Navigation Links
What bacteria don't know can hurt them
Date:11/17/2011

teria to antibiotics could require stimulating their growth, and this could be dangerous during human infections."

Nguyen and Singh explored an alternative mechanism.

Microbiologists have long known that when bacteria sense that their nutrient supply is running low, they issue a chemical alarm signal. The alarm tells the bacteria to adjust their metabolism to prepare for starvation. Could this alarm also turn on functions that produce antibiotic resistance?

To test this idea, the team engineered bacteria in which the starvation alarm was inactivated, and then measured antibiotic resistance in experimental conditions in which bacteria were starved. To their amazement, bacteria unable to sense starvation were thousands of times more sensitive to killing than those that could, even though starvation arrested growth and the activity of antibiotic targets.

"That experiment was a turning point," Singh said. "It told us that the resistance of starved bacteria was an active response that could be blocked. It also indicated that starvation-induced protection only occurred if bacteria were aware that nutrients were running low."

With the exciting result in hand, the researchers turned to two key questions. First does the starvation alarm produce resistance during actual infections? To test this the team examined naturally starved bacteria, biofilms, isolates taken from patients, and bacterial infections in mice. Sure enough, in all cases the bacteria unable to sense starvation were far easier to kill.

The second question was about the mechanism of the effect. How does starvation sensing produce such profound antibiotic resistance?

Again, the results were surprising.

Instead of well-described resistance mechanisms, like pumps that expel antibiotics from bacterial cells, the researchers found that the bacteria's protective mechanism defended them against toxic forms of oxyge
'/>"/>

Contact: Leila Gray
leilag@u.washington.edu
206-685-0381
University of Washington
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Disinfectants can make bacteria resistant to treatment
2. H. Pylori bacteria may help prevent some esophageal cancers
3. Scientists discover bacteria that can cause bone infections
4. Waste from gut bacteria helps host control weight, UT Southwestern researchers report
5. Gene against bacterial attack unravelled
6. Predatory bacterial swarm uses rippling motion to reach prey
7. Bacteria manage perfume oil production from grass
8. Nature study demonstrates that bacterial clotting depends on clustering
9. Battling bacteria in the blood: Researchers tackle deadly infections
10. Shifts in soil bacterial populations linked to wetland restoration success
11. New bacteria discovered in raw milk
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
What bacteria don't know can hurt them
(Date:12/4/2014)... , Dec. 3, 2014  Crossmatch™, a ... announced that its DigitalPersona ® Pro Enterprise ... have been deployed throughout First Bank branch locations ... South Carolina and Virginia. First Bank, ... Southern Pines, North Carolina , selected ...
(Date:11/21/2014)... -- Earlier this year Donald Spector , Chairman of ... the most prolific inventors in the world, got a ... to third party agencies. Spector envisioned this technology even ... earliest known patents in this area. Now major technology ... care, elder care and hospital applications. This technology has ...
(Date:11/18/2014)... 2014  The Secure Identity & Biometrics Association ... announce the formation of The Airport Entry and ... Identity and Biometric Entry and Exit Solutions Framework ... support from BORDERPOL, the international non-profit organization that ... expertise regarding border security, traveler and migration systems. ...
Breaking Biology News(10 mins):First Bank Partners with Crossmatch to Increase Log In Security 2First Bank Partners with Crossmatch to Increase Log In Security 3Patented Biosensor Wearable Technology Provides a More Civilized Method of Quarantine 2Patented Biosensor Wearable Technology Provides a More Civilized Method of Quarantine 3Patented Biosensor Wearable Technology Provides a More Civilized Method of Quarantine 4Identity Management, Document Authentication and Biometric Companies Form "The Airport Entry and Exit Working Group", Releasing the Framework to Help Guide the Department of Homeland Security and Congress Towards Solutions 2Identity Management, Document Authentication and Biometric Companies Form "The Airport Entry and Exit Working Group", Releasing the Framework to Help Guide the Department of Homeland Security and Congress Towards Solutions 3
... NEW YORK (January 14, 2008) Outbreaks of the notorious ... richest center of coral reef biodiversity on Earth, according to ... ARC Centre of Excellence for Coral Reef Studies. The ... its stomach over them and using digestive enzymes to liquefy ...
... Service Weekly PressPac with news from ACS 36 peer-reviewed journals ... the American Chemical Society as the source for this information. ... which is embargoed for 9 A. M., Eastern Time, Jan. ... Seagull blood shows promise for monitoring pollutants ...
... ARBOR, Mich.---An international study of 20,000 people found seven ... factor in heart disease, and confirmed 11 other genes ... international study led by researchers from the University of ... or confirm genetic variants that influence lipid levels, and ...
Cached Biology News:Starfish outbreak threatens corals 2American Chemical Society's weekly PressPac -- Jan. 9, 2008 2American Chemical Society's weekly PressPac -- Jan. 9, 2008 3American Chemical Society's weekly PressPac -- Jan. 9, 2008 4American Chemical Society's weekly PressPac -- Jan. 9, 2008 5American Chemical Society's weekly PressPac -- Jan. 9, 2008 6American Chemical Society's weekly PressPac -- Jan. 9, 2008 7American Chemical Society's weekly PressPac -- Jan. 9, 2008 8American Chemical Society's weekly PressPac -- Jan. 9, 2008 9Study locates cholesterol genes; finds surprises about good, bad cholesterol 2
(Date:12/19/2014)... iLab Solutions, the global leader in ... Bryant as the new Director of Institutional Implementations and ... These two new leadership positions were created to support ... that iLab continues to meet the needs of its ... iLab has been deployed at over 450 core facilities ...
(Date:12/19/2014)... MILLBROOK, N.Y. , Dec. 18, 2014 Egenix, ... has been elected Chairman of the Board, to succeed ... President and CEO, but will continue as a member of ... that he has added to the company over almost twenty ... The Board of Directors has established a Search ...
(Date:12/17/2014)... December 16, 2014 “Never say, ... Philipps- Universität Marburg’s Department of Physics, advises young ... the newly released SPIE Women in Optics ... too shy to ask questions.” , In the ... and mathematics) occupations ranging from university professor and ...
(Date:12/17/2014)... Xeno Diagnostics has again received ... recent COLA inspection. Xeno has met all criteria ... accreditation organization. Accreditation is earned only by laboratories ... operations, demonstrate continued accuracy in the performance of ... survey. , While the Laboratory Excellence ...
Breaking Biology Technology:iLab Solutions Announces Two New Leadership Positions to Meet the Needs of Its Growing Customer Base 2Network, Multitask, Persevere: SPIE Women in Optics Planner Subjects Share from Experience 2Network, Multitask, Persevere: SPIE Women in Optics Planner Subjects Share from Experience 3Xeno Diagnostics Receives 3rd Award for Laboratory Excellence 2
... Call on Thursday, November 5, 2009 at 4:30 p.m. ... /PRNewswire-FirstCall/ - OncoGenex Pharmaceuticals, Inc. ("OncoGenex" or the "Company") ... for the third quarter and nine months ended September ... third quarter of 2009. , The following consolidated results ...
... Wound Management Technologies, Inc., (WNDM), announced today that it has ... assets of Virtual Health Technologies, Inc. (OTC Bulletin Board: VHGI). ... cash and debt, 4,000,000 shares of WNDM and a royalty ... being acquired from VHGI. WNDM closed at $2.00 ...
... Nov. 5 /PRNewswire-Asia-FirstCall/ -- BMP Sunstone,Corporation (Nasdaq: BJGP ) ... to release third quarter 2009 financial results on,Monday, November 9, ... The Company will hold a conference call at 5:00 pm ... Listeners may access the call by,dialing 1-888-713-4211 or 1-617-213-4864 ...
Cached Biology Technology:OncoGenex Reports Third Quarter 2009 Financial Results 2OncoGenex Reports Third Quarter 2009 Financial Results 3OncoGenex Reports Third Quarter 2009 Financial Results 4OncoGenex Reports Third Quarter 2009 Financial Results 5OncoGenex Reports Third Quarter 2009 Financial Results 6OncoGenex Reports Third Quarter 2009 Financial Results 7OncoGenex Reports Third Quarter 2009 Financial Results 8OTCBB-WNDM Announces LOI to Acquire VHGI Assets for $10 Million Cash/Stock 2OTCBB-WNDM Announces LOI to Acquire VHGI Assets for $10 Million Cash/Stock 3BMP Sunstone to Report Third Quarter 2009 Financial Results 2
... the consumable measurement plate for ... individually controlled measurement sites. Each ... liquid flow channel system that ... solution and compound applications necessary ...
This bispecific antibody complex has been tested for efficient depletion of CD41+ cells using the StemSep ; negative immunomagnetic cell separation system....
... Caliper's iLink makes it easy to supply ... instruments. Developed with operator convenience in mind, ... shoot' ease of use. The iLink software ... for assays or sub-assays, that can be ...
No-Weigh Dithiothreitol (DTT) ,7.7 mg DTT/Tube x 48 tubes...
Biology Products: