Navigation Links
UofL researchers replicate human kidney gene changes in mouse model
Date:5/23/2011

LOUISVILLE, Ky. University of Louisville researchers have replicated the inflammatory gene changes of a human kidney as it progresses from mild to severe diabetic nephropathy, using a mouse model developed by a UofL researcher, according to an article published today in the journal Experimental Nephrology. Diabetic nephropathy is the foremost cause of kidney failure.

"In 2004 we published an article that showed that our diabetic mouse model, OVE26, excreted high levels of protein in the urine, as humans with diabetes do. We continue to see resemblance to human diabetes as we test different aspects of the disease using this mouse model," said Paul Epstein, Ph.D., acting director of the Kosair Children's Hospital Research Institute.

The processes leading to advanced diabetic nephropathy are poorly understood. Researchers have not been able to observe kidney failure through its full cycle of development, because of the natural lifespan and other limitations of available diabetic animal models.

Because of these limitations, changes in renal gene expression can be used to evaluate the progression of diabetic nephropathy. Gene expression studies, which measure the gene's synthesis of messenger RNA, identify individual genes or major signaling pathways activated as diabetic nephropathy progresses.

This is the first study of gene expression changes of whole kidney during the progression from mild to very severe albuminuria, a condition common to patients with longstanding diabetes.

Researchers found that some gene expression differences between control and diabetic mice increased 10-fold. The change was most obvious for inflammatory genes.

This suggests that this strain of diabetic mice could be used to look for new insights into human diabetic nephropathy and raises questions about the role of inflammation in kidney failure.

"They provide an excellent model of diabetic nephropathy to assess the effect of inflammatory proteins," Epstein said. "In future studies, we can use this mouse model to explore whether inflammation causes disease progression or if the progression of the disease causes further inflammation. If it turns out that inflammation is causal, the next step would be to test the effectiveness of anti-inflammatory drugs."


'/>"/>

Contact: Anne Eldridge
anne.eldridge@louisville.edu
502-852-0943
University of Louisville
Source:Eurekalert

Related biology news :

1. NC State researchers get to root of parasite genome
2. Researchers find animal with ability to survive climate change
3. Researchers find an essential gene for forming ears of corn
4. Researchers note differences between people and animals on calorie restriction
5. Researchers study acoustic communication in deep-sea fish
6. Researchers discover that growing up too fast may mean dying young in honey bees
7. Researchers study how pistachios may improve heart health
8. UI researchers find potentially toxic substance present in Chicago air
9. Researchers develop new self-training gene prediction program for fungi
10. Case Western Reserve University researchers track Chernobyl fallout
11. Childrens National researchers develop novel anti-tumor vaccine
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/28/2016)... -- First quarter 2016:   , Revenues ... first quarter of 2015 The gross margin was 49% ... and the operating margin was 40% (-13) Earnings per ... from operations was SEK 249.9 M (21.2) , Outlook ... 7,000-8,500 M. The operating margin for 2016 is estimated ...
(Date:4/15/2016)... -- Research and Markets has announced the ...  report to their offering.  ,      ... gait biometrics market is expected to grow at ... Gait analysis generates multiple variables such ... compute factors that are not or cannot be ...
(Date:3/29/2016)... Florida , March 29, 2016 ... the "Company") LegacyXChange "LEGX" and SelectaDNA/CSI Protect are pleased ... in ink used in a variety of writing instruments, ... Buyers of originally created collectibles from athletes on LegacyXChange ... forensic analysis of the DNA. Bill ...
Breaking Biology News(10 mins):
(Date:6/24/2016)... Brooklyn, NY (PRWEB) , ... June 24, 2016 , ... ... 15mm, machines such as the Cary 5000 and the 6000i models are higher end ... height is the height of the spectrophotometer’s light beam from the bottom of the ...
(Date:6/23/2016)... , June 23, 2016 /PRNewswire/ - FACIT ... Ontario biotechnology company, Propellon Therapeutics ... development and commercialization of a portfolio of first-in-class ... Epigenetic targets such as WDR5 represent an exciting ... significantly in precision medicine for cancer patients. Substantial ...
(Date:6/23/2016)... June, 23, 2016  The Biodesign Challenge (BDC), a ... ways to harness living systems and biotechnology, announced its ... in New York City . ... students, showcased projects at MoMA,s Celeste Bartos Theater during ... , MoMA,s senior curator of architecture and design, and ...
(Date:6/23/2016)... 2016 Apellis Pharmaceuticals, Inc. today announced ... of its complement C3 inhibitor, APL-2. The trials ... dose studies designed to assess the safety, tolerability, ... in healthy adult volunteers. Forty subjects ... single dose (ranging from 45 to 1,440mg) or ...
Breaking Biology Technology: