Navigation Links
Using bone marrow to protect the brain
Date:9/19/2011

The ability to produce neuroprotectors, proteins that protect the human brain against neurodegenerative disorders such as Parkinson's and ALS, is the holy grail of brain research. A technology developed at Tel Aviv University does just that, and it's now out of the lab and in hospitals to begin clinical trials with patients suffering from amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease.

Developed by Prof. Daniel Offen and Prof. Eldad Melamed of TAU's Sackler Faculty of Medicine and Felsenstein Medical Research Center, the technology is now a patent-pending process that takes stem cells from a patient's own bone marrow and causes them to differentiate into astrocyte-like cells, which are responsible for the well-being of the brain's neurons. The cells release neurotrophic factors, or neuroprotectants, which have been shown to play a key role in reducing the progress of ALS, a debilitating disease characterized by the progressive degeneration of motor neurons, resulting in paralysis of a patient's limbs and organ function.

The research has appeared in the Journal of Stem Cells Reviews and Reports and a number of other publications.

Trials in Jerusalem and Boston

This stem cell technology, says Prof. Offen, represents 10 years of development. Inspired by advances in embryonic stem cell research and its huge potential but trying to bypass the ethical and safety issues Prof. Offen and his fellow researchers turned to stem cells derived from a patient's own bone marrow.

After coaxing the cells to differentiate into astrocyte-like cells, whose natural function is to guard the brain's neurons and prevent deterioration, the researchers began testing the concept in animal models. "In the mouse model," Prof. Offen explains, "we were able to show that the bone marrow derived stem cells prevent degeneration in the brain following injection of selective neurotoxins." Researchers also demo
'/>"/>

Contact: George Hunka
ghunka@aftau.org
212-742-9070
American Friends of Tel Aviv University
Source:Eurekalert

Page: 1 2

Related biology news :

