Navigation Links
Unleashing the watchdog protein
Date:5/9/2013

Our structural studies show that Parkin is normally kept in check by a part of the protein that acts as a leash to restrict Parkin activity. When we made mutations in this specific 'leash' region in the protein, we found that Parkin recognized damaged mitochondria more quickly. If we can reproduce this response with a drug rather than mutations, we might be able to slow the progression of disease in Parkinson's patients."

Parkin is an enzyme in cells that attaches a small protein, ubiquitin, to other proteins to mark them for degradation. For example, when mitochondria are damaged, Parkin is switched on which leads to the clearing of the dysfunctional mitochondria. This is an important process because damaged mitochondria are a major source of cellular stress and thought to play a central role in the death of neurons in neurodegenerative diseases.

Husband and wife team, Drs. Jean-Franois Trempe and Vronique Sauv, are lead authors on the paper. Dr. Sauv led the Gehring team that used X-ray crystallography to determine the structure of Parkin. Dr. Trempe in the Fon laboratory directed the functional studies of Parkin.

"We are proud to invest in scientific excellence and to fund discovery stage research so that investigators like Dr. Gehring and Fon in Canada can test new theories and pursue promising new leads. We believe that our National Research Program plays an important role in the global search for better treatments and a cure for Parkinson's disease," says Joyce Gordon, President and CEO, Parkinson Society Canada.


'/>"/>

Contact: Anita Kar
anita.kar@mcgill.ca
514-398-3376
McGill University
Source:Eurekalert

Page: 1 2

Related biology news :

1. Pathogen turns protein into a virulence factor in 1 easy step
2. New plant protein discoveries could ease global food and fuel demands
3. Protein improves efficacy of tumor-killing enzyme
4. Rare, lethal childhood disease tracked to protein
5. National survey highlights perceived importance of dietary protein to prevent weight gain
6. Scientists discover new way protein degradation is regulated
7. Science surprise: Toxic protein made in unusual way may explain brain disorder
8. Metabolic fingerprinting: Using proteomics to identify proteins in gymnosperm pollination drops
9. AACR news: Six2 homeoprotein allows breast cancer cells to detach and metastasize
10. A proteins well-known cousin sheds light on its gout-linked relative
11. Mechanism of mutant histone protein in childhood brain cancer revealed
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/12/2015)... 2015 NXT-ID, Inc. (NASDAQ: NXTD ... authentication company focused on the growing mobile commerce market, ... for DISTRIBUTED METHOD AND SYSTEM TO IMPROVE ... further establishes NXT-ID,s position in the emerging "Internet of ... ability for multiple devices to collaborate with one another ...
(Date:2/5/2015)... PARK, N.C. , Feb. 5, 2015  Marken ... specialist logistics company and has launched a new marketing ... Clinical Logistics Organization (CLO).  The new campaign focuses on ... on patient, protocol and shipments. The first ... , aligns Marken,s priorities with its client,s priorities. ...
(Date:2/5/2015)... 28, 2015 NXT-ID, Inc. (NASDAQ: ... biometric authentication company focused on the growing mobile commerce ... Global Online CEO Conference on January 29 th ... Pereira , CEO of NXT-ID will present and host ... Wocket smart wallet and its full suite of biometric ...
Breaking Biology News(10 mins):NXT-ID Patents Collaborative Services to Enable the "Internet of Things" 2NXT-ID Patents Collaborative Services to Enable the "Internet of Things" 3Marken Launches New Patient-Centric Campaign 2CEO of NXT-ID, Inc. to Discuss Company's Biometric Technologies at RedChip Online Conference January 29th 2CEO of NXT-ID, Inc. to Discuss Company's Biometric Technologies at RedChip Online Conference January 29th 3
... animals living in the deep sea, it seems that there ... conditions, it,s generally best to be transparent. But in the ... function as searchlights, it,s much better to go in darker ... November 10 in Current Biology , a Cell Press ...
... The hermaphroditic cleaner shrimp Lysmata amboinensis usually ... structure. New research published in BioMed Central,s open access journal ... any group larger than two, viciously attack and kill each ... amboinensis are protandric simultaneous hermaphrodites. This means that they ...
... November 10, 2011 ─ (BRONX, NY) ─ Researchers ... Medicine of Yeshiva University have uncovered a mechanism that ... could have implications for human health and disease and ... journal Cell . A fundamental question ...
Cached Biology News:For deep-sea cephalopods, 'switchable' camouflage saves the day 2Violent passions jealous cleaner shrimp murder their rivals 2Einstein researchers discover key to cell specialization 2
(Date:3/5/2015)... and TORONTO , March 5, 2015 ... clinical-stage company developing new therapeutics and molecular diagnostics that ... William G. Rice , Ph.D., Chairman, President and ... Annual ROTH Conference on Tuesday, March 10 th ... Laguna Niguel, CA. Dr. Rice ...
(Date:3/5/2015)... SAN DIEGO , March 5, 2015  In ... Marketwired in Miami, FL on ... company are both of strong financial health and their ... as clinical research has indicated. Furthermore, Impeto prefers to have ... There are more than 40 articles written ...
(Date:3/5/2015)... 05, 2015 RMI ... chronic orthopedic conditions such as meniscal tears, ACL ... and joint pain due to degenerative conditions like ... orthopedic surgeries to promote better post-surgical outcomes. , ... nearly pain-free bone marrow harvesting with two complimentary ...
(Date:3/4/2015)... 2015 The UPMC Center for Health Security ... the Emerging Leaders in Biosecurity Initiative (ELBI). As part ... field of biosecurity, UPMC has selected 28 US and ... of backgrounds, including biological science, medicine, policy, the military, ... "With the vision and support of the Defense Threat ...
Breaking Biology Technology:Aptose Biosciences to Present at the 27th Annual ROTH Conference 2Aptose Biosciences to Present at the 27th Annual ROTH Conference 3Impeto Medical Responds to Published Allegations by LD Technology LLC ("LD") 2Riordan-McKenna Institute of Regenerative Orthopedics and Stem Cell Therapy Announces Open House in Southlake, Texas on Friday, March 6th from 5:30 pm to 7:30 pm. 2Riordan-McKenna Institute of Regenerative Orthopedics and Stem Cell Therapy Announces Open House in Southlake, Texas on Friday, March 6th from 5:30 pm to 7:30 pm. 3Riordan-McKenna Institute of Regenerative Orthopedics and Stem Cell Therapy Announces Open House in Southlake, Texas on Friday, March 6th from 5:30 pm to 7:30 pm. 4Riordan-McKenna Institute of Regenerative Orthopedics and Stem Cell Therapy Announces Open House in Southlake, Texas on Friday, March 6th from 5:30 pm to 7:30 pm. 5UPMC Center for Health Security Announces 2015 Emerging Leaders in Biosecurity 2UPMC Center for Health Security Announces 2015 Emerging Leaders in Biosecurity 3
... , , , , 7.6.5 PCR "Fingerprinting" ... and cooling rates, which can be programmed as desired with , each ... temperature. , , With the RAPD-PCR ... necessary to heat , up carefully after annealing. , ...
... , , , , , 7.6.4 ... increment, which can be programmed as desired with every temperature , command, enables ... each cycle. , , With Long PCR, ... extension of the , elongation. , , ...
... , , , , , ... Brinkmann Instruments Inc., Westbury, New York , , ... , Perhaps the most critical parameter for successful , ... primer can result in a PCR reaction that will not work. The ...
Cached Biology Technology:General Notes on Primer Design in PCR* 2General Notes on Primer Design in PCR* 3General Notes on Primer Design in PCR* 4General Notes on Primer Design in PCR* 5General Notes on Primer Design in PCR* 6
The Programmable MP-5000P-F Power Supply can be applied for any Microfluidic application....
...
Handy 100V Power Supply is Low-cost, compact and lightweight. Easy to operate - either 50 or 100 VDC is selectable as the output voltage. These voltages are sufficient for ordinary electrophoresis....
... Science Smart Minis 150V power supply (Cat. ... power supplies designed to meet most electrophoresis ... use unit. The Minis 150V power supply ... Minis Power Supply is designed for individuals ...
Biology Products: