Navigation Links
UofL researchers replicate human kidney gene changes in mouse model
Date:5/23/2011

LOUISVILLE, Ky. University of Louisville researchers have replicated the inflammatory gene changes of a human kidney as it progresses from mild to severe diabetic nephropathy, using a mouse model developed by a UofL researcher, according to an article published today in the journal Experimental Nephrology. Diabetic nephropathy is the foremost cause of kidney failure.

"In 2004 we published an article that showed that our diabetic mouse model, OVE26, excreted high levels of protein in the urine, as humans with diabetes do. We continue to see resemblance to human diabetes as we test different aspects of the disease using this mouse model," said Paul Epstein, Ph.D., acting director of the Kosair Children's Hospital Research Institute.

The processes leading to advanced diabetic nephropathy are poorly understood. Researchers have not been able to observe kidney failure through its full cycle of development, because of the natural lifespan and other limitations of available diabetic animal models.

Because of these limitations, changes in renal gene expression can be used to evaluate the progression of diabetic nephropathy. Gene expression studies, which measure the gene's synthesis of messenger RNA, identify individual genes or major signaling pathways activated as diabetic nephropathy progresses.

This is the first study of gene expression changes of whole kidney during the progression from mild to very severe albuminuria, a condition common to patients with longstanding diabetes.

Researchers found that some gene expression differences between control and diabetic mice increased 10-fold. The change was most obvious for inflammatory genes.

This suggests that this strain of diabetic mice could be used to look for new insights into human diabetic nephropathy and raises questions about the role of inflammation in kidney failure.

"They provide an excellent model of diabetic nephropathy to assess th
'/>"/>

Contact: Anne Eldridge
anne.eldridge@louisville.edu
502-852-0943
University of Louisville
Source:Eurekalert

Page: 1 2

Related biology news :

1. NC State researchers get to root of parasite genome
2. Researchers find animal with ability to survive climate change
3. Researchers find an essential gene for forming ears of corn
4. Researchers note differences between people and animals on calorie restriction
5. Researchers study acoustic communication in deep-sea fish
6. Researchers discover that growing up too fast may mean dying young in honey bees
7. Researchers study how pistachios may improve heart health
8. UI researchers find potentially toxic substance present in Chicago air
9. Researchers develop new self-training gene prediction program for fungi
10. Case Western Reserve University researchers track Chernobyl fallout
11. Childrens National researchers develop novel anti-tumor vaccine
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/5/2014)... the UTSA College of Sciences, is one of ... a two-year $300,00 National Science Foundation (NSF) Early ... supports President Obama,s BRAIN Initiative, a federal effort ... will demystify complex brain processes. , According ... into the interactions of multiple components, each working ...
(Date:11/4/2014)... (Philadelphia, PA) – Temple University School of Medicine ... Explorations winner, an initiative funded by the Bill ... MPH, Professor of Obstetrics, Gynecology and Reproductive Sciences; ... at Temple University School of Medicine will pursue ... titled "Maternal Blood Biomarkers to Assess Fetal Neurodevelopment.", ...
(Date:11/4/2014)...   Neurotechnology , a provider of high-precision ... version of its fingerprint matching algorithm has achieved ... evaluation organized by NIST. The MINEX test measures ... 378 fingerprint standard template format. MINEX compliance is ... the United States and ...
Breaking Biology News(10 mins):UTSA biology professor awarded $300,000 NSF grant for brain research 2UTSA biology professor awarded $300,000 NSF grant for brain research 3Temple University School of Medicine receives Grand Challenges Explorations grant 2Neurotechnology Places Second in Ongoing MINEX Ranking for Fingerprint Matching Algorithms 2Neurotechnology Places Second in Ongoing MINEX Ranking for Fingerprint Matching Algorithms 3
... to the obesity puzzle, showing how and why a certain ... brain contributes to weight gain. This research appeared today in ... his team in the Institute,s Molecular Genetics Department made the ... to lack this protein, called protein tyrosine phosphatase epsilon (PTPe, ...
... A group of 12 biology educators at US ... in the May issue of BioScience ... teaching of ecology conducted at these institutions. ... to continental-scale observations, argues that better coordination of ...
... predator to an ecosystem can produce dramatic changes in the ... observed the same dynamics in the fossil record, thanks to ... ago. What was bad for fish was good for ... Proceedings of the National Academy of Sciences . Researchers ...
Cached Biology News:Weizmann Institute scientists discover: A protein that contributes to obesity 2The winners of mass extinction: With predators gone, prey thrives 2The winners of mass extinction: With predators gone, prey thrives 3
(Date:11/18/2014)... pH measurement and control is vital in a ... food and beverage industries. But what exactly is pH, ... sensors work? METTLER TOLEDO has produced a guide to ... these questions and more. , METTLER TOLEDO provides a ... The actual sensor, the pH electrode, is therefore the ...
(Date:11/18/2014)... American Process Inc. (Atlanta, GA) and ... with researchers at Georgia Institute of Technology, Clark ... USDA’s Forest Products Laboratory to develop ultra-strong, lightweight ... a rapidly emerging high performance nanomaterial extracted from ... replace heavy steel structures within cars, such as ...
(Date:11/18/2014)... PA (PRWEB) November 18, 2014 Array ... planning and design expertise to the nation's hospitals and ... best served by those dedicating their careers to the ... a respected contributor in her respective field, Laura Silvoy ... expertise at the 2014 Winter Simulation Conference. , ...
(Date:11/18/2014)...  Great Basin Scientific, Inc. (NASDAQ: GBSN ), ... host a conference call and webcast to provide an update ... 20, at 4:30 pm EST time. "We are ... recent IPO and would like to provide our investors with ... Ashton , President and Chief Executive Officer of Great Basin ...
Breaking Biology Technology:pH Guide from METTLER TOLEDO Explains Measurement, Theory and Practice of pH Applications 2American Process Inc. Announces Partnership to Develop Ultra-Strong, Lightweight Automotive Components Using Nanotechnology from Nature 2American Process Inc. Announces Partnership to Develop Ultra-Strong, Lightweight Automotive Components Using Nanotechnology from Nature 3Array Healthcare Simulation Expert Slated to Speak at Winter Simulation Conference 2Great Basin Scientific Announces Conference Call to Provide Update on Corporate Progress 2
... SAFC(R), a member of the,Sigma-Aldrich(TM) Group ... plans to begin,construction of a new cGMP ... its Pharma sector,s St. Louis manufacturing campus.,This ... substance requirements,that demand a combination of small ...
... Inc. (Other,OTC: BMXSF), is pleased to announce the ... 2007. BioMaxx Systems has been extremely,pleased with the ... of,our involvement with Bioenergy Australia. Bioenergy Australia is ... promote renewable,energy solutions. Dr. Stephen Schuck, the ...
... WASHINGTON, Oct. 1 Today a promising young,scholar ... Mexico, accepted,the Manuel Velasco-Suarez Award in Bioethics for ... field of bioethics in Latin America during,the 27th ... Naftolin, a trustee of the Pan American Health ...
Cached Biology Technology:SAFC Supports Potent API Conjugate Manufacturing With New St. Louis Production Suite 2SAFC Supports Potent API Conjugate Manufacturing With New St. Louis Production Suite 3Biomaxx Systems Inc. Renews Membership With Bioenergy Australia 2Prestigious Bioethics Award for Scholar from Mexico 2
MOUSE ANTI PROTEIN KINASE C BETA 2 Immunogen: Protein kinase C beta 2...
Antibodies were affinity purified using epitopes specific to JLP immobilized on solid support....
... et.al. (1997) • Contains short ... biochemistry & molecular biology, arranged ... Entries give details of biochemical ... which they are involved and ...
...
Biology Products: