Navigation Links
Unprecedented control of genome editing in flies promises insight into human development, disease
Date:8/23/2013

MADISON In an era of widespread genetic sequencing, the ability to edit and alter an organism's DNA is a powerful way to explore the information within and how it guides biological function.

A paper from the University of WisconsinMadison in the August issue of the journal GENETICS takes genome editing to a new level in fruit flies, demonstrating a remarkable level of fine control and, importantly, the transmission of those engineered genetic changes across generations.

Both features are key for driving the utility and spread of an approach that promises to give researchers new insights into the basic workings of biological systems, including embryonic development, nervous system function, and the understanding of human disease.

"Genome engineering allows you to change gene function in a very targeted way, so you can probe function at a level of detail" that wasn't previously possible, says Melissa Harrison, an assistant professor of biomolecular chemistry in the UWMadison School of Medicine and Public Health and one of the three senior authors of the new study.

Disrupting individual genes has long been used as a way to study their roles in biological function and disease. The new approach, based on molecules that drive a type of bacterial immune response, provides a technical advance that allows scientists to readily engineer genetic sequences in very detailed ways, including adding or removing short bits of DNA in chosen locations, introducing specific mutations, adding trackable tags, or changing the sequences that regulate when or where a gene is active.

The approach used in the new study, called the CRISPR RNA/Cas9 system, has developed unusually fast. First reported just one year ago by scientists at the Howard Hughes Medical Institute and University of California, Berkeley, it has already been applied to most traditional biological model systems, including yeast, zebrafish, mice, the nematod
'/>"/>

Contact: Melissa Harrison
mharrison3@wisc.edu
608-262-2383
University of Wisconsin-Madison
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Genome sequencing provides unprecedented insight into causes of pneumococcal disease
2. Study by Haverford College professor reveals unprecedented impact of Deepwater Horizon on deep ocean
3. Target 2 forms of iron to control cystic fibrosis lung infection
4. Journal of Control, Automation and Electrical Systems now published by Springer
5. Natural pest control protein effective against hookworm: A billion could benefit
6. Controlling genes with light
7. Gallo Center scientists identify key brain circuits that control compulsive drinking in rats
8. Circadian rhythms control bodys response to intestinal infections, UCI-led study finds
9. Single-cell transfection tool enables added control for biological studies
10. New formula invented for microscope viewing, substitutes for federally controlled drug
11. Global Biometrics and Border Control Award for DERMALOG
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/21/2015)... 21, 2015 According to ... Solutions (Hardware, Software, Services), by Applications (Surveillance (Airborne, ... by End-Users (Military & Defense & Commercial) - ... Imaging Market is expected to grow from $7252.0 ... at a Compound Annual Growth Rate (CAGR) of ...
(Date:5/20/2015)... 20, 2015 ... announced the addition of the  "5-year ... Recognition Market"  report to their offering.  ... service analyses trends in the iris ... commercial sectors, globally. Despite hardware pricing ...
(Date:5/19/2015)... May 18, 2015 Fingerprint Cards (FPC) ... FPC1025, FPC1145, FPC1155 and FPC1035 from one if its module ... and including Q3 2015 and the sensors will be used ... order values for 2015 hereby amount to 740 MSEK to ... of 140 MSEK and a number of smaller orders not ...
Breaking Biology News(10 mins):Thermal Imaging Market Worth $9,998.9 Million by 2020 2Thermal Imaging Market Worth $9,998.9 Million by 2020 3Thermal Imaging Market Worth $9,998.9 Million by 2020 4Global Iris Recognition Market Report 2015 - 5-Year Opportunity Analysis 2Fingerprint Cards Receives Touch Fingerprint Sensor Order of SEK 230 Million and Raises Revenue Guidance for 2015 2
... research team has developed a process that removes a ... team has programmed a photosynthetic microbe to self-destruct, making ... potentially less costly. "The real costs involved ... turning them into fuel," said Roy Curtiss, director of ...
... , TORONTO, Dec. 7 ... the assets of the healthcare communications company previously operating as ... move forward under new leadership and funding. , IgeaCare Solutions ... Chief Executive Officer. Under his direction, the new company will ...
... air and water pollution along the Athabasca River and ... say pollution levels have increased as a direct result ... biological sciences professor David Schindler was part of the ... study and found high levels of Polycyclic Aromatic Compounds. ...
Cached Biology News:Self-destructing bacteria improve renewable biofuel production 2Self-destructing bacteria improve renewable biofuel production 3IgeaCare Solutions Inc. Emerges Under New Leadership and Funding 2
(Date:5/28/2015)...  Quest Diagnostics Incorporated (NYSE: DGX ), the ... it is scheduled to speak at the Jefferies 2015 ... , the company,s President and CEO, will discuss the ... is scheduled for Tuesday, June 2, 2015 at 8:00 ... webcast live during the conference and will be available ...
(Date:5/28/2015)... May 27, 2015 Research and Markets( http://www.researchandmarkets.com/research/l9dqwt/animal_genetics ... Genetics Market by Products, by Testing services - Global ... The global animal genetics market is estimated to ... at a CAGR of 8-9% during the forecast period ... mainly driven by increasing animal protein consumption, increasing adoption ...
(Date:5/28/2015)... The Academy of Model Aeronautics Foundation will ... August 15, 2015. National Model Aviation Day was created to ... model flying to the general public. , The AMA has ... in the celebration by hosting events in their own communities. ... Aviation Day events. View our online event map to ...
(Date:5/28/2015)... McKinney, Texas (PRWEB) May 28, 2015 ... products for use in applications such as animal ... fat and oil reduction in wastewater treatment plants ... be attending the World Pork Expo, June 3-5 ... earlier this year in a Wall Street Journal ...
Breaking Biology Technology:Quest Diagnostics to Speak at the Jefferies 2015 Global Healthcare Conference 2Global Animal Genetics (Canine, Equine, Poultry, Porcine, Bovine, and Genetic Material) Market 2015 - Global Forecast to 2020 2Model flying pilots celebrate the Academy of Model Aeronautics Foundation’s Third Annual National Model Aviation Day 2DryLet to Showcase Patented ManureMagic™ at the 2015 World Pork Expo, June 3-5 in Des Moines, Iowa 2
... MedCap press releases contain false and misleading ... 25 /PRNewswire-FirstCall/-- VaxGen,Inc. (OTC Bulletin Board: VXGN.OB), ... ), Dear Stockholders, On March ... stockholder in,VaxGen, issued a press release entitled ...
... BEIJING, March 25 /Xinhua-PRNewswire/ -- Sinovac Biotech Ltd. (Amex:,SVA), ... that its,Annual General Meeting originally scheduled for March 25, ... the March 25, 2008 Annual General Meeting, the required ... present. In accordance with,Antigua law, the meeting is adjourned ...
... N.J., March 24 Osteotech, Inc.,(Nasdaq: OSTE ... biologic solutions for,regenerative medicine, announced today that the ... validity of its U.S. Patent No.,5,676,146. The ,146 ... demineralized bone, with a radiopaque material, such as ...
Cached Biology Technology:VaxGen Issues Rebuttal to MedCap Letter 2VaxGen Issues Rebuttal to MedCap Letter 3VaxGen Issues Rebuttal to MedCap Letter 4VaxGen Issues Rebuttal to MedCap Letter 5VaxGen Issues Rebuttal to MedCap Letter 6VaxGen Issues Rebuttal to MedCap Letter 7VaxGen Issues Rebuttal to MedCap Letter 8VaxGen Issues Rebuttal to MedCap Letter 9VaxGen Issues Rebuttal to MedCap Letter 10VaxGen Issues Rebuttal to MedCap Letter 11Sinovac Announces Adjournment of Annual General Meeting 2U.S. Patent Office Confirms Validity of Osteotech's U.S. Patent No. 5,676,146 2
Anti-MMP-25 (Membrane-type MMP-6, Mt6MMP), hinge region; rabbit host...
Anti-MMP-25 (Membrane-type MMP-6, Mt6MMP), hinge region; rabbit host...
Desmosomal Protein Immunogen: Full length, native protein purified from human epidermal keratins. Storage: -20 C, Avoid Freeze/Thaw Cycles...
D4-GDI rabbit polyclonal antibody...
Biology Products: