Navigation Links
Versatility of zebrafish research highlighted at international conference
Date:6/21/2012

rugs to stop smoking, have shown moderate success but do not work for all patients.

Professor Stephen Ekker's research group at the Mayo Clinic in Rochester, Minnesota, works closely with the Nicotine Dependence Center.

"We're working together to try to create better treatment options for patients suffering from tobacco dependence," says graduate student Margot Cousin. "There are some patients who receive these treatments and do well, but for other people they have almost no effect. There is a huge amount of variability in that treatment response. We're using the zebrafish model to look for novel candidate genes that might be involved in this process."

Dr. Ekker's lab has created hundreds of zebrafish lines with genetic mutations randomly scattered throughout the genome. Cousin uses a simple behavioral test to look at how the different mutant lines respond to nicotine exposure and drug treatment. Normal fish increase their swimming activity when treated with nicotine, she explains, but pre-treatment with varenicline usually blocks the nicotine response.

As she screens the genetically altered fish, she is looking for those that respond abnormally to either nicotine or the drug. Identification of the specific gene altered in each fish will provide clues to the pathways involved in nicotine addiction.

"We're looking to inform both the science as well as have ramifications for patient treatment. We can gain a lot of knowledge in a relatively short period of time using this as a model," Cousin says.

They hope to expand the available nicotine addiction treatment options to allow a more targeted approach and improve patient outcomes.

Variable Recovery After Chemotherapy

Anti-cancer treatments such as radiotherapy and chemotherapy can have serious side effects due to the death of blood cells, including several types important in the immune system. Those cells can be replenished by regenerative c
'/>"/>

Contact: Phyllis Edelman
pedelman@genetics-gsa.org
301-351-0896
Genetics Society of America
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. Environmental estrogens affect early developmental activity in zebrafish
2. Zebrafish could hold the key to understanding psychiatric disorders
3. Better housing conditions for zebrafish could improve research results
4. Autism Speaks awards nearly $2.9 million to fund autism research
5. Researchers advance biometric security
6. University of Tennessee professor receives funding for clean coal research
7. Research could help track stem cells in the body
8. Argonne researchers receive 4 R&D 100 awards
9. CRN assesses current state of scientific research for nutritional supplements
10. University of North Texas Health Science Center Advances Forensic Research by Investing in Semiconductor DNA Sequencing Technology
11. Research identifies specific bacteria linked to indoor water-damage and mold
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/2/2015)... 2015 Fingerprint Cards has received an ... FPC1155 from the distributor World Peace Industrial Group (WPI), part ... Asia . Deliveries are planned to take ... used by smartphone manufacturers in Asia . ... communicated revenue guidance of approximately 2,200 MSEK for 2015. ...
(Date:6/26/2015)... SPRINGVILLE, Utah , June 26, 2015 ATL ... assemblies and devices with specialties in single use solutions, headquartered ... acquisition of MedConx, Inc. (a California ... , and San Jose, Costa Rica ). ... Costa Rica with ATL Technology,s existing ...
(Date:6/24/2015)... , June 24, 2015 The biologics safety ... major drivers for the market include growth of the ... new drug launches. Over the years, the number of ... 2001 and 2010, the FDA approved 225 drug applications ... WIPO, Europe accounted for 3,822 ...
Breaking Biology News(10 mins):FPC Receives Order for Touch Fingerprint Sensors of 268 MSEK 2ATL Technology Announces Acquisition of MedConx, Inc. and Expanded Global Footprint 2Biological Safety Testing Market by Application, Product, & Test - Global Forecast to 2019 2Biological Safety Testing Market by Application, Product, & Test - Global Forecast to 2019 3Biological Safety Testing Market by Application, Product, & Test - Global Forecast to 2019 4
... one of the first human studies of its kind, researchers ... A, or BPA, may be related to decreased sperm quality ... to point out that these results are preliminary and more ... BPA on semen in rodents, but none are known to ...
... to cap it, and it could take billions more to ... Mexico is acknowledged the environmental catastrophe of the century. But ... the remaining problems. Prof. Eugene Rosenberg and Prof. ... and Biotechnology are using naturally occurring oil-munching bacteria, grown at ...
... understand how cells work may get a boost from a ... cells. The new technique, developed by a research ... of chemistry Lawrence Miller, provides the clearest, most dynamic view ... specially modified microscope. The finding is reported in ...
Cached Biology News:Sperm may be harmed by exposure to BPA, study suggests 2A nemesis for oil spills 2New tagging technique enhances view of living cells 2
(Date:7/29/2015)... ... 2015 , ... Brady (NYSE:BRC), a global leader in product ... align chemical container labeling with OSHA’s updated Hazard Communication (HazCom) Standard and the ... of an accurate label, and pictogram uses and meanings. , “With changes to ...
(Date:7/29/2015)... , July 29, 2015  Therapath Neuropathology ... announces increased partnerships with VA and Military Medical ... Nerve Fiber Density (ENFD) and Sweat Gland Nerve ... fiber neuropathy ( https://therapath.com/skin ). ... Fiber Density (ENFD) on punch skin biopsy is ...
(Date:7/29/2015)... , July 29, 2015  Indivior PLC (LON: INDV) ... naloxone nasal spray was accepted and received Priority Review ... the treatment of opioid overdose. This naloxone nasal spray ... formulated for optimal absorption into the nasal mucosa. 1 ... training so individuals may be better equipped to help ...
(Date:7/29/2015)... , July 29, 2015 /PRNewswire/ - RepliCel Life ... stage regenerative medicine company, is pleased to announce that ... injector (RCI-02) have been locked.  Prototypes for industrial ... prepare for an application for CE mark clearance ... in 2016. (Photo: ...
Breaking Biology Technology:Brady Announces a New GHS Label Guide 2Neuropathology services for VA and Military health systems 2Indivior PLC Announces FDA Acceptance of Naloxone Nasal Spray New Drug Application With Priority Review 2Indivior PLC Announces FDA Acceptance of Naloxone Nasal Spray New Drug Application With Priority Review 3Indivior PLC Announces FDA Acceptance of Naloxone Nasal Spray New Drug Application With Priority Review 4Indivior PLC Announces FDA Acceptance of Naloxone Nasal Spray New Drug Application With Priority Review 5RepliCel Life Sciences Unveils Innovative Dermal Injector Prototype 2RepliCel Life Sciences Unveils Innovative Dermal Injector Prototype 3RepliCel Life Sciences Unveils Innovative Dermal Injector Prototype 4RepliCel Life Sciences Unveils Innovative Dermal Injector Prototype 5
... Lab to promote collaborative ventures between Belmont,s School of Pharmacy ... ... 1 Cumberland Emerging,Technologies, Inc. (CET) today announced that Belmont ... Laboratory at the CET Life Sciences Center. The Life Sciences,Center, ...
... Laboratories, a leading,global clinical-diagnostics and biomedical-research laboratory ... Maureen Loftus has joined,the company as president ... and Chief Executive Officer, John F. (Jack) ... experience, garnered from more than,a dozen years ...
... Mich., July 1 Neogen Corporation,(Nasdaq: NEOG ... product line used in,animal health and hygiene applications ... includes 14 different product formulations,along with manufacturing process ... terms were not disclosed., The addition of ...
Cached Biology Technology:CET Life Sciences Center Welcomes Belmont University School of Pharmacy as New Tenant 2IBT Laboratories Names Maureen Loftus President and Chief Operating Officer 2IBT Laboratories Names Maureen Loftus President and Chief Operating Officer 3Neogen Acquires Product Line From DuPont Animal Health Solutions 2
... Our Smart Solutions has now entered ... Screening (HCS) by partnering up with Cellomics, ... from the integration of Beckman Coulter‘s automated ... uncovers deeper biological information at the sub-cellular ...
... in conjunction with the EasyCount System to count ... ViaSure Staining Reagent uses a mixture of ready-to-use ... Bromide to identify live and dead cells, respectively, ... 6 Multi-well Slide provides the ability to ...
... laser scanners is the starting point of ... ,Gene expression analysis, SNP (Single Nucleotide Polymorphism) ... the advancement of research in the post-genomics ... formats and sizes. These arrays call for ...
... This kit allows for rapid, convenient, and ... simple bind/wash/elute process utilizes a spin column ... beads for concentration of proteins which were ... are strong ion exchangers, offering high binding ...
Biology Products: