Navigation Links
Vanderbilt study shows therapeutic bacteria prevent obesity in mice
Date:7/22/2014

ompound called NAPE, which is normally synthesized in the small intestine in response to feeding. NAPE is rapidly converted to NAE, a compound that reduces both food intake and weight gain. Some evidence suggests that NAPE production may be reduced in individuals eating a high-fat diet.

"NAPE seemed like a great compound to try since it's something that the host normally produces," Davies said.

The investigators added the NAPE-producing bacteria to the drinking water of mice eating a high-fat diet for eight weeks. Mice that received the modified bacteria had dramatically lower food intake, body fat, insulin resistance and fatty liver compared to mice receiving control bacteria.

They found that these protective effects persisted for at least four weeks after the NAPE-producing bacteria were removed from the drinking water. And even 12 weeks after the modified bacteria were removed, the treated mice still had much lower body weight and body fat compared to the control mice. Active bacteria no longer persisted after about six weeks.

"We still haven't achieved our ultimate goal, which would be to do one treatment and then never have to administer the bacteria again," Davies said. "Six weeks is pretty long to have active bacteria, and the animals are still less obese 12 weeks out.

"This paper provides a proof of concept," he said. "Clearly, we can get enough bacteria to persist in the gut and have a sustained effect. We would like for that effect to last longer."

Davies noted that the researchers also observed effects of the compounds in the liver, suggesting that it may be possible to use modified bacteria to deliver therapeutics beyond the gut.

The investigators are currently working on strategies to address regulatory issues related to containing the bacteria, for example by knocking out genes required for the bacteria to live outside the treated host.
'/>"/>

Contact: Leigh MacMillan
leigh.macmillan@vanderbilt.edu
615-322-4747
Vanderbilt University Medical Center
Source:Eurekalert

Page: 1 2

Related biology news :

1. Vanderbilt-led team to develop microbrain to improve drug testing
2. Yale Universitys Joan Steitz awarded 2012 Vanderbilt Prize
3. Vanderbilt diabetes researchers track cells ability to regenerate
4. Vanderbilt researchers discover how intestinal cells build nutrient-absorbing surface
5. Study by UC Santa Barbara researchers suggests that bacteria communicate by touch
6. Law that regulates shark fishery is too liberal: UBC study
7. New study will help protect vulnerable birds from impacts of climate change
8. Study jointly led by UCSB researcher supports theory of extraterrestrial impact
9. BYU study: Using a gun in bear encounters doesnt make you safer
10. 15-year study: When it comes to creating wetlands, Mother Nature is in charge
11. Pycnogenol (French maritime pine bark extract) shown to improve menopause symptoms in new study
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/16/2014)... the Columbia Center for Children,s Environmental Health at the ... demonstrate an association between childhood asthma and prenatal exposure ... household products. Results appear online in the journal ... mothers exposed during pregnancy to higher levels of the ... a 72 percent and 78 percent increase in risk ...
(Date:9/16/2014)... brakes" that time the generation of important cells in ... translate sound waves into electrical signals that are carried ... the arrangement of the cells is disordered, hearing is ... be published in The Journal of Neuroscience ... act as brakes to prevent hair cell generation until ...
(Date:9/16/2014)... species has its own bacterial identity. That,s the conclusion ... institutions who studied the genetic fingerprints of bacteria on ... , "This study demonstrates for the first time that ... ecological strategies possess very different microbial communities on their ... postdoctoral researcher in the UO,s Institute of Ecology and ...
Breaking Biology News(10 mins):Phthalates heighten risk for childhood asthma 2Phthalates heighten risk for childhood asthma 3Hey1 and Hey2 ensure inner ear 'hair cells' are made at the right time, in the right place 2Microbiome research shows each tree species has a unique bacterial identity 2
... an infectious question about eating at restaurants: How clean ... Pascall found that even when they washed dishes in ... to levels accepted in the Food and Drug Administration's ... and milk—can be safe havens for bacteria when dried ...
... with an overt reaction to toxins that cause oxidative ... health threats. , At the 233rd American Chemical Society ... Tech and the Edward Via Virginia College of Osteopathic ... biosensor prototype and correlations to brain tissue damage. ...
... level have on the activation of the female ... a researcher at the Cognitive Neuroscience Center (CNRS/Université ... from the National Institute of Mental Health (Bethesda, ... the first time, the neural networks involved in ...
Cached Biology News:Manual dishwashing study digs up dirt on dish cleanliness 2Manual dishwashing study digs up dirt on dish cleanliness 3Bacterial response to oxidation studied as toxin barometer 2Bacterial response to oxidation studied as toxin barometer 3The influence of the menstrual cycle on the female brain 2The influence of the menstrual cycle on the female brain 3The influence of the menstrual cycle on the female brain 4
(Date:9/17/2014)... , Sept. 17, 2014 A long-term ... partial breast irradiation (APBI) via interstitial brachytherapy suggests ... positive lymph nodes could be suitable to receive ... (ASTRO) guidelines place these patients in the "unsuitable" ... the 2014 ASTRO meeting, Beaumont Health System,s ...
(Date:9/17/2014)... PRINCETON, N.J. , Sept. 17, 2014 /PRNewswire/ ... developing targeted therapeutic devices to address infectious disease, cancer ... Sciences, Inc. (ESI), disclosed today that each company will ... Summit. On September 18 th , ... presentation entitled: "Exosomes: A Multiplexed Platform for Clinical Management." ...
(Date:9/17/2014)... 2014 JH Technologies announces ... in Irvine. JH Technologies, a leader in sales ... announced an expanded partnership with Leica Microsystems into the ... image analysis solutions will be featured at the grand ... new showroom facility is located within the JH Technologies ...
(Date:9/17/2014)... Intarcia Therapeutics, Inc. today announced the presentation ... cost and predictability of non-adherence in type 2 diabetes ... the European Association for the Study of Diabetes (EASD). ... Ph.D., of Analysis Group, Inc. presented data from the ... to characterize the prevalence of non-adherence and serial non-adherence, ...
Breaking Biology Technology:Partial Breast Irradiation With Interstitial Brachytherapy Appears Appropriate For Women Previously Considered Unsuitable 2Partial Breast Irradiation With Interstitial Brachytherapy Appears Appropriate For Women Previously Considered Unsuitable 3Partial Breast Irradiation With Interstitial Brachytherapy Appears Appropriate For Women Previously Considered Unsuitable 4Aethlon Medical and Exosome Sciences To Present at the Exosomes & SingleCell Analysis Summit 2Aethlon Medical and Exosome Sciences To Present at the Exosomes & SingleCell Analysis Summit 3JH Technologies displays newest microscope imaging technology at Southern California showroom grand opening 2JH Technologies displays newest microscope imaging technology at Southern California showroom grand opening 3Intarcia Reveals New Insights At EASD Meeting Characterizing The Burden Of Poor Control And Non-Adherence To Anti-Diabetic Therapies 2Intarcia Reveals New Insights At EASD Meeting Characterizing The Burden Of Poor Control And Non-Adherence To Anti-Diabetic Therapies 3Intarcia Reveals New Insights At EASD Meeting Characterizing The Burden Of Poor Control And Non-Adherence To Anti-Diabetic Therapies 4Intarcia Reveals New Insights At EASD Meeting Characterizing The Burden Of Poor Control And Non-Adherence To Anti-Diabetic Therapies 5
... ST. JOSEPH, Mich., July 16 GeneGo, Inc., ... biology and pathway,analysis, today announced that the University ... certified GeneGo Center of Excellence (COE). Miller,School of ... and advanced support. COE will provide a pathway ...
... Cell Therapeutics, Inc.,(CTI) (Nasdaq and MTA: CTIC) ... Patients and Providers Act of 2008, which,includes an ... such as Zevalin(R) (Ibritumomab Tiuxetan), overriding,President Bush,s veto., ... U.S. House of Representatives on,June 24, 2008 and ...
... the ... Treatment of Stuttering, ROANOKE, Va., ... non-profit research and,clinical center ( http://www.stuttering.org ) specializing ... stuttering,therapy with advanced behavioral, electronic and computer technologies that,significantly improve ...
Cached Biology Technology:University of Miami Miller School of Medicine Becomes a GeneGo Center of Excellence 218-Month Extension of Reimbursement Rates for Radioimmunotherapies Becomes Law After Congressional Override of Presidential Veto 218-Month Extension of Reimbursement Rates for Radioimmunotherapies Becomes Law After Congressional Override of Presidential Veto 3Video: New, Advanced Therapy Program Helps People Who Stutter Acquire Fluent Speech 2Video: New, Advanced Therapy Program Helps People Who Stutter Acquire Fluent Speech 3
... Software has been optimized for the analysis ... the software to quickly and accurately locate ... of an ELISA plate or each section ... has been customized to incorporate standard ELISA ...
For microscopy...
... description: Humidity wells in the base hold ... humidity and probe hydration around the edges ... the risk of waterbath contamination. This chamber ... waterbaths or hybridisation ovens. Linkage: This CLS ...
... R offers maximum application versatility for ... and cooling. Its active heating/cooling function ... temperature control ranges. Five different thermoblocks, ... test tubes, are available for: 0.5 ...
Biology Products: