Navigation Links
University of Toronto biologists predict extinction for organisms with poor quality genes
Date:4/16/2012

TORONTO, ON Evolutionary biologists at the University of Toronto have found that individuals with low-quality genes may produce offspring with even more inferior chromosomes, possibly leading to the extinction of certain species over generations.

A study published in Proceedings of the National Academy of Sciences (PNAS) predicts that organisms with such genetic deficiencies could experience an increased number of mutations in their DNA, relative to individuals with high-quality genes. The research was done on fruit flies whose simple system replicates aspects of biology in more complex systems, so the findings could have implications for humans.

"Mutations play a key role in cancer and other health problems affecting humans and other species," says Nathaniel Sharp, PhD candidate in U of T's Department of Ecology & Evolutionary Biology (EEB) and lead author of the study. "Our research suggests that the problem is likely to compound over time, leading to a mutational meltdown that may devastate endangered populations, and increase the risk of health problems in families in poor condition."

Sharp and EEB professor Aneil Agrawal examined the accumulation of mutations in the fruit fly Drosophila melanogaster, the genes of which are arranged on three major chromosomes. To manipulate genetic quality, they introduced harmful mutations onto the fly's third chromosome. They then observed how the presence of these mutations affected the fitness of the second chromosome over 46 generations.

"Copies of chromosome two maintained in strains with poor-quality copies of chromosome three declined in fitness two to three times faster than those with good copies of chromosome three, suggesting that poor genetic quality elevates the mutation rate," says Sharp. While the underlying mechanism remains unknown, it could be tied to how an affected individual is less capable of repairing DNA or is more susceptible to DNA damage.

Fruit flies are especially useful for genetic studies such as this for the ability to screen for thousands of genes in thousands of flies much faster than in mammals. Flies are inexpensive to care for and reproduce rapidly, allowing for several generations to be studied in just a few months.

The researchers do, however, offer a more positive possible result of the process. "An elevated mutation rate under conditions of genetic or environmental stress could also accelerate adaptation to new environments," says Sharp.


'/>"/>

Contact: Sean Bettam
s.bettam@utoronto.ca
416-946-7950
University of Toronto
Source:Eurekalert  

Related biology news :

1. Rice University establishes National Corrosion Center
2. Case Western Reserve University researchers track Chernobyl fallout
3. Case Western Reserve University project ties soil conservation and river management together
4. Brown University and Women & Infants Hospital expand national childrens study to Bristol County
5. NIH selects Case Western Reserve University to participate in National Childrens Study
6. US Senate confirms Clemson University engineering Dean Esin Gulari to National Science Board
7. University professor stresses links between US Navy sonar and whale strandings
8. Scent on demand: Hebrew University scientists enhance the scent of flowers
9. University success at national engineering awards
10. University of Leicester professor adds new perspective to rainforest debate
11. Providing toilets, safe water is top route to reducing world poverty: UN University
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
University of Toronto biologists predict extinction for organisms with poor quality genes
(Date:6/3/2016)... , June 3, 2016 ... Management) von Nepal ... und Lieferung hochsicherer geprägter Kennzeichen, einschließlich Personalisierung, ... führend in der Produktion und Implementierung von ... der Ausschreibung im Januar teilgenommen, aber Decatur ...
(Date:6/2/2016)... June 2, 2016   The Weather Company , an ... Ads, an industry-first capability in which consumers will be able ... to ask questions via voice or text and receive relevant ... Marketers have long sought an advertising solution ... can be personal, relevant and valuable; and can scale across ...
(Date:6/1/2016)... -- Favorable Government Initiatives Coupled With Implementation ... to Boost Global Biometrics System Market Through 2021  ... " Global Biometrics Market By Type, By End ... - 2021", the global biometrics market is projected to ... growing security concerns across various end use sectors such ...
Breaking Biology News(10 mins):
(Date:12/5/2016)... ... December 05, 2016 , ... The ... the nation’s premier cannabis technology and application experts, Chip Baker. Chip Baker formerly ... Colorado. Over the past 30 years, Chip Baker other industry veterans have made ...
(Date:12/5/2016)... According to the new ... (Consumable, Instruments, Automated Cell Expansion System), Cells Types ... Research, Cancer, and Cell-Based Research), End-users (Biopharmaceutical and ... Revenue, Trends, Growth, Share, Size and Forecast to ... cell expansion market is expected to reach USD ...
(Date:12/5/2016)... Dec. 5, 2016 /PRNewswire/ - Resverlogix Corp. ("Resverlogix" ... independent Data and Safety Monitoring Board (DSMB) for ... cardiovascular disease (CVD) patients has completed a second ... should continue as planned without any modifications. The ... no safety or efficacy concerns were identified. The ...
(Date:12/5/2016)... 2016  Eisai Inc. announced today final results ... rufinamide, which were presented at the 2016 Annual ... from December 2-6 in Houston, Texas ... and cognitive data showed that patients who received ... tolerability profiles, cognitive development and behavior, compared to ...
Breaking Biology Technology: