Navigation Links
What bacteria don't know can hurt them
Date:11/17/2011

teria to antibiotics could require stimulating their growth, and this could be dangerous during human infections."

Nguyen and Singh explored an alternative mechanism.

Microbiologists have long known that when bacteria sense that their nutrient supply is running low, they issue a chemical alarm signal. The alarm tells the bacteria to adjust their metabolism to prepare for starvation. Could this alarm also turn on functions that produce antibiotic resistance?

To test this idea, the team engineered bacteria in which the starvation alarm was inactivated, and then measured antibiotic resistance in experimental conditions in which bacteria were starved. To their amazement, bacteria unable to sense starvation were thousands of times more sensitive to killing than those that could, even though starvation arrested growth and the activity of antibiotic targets.

"That experiment was a turning point," Singh said. "It told us that the resistance of starved bacteria was an active response that could be blocked. It also indicated that starvation-induced protection only occurred if bacteria were aware that nutrients were running low."

With the exciting result in hand, the researchers turned to two key questions. First does the starvation alarm produce resistance during actual infections? To test this the team examined naturally starved bacteria, biofilms, isolates taken from patients, and bacterial infections in mice. Sure enough, in all cases the bacteria unable to sense starvation were far easier to kill.

The second question was about the mechanism of the effect. How does starvation sensing produce such profound antibiotic resistance?

Again, the results were surprising.

Instead of well-described resistance mechanisms, like pumps that expel antibiotics from bacterial cells, the researchers found that the bacteria's protective mechanism defended them against toxic forms of oxyge
'/>"/>

Contact: Leila Gray
leilag@u.washington.edu
206-685-0381
University of Washington
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Disinfectants can make bacteria resistant to treatment
2. H. Pylori bacteria may help prevent some esophageal cancers
3. Scientists discover bacteria that can cause bone infections
4. Waste from gut bacteria helps host control weight, UT Southwestern researchers report
5. Gene against bacterial attack unravelled
6. Predatory bacterial swarm uses rippling motion to reach prey
7. Bacteria manage perfume oil production from grass
8. Nature study demonstrates that bacterial clotting depends on clustering
9. Battling bacteria in the blood: Researchers tackle deadly infections
10. Shifts in soil bacterial populations linked to wetland restoration success
11. New bacteria discovered in raw milk
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
What bacteria don't know can hurt them
(Date:3/20/2015)... , March 20, 2015 NXT-ID, Inc. (NASDAQ: ... authentication company focused on the growing mobile commerce market, ... is one of the products featured in 2015 "I ... at 11:00 PM EST on the DIY Network.   ... Las Vegas , site of the 2015 ...
(Date:3/19/2015)... , March 19, 2015  NXT-ID, Inc. (NASDAQ: ... company focused on the growing mobile commerce market, announces its ... a news clip that aired this week on ... . In a segment "The Next Great Thing", ... ,a new way to pay, and ,a really big breakthrough ...
(Date:3/17/2015)... MINNETONKA, Minn. , March 17, 2015 /PRNewswire/ ... sciences technology company specializing in clinical study management ... will be in attendance at ARENA,s Outsourcing in ... Cary, NC.  This event provides an excellent forum ... company,s easy-to-use, flexible and affordable software-as-a-service (SaaS) eClinical ...
Breaking Biology News(10 mins):NXT-ID's Wocket Biometric Smart Wallet to Air on "I Want That" International CES Special 2NXT-ID's Wocket Biometric Smart Wallet to Air on "I Want That" International CES Special 3NXT-ID's Wocket Smart Wallet Featured on Fox News Segment, "The Next Great Thing" 2NXT-ID's Wocket Smart Wallet Featured on Fox News Segment, "The Next Great Thing" 3Connect With MedNet Solutions At Outsourcing In Clinical Trials Southeast 2
... -- Reseachers at The Ohio State University have ... an effective method for preserving the important genetic diversity ... geranium, are some of the most popular flowers the ... Society listed more than 3,000 varieties of geranium in ...
... -- Two common dietary molecules found in legumes ... effects of radiation, researchers from the University of ... both human skin cells and a skin cancer-prone ... the damaging radiation found in sunlight, the team ...
... scientists today announced the results of a systematic effort ... worlds leading cause of cancer deaths. Appearing in the ... the research provides a comprehensive view of the abnormal ... 50 genomic regions that are frequently gained or lost ...
Cached Biology News:'TRAP' preserves genetic properties of popular geranium 2Antioxidants could provide all-purpose radiation protection 2Antioxidants could provide all-purpose radiation protection 3Genome study charts genetic landscape of lung cancer 2Genome study charts genetic landscape of lung cancer 3
(Date:4/16/2015)... and OSAKA, Japan ... Cell Research Application (CiRA) of Kyoto University and ... they will work together to develop clinical applications ... as heart failure, diabetes mellitus, neurological disorders and ... Cell Applications" (T-CiRA) is designed to expedite multiple ...
(Date:4/16/2015)... Irvine, CA (PRWEB) April 16, 2015 ... in the Buzz of BIO Contest for ... Industry Organization (BIO), the 2015 BIO International Convention will ... in Philadelphia, Pennsylvania. During the Buzz of BIO contest, ... like to see present at the conference. The community ...
(Date:4/16/2015)... April 16, 2015 OncoTAb, ... Charlotte (UNC Charlotte) spin-out company, announced today the ... Ph.D., M.D., as Chief Operating Officer (COO). Cooper ... experience in developing clinical diagnostic and biotechnology platforms ... disease. , Cooper’s extensive career transcends the field ...
(Date:4/16/2015)... 2015  RegeneRx Biopharmaceuticals, Inc. (OTCQB: RGRX) ("the ... venture with G-treeBNT (ReGenTree LLC) has retained Ora, ... for the orphan disorder, neurotrophic keratopathy (NK), and ... syndrome (DES) in the U.S.  Both trials will ... year.  Each of these eye disorders was being ...
Breaking Biology Technology:CiRA and Takeda Enter 10-year Collaboration on iPS Cell Research 2CiRA and Takeda Enter 10-year Collaboration on iPS Cell Research 3Proove Bisociences to Participate in the Buzz of BIO at the 2015 BIO International Convention 2Proove Bisociences to Participate in the Buzz of BIO at the 2015 BIO International Convention 3OncoTAb Names Dr. David L. Cooper as COO 2RegeneRx JV Retains Ora, Inc. to Conduct Phase 3 Trial for NK and Phase 2b/3 Trial for Dry Eye Syndrome in U.S. 2RegeneRx JV Retains Ora, Inc. to Conduct Phase 3 Trial for NK and Phase 2b/3 Trial for Dry Eye Syndrome in U.S. 3RegeneRx JV Retains Ora, Inc. to Conduct Phase 3 Trial for NK and Phase 2b/3 Trial for Dry Eye Syndrome in U.S. 4RegeneRx JV Retains Ora, Inc. to Conduct Phase 3 Trial for NK and Phase 2b/3 Trial for Dry Eye Syndrome in U.S. 5
... Research Group plc (AIM:,PRG) announces the appointment of ... Resources. Mr. Keenen will be responsible for setting ... the,effectiveness of Premier Research,s people and organization in ... McCall, COO, commented: "We are very pleased to ...
... biometrics access control ... approved products list for airports, TORONTO, Sept. 18 /PRNewswire-FirstCall/ ... control technology, today announced,that its V-Station MIFARE V9.50 has been ... TSA,s "Biometrics for,Access Control" Qualified Products List (QPL). Products ...
... BOSTON, Sept. 18 PAREXEL Consulting, a,business unit ... a leading global,life sciences consultancy serving the bio/pharmaceutical ... strengthening its Good Manufacturing,Practice (GMP) capabilities in Europe ... European Union (EU) directives in areas such as,manufacturing ...
Cached Biology Technology:Premier Research Appoints Global Head of Human Resources 2Bioscrypt's V-Station MIFARE Placed on Transportation Security Administration's Qualified Products List 2Bioscrypt's V-Station MIFARE Placed on Transportation Security Administration's Qualified Products List 3Parexel Consulting Strengthens Good Manufacturing Practice Capabilities in Europe 2Parexel Consulting Strengthens Good Manufacturing Practice Capabilities in Europe 3Parexel Consulting Strengthens Good Manufacturing Practice Capabilities in Europe 4Parexel Consulting Strengthens Good Manufacturing Practice Capabilities in Europe 5Parexel Consulting Strengthens Good Manufacturing Practice Capabilities in Europe 6
...
... Gene expression profiling allows a high-throuput ... that naturally occuring or artifitially induced changes ... in that system can be detected, studied, ... a broad range of genes at a ...
Rabbit polyclonal to Esa1 ( Abpromise for all tested applications)....
RORgamma (S-14)...
Biology Products: