Navigation Links
Unlocking the genetics and biology of ankylosing spondylitis
Date:7/10/2011

netic regions, the first time that associations have been found in HLA-B27 negative individuals. These findings indicate considerable similarity between the way HLA-B27 positive and negative ankylosing spondylitis develop.

Professor Matt Brown from the University of Queensland, Australia, says: "Our work shows the great value of partnering genetics research with functional investigations to determine the basic biology which leads to common diseases such as ankylosing spondylitis, the causes of which have remained an enigma for so long.

"At the moment, whilst we have effective treatments to suppress the inflammation in ankylosing spondylitis, we have no treatment to substantially improve its long-term outcome, particularly the chronic pain, marked loss of movement and disability and that are common consequences of this disease. We must be cautious about the promise that these findings offer, but they are a promising step in the right direction."

Professor Alan Silman, Medical Director of Arthritis Research UK , which funded the preliminary work for the genetics research said the study was important, but added that it needed to be followed up before its significance could be measured clinically. "We're supporting further intensive work needed to investigate whether these genetic targets could offer scope for novel treatment approaches," he said.

Debbie Cook, Director of The National Ankylosing Spondylitis Society (UK) added: "We are delighted with the results of these genetic studies in ankylosing spondylitis which will help us to understand the causes of the disease better, and hopefully to develop new ideas about its treatment. Our members have been heavily involved in these studies with scientists at the University of Oxford over the past 10 years and it is good to see the progress that has been made. It has long been recognised that there is a genetic element to the condition and that it has a tendency to run in families. The
'/>"/>

Contact: Craig Brierley
c.brierley@wellcome.ac.uk
44-207-611-7329
Wellcome Trust
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. Unlocking the secret(ase) of building neural circuits
2. Unlocking the secrets of a plants light sensitivity
3. Unlocking the secrets of a plant’s light sensitivity
4. Unlocking the secrets of RNA biology with WIREs
5. Unlocking the opium poppys biggest secret
6. Unlocking mysteries of the brain with PET
7. Unlocking the secret of the bladders bouncers
8. Adult stem cells carry their own baggage: Epigenetics guides stem cell fate
9. Genetics of melanoma chemoresistance
10. Population genetics reveals shared ancestries
11. MARC travel awards announced for GSA Mouse Genetics Conference
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/23/2014)... Ill. Antarctic fishes that manufacture their own ... Ocean also suffer an unfortunate side effect, researchers ... their bodies resist melting even when temperatures warm. ... Proceedings of the National Academy of Sciences ... an undesirable consequence of the evolution of antifreeze ...
(Date:9/23/2014)... has domesticated animals, selecting the best traits possible ... an intriguing animal to examine adaptation to climate ... selected breeding and a wealth of livestock genome-wide ... study that combined molecular and environmental data, professor ... genes under environmental selection from domesticated sheep breeds. ...
(Date:9/23/2014)... successful rise and fall of an athlete,s moving body relies ... putting the many angles and intersecting planes literally the ... to the test. But it,s more than just a footfall ... of sports injuries: the ACL or anterior cruciate ligament tear. ... at the center of the knee joint and volume ...
Breaking Biology News(10 mins):Study: Antifreeze proteins in Antarctic fishes prevent freezing ... and melting 2Study: Antifreeze proteins in Antarctic fishes prevent freezing ... and melting 3Being sheepish about climate adaptation 2Does size matter? MRI imaging sheds light on athletes most at risk for severe knee injury 2Does size matter? MRI imaging sheds light on athletes most at risk for severe knee injury 3
... in 100 inhabitants died from Spanish flu in 1918, but ... An important explanation for the differences is due to different ... came. Those living in urban communities probably had a higher ... in 1918 than those living in very isolated rural areas. ...
... other businesses step up efforts to cut waste, reduce ... products and processes, the number of planet-friendly standards and ... a sometimes-confusing array of options for "going green." National ... a framework to help organizations of all types sort ...
... Article highlights from the May issue of The American Naturalist ... a second, Genes control fruit flies, social groupings, What can twins ... issue table of contents, go to www.journals.uchicago.edu/an . ... kstacey@press.uchicago.edu . Cuttlefish: From camo to tuxedo ...
Cached Biology News:Large differences in mortality between urban and isolated rural areas 2Large differences in mortality between urban and isolated rural areas 3NIST prototypes framework for evaluating sustainability standards 2Tipsheet for the May issue of the American Naturalist 2Tipsheet for the May issue of the American Naturalist 3
(Date:9/23/2014)... Carolina (PRWEB) September 24, 2014 Spirax ... trap constructed to withstand corrosion from clean and ... ASME standards and is designed to remove condensate from ... ideal for the pharmaceutical, biotechnology, and food and beverage ... to steam saturation temperatures, reducing condensate back up and ...
(Date:9/23/2014)... University of Texas at Austin and Northwestern University ... reliability and performance of transistors and circuits based ... has long been considered by scientists as one ... smaller, faster and cheaper electronic devices. The result ... journal Applied Physics Letters , from AIP ...
(Date:9/23/2014)... the University of Southampton,s Optoelectronics Research Centre (ORC) ... potential challenger to graphene. , Graphene, a single ... is increasingly being used in new electronic and ... sources, thanks to the unprecedented properties it offers: ... mechanically stretchable yet harder than diamond. , Now, ...
(Date:9/23/2014)... ceramics have potential uses as ferroelectrics, fast ion ... waste, generating a great deal of scientific interest ... blended materials. , "The interfaces separating the different ... properties of the material as a whole," said ... on the project. "It is in the chemical ...
Breaking Biology Technology:Spirax Sarco Announces the BTS7.1 Stainless Steel Clean Steam Trap 2Future flexible electronics based on carbon nanotubes 2Future flexible electronics based on carbon nanotubes 3Future flexible electronics based on carbon nanotubes 4Southampton scientists grow a new challenger to graphene 2Los Alamos researchers uncover properties in nanocomposite oxide ceramics for reactor fuel 2
... Calif., Feb. 6 Onyx,Pharmaceuticals, Inc. (Nasdaq: ... the BIO CEO & Investor Conference on Wednesday, ... may access a live webcast of the,presentation at:, ... log on 15 minutes early in order to,register ...
... Avatar Software Platform Further Solidifies Netsmart as Leader in Behavioral ... ... Florida, GREAT RIVER, N.Y., Feb. 6 Netsmart Technologies, ... services organizations, today announced it has signed a contract to,provide comprehensive ...
... Global Probiotics Council,(GPC), a committee established in 2004 ... the Young Investigator Grant for probiotics research,program (YIGPRO) ... stimulate,innovative research and to support young investigators and ... field of probiotics and gut,microbiota., "Our two ...
Cached Biology Technology:Netsmart Technologies Extends Relationship with Manatee Glens for Enterprise Behavioral Health Software Solutions 2Netsmart Technologies Extends Relationship with Manatee Glens for Enterprise Behavioral Health Software Solutions 3Global Probiotics Council Announces Young Investigator Grant for Probiotics Research to Fund the Next Generation of Gut Microbiota Research 2Global Probiotics Council Announces Young Investigator Grant for Probiotics Research to Fund the Next Generation of Gut Microbiota Research 3Global Probiotics Council Announces Young Investigator Grant for Probiotics Research to Fund the Next Generation of Gut Microbiota Research 4
Umbilical cord blood CD4+ T cells, For immunohistochemistry (IHC) Cell Chip with Human Umbilical Cord Blood MNCs and T Cells...
Human peripheral blood CD14+ monocytes, For immunohistochemistry (IHC) Cell Chip with Human Peripheral Blood Monocytes, B Cells, NK Cells and Stem Cells...
Human endothelial progenitor cells, For immunohistochemistry (IHC) Cell Chip with Human Peripheral Blood Dendritic Cells and EPCs...
Yeast tRNA 50 l...
Biology Products: