Navigation Links
Watching the cogwheels of the biological clock in living cells
Date:10/26/2012

Our master circadian clock resides in a small group of about 10'000 neurons in the brain, called the suprachiasmatic nucleus. However, similar clocks are ticking in nearly all cells of the body, as demonstrated by the group of Ueli Schibler, professor at the Department of Molecular Biology of the University of Geneva, Switzerland. The molecular mechanisms of circadian clocks can thus be studied outside of the animals, in cultured cells.

A system to study gene regulation live in single cells

"Given the important role of the DBP protein in the regulation of detoxifying enzymes, we were interested in studying the molecular mechanisms underlying the rhythmic transcription of the DBP gene", points out the biologist, who is member of the NCCR Frontiers in Genetics. To do so, his team devised an elegant method to watch directly under the microscope how the clock's molecular "cogwheels" govern the activity rhythms of this gene in individual living cells. To this end, the scientists engineered a cell line with a piece of a chromosome exclusively composed of repeated DBP gene copies. They showed that the daily transcription of DBP is due to the rhythmic association of an essential clock component, the transcription factor BMAL1. "This is the first time a transcription factor binding to a circadian gene could be visualized in real time in single cells" explains Markus Stratmann, first author of the article.

The clock transcription factor must be sacrificed

To their surprise, the scientists found that the clock protein BMAL1 is destroyed while stimulating the expression of the DBP gene. By applying a variety of sophisticated imaging and biochemical techniques, they showed that the BMAL1 molecules bound to the DBP gene are degraded by an intracellular protein destruction machine, termed the proteasome.

Curiously, the chopping of the triggering protein BMAL1 is absolutely required for the efficient activation of the DBP gene. In oth
'/>"/>

Contact: Ueli Schibler
ueli.schibler@unige.ch
41-223-796-175
Universit de Genve
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Self-forming biological scaffolding
2. Merging the biological and the electronic
3. Boston subway system to be used to test new sensors for biological agents
4. Making sense out of the biological matrix of bipolar disorder
5. Understanding the biological and ecological implications of safe nanotechnology
6. Iowa State, Ames Lab researchers invent new tool to study single biological molecules
7. Mathematicians find solution to biological building block puzzle
8. Allergies? Your sneeze is a biological response to the noses blue screen of death
9. Johns Hopkins researchers link 2 biological risk factors for schizophrenia
10. Golden West Biologicals, Inc. Exhibiting at AACC Clinical Lab Expo 2012
11. Biological and Pharmaceutical Complex Fluids Conference
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Watching the cogwheels of the biological clock in living cells
(Date:3/24/2015)... DUBLIN , Mar. 24, 2015 Research and ... addition of the "Global Iris Recognition Market 2015-2019" ... forecast the Global Iris Recognition market to grow at ... This report covers the present scenario and ... for the period 2015-2019. To calculate the market size, ...
(Date:3/23/2015)... 23, 2015   HOYOS Labs , a leading ... announced that the Company will demonstrate multiple biometrics-based technologies ... consumers at Connect:ID on March 23 through 25, 2015, ... will highlight the IEEE Biometric Open Protocol Standard; free ... enterprise access control system. BOPS was invented by HOYOS ...
(Date:3/20/2015)... 20, 2015 NXT-ID, Inc. (NASDAQ: NXTD ... focused on the growing mobile commerce market, announces its ... of the products featured in 2015 "I Want That" ... PM EST on the DIY Network.   ... Vegas , site of the 2015 International CES ...
Breaking Biology News(10 mins):Global Iris Recognition Market 2015-2019 with 3M Cogent, Bioenable Technologies, Cross Match Technology, Iris ID Systems & Safran Dominating 2HOYOS Labs to Showcase Host of Biometrics Technologies at Connect:ID in Washington, D.C. 2HOYOS Labs to Showcase Host of Biometrics Technologies at Connect:ID in Washington, D.C. 3NXT-ID's Wocket Biometric Smart Wallet to Air on "I Want That" International CES Special 2NXT-ID's Wocket Biometric Smart Wallet to Air on "I Want That" International CES Special 3
... May 22, 2011 -- The stomach bacteria responsible ... development of Parkinson,s disease according to research presented today ... for Microbiology. "Infection of late middle-aged mice with ... results in development of Parkinson,s disease symptoms after ...
... Texas No one knows the cause of most ... researchers have found that certain factors are consistently associated ... reactive oxygen species, highly destructive molecules usually formed as ... of excessive levels of copper and iron in regions ...
... New research at UC Santa Barbara is contributing to ... is part of the campus,s expanding vision research. The ... Proceedings of the National Academy of Sciences (PNAS), ... The scientists document how they used mice as a research ...
Cached Biology News:Ulcer bacteria may contribute to development of Parkinson's disease 2High iron, copper levels block brain-cell DNA repair 2UCSB scientists make strides in vision research 2
(Date:4/23/2015)... April 23, 2015 Follow ... to a series of genetic tests that determine ... Lou Gehrig's disease, Huntington's disease, and Alzheimer's disease. ... gene composition and interaction in diseased tissue/cells to ... well as the response to treatment, such as ...
(Date:4/23/2015)... (PRWEB) April 23, 2015 ... is the first EMC® Enterprise Content Division (ECD) ... entire EMC Documentum® for Life Sciences Solution ... proven knowledge and capabilities to provide life sciences ... solutions. , The EMC Documentum Solution Suite ...
(Date:4/23/2015)... , April 23, 2015 /PRNewswire/ - Crystal Research ... Executive Informational Overview ® (EIO) on Aeterna Zentaris ... report is available on Crystal Research Associates, website at ... Aeterna Zentaris, website at www.aezsinc.com . ... a specialty biopharmaceutical company in oncology, endocrinology, and women,s ...
(Date:4/22/2015)...  Sangamo BioSciences, Inc. (NASDAQ: SGMO ) today ... For the first quarter ended March 31, ... million, or $0.08 per share, compared to a net ... the same period in 2014. As of March 31, ... and interest receivable of $226.1 million. Revenues ...
Breaking Biology Technology:Increasing Disease Prevalence & Focus on Preventive Healthcare Drive the Predictive Diagnostics Market, According to a New Report by Global Industry Analysts, Inc. 2Increasing Disease Prevalence & Focus on Preventive Healthcare Drive the Predictive Diagnostics Market, According to a New Report by Global Industry Analysts, Inc. 3Glemser Earns Accreditation for Life Sciences Solution Suite 2Crystal Research Associates, LLC Issues Executive Informational Overview (EIO) on Aeterna Zentaris Inc. 2Crystal Research Associates, LLC Issues Executive Informational Overview (EIO) on Aeterna Zentaris Inc. 3Sangamo BioSciences Reports First Quarter 2015 Financial Results 2Sangamo BioSciences Reports First Quarter 2015 Financial Results 3Sangamo BioSciences Reports First Quarter 2015 Financial Results 4Sangamo BioSciences Reports First Quarter 2015 Financial Results 5Sangamo BioSciences Reports First Quarter 2015 Financial Results 6Sangamo BioSciences Reports First Quarter 2015 Financial Results 7Sangamo BioSciences Reports First Quarter 2015 Financial Results 8
... , CLEVELAND , June 28 ... Association as a Venture of Year Award Finalist. Founded ... engineering based therapies, Arteriocyte focuses on developing commercially available ... derived stem cells (marrow, peripheral cord blood, and cartilage) ...
... ... tool for the analysis of metabolites in plants , ... Amsterdam, The Netherlands (PRWEB) June 28, 2010 -- Genedata, a leading ... new Refiner MS at the 6th Metabolomics Conference 2010. Part of Genedata Expressionist ...
... ... 2009, to $295M worldwide; and is forecasted to reach $4B in 2015. , ... San Francisco, CA (PRWEB) June 28, 2010 ... and treat cognition, or digital brain health and fitness tools, grew 35% in ...
Cached Biology Technology:Arteriocyte Named Top Biotech Start Up Venture by the Ohio Venture Association for 2010 2Arteriocyte Named Top Biotech Start Up Venture by the Ohio Venture Association for 2010 3Genedata's Refiner MS Used by Max Planck Institute will Demo at Metabolomics Conference 2010 2Genedata's Refiner MS Used by Max Planck Institute will Demo at Metabolomics Conference 2010 3Genedata's Refiner MS Used by Max Planck Institute will Demo at Metabolomics Conference 2010 4New Report Finds A Brain Health Revolution in the Making, Driven by Digital Technology and Neuroplasticity Research 2New Report Finds A Brain Health Revolution in the Making, Driven by Digital Technology and Neuroplasticity Research 3New Report Finds A Brain Health Revolution in the Making, Driven by Digital Technology and Neuroplasticity Research 4New Report Finds A Brain Health Revolution in the Making, Driven by Digital Technology and Neuroplasticity Research 5
... The FP-6500 is the research-grade spectrofluorometer ... a highest sensitivity S/N ratio 200 or ... ,The FP-6500 is especially designed to keep ... in biochemistry as kinetics, stopped-flow, titration, or ...
... microRNA expression profiling and built on ... on-chip synthesis platform. These microarrays are ... microRNA Expression Profiling Service. ... Microarray contains all known arabidopsis microRNAs ...
... Microarrays designed for genome-wide microRNA expression profiling ... Paraflo microfluidic on-chip synthesis platform. These microarrays ... microRNA Expression Profiling Service. Probe ... all known cow microRNAs (108 unique mature ...
... genome-wide microRNA expression profiling and built ... microfluidic on-chip synthesis platform. These microarrays ... comprehensive microRNA Expression Profiling Service. ... microRNA Microarray contains all known virus ...
Biology Products: