Navigation Links
Using bone marrow to protect the brain
Date:9/19/2011

The ability to produce neuroprotectors, proteins that protect the human brain against neurodegenerative disorders such as Parkinson's and ALS, is the holy grail of brain research. A technology developed at Tel Aviv University does just that, and it's now out of the lab and in hospitals to begin clinical trials with patients suffering from amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease.

Developed by Prof. Daniel Offen and Prof. Eldad Melamed of TAU's Sackler Faculty of Medicine and Felsenstein Medical Research Center, the technology is now a patent-pending process that takes stem cells from a patient's own bone marrow and causes them to differentiate into astrocyte-like cells, which are responsible for the well-being of the brain's neurons. The cells release neurotrophic factors, or neuroprotectants, which have been shown to play a key role in reducing the progress of ALS, a debilitating disease characterized by the progressive degeneration of motor neurons, resulting in paralysis of a patient's limbs and organ function.

The research has appeared in the Journal of Stem Cells Reviews and Reports and a number of other publications.

Trials in Jerusalem and Boston

This stem cell technology, says Prof. Offen, represents 10 years of development. Inspired by advances in embryonic stem cell research and its huge potential but trying to bypass the ethical and safety issues Prof. Offen and his fellow researchers turned to stem cells derived from a patient's own bone marrow.

After coaxing the cells to differentiate into astrocyte-like cells, whose natural function is to guard the brain's neurons and prevent deterioration, the researchers began testing the concept in animal models. "In the mouse model," Prof. Offen explains, "we were able to show that the bone marrow derived stem cells prevent degeneration in the brain following injection of selective neurotoxins." Researchers also demo
'/>"/>

Contact: George Hunka
ghunka@aftau.org
212-742-9070
American Friends of Tel Aviv University
Source:Eurekalert

Page: 1 2

Related biology news :

1. New data from studies bolsters case for using aldosterone antagonists in heart failure
2. A 3-D reconstructed image of neural dendritic trees using the advanced electron microscope technology
3. Using a mathematical model to evaluate microsatellite genotyping from low-quality DNA
4. Lack of free play among children is causing harm, say experts in American Journal of Play
5. UC Davis researchers find disease-causing fat cells in those with metabolic syndrome
6. Using a systems biology approach to look under the hood of an aggressive form of breast cancer
7. BUSM awarded $9 million to investigate treatment for sickle cell disease using iPS cells
8. For the first time, the European IVF Monitoring Group reports on cycles using frozen eggs
9. Using DNA in fight against illegal logging
10. Using olive oil in your diet may prevent a stroke
11. Using living cells as an invisibility cloak
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/21/2014)... pancreatitis involves the pancreas digesting itself resulting in severe ... the UK around 20,000 patients are diagnosed with the ... cure and treatment is restricted to intravenous fluid and ... Faculty of Life Sciences, who led the research, said ... from gall stones and excessive alcohol intake combined with ...
(Date:8/20/2014)... Cancer Institute (HCI) at the University of Utah have ... encodes BCR-ABL, the unregulated enzyme driving the blood cancer ... Society, nearly 6,000 new cases of CML will be ... tyrosine kinase inhibitors (TKIs), target BCR-ABL and are effective ... but control it in a way that allows patients ...
(Date:8/20/2014)... the University of Tbingen, Arizona State University, the Wellcome ... Health Institute (Swiss TPH) isolated Mycobacterium pinnipedii ... 1000 years old. The pathogen is a relative of ... causes disease in humans today. These researchers assume that ... coast. "The link to sea lions was unexpected" comments ...
Breaking Biology News(10 mins):Insulin offers new hope for the treatment of acute pancreatitis 2Blueprint for next generation of chronic myeloid leukemia treatment 2
... - University of Kansas scientists have found that infants ... acids (LCPUFA) from birth to 12 months scored significantly ... intelligence conducted between the ages of three to six ... on detailed tasks involving pattern discrimination, rule-learning and inhibition ...
... Ill. A successful program that increased the number ... consumption by 50 percent among Latino children had two ... "First, we got mothers and other relatives ... for Latinos. Many programs, delivered at school, target only ...
... Colorado Cancer Center member recently published in the journal ... young, female cancer survivors, quality of life is significantly ... survivors to 66 healthy controls and found that, as ... the general population. Of note, survivors reported particular stress ...
Cached Biology News:DHA-enriched formula in infancy linked to positive cognitive outcomes in childhood 2Latino families in study eat more fruits and veggies, drink less soda 2Latino families in study eat more fruits and veggies, drink less soda 3Perception of fertility affects quality of life in young, female cancer survivors 2
(Date:8/20/2014)... 20, 2014 The 6th Annual ... held on October 29-30 in San Francisco, CA. This ... and government researchers and clinicians focused on addressing and ... , In the twelve years since the sequencing of ... been introduced with pharmacogenetic information in the label and ...
(Date:8/20/2014)... ear could improve the health of your heart, researchers ... Leeds used a standard TENS machine like those designed ... the tragus, the small raised flap at the front ... canal. , The stimulation changed the influence of the ... signals that can drive failing hearts too hard. , ...
(Date:8/19/2014)... One of the major limitations in ... vascular supply. Nutrient and gas transport throughout synthetic ... for successful regeneration and integration into the patient’s ... vascularization and promote angiogenesis in a variety of ... and architecture, and enhancing scaffolds with stem cells. ...
(Date:8/19/2014)... DANVILLE, Pa. , Aug. 19, 2014 ... C has been nominated for a Centers for Disease ... to addressing a major public health concern. ... Health System, is one of a team of researchers ... (CDC) Charles C. Shepard Science Award for Data Methods ...
Breaking Biology Technology:6th Annual Personalized and Precision Medicine Conference Bringing Together Thought Leaders to Discuss Clinical Implementation, Dx Reimbursement, Big Data, and Sequencing 2'Tickling' your ear could be good for your heart 2Vascularization in Tissue Engineering Highlighted at 12th New Jersey Symposium on Biomaterials Science 2Geisinger investigator nominated for federal award 2Geisinger investigator nominated for federal award 3
... Haven, Conn.A team led by Yale University researchers has ... step toward the ultimate dream of building a quantum ... chip to successfully run elementary algorithms, such as a ... device for the first time. Their findings will appear ...
... run 30-second spot on Pyratine XR(TM) and Rosacea - , ... Bulletin Board: SNKTY), a Life Sciences company engaged in the ... announced today that on June 27, 2009 at 7:19 AM ... tetrahydropyranyl adenine) and rosacea, a condition afflicting more than 14 ...
... N.C., June 26 Syngenta Biotechnology, Inc. announced today ... Evogene, Ltd., focusing on identifying plant genes related to ... exclusive licensing rights to candidate genes discovered by Evogene ... is a soil parasite which attacks the roots of ...
Cached Biology Technology:Scientists create first electronic quantum processor 2Television News Segment Featuring Pyratine XR to Air to 18 Million + Households on DIRECTV NewsCluster 2Syngenta and Evogene to Collaborate on Soybean Nematode Resistance 2
The VersArray hybridization chamber is used for manual (coverslip) hybridization of microarrays. The chamber accommodates 2 slides and is watertight to allow incubation of slides in a water bath. Dim...
... state-of-the-art separation system using the asymmetric flow ... integrates easily with Wyatts multi-angle light scattering ... as the Optilab DSP. The combined system ... of the particles/molecules separated by the AFFF ...
Monoclonal antibodies conjugated with rhodamine...
... Moticam 2300 camera (MC2300) attaches to virtually ... trinocular port. Included in the standard package, ... software offers quick and accurate image capture, ... for examination or documentation purposes. The MC2300s ...
Biology Products: