Navigation Links
Unlocking the genetics and biology of ankylosing spondylitis
Date:7/10/2011

netic regions, the first time that associations have been found in HLA-B27 negative individuals. These findings indicate considerable similarity between the way HLA-B27 positive and negative ankylosing spondylitis develop.

Professor Matt Brown from the University of Queensland, Australia, says: "Our work shows the great value of partnering genetics research with functional investigations to determine the basic biology which leads to common diseases such as ankylosing spondylitis, the causes of which have remained an enigma for so long.

"At the moment, whilst we have effective treatments to suppress the inflammation in ankylosing spondylitis, we have no treatment to substantially improve its long-term outcome, particularly the chronic pain, marked loss of movement and disability and that are common consequences of this disease. We must be cautious about the promise that these findings offer, but they are a promising step in the right direction."

Professor Alan Silman, Medical Director of Arthritis Research UK , which funded the preliminary work for the genetics research said the study was important, but added that it needed to be followed up before its significance could be measured clinically. "We're supporting further intensive work needed to investigate whether these genetic targets could offer scope for novel treatment approaches," he said.

Debbie Cook, Director of The National Ankylosing Spondylitis Society (UK) added: "We are delighted with the results of these genetic studies in ankylosing spondylitis which will help us to understand the causes of the disease better, and hopefully to develop new ideas about its treatment. Our members have been heavily involved in these studies with scientists at the University of Oxford over the past 10 years and it is good to see the progress that has been made. It has long been recognised that there is a genetic element to the condition and that it has a tendency to run in families. The
'/>"/>

Contact: Craig Brierley
c.brierley@wellcome.ac.uk
44-207-611-7329
Wellcome Trust
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. Unlocking the secret(ase) of building neural circuits
2. Unlocking the secrets of a plants light sensitivity
3. Unlocking the secrets of a plant’s light sensitivity
4. Unlocking the secrets of RNA biology with WIREs
5. Unlocking the opium poppys biggest secret
6. Unlocking mysteries of the brain with PET
7. Unlocking the secret of the bladders bouncers
8. Adult stem cells carry their own baggage: Epigenetics guides stem cell fate
9. Genetics of melanoma chemoresistance
10. Population genetics reveals shared ancestries
11. MARC travel awards announced for GSA Mouse Genetics Conference
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/28/2015)... , May 28, 2015 Industry analyst ... a new report titled "Markets for Self-Healing Materials: ... inorganic capsule and vascular systems, biomaterials, relevant shape ... to around $2.7 billion by 2020. ... extensive coverage of smart materials. Other recent n-tech reports ...
(Date:5/27/2015)... 27, 2015   Codonics (codonics.com), ... and image documentation solutions and Omnicell ... automation solutions, is pleased to announce their ... Safe Label System® (SLS), an award-winning FDA ... the Omnicell Anesthesia Workstation, helps prevent medication ...
(Date:5/26/2015)... Research and Markets ( ... "Saudi Arabia Biometric Systems Market Forecast and ... (Logo: http://photos.prnewswire.com/prnh/20130307/600769) , ,The biometric systems market in ... to grow at over 22% CAGR through 2020 ... the surging demand for better biometric technologies in ...
Breaking Biology News(10 mins):The Market for Self-Healing Materials to Reach $2.7 Billion by 2020 Says New n-tech Research Study 2The Market for Self-Healing Materials to Reach $2.7 Billion by 2020 Says New n-tech Research Study 3Codonics and Omnicell Expand Partnership 2Codonics and Omnicell Expand Partnership 3Codonics and Omnicell Expand Partnership 4Saudi Arabia Biometric Systems Market Forecast and Opportunities, 2020 with Morpho Safran, ZK Technlogy, and Suprema Dominating 2
... A new study investigating the respiratory system of insects ... for decades: why insects routinely stop breathing for minutes ... UC Irvine and Humboldt University propose that insects such ... beetles and bugs close off their respiratory systems periodically ...
... a stunning example of evolution at work, scientists have now ... changes in the skeletal armor of fish living in the ... 2005, issue of journal Science, bring new data to long-standing ... motivation is to try to understand how new animal types ...
... accustomed to nesting on islands free of predators began ... in the Aleutian archipelago in the 18th century. The ... study published this week in the journal Science now ... through entire island ecosystems, transforming the vegetation from lush ...
Cached Biology News:Why do insects stop 'breathing'? To avoid damage from too much oxygen, say researchers 2Why do insects stop 'breathing'? To avoid damage from too much oxygen, say researchers 3Octopuses occasionally stroll around on two arms, UC Berkeley biologists report 2Octopuses occasionally stroll around on two arms, UC Berkeley biologists report 3Octopuses occasionally stroll around on two arms, UC Berkeley biologists report 4Octopuses occasionally stroll around on two arms, UC Berkeley biologists report 5Introduced foxes transformed vegetation on Aleutian Islands from lush grasslands to tundra 2Introduced foxes transformed vegetation on Aleutian Islands from lush grasslands to tundra 3Introduced foxes transformed vegetation on Aleutian Islands from lush grasslands to tundra 4
(Date:5/28/2015)... 28, 2015  Quest Diagnostics Incorporated (NYSE: DGX ... announced that it is scheduled to speak at the ... Steve Rusckowski , the company,s President and CEO, will ...  The presentation is scheduled for Tuesday, June 2, 2015 ... will be webcast live during the conference and will ...
(Date:5/28/2015)... 28, 2015 ... announced the addition of Jain PharmaBiotech,s ... Markets and Companies"  to their offering.  ... describes and evaluates animal biotechnology and ... pharmaceuticals as well as improvement in ...
(Date:5/28/2015)... , May 27, 2015 Research ... addition of Jain PharmaBiotech,s new report ... their offering. An increasing use ... industries is anticipated. Nanotechnology will be applied ... from formulations for optimal delivery to diagnostic ...
(Date:5/28/2015)... 2015 Research and Markets( http://www.researchandmarkets.com/research/l9dqwt/animal_genetics ) has ... by Products, by Testing services - Global Forecast to ... global animal genetics market is estimated to be worth ... CAGR of 8-9% during the forecast period of 2014 ... by increasing animal protein consumption, increasing adoption of advanced ...
Breaking Biology Technology:Quest Diagnostics to Speak at the Jefferies 2015 Global Healthcare Conference 2Global Animal Biotechnology Report 2015 - Technologies, Markets and Companies Analysis to 2024 2Global Animal Biotechnology Report 2015 - Technologies, Markets and Companies Analysis to 2024 3Global Nanobiotechnology Market 2015-2024 - Applications, Markets and Companies 2Global Nanobiotechnology Market 2015-2024 - Applications, Markets and Companies 3Global Animal Genetics (Canine, Equine, Poultry, Porcine, Bovine, and Genetic Material) Market 2015 - Global Forecast to 2020 2
... plant-derived insulin program, scheduled to enter the ... SBS, CALGARY, July 29 /PRNewswire-FirstCall/ - SemBioSys ... of therapeutic,proteins for metabolic and cardiovascular diseases, today ... (IND) application for,safflower-produced recombinant human insulin to the ...
... American College of Chest Physicians (ACCP) Guidelines Will Increase ... Use of Trellis(R) Peripheral Infusion ... College of Chest,Physicians (ACCP) has published new evidence-based clinical ... use of pharmacomechanical,thrombolysis for acute iliofemoral deep vein thrombosis ...
... Washington, DC State and local officials have taken ... nanomaterials, a major step for a cutting-edge technology that ... , On July 28, the Cambridge (Mass.) Public ... take several steps to gain a better understanding of ...
Cached Biology Technology:SemBioSys submits IND for safflower-produced insulin to U.S. FDA 2SemBioSys submits IND for safflower-produced insulin to U.S. FDA 3Chest Physicians Now Suggest Early Intervention for Certain Blood Clots in DVT 2Local officials move toward monitoring nanotechnologies 2Local officials move toward monitoring nanotechnologies 3
Rabbit polyclonal to Staphylococcus Enterotoxin A (HRP) ( Abpromise for all tested applications)....
... SigmaStat 3.5 is a user-friendly statistical ... allows them to perform statistical analysis without ... questions about your data and research and ... your data against the tests underlying assumptions ...
... Novexin offers bespoke, cost-effective solutions for complex protein ... extensive expertise and experience to help you develop a ... , , ... , transfer all methodology ...
... ChemiLucent™ Plus is a chemiluminescent ... used independently to boost the signal ... blot detection kits. ChemiLucent™ Plus is ... technology. Unlike conjugated complex- or chemiluminescent ...
Biology Products: