Navigation Links
Vanderbilt study shows therapeutic bacteria prevent obesity in mice
Date:7/22/2014

A probiotic that prevents obesity could be on the horizon. Bacteria that produce a therapeutic compound in the gut inhibit weight gain, insulin resistance and other adverse effects of a high-fat diet in mice, Vanderbilt University investigators have discovered.

"Of course it's hard to speculate from mouse to human," said senior investigator Sean Davies, Ph.D., assistant professor of Pharmacology. "But essentially we've prevented most of the negative consequences of obesity in mice, even though they're eating a high-fat diet."

Regulatory issues must be addressed before moving to human studies, Davies said, but the findings published in the August issue of the Journal of Clinical Investigation suggest that it may be possible to manipulate the bacterial residents of the gut the gut microbiota to treat obesity and other chronic diseases.

Davies has a long-standing interest in using probiotic bacteria "friendly" bacteria like those in yogurt to deliver drugs to the gut in a sustained manner, in order to eliminate the daily drug regimens associated with chronic diseases.

In 2007, he received a National Institutes of Health Director's New Innovator Award to develop and test the idea.

"The NIH basically said, 'we like this idea, now make it work,'" Davies said. "The New Innovator Award was critical to our success."

Other studies have demonstrated that the natural gut microbiota plays a role in obesity, diabetes and cardiovascular disease.

"The types of bacteria you have in your gut influence your risk for chronic diseases," Davies said. "We wondered if we could manipulate the gut microbiota in a way that would promote health."

To start, the team needed a safe bacterial strain that colonizes the human gut. They selected E. coli Nissle 1917, which has been used as a probiotic treatment for diarrhea since its discovery nearly 100 years ago.

They genetically modified the E. coli Nissle strain to produce a lipid c
'/>"/>

Contact: Leigh MacMillan
leigh.macmillan@vanderbilt.edu
615-322-4747
Vanderbilt University Medical Center
Source:Eurekalert

Page: 1 2

Related biology news :

1. Vanderbilt-led team to develop microbrain to improve drug testing
2. Yale Universitys Joan Steitz awarded 2012 Vanderbilt Prize
3. Vanderbilt diabetes researchers track cells ability to regenerate
4. Vanderbilt researchers discover how intestinal cells build nutrient-absorbing surface
5. Study by UC Santa Barbara researchers suggests that bacteria communicate by touch
6. Law that regulates shark fishery is too liberal: UBC study
7. New study will help protect vulnerable birds from impacts of climate change
8. Study jointly led by UCSB researcher supports theory of extraterrestrial impact
9. BYU study: Using a gun in bear encounters doesnt make you safer
10. 15-year study: When it comes to creating wetlands, Mother Nature is in charge
11. Pycnogenol (French maritime pine bark extract) shown to improve menopause symptoms in new study
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/13/2015)... 2015 ACT Genomics Co., Ltd., a ... transform cancer genomic information into precision diagnosis and ... raised US$ 8 million in the its first private ... Taipei, Taiwan , ACT Genomics has developed ... aim to implement next generation sequencing (NGS) and ...
(Date:2/11/2015)... According to a ... Product (Cards and Readers, Biometrics, Controllers, Management Software), ... Healthcare, Education) and By Geography - Global Forecast and Analysis to ... Control Market is expected to reach $10.4 ... of 10.6% between 2014 and 2020. ...
(Date:2/5/2015)... North Carolina , 5. Februar 2015 ... Jahr als spezialisiertes Logistikunternehmen und hat eine ... einzige klinische Logistikfirma (Clinical Logistics Organization – ... der neuen Kampagne lautet First , ... Foto: http://photos.prnewswire.com/prnh/20150205/173753 ...
Breaking Biology News(10 mins):ACT Genomics Raises $8 Million in its First Private Funding Round 2Access Control Market Worth $10.4 Billion by 2020 2Access Control Market Worth $10.4 Billion by 2020 3Access Control Market Worth $10.4 Billion by 2020 4Marken startet Kampagne mit Patienten im Mittelpunkt 2Marken startet Kampagne mit Patienten im Mittelpunkt 3
... has been the inspiration for countless books and movies, ... engineers. Researchers at the California Institute of Technology (Caltech) ... intelligencenot in a robot or a silicon chip, but ... to have made an artificial neural network out of ...
... Mobile devices have become as common as the stethoscope in ... read test results, access diagnostic tools and take patient notes, ... smartphone or using a flash drive. These mobile devices are ... huge security risks to patient information. In less ...
... LOS ALAMOS, New Mexico, July 20, 2011Researchers at the ... Great Lakes Bioenergy Research Center have found a potential ... materials such as corn leaves and stalks, or switch ... Journal of the American Chemical Society , Los Alamos ...
Cached Biology News:Caltech researchers create the first artificial neural network out of DNA 2Caltech researchers create the first artificial neural network out of DNA 3Caltech researchers create the first artificial neural network out of DNA 4Mobile Devices Pose New Security Risks for Patients; Five Experts Share Insights on mHealth 2Mobile Devices Pose New Security Risks for Patients; Five Experts Share Insights on mHealth 3Mobile Devices Pose New Security Risks for Patients; Five Experts Share Insights on mHealth 4Mobile Devices Pose New Security Risks for Patients; Five Experts Share Insights on mHealth 5Researchers find potential key for unlocking biomass energy 2
(Date:3/2/2015)... Resilinc released online today its ... summarizes and analyzes nearly 700 unique supply chain notifications ... global event monitoring and alert reporting service. Supply chain ... period of the email service to receive early warnings ... impact revenue, market share, customer satisfaction, and shareholder value. ...
(Date:3/2/2015)... 2015  Pfenex Inc. (NYSE MKT: PFNX), a ... biosimilar therapeutics, today announced that it will be ... in Miami, FL at the Loews Miami Beach Hotel.  Dr. ... Pfenex, will provide an overview of the company,s ... ET. A live audio webcast and archive of ...
(Date:3/2/2015)... BARBARA, Calif. , March 2, 2015 /PRNewswire/ ... biotechnology company developing therapies for autoimmune and infectious ... Office (USPTO) has issued an important new composition ... system function through the targeting of CLIP. ... targeted peptide technology underlying VG Life Sciences, VG1177, ...
(Date:3/1/2015)... London, UK (PRWEB) March 01, 2015 ... a partnership agreement for quality market research promotion ... and sell research reports worked out by DataGroup ... Department at Market Publishers Ltd, commented on the ... to have DataGroup Booksellers in our team of ...
Breaking Biology Technology:Resilinc Publishes 2014 EventWatch™ Supply Chain Disruption Annual Report 2Resilinc Publishes 2014 EventWatch™ Supply Chain Disruption Annual Report 3VG Life Sciences Granted Key Composition Of Matter Patent 2VG Life Sciences Granted Key Composition Of Matter Patent 3Market Publishers Ltd and DataGroup Booksellers Sign Partnership Agreement 2Market Publishers Ltd and DataGroup Booksellers Sign Partnership Agreement 3
... AMEX: SNT ) announced that that Leslie J. ... DATE: December 1, 2011 TIME: 10:00 AM EST LINK: ... now" button. This will be a live, interactive ... questions in real-time both in the presentation hall as well ...
... Molecular Devices, LLC, the prominent source of powerful ... release of a much-anticipated customizable extension to its suite ... (Logo:  http://photos.prnewswire.com/prnh/20100406/SF82092LOGO ) Version ... the 51st annual meeting of the American Society for ...
... lead roles in a study that identified a portion ... embryonic stem cells (hESCs). The study was a worldwide ... of Sheffield (UK), Paul Robson of the Genome Institute ... Institute (BTI), and Barbara Knowles and others in the ...
Cached Biology Technology:Senesco Technologies, Inc. to Webcast, Live, at RetailInvestorConferences.com on December 1st 2Senesco Technologies, Inc. to Webcast, Live, at RetailInvestorConferences.com on December 1st 3Innovative MetaMorph® NX Software Shatters Barriers Between Researchers and Image Analysis Goals with Exclusive Visual Workflow 2Innovative MetaMorph® NX Software Shatters Barriers Between Researchers and Image Analysis Goals with Exclusive Visual Workflow 3Singapore scientists lead human embryonic stem cell study 2Singapore scientists lead human embryonic stem cell study 3
... PGE2 is one of several isoprostanes produced from ... potent renal vasoconstrictor in the rat. 8-iso PGE2 ... values of 0.5 and 5 µM, respectively. When ... at a concentration of 4 mg/kg/min, 8-iso PGE2 ...
... Source: Tritirachium album Description: Proteinase ... used in a wide range of applications purified ... bonds mainly following the carboxyl group of N-substituted ... and is classified as a serine protease. Proteinase ...
Proliferin (C-14)...
Porcine Pulmonary Artery Endothelial Cells (PPAEC) (>500,000 cells)...
Biology Products: