Navigation Links
University of Toronto biologists predict extinction for organisms with poor quality genes
Date:4/16/2012

TORONTO, ON Evolutionary biologists at the University of Toronto have found that individuals with low-quality genes may produce offspring with even more inferior chromosomes, possibly leading to the extinction of certain species over generations.

A study published in Proceedings of the National Academy of Sciences (PNAS) predicts that organisms with such genetic deficiencies could experience an increased number of mutations in their DNA, relative to individuals with high-quality genes. The research was done on fruit flies whose simple system replicates aspects of biology in more complex systems, so the findings could have implications for humans.

"Mutations play a key role in cancer and other health problems affecting humans and other species," says Nathaniel Sharp, PhD candidate in U of T's Department of Ecology & Evolutionary Biology (EEB) and lead author of the study. "Our research suggests that the problem is likely to compound over time, leading to a mutational meltdown that may devastate endangered populations, and increase the risk of health problems in families in poor condition."

Sharp and EEB professor Aneil Agrawal examined the accumulation of mutations in the fruit fly Drosophila melanogaster, the genes of which are arranged on three major chromosomes. To manipulate genetic quality, they introduced harmful mutations onto the fly's third chromosome. They then observed how the presence of these mutations affected the fitness of the second chromosome over 46 generations.

"Copies of chromosome two maintained in strains with poor-quality copies of chromosome three declined in fitness two to three times faster than those with good copies of chromosome three, suggesting that poor genetic quality elevates the mutation rate," says Sharp. While the underlying mechanism remains unknown, it could be tied to how an affected individual is less capable of repairing DNA or is more susceptible to DNA damage.

'/>"/>
Contact: Sean Bettam
s.bettam@utoronto.ca
416-946-7950
University of Toronto
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Rice University establishes National Corrosion Center
2. Case Western Reserve University researchers track Chernobyl fallout
3. Case Western Reserve University project ties soil conservation and river management together
4. Brown University and Women & Infants Hospital expand national childrens study to Bristol County
5. NIH selects Case Western Reserve University to participate in National Childrens Study
6. US Senate confirms Clemson University engineering Dean Esin Gulari to National Science Board
7. University professor stresses links between US Navy sonar and whale strandings
8. Scent on demand: Hebrew University scientists enhance the scent of flowers
9. University success at national engineering awards
10. University of Leicester professor adds new perspective to rainforest debate
11. Providing toilets, safe water is top route to reducing world poverty: UN University
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
University of Toronto biologists predict extinction for organisms with poor quality genes
(Date:12/11/2014)... Research and Markets , ... http://www.researchandmarkets.com/research/twhjll/biometrics_market ) has announced the addition of the ...  report to their offering. One ... in technology. With continuous advances in technology, it ... latest standard that meets the needs and expectations ...
(Date:12/11/2014)... 2014  Data Sciences International (DSI), the global ... new series of digital telemetry implants to meet ... series, part of the PhysioTel™ Digital platform, was ... physiologic data when incorporating functional endpoints into repeat-dose ... toxicology studies has evolved from short ECG strips ...
(Date:12/10/2014)... WINSTON-SALEM, N.C. , Dec. 9, 2014  Wake Forest ... medical education building for its School of Medicine. Funding ... a larger capital campaign that will be publicly launched ... will be located in the former 60 series R.J. ... Forest Innovation Quarter. Construction will begin immediately with plans ...
Breaking Biology News(10 mins):Biometrics Market in the APAC Region 2015-2019: Key Vendors are 3M Cogent, NEC, Safran and Suprema 2New telemetry implants expected to change how large animal toxicology studies are conducted 2Wake Forest Baptist to Build New Medical Education Facility In Wake Forest Innovation Quarter 2Wake Forest Baptist to Build New Medical Education Facility In Wake Forest Innovation Quarter 3Wake Forest Baptist to Build New Medical Education Facility In Wake Forest Innovation Quarter 4
... time, completely characterized an important chemical reaction that is critical ... team,s results indicate that computer models may be underestimating ozone ... (smoggy days) by as much as five to 10 percent. ... animals and plants; is the primary ingredient of smog; and ...
... Boulder, CO, USA - The meters-long, carnivorous "shrimp" from hell ... ago may have been a real softy, it turns out. A ... with evidence that these parts were not hard like teeth, but ... on the hard shells of trilobites and other such creatures of ...
... gut bacteria harbouring antibiotic resistance genes for up to ... latest issue of Microbiology , published on 3 ... the chances of resistance genes being surrendered to pathogenic ... effects of antibiotic therapy are more significant than previously ...
Cached Biology News:Study improves accuracy of models for predicting ozone levels in urban areas 2Study improves accuracy of models for predicting ozone levels in urban areas 3Study improves accuracy of models for predicting ozone levels in urban areas 4Earth's first great predator wasn't 2Antibiotics have long-term impacts on gut flora 2
(Date:12/22/2014)... VANCOUVER , Dec. 22, 2014 /PRNewswire/ - RepliCel ... stage regenerative medicine company focused on the development of ... paper out of the University of Calgary in conjunction ... North Carolina, which further validates the company,s ongoing clinical ... the effects of pattern baldness. The paper ...
(Date:12/22/2014)... December 22, 2014 ITRA Global, one ... occupiers of commercial real estate, has further expanded its ... in Perth and Brisbane, Western Australia, reports Mylinda Vick, ... , ITRA Global / ACORPP (Australian Corporate Property ... consultancy company providing property services to a wide range ...
(Date:12/19/2014)... Naurex Inc., a biopharmaceutical company leveraging its ... the central nervous system, today announced that Norbert ... present at the 33 rd annual J.P. Morgan ... 3:00 p.m. PST on Tuesday, January 13, 2015, at ... Calif. About Naurex Inc. ...
(Date:12/19/2014)... 2014 BioPlus Specialty Pharmacy ... pharmacies, has an expanded team of Regional Pharmaceutical ... for prescriber offices in their regions, with specific ... have a variety of Regional Pharmaceutical Care Liaisons ... in hepatitis C help prescribers understand all the ...
Breaking Biology Technology:Newly Released Peer-Reviewed Publication Further Validates RepliCel's Use of Dermal Sheath Cup Cells to Treat Pattern Baldness 2Newly Released Peer-Reviewed Publication Further Validates RepliCel's Use of Dermal Sheath Cup Cells to Treat Pattern Baldness 3Newly Released Peer-Reviewed Publication Further Validates RepliCel's Use of Dermal Sheath Cup Cells to Treat Pattern Baldness 4Newly Released Peer-Reviewed Publication Further Validates RepliCel's Use of Dermal Sheath Cup Cells to Treat Pattern Baldness 5ITRA Global Continues International Expansion in Perth and Brisbane, Australia 2Naurex to Present at 33rd Annual J.P. Morgan Healthcare Conference 2BioPlus Specialty Pharmacy Expands ‘Regional Pharmaceutical Care Liaison’ Team 2BioPlus Specialty Pharmacy Expands ‘Regional Pharmaceutical Care Liaison’ Team 3
... , Introduction ... Many companies claim high sensitivity for their spectrofluorometers. In their specifications, ... which results in Raman emission at 397 nm (an energy loss ... used, because the signal is red-shifted and weak, thus mimicking weak ...
... Introduction , ... all countries. The ability to produce enough crops is essential to the well-being ... can advance to higher endeavors. , <P,>Uncontrollable changes ... erosion, etc., can be detrimental to the success of a harvest. The stress ...
... Introduction , ... exposure of human hair can be quantified with fluorescence spectroscopy. This is of ... and conditioners. , , ... For customers involved in hair-care products, we performed the following evaluation using fluorescence ...
Cached Biology Technology:Wideband sensitivity of the FluoroLog-3 2Food science: increasing crop yields 2Assessing UV damage of hair 2
... The expertise that made the original Gene Pulser ... system available has been applied in the Gene ... The modular design of the Gene Pulser II ... accessory that has the widest range of settings ...
... and supplies, for 10 chips, provides ... perform protein analysis with 10 chips ... Supplied are 3 x 520 microliters ... 60 microliters Pro260 ladder (10-260 kD), ...
... and reliable automation for today's drug ... laboratories. Staccato Mini-Workstations offer the minimal ... liquid handling and material management tasks. ... Caliper's time proven CLARA™ assay development ...
...
Biology Products: