Navigation Links
Unlocking the genetics and biology of ankylosing spondylitis
Date:7/10/2011

rlying the condition, the findings also strengthen evidence that a particular process by which signals are transmitted within cells known as the IL-23R pathway is involved in the disorder and could be a target for drugs.

The study also provided clues as to why a particular genetic variant known as HLA-B27 is associated with the disease. Scientists have known for almost forty years that this variant significantly increases the risk of developing the disease. Nine out of ten people with ankylosing spondylitis carry the variant. Whilst not everyone with the variant develops the condition, those who carry the variant are up to eighty times more likely to develop it than non-carriers. Yet despite this knowledge, the mechanism by which the variant causes the disease is still unknown.

The researchers found that variants of the gene ERAP1 interact with HLA-B27 to affect disease susceptibility one of the first confirmed examples of gene-gene interaction seen in humans. For individuals who carry HLA-B27, their risk of developing ankylosing spondylitis decreases by a factor of four if they also carry two copies of the protective variants of ERAP1.

ERAP1 plays a role in breaking down proteins within the body into smaller molecules known as peptides. The gene interacts with HLA-B27 to affect how these peptides are presented to the immune system. This is an essential process for mounting an immune response to invading pathogens, but when it goes awry it can result in the immune system causing inflammation and damaging tissue. The researchers found that some variants of ERAP1 protect against the development of ankylosing spondylitis by reducing the amount of peptide available to HLA-B27 within cells. The researchers believe that inhibiting ERAP1 may help treat the condition.

The researchers also analysed the genetic make-up of individuals with ankylosing spondylitis who did not carry the HLA-B27 variant and found associations with several ge
'/>"/>

Contact: Craig Brierley
c.brierley@wellcome.ac.uk
44-207-611-7329
Wellcome Trust
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. Unlocking the secret(ase) of building neural circuits
2. Unlocking the secrets of a plants light sensitivity
3. Unlocking the secrets of a plant’s light sensitivity
4. Unlocking the secrets of RNA biology with WIREs
5. Unlocking the opium poppys biggest secret
6. Unlocking mysteries of the brain with PET
7. Unlocking the secret of the bladders bouncers
8. Adult stem cells carry their own baggage: Epigenetics guides stem cell fate
9. Genetics of melanoma chemoresistance
10. Population genetics reveals shared ancestries
11. MARC travel awards announced for GSA Mouse Genetics Conference
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/21/2014)... the eve of United Nations General Assembly events focussed ... mothers, newborns and children, Grand Challenges Canada, funded by ... grants for 22 bold ideas to address this challenge. ... A program for Bangladeshi mothers working in garment factories ... improving infant nutrition, reducing absenteeism due to child illnesses, ...
(Date:9/21/2014)... the main contributor to global warming, are set to rise ... billion tonnes. , The 2.5 per cent projected rise in ... which is co-led in the UK by researchers at the ... East Anglia and the College of Engineering, Mathematics and Physical ... of the New York Climate Summit, where world leaders will ...
(Date:9/21/2014)... thought, newborn immune T cells may have the ability ... a new study led by King,s College London. Although ... adults, babies may still be able to mount a ... journal Nature Medicine . , Our immune system ... cells, including neutrophils which play an important role in ...
Breaking Biology News(10 mins):Canada funds 22 innovative projects to help save 'Every Woman, Every Child' 2Canada funds 22 innovative projects to help save 'Every Woman, Every Child' 3Canada funds 22 innovative projects to help save 'Every Woman, Every Child' 4Canada funds 22 innovative projects to help save 'Every Woman, Every Child' 5Canada funds 22 innovative projects to help save 'Every Woman, Every Child' 6Canada funds 22 innovative projects to help save 'Every Woman, Every Child' 7Canada funds 22 innovative projects to help save 'Every Woman, Every Child' 8Canada funds 22 innovative projects to help save 'Every Woman, Every Child' 9Canada funds 22 innovative projects to help save 'Every Woman, Every Child' 10Canada funds 22 innovative projects to help save 'Every Woman, Every Child' 11Canada funds 22 innovative projects to help save 'Every Woman, Every Child' 12Canada funds 22 innovative projects to help save 'Every Woman, Every Child' 13Canada funds 22 innovative projects to help save 'Every Woman, Every Child' 14Canada funds 22 innovative projects to help save 'Every Woman, Every Child' 15CO2 emissions set to reach new 40 billion ton record high in 2014 2CO2 emissions set to reach new 40 billion ton record high in 2014 3Immune system of newborn babies is stronger than previously thought 2
... a New Zealand snail and its worm parasite makes ... reproduction in the absence of parasites, say Indiana University ... this week,s Current Biology . The scientists, ... Hypothesis" of sex, which suggests sexual reproduction allows host ...
... received a $3 million grant from the National Science ... Festival and fund the creation and growth of Science ... first annual San Diego Science Festival, held March-April 2009. ... San Diego as a national and global leader in ...
... Cornell Medical Center have discovered a new gene fusion that ... results may lead to more accurate prostate cancer testing and ... -- a hybrid gene formed from two previously separated genes ... cells to grow more quickly than normal cells. The ...
Cached Biology News:Parasitic worms make sex worthwhile 2Parasitic worms make sex worthwhile 3UC San Diego's $3 million NSF grant to fund science festivals 2UC San Diego's $3 million NSF grant to fund science festivals 3Newly discovered gene fusion may lead to improved prostate cancer diagnosis 2Newly discovered gene fusion may lead to improved prostate cancer diagnosis 3
(Date:9/19/2014)... is rarely simple. From crop yields to disease risks, ... those considered "complex traits." Just as for heightthe textbook ... particular human disease are shaped by multiple genetic and ... involved. To track down such genes, geneticists typically mate ... large mouse and a small mouseand then study their ...
(Date:9/19/2014)... than electricity, to move data would consume much ... growing concern as chips, transistor counts rise. , ... light emitters, modulators, and detectors emitters ... source for optical chips is molybdenum disulfide (MoS2), ... a single, atom-thick layer. Other experimental on-chip light ...
(Date:9/19/2014)... NEW YORK , Sept. 19, 2014  An ... common forms of inherited neuropathies – Charcot-Marie-Tooth disease (CMT) ... feet and legs, causing extreme muscle atrophy, weakness, and ... in the US and millions worldwide. CMT is a ... use of their legs, requiring mobility devices such as ...
(Date:9/19/2014)... SAN FRANCISCO , Sept. 19, 2014 /PRNewswire/ ... announced results from preclinical studies characterizing the analgesic ... oral, peripherally-acting kappa opioid receptor agonist molecules. The ... molecule polymer medicinal chemistry platform. The ... described in the medical literature. 1,2 Kappa ...
Breaking Biology Technology:Want to link genes to complex traits? Start with more diversity 2Toward optical chips 2Toward optical chips 3September is Charcot-Marie-Tooth (CMT) Awareness Month - Scheduled events, activities and important partnerships announced throughout the month! 2Nektar Presents Positive Preclinical Data on Oral, Peripherally-Acting Kappa Agonist Molecules at 2014 American Academy of Pain Management Meeting 2Nektar Presents Positive Preclinical Data on Oral, Peripherally-Acting Kappa Agonist Molecules at 2014 American Academy of Pain Management Meeting 3Nektar Presents Positive Preclinical Data on Oral, Peripherally-Acting Kappa Agonist Molecules at 2014 American Academy of Pain Management Meeting 4Nektar Presents Positive Preclinical Data on Oral, Peripherally-Acting Kappa Agonist Molecules at 2014 American Academy of Pain Management Meeting 5
... and HILDEN, Germany , May 25, ... , Prime Standard:,QIA) today announced that it has entered ... pursuant to which QIAGEN has acquired all rights,to 70 ... -based specialized,laboratory center for food analysis. The transaction further ...
... Carolina Conceptions, an infertility practice in Raleigh, NC , announces IRB ... newer technology that is growing in demand. While embryo and sperm freezing have ... achieve the same level of success. , ... Unlike fertilized eggs (embryos) and sperm, which thaw well, the larger egg ...
... ... Mills is the latest company to become a tenant at the North ... partnership between David Murdock and the University of North Carolina System. ... Other tenants on the Campus include: Dole Food Inc, Monsanto, NC State ...
Cached Biology Technology:QIAGEN Acquires Comprehensive Portfolio of Molecular Food Safety Tests 2QIAGEN Acquires Comprehensive Portfolio of Molecular Food Safety Tests 3QIAGEN Acquires Comprehensive Portfolio of Molecular Food Safety Tests 4QIAGEN Acquires Comprehensive Portfolio of Molecular Food Safety Tests 5QIAGEN Acquires Comprehensive Portfolio of Molecular Food Safety Tests 6QIAGEN Acquires Comprehensive Portfolio of Molecular Food Safety Tests 7Carolina Conceptions Announces New Egg Freezing Study to Help Women Preserve their Fertility 2General Mills Joins Kannapolis Research Campus 2General Mills Joins Kannapolis Research Campus 3