Navigation Links
Versatility of zebrafish research highlighted at international conference
Date:6/21/2012

parency of the young zebrafish to image the cancer process as it unfolds within a whole, living embryo.

"We can visualize the birth of a cancer," Dr.Ignatius says. "How a tumor forms, how tumor cells migrate, and the functional consequences of differentiation within individual cancer cells."

What they saw surprised them. Instead of the expected green stem cells leaving the existing tumor and establishing a new tumor, they saw highly migratory red mid-differentiated cells enter the blood vessels and move to a new site in the body. Over several days, it appeared that the green stem cells then slowly migrated toward the red ones to multiply and form a new tumor. Terminally differentiated blue tumor cells were largely stationary and did not contribute to local metastasis.

"Our data support a model where the first cell type to migrate into new areas of tumor growth is not a cancer stem cell, but is paradoxically a mid-differentiated ERMS cell, which has no intrinsic ability to proliferate and remake a tumor. Only after this cell primes the newly colonized area do slow-moving stem cells become recruited and drive continued tumor growth," says Dr. Langenau.

Their results suggest that efforts to control metastatic potential may need to target multiple cell populations within a tumor. Dr. Ignatius suggests, "New therapies should target both the cancer stem cell pool as well as highly migratory cell types that facilitate tumor spread. We believe our zebrafish model of disease will be useful in identifying novel drug targets for both of these processes."

Genetic Factors in Nicotine Dependence and Treatment Success

Nicotine dependence is one of the largest causes of preventable death and is associated with very high health care costs. The few approved treatment options currently available for people looking to kick their habit, primarily varenicline and buproprion, the generic names of two brand-name prescription d
'/>"/>

Contact: Phyllis Edelman
pedelman@genetics-gsa.org
301-351-0896
Genetics Society of America
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. Environmental estrogens affect early developmental activity in zebrafish
2. Zebrafish could hold the key to understanding psychiatric disorders
3. Better housing conditions for zebrafish could improve research results
4. Autism Speaks awards nearly $2.9 million to fund autism research
5. Researchers advance biometric security
6. University of Tennessee professor receives funding for clean coal research
7. Research could help track stem cells in the body
8. Argonne researchers receive 4 R&D 100 awards
9. CRN assesses current state of scientific research for nutritional supplements
10. University of North Texas Health Science Center Advances Forensic Research by Investing in Semiconductor DNA Sequencing Technology
11. Research identifies specific bacteria linked to indoor water-damage and mold
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/2/2015)... FELTON, California , September 2, 2015 /PRNewswire/ ... with the security purpose implied in a system ... hand geometry, voice, signature, iris, vein, DNA and ... crimes has forced to develop such system which ... by username, password, PIN, Patterns and tokens are ...
(Date:8/26/2015)... India , August 26, 2015 ... Three, Four, and Five Factor), Application (Travel & Immigration, ... Geography - Global Forecast to 2020", published by MarketsandMarkets, ... Billion by 2020, growing at a CAGR of 17.7% ... Tables and 82 F igures spread through 169 ...
(Date:8/20/2015)... Aug. 20, 2015   Sensory, Inc ., ... the user experience and security of consumer electronics ... announced that its TrulySecure™ is the ... to be FIDO Certified™. The FIDO ... with the FIDO UAF (Universal Authentication Framework) 1.0 ...
Breaking Biology News(10 mins):Biometrics Technology Market is Expected to Reach $13.8 Billion by 2015: Hexa Research Inc. 2Biometrics Technology Market is Expected to Reach $13.8 Billion by 2015: Hexa Research Inc. 3Biometrics Technology Market is Expected to Reach $13.8 Billion by 2015: Hexa Research Inc. 4Multi-Factor Authentication Market Worth 9.60 Billion USD by 2020 2Multi-Factor Authentication Market Worth 9.60 Billion USD by 2020 3Multi-Factor Authentication Market Worth 9.60 Billion USD by 2020 4Multi-Factor Authentication Market Worth 9.60 Billion USD by 2020 5TrulySecure From Sensory Becomes First Face and Voice Biometrics Technology to be FIDO UAF Certified 2TrulySecure From Sensory Becomes First Face and Voice Biometrics Technology to be FIDO UAF Certified 3TrulySecure From Sensory Becomes First Face and Voice Biometrics Technology to be FIDO UAF Certified 4TrulySecure From Sensory Becomes First Face and Voice Biometrics Technology to be FIDO UAF Certified 5
... GAINESVILLE, Fla. --- The observation that males evolve more ... biologist Charles Darwin noted the majesty of a peacocks ... peahens. No matter the species, males apparently ramp ... eternal competition to win the best mates, a concept ...
... and groundwater as well as snow fields and glaciers ... life and human livelihoods. Continuous observations are crucial ... mankind and the environment and also to provide crucial ... and droughts. These tasks are routinely undertaken by the ...
... for North America, released online this week by the U.S. ... overwhelmed by human-caused emissions. North American sources release nearly ... mostly as carbon dioxide. Carbon sinks such as ... these current sinks may turn into new sources as climate ...
Cached Biology News:Simple reason helps males evolve more quickly 2Simple reason helps males evolve more quickly 3Space technology put into service for global water resources observations 2First-ever 'State of the Carbon Cycle Report' finds troubling imbalance 2
(Date:9/1/2015)... ... September 02, 2015 , ... Spirax Sarco , the leader in ... site Spirax Sarco Anytime. This platform, offering unique online ordering capabilities, is only ... order? Log on to Spirax Sarco Anytime and within minutes you can be ...
(Date:9/1/2015)... 1, 2015  ContraVir Pharmaceuticals, Inc. (NASDAQ: CTRV ... commercialization of targeted antiviral therapies, announced today that it ... Annual Global Investment Conference sponsored by H.C. ... at The St. Regis Hotel in New ... Sapirstein , Chief Executive Officer, will provide an overview ...
(Date:9/1/2015)... (PRWEB) , ... September 01, ... ... the launch of the new ImageXpress® Micro Confocal High-Content Imaging System. This ... emerging assays that use 3D cellular models such as spheroids, tissues, and ...
(Date:9/1/2015)... Branford, Conn. (PRWEB) , ... September 01, 2015 ... ... development of high-quality recombinant antibodies, announced today that the National Institutes of Health ... grant (1R41DK104602-01), which will be administered by the NIH’s National Institute of Diabetes ...
Breaking Biology Technology:Spirax Sarco Announces New Features to Anytime Platform 2ContraVir to Present at Rodman & Renshaw 17th Annual Global Investment Conference 2ImageXpress Micro Confocal High-Content Imaging System Expands the Boundaries of Research 2ImageXpress Micro Confocal High-Content Imaging System Expands the Boundaries of Research 3AxioMx Announces Receipt of SBIR Grant for DNA-Protein Complex Antigen Development 2AxioMx Announces Receipt of SBIR Grant for DNA-Protein Complex Antigen Development 3
... 19 Abbott (NYSE:,ABT) will announce its 2008 third-quarter ... opens., The announcement will be followed by a ... Central time (9 a.m. Eastern), and will be,accessible through ... archived edition of the call will be,available after 11 ...
... China, Sept. 19 /Xinhua-PRNewswire-FirstCall/ --,China-Biotics, Inc. (OTC ... Chinese firm specializing in the manufacture,research, development, ... that at its 2008 Annual General Meeting ... the Company,s nominees to the,Board of Directors., ...
... Quarter 2008 Earnings Conference Call Tuesday, October 28, 2008, 5:00 ... p.m. U.S. EDT, FRAZER, Pa., Sept. ... quarter 2008 results for 5:00 p.m. EDT on Tuesday,October 28, 2008., ... October 28, 2008 Schedule, 4:10 p.m. EDT Q3 2008 results ...
Cached Biology Technology:China-Biotics, Inc. Announces Results of 2008 Annual General Meeting of Shareholders 2
Troponin I (22B11)...
Microlite 1+ 1x12 Strip assembled, flat bottom; the ideal vessel for low signal luminescent reactions, offering medium binding with enhanced dynamic range, extra high reflectivity and minimal cross t...
Immulon 4 HBX 1x12 Strip, flat bottom; high binding extra surface with special resin and irradiation, offers maximum protein uptake....
... 0-10 psi precision pressure regulator and pressurized syringe ... Faster liquid-switching Steady flow rate Microinjecting ... Can be added to any new ... any third-party manufacturer, even homemade. Connect to house ...
Biology Products: