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Watching the cogwheels of the biological clock in living cells
Date:10/26/2012

er words, BMAL1 must die while embracing that gene in order to do its job. "In a sense, these transcription factors have the same cruel fate as males of the carnivorous insect Mantis. Sadly, Mantis females decapitate and then start eating their partners before the act of love is even completed" says Markus Stratmann.

At the moment, the biologists can only speculate about the broader impact of their findings. "We do not yet understand why the destruction of the BMAL1 protein is mandatory for the optimal functioning of the DBP gene" remarks Ueli Schibler. In fact, BMAL1 molecules regulate the daily activity of many other genes without getting killed while doing their work. The researchers noticed, however, that genes whose activity is not associated with the destruction of BMAL1 are expressed many hours later than the DBP gene. Their work thus offers a plausible explanation to the enigma of how one and the same transcription factor, BMAL1, can impose dramatically different daily cycles of gene expression.


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Contact: Ueli Schibler
ueli.schibler@unige.ch
41-223-796-175
Universit de Genve
Source:Eurekalert  

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