mechanism for nutrient uptake discovered 3Angelman syndrome deficits rescued in mice 2Angelman syndrome deficits rescued in mice 3
(Date:8/31/2014)... Available spectra is similar for ... and cultivation of a wide range of plants. ... with proven patented and pending wide spectrum technology. ... in critical applications in contrast to growth spectra ... customers have a large variety of differently sized ...
(Date:8/29/2014)... Electronic circuits are based on electrons, but one of ... photonic circuits, i.e. circuits based on light (photons) instead ... to create a stream of single photons and control ... sorts of attempts to achieve this control, but now ... creating a steady stream of photons emitted one at ...
(Date:8/29/2014)... 29, 2014 Local veterinarian, Dr. Keith ... are seeking candidates to participate in an investigational study ... The ultimate goal of this study is to determine ... one or two arthritically affected joints can help reduce ... Candidates for the current investigational study must be older ...
(Date:8/28/2014)... (PRWEB) August 28, 2014 SPIE Fellow ... Physics and Optical Science and Director of the Center ... North Carolina at Charlotte, and co-founder and Chairman of ... serve as the 2015 Vice President of SPIE, the ... President Philip Stahl announced recent election results at the ...
Breaking Biology Technology:Breakthrough in light sources for new quantum technology 2Burnt Hills Veterinary Hospital Seeks Candidates for an Investigational Study of Stem Cells for Dogs with Arthritis 2Glenn Boreman, UNC Professor and Plasmonics Co-Founder, Elected to SPIE Presidential Chain 2
... SAN FRANCISCO, May 22 Takeda San ... Haak-Frendscho, Ph.D., as president,and chief scientific officer. ... activities at Takeda San Francisco including overall ... operations for,antibody therapeutics., Takeda San Francisco ...
... ... Emerging Pattern, NORTH BERGEN, N.J., ... Friday, 20 people arrived, one by one, for emergency care at,the ... nausea and diarrhea., A coincidence? Or the harbinger of a ...
... AstraZeneca (NYSE:,AZN) announced today that it supports ... the company,s latest step to provide the public,with ... Sponsored by Sens. Charles Grassley of Iowa ... a national registry of payments that,biopharmaceutical companies, device ...
Cached Biology Technology:Takeda's Antibody Therapeutics Research Company, Takeda San Francisco, Inc. Appoints Mary Haak-Frendscho, Ph.D. as President and CSO 2E. coli Outbreak in New Jersey? 2E. coli Outbreak in New Jersey? 3AstraZeneca Supports Transparency Legislation on Payments to Health Care Providers 2
Form: Ready to use Applications: ELISA...
EnzChek Ultra Xylanase Assay Kit *500 assays*...
Goat polyclonal to p27 KIP 1 ( Abpromise for all tested applications). Antigen: Synthetic peptide: C-KRPATDDS STQNK, corresponding to Internal sequence amino acids 153-165 of Human p27 KIP 1 ...
Defender against cell death 1...
Biology Products: