tion is a process that occurs in all cells; the details of how the small protein termed "ubiquitin" modifies proteins and regulates cellular processes, however, are not yet well understood. The lab of German-born Dr. Rape is dedicated to exploring these mechanisms. To date, he has been successful in establishing structural characteristics of ubiquitylation at specific points in development, as well as identifying new ubiquitylation signals and linking them to different outcomes. Recently, Dr. Rape co-founded Nurix, a drug development company utilizing the biology of ubiquitylation, hoping to uncover new pathways for chemotherapy. He is an associate professor at University of California, Berkeley.
Joanna Wysocka Polish-born Dr. Wysocka, associate professor at Stanford University, focuses on epigenetic mechanisms that regulate self-renewal and differentiation. Interested in the molecular basis of developmental plasticity, her work centers on two cell types: embryonic stem cells and neural crest cells. Dr. Wysocka also studies how instructions encoded by the genome are interpreted in the context of a cellular state and signaling milieu to establish chromatin states permissive or restrictive for gene expression. In the future, Dr. Wysocka is interested in exploring several major questions, one of which is the genetic basis of human diversity, as most characteristically exemplified in human facial variety.
All prizewinners were selected by independent juries composed of leading experts in the scientific community, representing institutions such as the New York University School of Medicine, Rockefeller University, Salk Institute, and the Memorial Sloan-Kettering Cancer Center.
The prizes will be presented at an awards ceremony at the Mandarin Oriental in New York City in April 2013. Titia de Lange, Leon Hess Professor at Rockefeller University and recipient of the 2011 Vilcek Prize in Biomedical Science, will be presenting. In add
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