1. New data from studies bolsters case for using aldosterone antagonists in heart failure
2. A 3-D reconstructed image of neural dendritic trees using the advanced electron microscope technology
3. Using a mathematical model to evaluate microsatellite genotyping from low-quality DNA
4. Lack of free play among children is causing harm, say experts in American Journal of Play
5. UC Davis researchers find disease-causing fat cells in those with metabolic syndrome
6. Using a systems biology approach to look under the hood of an aggressive form of breast cancer
7. BUSM awarded $9 million to investigate treatment for sickle cell disease using iPS cells
8. For the first time, the European IVF Monitoring Group reports on cycles using frozen eggs
9. Using DNA in fight against illegal logging
10. Using olive oil in your diet may prevent a stroke
11. Using living cells as an invisibility cloak
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/30/2014)... therapeutics present unique challenges when it comes to ... harm. New consensus guidelines for toxicity testing that ... characteristics of these novel biopharmaceuticals are presented in ... from Mary Ann Liebert, Inc. publishers . ... Nucleic Acid Therapeutics website until November 30, ...
(Date:10/30/2014)... Biological membranes are mainly composed of lipid bilayers. ... ions onto lipid membranes helps clarify functional processes ... a quantitative description of the equilibria between lipid ... Zbigniew Figaszewski from the University of Bialystok, Poland, ... findings, just published in EPJ E . ...
(Date:10/29/2014)... as a consequence of chemotherapy will benefit from a ... technology that prevents hair loss. , The research is ... scalp cooling manufacturing company, Paxman Coolers, of Fenay Bridge, ... University of Huddersfield. , The research will be led ... in the pharmacology of cancer treatment, which he will ...
Breaking Biology News(10 mins):New guidelines for reproductive & developmental toxicity testing of oligonucleotide drugs 2Ion adsorption matter in biology 2New technology on the way to aid cancer suffers who lose their hair after chemotherapy 2
... When North Carolina,s "Laura,s Law" was signed by Governor ... in the last year to pass progressive DUI legislation that ... cars to required—and enforced—sobriety for the most dangerous drivers on ... movement, as state lawmakers look at incorporating required 24/7 alcohol ...
... Calif., Oct. 18, 2011 DigitalPersona, ... and endpoint protection solutions, today launched a new ... the growing market of battery-powered mobile identification devices. ... of fingerprint modules and readers make high-efficiency, standards-compliant ...
... the first time have identified and mapped the chemical structure ... kill or inhibit the growth of reef-building coral. Chemicals ... been shown to harm coral, suggesting that competition with these ... and lack of recovery of coral reefs. Seaweed ...
Cached Biology News:Are Alcohol Anklets the New Ignition Interlock? 2Are Alcohol Anklets the New Ignition Interlock? 3Are Alcohol Anklets the New Ignition Interlock? 4DigitalPersona Goes Mobile with New U.are.U 5100 Fingerprint Sensors for Battery-Powered Mobile ID Devices 2DigitalPersona Goes Mobile with New U.are.U 5100 Fingerprint Sensors for Battery-Powered Mobile ID Devices 3DigitalPersona Goes Mobile with New U.are.U 5100 Fingerprint Sensors for Battery-Powered Mobile ID Devices 4Study identifies molecules used by certain species of seaweed to harm corals 2Study identifies molecules used by certain species of seaweed to harm corals 3Study identifies molecules used by certain species of seaweed to harm corals 4
(Date:10/30/2014)... Isis Pharmaceuticals, Inc. (NASDAQ: ISIS ), ... present a company overview at the Nomura Biotechnology Conference on ... Boston, MA. A live webcast ... Media" section of the Company,s website, www.isispharm.com .  A ... hours and will be archived for a limited time. ...
(Date:10/30/2014)... RIDGE, N.J. , Oct. 30, 2014  Regado ... that it will hold a conference call and live ... a.m. EST to discuss its third quarter 2014 financial ... the conference call by dialing (888) 347-1165 for domestic ... call will be webcast live under the investor relations ...
(Date:10/30/2014)... 29, 2014) – The severe flooding that devastated a ... less destructive if the bridges, roads and other infrastructure ... study from the University of Colorado Denver. , "People ... said Jimmy Kim, PhD, associate professor of structural engineering ... Science and lead author the study. "There is an ...
(Date:10/27/2014)... 27, 2014 The new research ... (High & Medium), Sub-type (Primary & Secondary), and ... & Transportation & Power Generation) - Trends and ... market with analysis and forecasting of the market ... Tables with 52 Figures spread through 146 Pages ...
Breaking Biology Technology:Isis Pharmaceuticals to Present at the Nomura Biotechnology Conference 2Regado Biosciences to Provide Third Quarter 2014 Financial Results 2CU Denver study says upgrading infrastructure could reduce flood damage 2Gas Insulated Switchgear Market worth $21,951.9 Million by 2019 - New Report by MarketsandMarkets 2Gas Insulated Switchgear Market worth $21,951.9 Million by 2019 - New Report by MarketsandMarkets 3Gas Insulated Switchgear Market worth $21,951.9 Million by 2019 - New Report by MarketsandMarkets 4
... ... users to easily find and schedule an appointment for a local health screening, learn ... with the company via Facebook, Twitter, and YouTube. The health screening company’s ... ...
... passed as fact among historians, journalists and politicians, and has ... the U.S. Congress: British forces used chemical weapons on Iraqis ... has never been fully squared with the historical record, says ... Douglas,s research, forthcoming in the December issue of The ...
... of death from roadside bombs to freeway crashes. Traumatic injury, ... 44, often overwhelms the body,s natural blood-clotting process. In ... by Erin Lavik, a new Case Western Reserve University biomedical ... built synthetic platelets that show promise in halting internal and ...
Cached Biology Technology:Website Redesign Enhances Global Health Screening Service's Online Presence 2Website Redesign Enhances Global Health Screening Service's Online Presence 3Despite claims, UK did not gas Iraqis in the 1920s, new research finds 2Despite claims, UK did not gas Iraqis in the 1920s, new research finds 3Despite claims, UK did not gas Iraqis in the 1920s, new research finds 4Researchers take the inside route to halt bleeding 2
... Fiberboard boxes are ideal for use in refrigerators, freezers, ... racks. Four vibrant colors allow for color coding to ... liquid nitrogen drainage or promote cool air circulation. Supplied ... holds 81 tubes. Box dimensions: 13 x ...
Sterile glass 5 mm beads that make spreading bacterial and yeast cultures easy. Can be washed, autoclaved and reused....
Similar to proteasome (prosome, macropain) 26S subunit, ATPase, 1 Antigen: Recombinant Protein...
RABBIT ANTI AMPHOTERIN...
Biology Products: